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Dental pulp stem cells as a promising model to study imprinting diseases

International Journal of Oral Science 2022年第2期14卷 174-181页

作者： Eloïse Giabicani Aurélie Pham Céline Sélénou Marie-Laure Sobrier caroline Andrique Julie Lesieur Agnès Linglart Anne Poliard Catherine Chaussain Irène Netchine Universitéde Paris URP2496Laboratoire Pathologiesimagerie et biothérapies oro-facialesMontrougeFrance INSERM UMRS_938 Centre de Recherche Saint AntoineParisFrance APHP Hôpital de BicêtreEndocrinologie et Diabétologie de l’EnfantCentre de Référence des Maladies Rares du Métabolisme du Calcium et du PhosphateLe Kremlin-BicêtreFrance APHP Hôpital BretonneauCentre de Référence des Maladies Rares du Métabolisme du Calcium et du Phosphate et FHU DDS-netParisFrance Sorbonne Université INSERMUMRS_938APHPHôpital Armand TrousseauExplorations Fonctionnelles EndocriniennesParisFrance

Parental imprinting is an epigenetic process leading to monoallelic expression of certain genes depending on their parental *** diseases are characterized by growth and metabolic issues starting from birth to *** are mainly due to methylation defects in imprinting control region that drive the abnormal expression of imprinted *** currently lack relevant animal or cellular models to unravel the pathophysiology of growth failure in these *** aimed to characterize the methylation of imprinting regions in dental pulp stem cells and during their differentiation in osteogenic cells(involved in growth regulation)to assess the interest of this cells in modeling imprinting *** collected dental pulp stem cells from five controls and four patients(three with Silver-Russell syndrome and one with Beckwith-Wiedemann syndrome).Methylation analysis of imprinting control regions involved in these syndromes showed a normal profile in controls and the imprinting defect in *** results were maintained in dental pulp stem cells cultured under osteogenic ***,we confirmed the same pattern in six other loci involved in imprinting diseases in *** also confirmed monoallelic expression of H19(an imprinted gene)in controls and its biallelic expression in one *** imprinting control regions methylation analysis shows the strong potential of dental pulp stem cells in modeling imprinting diseases,in which imprinting regions are preserved in culture and during osteogenic *** will allow to perform in vitro functional and therapeutic tests in cells derived from dental pulp stem cells and generate other cell-types.

关键词： pulp maintained fir

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Sepsis-induced mitochondrial dysfunction:A narrative review

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World Journal of Critical Care Medicine 2023年第3期12卷 139-152页

作者： Wagner Nedel caroline Deutschendorf Luis valmor Cruz Portela Intensive Care Unit Grupo Hospitalar ConceiçãoPorto Alegre 91350200Brazil Laboratory of Neurotrauma and Biomarkers Departamento de BioquímicaICBSUniversidade Federal do Rio Grande do SulPorto Alegre 90035-003Brazil Brazilian Research in Intensive Care Network-BRICNet São Paulo 04039-002Brazil Infection Control Committee Hospital de Clínicas de Porto AlegrePorto Alegre 90410-000Brazil

Sepsis represents a deranged and exaggerated systemic inflammatory response to infection and is associated with vascular and metabolic abnormalities that trigger systemic organic *** function has been shown to be severely impaired during the early phase of critical illness,with a reduction in biogenesis,increased generation of reactive oxygen species and a decrease in adenosine triphosphate synthesis of up to 50%.Mitochondrial dysfunction can be assessed using mitochondrial DNA concentration and respirometry assays,particularly in peripheral mononuclear *** of monocytes and lymphocytes seems to be the most promising strategy for measuring mitochondrial activity in clinical settings because of the ease of collection,sample processing,and clinical relevance of the association between metabolic alterations and deficient immune responses in mononuclear *** have reported alterations in these variables in patients with sepsis compared with healthy controls and non-septic ***,few studies have explored the association between mitochondrial dysfunction in immune mononuclear cells and unfavorable clinical *** improvement in mitochondrial parameters in sepsis could theoretically serve as a biomarker of clinical recovery and response to oxygen and vasopressor therapies as well as reveal unexplored pathophysiological mechanistic *** features highlight the need for further studies on mitochondrial metabolism in immune cells as a feasible tool to evaluate patients in intensive care *** evaluation of mitochondrial metabolism is a promising tool for the evaluation and management of critically ill patients,especially those with *** this article,we explore the pathophysiological aspects,main methods of measurement,and the main studies in this field.

