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Comparing 11 early warning scores and three shock indices in early sepsis prediction in the emergency department

World Journal of Emergency Medicine 2024年第4期15卷 273-282页

作者： Rex Pui Kin Lam Zonglin Dai Eric Ho Yin Lau carrie yuen ting ip Ho Ching Chan Lingyun Zhao Tat ChiTsang Matthew Sik Hon Tsui Timothy Hudson Rainer Department of Emergency Medicine School of Clinical MedicineLi Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina School of Public Health Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Accident and Emergency Department Queen Mary HospitalHong KongChina

BACKGROUND:This study aimed to evaluate the discriminatory performance of 11 vital sign-based early warning scores(EWSs)and three shock indices in early sepsis prediction in the emergency department(ED).METHODS:We performed a retrospective study on consecutive adult patients with an infection over 3 months in a public ED in Hong *** primary outcome was sepsis(Sepsis-3 definition)within 48 h of ED *** c-statistics and the DeLong test,we compared 11 EWSs,including the National Early Warning Score 2(NEWS2),Modified Early Warning Score,and Worthing Physiological Scoring System(WPS),etc.,and three shock indices(the shock index[SI],modified shock index[MSI],and diastolic shock index[DSI]),with Systemic Inflammatory Response Syndrome(SIRS)and quick Sequential Organ Failure Assessment(qSOFA)in predicting the primary outcome,intensive care unit admission,and mortality at different time ***:We analyzed 601 patients,of whom 166(27.6%)developed ***2 had the highest point estimate(area under the receiver operating characteristic curve[AUROC]0.75,95%CI 0.70-0.79)and was significantly better than SIRS,qSOFA,other EWSs and shock indices,except WPS,at predicting the primary ***,the pooled sensitivity and specificity of NEWS2≥5 for the prediction of sepsis were 0.45(95%CI 0.37-0.52)and 0.88(95%CI 0.85-0.91),*** discriminatory performance of all EWSs and shock indices declined when used to predict mortality at a more remote time ***:NEWS2 compared favorably with other EWSs and shock indices in early sepsis prediction but its low sensitivity at the usual cut-off point requires further modification for sepsis screening.

关键词： Sepsis Emergency department Clinical prediction rule Early warning score Shock index

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Prostate health index can stratify patients with Prostate Imaging Reporting and Data System score 3 lesions on magnetic resonance imaging to reduce prostate biopsies

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Asian Journal of Andrology 2024年第1期26卷 20-24页

作者： John Shung-Lai Leung Wai-Kit Ma Brian Sze-Ho Ho Stacia Tsun-Tsun Chun Rong Na Yongle Zhan Chi-yuen Ng Chi-Ho ip Ada Tsui-Lin Ng Yiu-Chung Lam Division of Urology Department of SurgeryQueen Mary HospitalUniversity of Hong KongHong KongChina Division of Urology Department of SurgeryPrincess Margaret HospitalHongKongChina

We aim to evaluate prostate health index as an additional risk-stratification tool in patients with Prostate Imaging Reporting and Data System score 3 lesions on multiparametric magnetic resonance *** with biochemical or clinical suspicion of having prostate cancer who underwent multiparametric magnetic resonance imaging in two tertiary centers(Queen Mary Hospital and Princess Margaret Hospital,Hong Kong,China)between January 2017 and June 2022 were ***-magnetic resonance imaging fusion biopsies were performed after prostate health index *** who only had Prostate Imaging Reporting and Data System score 3 lesions were further stratified into four prostate health index risk groups and the cancer detection rates were *** of the 747 patients,47.3%had Prostate Imaging Reporting and Data System score 3 lesions *** detection rate of clinically significant prostate cancer in this group was 15.0%.The cancer detection rates of clinically significant prostate cancer had statistically significant differences:5.3%in prostate health indexting and Data System score 3 *** could be avoided in patients with low prostate health index,with a small risk of missing clinically significant prostate cancer.

关键词： biopsy fusion biopsy magnetic resonance imaging prostate cancer prostate health index

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Expression, secretion and functional characterization of three laccases in E. coli

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Synthetic and Systems Biotechnology 2022年第1期7卷 474-480页

作者： Yating Mo Hou ip Lao Sau Wa Au Ieng Chon Li Jeremy Hu Hoi Man yuen Wai Man Cheong Owen Lok In Lo Leo Chi U.Seak Pui Ching Middle School(Macao) Edificio Pui Ching7A Av.de Horta e CostaMacao SARChina Department of Physiology Development of NeuroscienceUniversity of CambridgeCambridgeCB23DYUnited Kingdom The Centre for Inflammation Research University of Edinburgh47 Little France CrescentEdinburghEH164TJUnited Kingdom

Endocrine Disrupting Chemicals(EDCs)are a group of molecules that can influence hormonal balance,causing disturbance of the reproductive system and other health *** the efforts to eliminate EDC in the environment,all current approaches are inefficient and *** previous research,studies revealed that laccase-producing microorganisms may be a potential candidate for EDC degradation,as laccases have been found to be able to degrade many kinds of EDCs effectively and ***,we created two recombinant laccases,each fused with secretion peptide,Novel Signal Peptide 4(NSP4),and expressed them in Escherichia coli(***,BL21),together with one laccase without secretion *** first optimized the culture condition of expressing these ***,we test the activity of the recombinant laccases of decolorizing of a synthetic dye,indigo ***,we confirmed the secreted can degrade one of the EDCs,β-estradiol,showing the potential of using the laccase secretion system to degrade toxic compounds.

