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Soluble ST2:A new and promising activity marker in ulcerative colitis

World journal of Gastroenterology 2011年第17期17卷 2181-2190页

作者： David Díaz-jiménez Lucía E núez caroll j beltrán Enzo Candia Cristóbal Suazo Manuel varez-Lobos María-julieta González Marcela A Hermoso Rodrigo Quera Disciplinary Program of Immunology Institute of Biomedical SciencesFaculty of MedicineUniversidad de ChileSantiagoCL 8380453Chile Department of Clinical Investigation Hospital Clínico de la Universidad de ChileSantiagoCL 8380456Chile Laboratory of Oncology and Molecular Genetics Colorectal Surgery UnitClínica Las CondesLo Fontecilla 441SantiagoCL 7591046Chile Department of Gastroenterology Pontificia Universidad Católica de ChileSantiagoCL 8380074Chile Cell and Molecular Biology Program Biomedical Sciences InstituteFaculty of MedicineUniversidad de ChileSantiagoCL 8380453Chile Gastroenterology Unit Department of Internal MedicineHospital Clínico de la Universidad de ChileSantiagoCL 8380456Chile Gastroenterology Unit Clínica Las CondesLo Fontecilla 441SantiagoCL 7591046Chile

AIM:To correlate circulating soluble ST2(sST2) levels with the severity of ulcerative colitis(UC) and serum levels of pro-inflammatory cytokines,and to demonstrate the predictive power of sST2 levels for differentiation between active and inactive ***:We recruited 153 patients:82 with UC,26 with Crohn's disease(CD) and 43 disease controls [non-inflammatory bowel disease(IBD)].Subjects were excluded if they had diagnosis of asthma,autoimmune diseases or *** serum levels of sST2 and pro-inflammatory cytokines [pg/mL;median(25th-75th)] as well as clinical features,endoscopic and histological features,were subjected to *** sST2 performance for discrimination between active and inactive UC,non-IBD and healthy controls(HC) was determined with regard to sensitivity and specificity,and Spearman's rank correlation coefficient(r).To validate the method,the area under the curve(AUC) of receiver-operator characteristic(ROC) was determined(AUC,95% CI) and the total ST2 content of the colonic mucosa in UC patients was correlated with circulating levels of ***:The serum sST2 value was significantly higher in patients with active [235.80(90.65-367.90) pg/mL] rather than inactive UC [33.19(20.04-65.32) pg/mL],based on clinical,endoscopic and histopathological characteristics,as well as compared with non-IBD and HC(P n level of sST2 in CD patients was 54.17(35.02-122.0) pg/mL,significantly higher than that of the HC group only(P nactive UC in a multicenter cohort of *** of sensitivity,specificity,and ability to correctly classify UC,according to activity,were 83.33%,83.33% and 83.33%,*** AUC of the ROC curve to assess the ability of this molecule to discriminate between active vs inactive UC was 0.92(0.86-0.97,P n patients with UC significantly correlated with endoscopic and histo-pathological scores(r =

关键词：煽动性的肠疾病 Ulcerative 大肠炎可溶的 ST2 Biomarkers

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