关键词： Sepsis Mitochondria Mitochondrial dysfunction Oxidative phosphorylation Inflammation Respirometry

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Mirror,mirror on the wall,which is the greenest of them all?A critical comparison of chemo-and biocatalytic oxyfunctionalisation reactions

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Green Carbon 2023年第2期1卷 227-241页

作者： Yinqi Wu caroline E.Paul Frank Hollmann Biocatalysis section Department of BiotechnologyDelft University of TechnologyVan der Maasweg 92629HZ Delftthe Netherlands

This review article critically compares two widely used types of catalysis,chemo-and biocatalysis,and provides insights on their greenness according to specified parameters.A comparative analysis of the environmental impact of chemo-and biocatalytic oxyfunctionalisation reactions based on published experimental data reveals that both methods produce comparable amounts of waste,with the majority stemming from the solvent ***,it is emphasised that the synthesis of the catalysts themselves,including biocatalysts,should also be considered when assessing their environmental *** review underscores the complexity of assessing the environmental impact of catalytic oxyfunctionalisation *** article also discusses the relationship between solvent properties and the energy demands for chemical transformations and downstream processing,underlining that the choice of solvent can significantly influence the environmental impact of a catalytic ***,the review highlights the importance of considering the recyclability of reagents and the secondary CO_(2)emissions caused by the energy requirements of the reaction when evaluating the environmental impact of a catalytic *** chemo-and biocatalysis produce a certain environmental impact,the greenness of either method is dependent on several factors,including the type of waste generated,the recyclability of reagents,and secondary CO_(2)*** review therefore recommends using consistent metrics and a comprehensive life cycle assessment approach to evaluate this environmental impact,and highlights the importance of considering the synthesis of the catalysts themselves.

关键词： Green chemistry Catalysis Biocatalysis Chemocatalysis Environmental impact Oxidative reactions

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Revisiting the liver’s role in transplant alloimmunity

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World Journal of Gastroenterology 2019年第25期25卷 3123-3135页

作者： Nitin Abrol caroline C Jadlowiec Timucin Taner William J.von Liebig Center for Transplantation and Clinical Regeneration Massyo ClinicRochesterMN 55905United States Transplant Center Mayo ClinicPhoenixAZ 85259United States

The transplanted liver can modulate the recipient immune system to induce tolerance after *** phenomenon was observed nearly five decades ***,the liver’s role in multivisceral transplantation was recognized,as it has a protective role in preventing rejection of simultaneously transplanted solid organs such as kidney and *** liver has a unique architecture and is home to many cells involved in immunity and *** transplantation,these cells migrate from the liver into the *** studies identified chimerism as an important mechanism by which the liver modulates the human immune *** studies on human T-cell subtypes,cytokine expression,and gene expression in the allograft have expanded our knowledge on the potential mechanisms underlying *** this article,we discuss the privileged state of liver transplantation compared to other solid organ transplantation,the liver allograft’s role in multivisceral transplantation,various cells in the liver involved in immune responses,and the potential mechanisms underlying immunomodulation of host alloresponses.

关键词： Liver transplantation Alloimmunity Liver-kidney transplant Tolerance Rejection

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Histone Acetyltransferase AtGCN5/HAG1 Is a versatile Regulator of Developmental and Inducible Gene Expression in Arabidopsis

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Molecular Plant 2010年第4期3卷 670-677页

作者： caroline Servet Natalia Conde e Silva Dao-Xiu Zhou Institut de Biologie des Plantes Universite Paris-sud 11 91405 Orsay France