关键词： Laccase Endocrine disrupting chemicals(EDCs)

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Genetically modified foods in China and the United States:A primer of regulation and intellectual property protection

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Food Science and Human Wellness 2016年第3期5卷 124-140页

作者： Alice yuen-ting Wong Albert Wai-Kit Chan Albert Wai-Kit Chan Intellectual Property Limited Hong Kong Special Administrative Region United States-China Intellectual Property Institute New YorkUSA Law Offices of Albert Wai-Kit Chan PLLCNew YorkUSA

Food is a basic and personal necessity to *** of food is a prime factor to consider apart from nutrition,quality and *** modified(GM)foods first came on the market in *** safety,transparency and traceability ofGMfoods are still under hot ***,the market of GM foods is huge and *** affairs and intellectual property(ip)are two critical factors affecting the development and commercial success of a food *** article will take a look at the GM food technology and regulatory framework for GM foods in China and the United *** article will also discuss the unique patent issues and non-patent ip tools for safeguarding the technology in these two countries.

关键词： property modified attractive

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人输卵管素mRNA的体外表达

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Developmental and Reproductive Biology 2001年第B10期10卷 126-126页

作者： C M Briton-Jones I H Lok C P ip P M yuen L P Cheung C J Haines 香港中文大学妇产科学系中国香港

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香港部分严重急性呼吸综合征病人的分析

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解放军检验医学杂志 2003年第2期2卷 133-137页

作者： KennethW.Tsang,M.D. PakL.Ho,M.D. GaikC.Ooi,M.D. WilsonK.Yee,M.D. TeresaWang,M.D. MoiraChan-Yeung,M.D. WahK.Lam,M.D. WingH.Seto,M.D. LorettaY.Yam,M.D. ThomasM.Cheung,M.D. PoonC.Wong,M.D. BingLam,M.D. MaryS.ip,M.D. JaneChan,M.D. KwokY.yuen,M.D. KarN.Lai,M.D.,D.Sc From the University Departments of Medicine the Department of Medicine Pamela Youde Nethersole Eastern Hospital From the University Departments of Medicine Clinical Microbiology Diagnostic Radiology University of Hong Kong the Department of Medicine Kwong Wah Hospital

背景对已确诊的严重急性呼吸综合征的病人临床特点进行总结，为以后疑似病例的治疗和护理提供参考价值。方法对香港从2003年2月22日到2003年3月22日被确诊的10名患者(5男5女，38～72岁)进行分析。结果：潜伏期从2天至ll天。所有的患... 详细信息

背景对已确诊的严重急性呼吸综合征的病人临床特点进行总结，为以后疑似病例的治疗和护理提供参考价值。方法对香港从2003年2月22日到2003年3月22日被确诊的10名患者(5男5女，38～72岁)进行分析。结果：潜伏期从2天至ll天。所有的患者都表现有发热(体温>38℃，超过24小时)，大多数的患者有寒战、干咳、呼吸困难、周身不适、头痛、缺氧症状。物理检查听诊可有肺泡音、叩诊浊音。9名患者出现淋巴细胞降低。大多数患者出现转氨酶升高。但血清肌酐值维持正常水平。连续进行胸部X线检查，提示进行性充气区减少。两名患者死于进行性呼吸功能衰竭。组织活检表明肺组织内广泛性肺泡损伤。但未找到肺衣原体、肺炎支原体和军团菌感染的迹象。所有的患者都接受了皮质激素和病毒唑治疗。有8位患者接受了β-内酰胺类与大环内酯类药物的治疗，临床症状及x线检查都无明显改善。结论 SARS为传染性疾病。发热及继发的进行性呼吸困难是其主要的症状。病原体有待进一步确定。2002年秋冬季，中国广东省报道了305例高传染性的严重呼吸道疾患，表现为在医护人员中的局部流行。2003年2月，美国CDC将其命名为SARS，确定了它的临床表现。2003年3月13日，由于SARS由中国向世界范围内扩散，世界卫生组织发出SARS爆发公告，在全世界范围内进行调查。

关键词：严重急性呼吸综合征香港地区临床特点治疗护理

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