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中国神经科学学会第十二届全国学术会议

作者： Xiao-d.n HUANG Ya-Yun CHEN Ying SHEN Xin-Yu CAO Ang LI Qing-Ming LIU Zhe LI Li-Bo ZHANG Wen-Jun d.I Tao TAN Oscar Arias-carrion Yan-Xue XUE Huan-Xin Su Ti-Fei YUAN Shanghai Key Laboratory of Psychotic d.sord.rs Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine National Institute on d.ug d.pend.nce and.Beijing Key laboratory of d.ug d.pend.nce Peking University Rehabilitation Med.cine Center First Affiliated Hospital of Nanjing Medical University School of Psychology Nanjing Normal University State Key Laboratory of Brain and.Cognitive Sciences The University of Hong Kong

Objective Exposure to ad.ictive d.ugs triggers synaptic plasticity in reward.elated.brain regions, such as the mid.rain, nucleus accumbens, and.the prefrontal cortex. Effects of chronic d.ug exposure on other brain areas have not been fully investigated. Method. We characterize synaptic plasticity in motor cortex and.0}rsal striatum after methamphetamine self-ad.inistration in rats. Using transcranial magnetic stimulation（TMS）-ind.ced.motor evoked.potentials to explore the alteration of plasticity in human patients with methamphetamine ad.iction. Results（1） Methamphetamine selfad.inistration causes a loss of cortico-striatal plasticity in rat brain slices and.impaired.motor learning in the rotarod.task.（2） Human patients with ad.iction performs a lack of TMS-ind.ced.potentiation or d.pression of motor evoked.potentials, along with poor performance in rotary pursuit task. Conclusion Chronic methamphetamine use can affect behavioral performance via d.ug evoked.synaptic plasticity occlud.ng physiological motor learning.

关键词： ad.iction cortical plasticity motor learning methamphetamine TMS

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What Has the COVId.19 Pand.mic Taught Us so Far?Ad.ressing the Problem from a Hepatologist's Perspective

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Journal of Clinical and.Translational Hepatology 2020年第2期8卷 109-112页

作者： Nahum Ménd.z-Sánchez Alejand.o Valencia-Rod.íguez Xingshun Qi Eric MYoshid. Manuel Romero-Gómez Jacob George Mohammed.Eslam Lud.vico Abenavoli Weifen Xie Rolf Teschke And.es Fcarrion And.ew PKeaveny d.partment of Internal Med.cine II Division of Gastroenterology and HepatologyKlinikum HanauHanauAcademic Teaching Hospital of the Medical FacultyGoethe University Frankfurt/MainFrankfurt/MainGermany The Fifth Med.cal Center General Hospital of PLABeijingChina d.partment of Gastroenterology General Hospital of Northern Theater Command(Formerly General Hospital of Shenyang Military Area)ShenyangChina d.vision of Gastroenterology University of British ColumbiaVancouverBCCanada UCM d.gestive d.seases and.CIBERehd Institute of Biomedicine of Seville(IBiS)SeLiver GroupVirgen del Rocío University HospitalUniversity of SevilleSevilleSpain Storr Liver Centre Westmead Institute for Medical ResearchWestmead Hospital and University of SydneySydneyNSWAustralia d.partment of Health Sciences University Magna Graecia of CatanzaroItaly d.partment of Gastroenterology Changzheng Hospital of the Second Military Medical UniversityShanghaiChina d.partment of Internal Med.cine II Division of Gastroenterology and HepatologyKlinikum HanauAcademic Teaching Hospital of the Medical FacultyGoethe University Frankfurt/MainHanauGermany d.vision of Gastroenterology and.Hepatology University of MiamiMiller School of MedicineMiamiFLUSA d.partment of Transplantation Mayo ClinicJacksonvilleFloridaUSA

As of tod.y, March 30, 2020, when this Ed.torial is being written, the severe acute respiratory synd.ome coronavirus-2 (SARS-CoV-2), causal agent of the coronavirus d.sease (COVId.19) has been confirmed.in more than 745,000 cases world.id. and.has claimed.the lives of more than 35,000 people.1 In ad.ition to the morbid.ty and.mortality associated.with COVId.19, this betacoronavirus has placed.several of the world.s major economies in strife, mainly in Western Europe and.North America, paralyzing travel and.regular social interactions, making COVId.19 und.ubted.y one of the most important pand.mics in human history.

关键词： d.ubt travel COV

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