Histone acetylation/deacetylation is a dynamic process and plays an important role in gene regulation. Histone acetylation homeostasis is regulated by antagonist actions of histone acetyltransferases （HAT） and deacetylases （HDAC）. Plant genome encodes multiple HATs and HDACs. The Arabidopsis HAT gene AtGCNS/HAGlplays an essential role in many plant development processes, such as meristem function, cell differentiation, leaf and floral organogenesis, and responses to environmental conditions such as light and cold, indicating an important role of this HAT in the regulation of both long-term developmental switches and short-term inducible gene expression. AtGCN5 targets to a large number of promoters and is required for acetylation of several histone H3 lysine residues. Recruitment of AtGCN5 to target promoters is likely to be mediated by direct or indirect interaction with DNA-binding transcription factors and/or by interaction with acetylated histone lysine residues on the targets. Interplay between AtGCN5 and other HATand HDAC is demonstrated to control specific regulatory pathways. Analysis of the role of AtGCN5 in light-inducible gene expression suggests a function of AtGCN5 in preparing chromatin commitment for priming inducible gene activation in plants.

关键词： Light regulation chromatin structure and remodeling gene regulation leaf/vegetative development meristem development.

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Using ELECTRE-TRI and FlowSort methods in a stock portfolio selection context

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Financial Innovation 2022年第1期8卷 331-365页

作者： Mir Seyed Mohammad Mohsen Emamat caroline Maria de Miranda Mota Mohammad Reza Mehregan Mohammad Reza Sadeghi Moghadam Philippe Nemery Department of Industrial Management Faculty of Management and AccountingAllameh Tabataba’i UniversityTehran 14348-63111Iran Universidade Federal de Pernambuco RecifeBrazil University of Tehran TehranIran SAP BeLux BrusselsBelgium

In recent years,multi-criteria sorting problems have become an interesting topic for researchers working on multi-criteria *** and Choice Expressing REality(ELECTRE)-TRI and FlowSort are well-known approaches suggested for such a *** current study aimed to implement ELECTRE-TRI and FlowSort methods in the stock portfolio selection(SPS)as one of the most popular and important decision-making subjects and compare the outcomes of each method to understand how these methods perform in SPS *** this study,the best–worst method was applied to determine the weights of *** approaches for ELECTRE-TRI and 15 approaches for FlowSort were ***,19 different approaches were considered to select stocks from a large pool of *** indicated that the model parameter should be properly defined to minimize inconsistencies and improve the power of the model.

关键词： Multi-criteria decision-making ELECTRE-TRI FlowSort Best-worst method Finance

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Synthesis and purification of long copper nanowires. Application to high performance flexible transparent electrodes with and without PEDOT：PSS

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Nano Research 2014年第3期7卷 315-324页

作者： Celine Mayousse caroline Celle Alexandre Carella Jean-Pierre Simonato CEA LITEN / DTNM / LCRE 17 rue des Martyrs 38054 Grenoble France

We demonstrate the hydrothermal synthesis of long copper nanowires based on a simple protocol. We show that the purification of the nanowires is very important and can be achieved easily by wet treatment with glacial acetic acid. Fabrication of random networks of purified copper nanowires leads to flexible transparent electrodes with excellent optoelectronic performances (e.g., 55 Ω/sq. at 94% transparency). The process is carried out at room temperature and no post-treatment is necessary. Hybrid materials with the conductive polymer PEDOT:PSS show similar properties (e.g., 46 Ω/sq. at 93% transparency), with improved mechanical properties. Both electrodes were integrated in capacitive touch sensors.

关键词： PEDOT 透明电极光电性能纳米线 PSS 合成基纯化铜

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Human Performance in Critical Scenarios as a Benchmark for Highly Automated vehicles

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Automotive Innovation 2021年第3期4卷 274-283页

作者： Laura Quante Meng Zhang Katharina Preuk caroline Schießl Institute of Transportation Systems German Aerospace Center(DLR e.V.)Lilienthalplatz 738108 BraunschweigGermany

Before highly automated vehicles(HAvs)become part of everyday traffic,their safety has to be *** use of human performance as a benchmark represents a promising approach,but appropriate methods to quantify and compare human and HAv performance are *** adapting the method of constant stimuli,a scenario-based approach to quantify the limit of(human)performance is *** method is applied to a driving simulator study,in which participants are repeatedly confronted with a cut-in manoeuvre on a *** systematically manipulating the criticality of the manoeuvre in terms of time to collision,humans’collision avoidance performance is *** limit of human performance is then identified by means of logistic *** calculated regression curve and its inflection point can be used for direct comparison of human and HAv ***,the presented approach represents one means by which HAvs’safety performance could be proven.

关键词： Highly automated vehicles Automated driving Proof of safety Human performance Driving performance

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Molecular approaches for spinal cord injury treatment

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Neural Regeneration Research 2023年第1期18卷 23-30页

作者： Fernanda Martins de Almeida Suelen Adriani Marques Anne caroline Rodrigues dos Santos Caio Andrade Prins Fellipe Soares dos Santos Cardoso Luiza dos Santos Heringer Henrique Rocha Mendonça Ana Maria Blanco Martinez Laboratório de Neurodegeneração e Reparo Programa de Pós-Graduação em Medicina:Anatomia PatológicaDepartamento de PatologiaFaculdade de MedicinaHospital Universitário Clementino Fraga FilhoCentro de Ciências da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto de Ciências Biomédicas Centro de Ciências da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto de Biologia Departamento de NeurobiologiaLaboratório de Regeneração Neural e FunçãoUFFRio de JaneiroBrazil Laboratório Integrado de Morfologia Instituto de Biodiversidade e Sustentabilidade NUPEMPrograma de Pós-graduação Multicêntrico em Ciências Fisiológicas-SBFisCentro Multidisciplinar UFRJ-MacaéUniversidade Federal do Rio de JaneiroMacaéBrazil

Injuries to the spinal cord result in permanent disabilities that limit daily life *** main reasons for these poor outcomes are the limited regenerative capacity of central neurons and the inhibitory milieu that is established upon traumatic *** decades of research,there is still no efficient treatment for spinal cord *** strategies are tested in preclinical studies that focus on ameliorating the functional outcomes after spinal cord *** these,molecular compounds are currently being used for neurological recovery,with promising *** molecules target the axon collapsed growth cone,the inhibitory microenvironment,the survival of neurons and glial cells,and the re-establishment of lost *** this review we focused on molecules that are being used,either in preclinical or clinical studies,to treat spinal cord injuries,such as drugs,growth and neurotrophic factors,enzymes,and *** mechanisms of action of these molecules are discussed,considering traumatic spinal cord injury in rodents and humans.

关键词： axonal regeneration drugs enzymes growth factors molecular therapy neurotrophic factors purines spinal cord injury

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Are University Rankings Statistically Significant?A Comparison among Chinese Universities and with the USA

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Journal of Data and Information Science 2021年第2期6卷 67-95页

作者： Loet Leydesdorff caroline SWagner Lin Zhang Amsterdam School of Communication Research(ASCoR) University of AmsterdamPB 157931001 NG Amsterdamthe Netherlands John Glenn College of Public Affairs Ohio State UniversityColumbus 43210USA School of Information Management Wuhan UniversityWuhan 430072China

Purpose:Building on Leydesdorff,Bornmann,and Mingers(2019),we elaborate the differences between Tsinghua and Zhejiang University as an empirical *** address the question of whether differences are statistically significant in the rankings of Chinese *** propose methods for measuring statistical significance among different universities within or among ***/methodology/approach:Based on z-testing and overlapping confidence intervals,and using data about 205 Chinese universities included in the Leiden Rankings 2020,we argue that three main groups of Chinese research universities can be distinguished(low,middle,and high).Findings:When the sample of 205 Chinese universities is merged with the 197 US universities included in Leiden Rankings 2020,the results similarly indicate three main groups:low,middle,and *** this data(Leiden Rankings and Web of Science),the z-scores of the Chinese universities are significantly below those of the US universities albeit with some *** limitations:We show empirically that differences in ranking may be due to changes in the data,the models,or the modeling effects on the *** scientometric groupings are not always stable when we use different *** implications:Differences among universities can be tested for their statistical *** statistics relativize the values of decimals in the *** can operate with a scheme of low/middle/high in policy debates and leave the more fine-grained rankings of individual universities to operational management and local ***/value:In the discussion about the rankings of universities,the question of whether differences are statistically significant,has,in our opinion,insufficiently been addressed in research evaluations.

关键词： Ranking University China Significance of differences Indicators

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