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α,β-amyrin, a natural triterpenoid ameliorates L-arginine-induced acute pancreatitis in rats

World Journal of Gastroenterology 2010年第34期16卷 4272-4280页

作者： caroline mouro melo Karine Maria Martins Bezerra Carvalho Julliana Catharina de Sousa Neves Talita Cavalcante Morais Vietla Satyanarayana Rao Flávia Almeida Santos Gerly Anne de Castro Brito Mariana Helena Chaves Department of Physiology and Pharmacology Biomedical Institute of Brazilian Semiarid Faculty of Medicine Federal University of Ceará Department of Morphology Faculty of Medicine Federal University of Ceará Department of organic and Inorganic Chemistry Federal University of Piauí

AIM: To study the benef icial effects of triterpene α,β-amyrin and the underlying mechanisms in an experimental pancreatitis model. METHoDS: Acute pancreatitis was induced in five groups of rats (n = 8) by L-arginine (2 × 2.5 g/kg, intraperitoneal, 1 h apart) and 1 h later, they received a single oral dose of α,β-amyrin (10, 30 and 100 mg/kg),methylprednisolone (30 mg/kg) and vehicle (3% Tween 80). A saline (0.9% NaCl) treated group served as a normal control. Efficacy was assessed at 24 h by determination of serum levels of amylase, lipase and proinflammatory cytokines [tumor necrosis factor (TNF)-α and interleukin (IL)-6], pancreatic myeloperoxidase (MPo) activity, lipid peroxidation [thiobarbituric acid reactive substances (TBARS)], nitrate/nitrite levels, and the wet weight/body weight ratio. Tissue histology and the immunoreactivity for TNF-α and inducible nitric oxide synthetase (iNoS) were performed. RESULTS: α,β-amyrin and methylprednisolone treatments significantly (P ody weight ratio, and decreased the serum levels of amylase and lipase, and TNF-α and IL-6, as compared to the vehicle control. Also, pancreatic levels of MPo activity, TBARS, and nitrate/nitrite were signifi cantly lower. Histological f indings and TNF-α and iNoS immunostaining further confirmed the amelioration of pancreatic injury by α,β-amyrin. CoNCLUSIoN: α,β-amyrin has the potential to combat acute pancreatitis by acting as an anti-in? ammatory and antioxidant agent.

关键词： Acute pancreatitis L-arginine Cytokines Lipid peroxidation α,β-amyrin

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Downscaling Climate Projections over La Plata Basin

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Atmospheric and Climate Sciences 2016年第1期6卷 1-12页

作者： caroline mourão Sin Chan Chou José Marengo National Institute for Space Research Cachoeira Paulista Brazil National Center for Natural Disaster Monitoring and Early Warning S&#227o José dos Campos Brazil

Regional Climate Models are important tools, which are increasingly being used in studies of impacts and adaptation to climate change at local scale. The goal of this work is to assess the climate change over the La Plata Basin, using the Eta Regional model with a resolution of 10 km. Initial and boundary conditions used by the model are provided by the Eta-20 km model and the HadGEM2-ES Global model. The RCP 4.5 scenario was used for simulations of the future climate. The evaluation of the present climate (1961-1990) shows that the model represents well the spatial and temporal distribution of precipitation and temperature in the region. The model underestimates precipitation over large areas in summer, and overestimates in Southern Brazil in winter. Simulated temperature shows a good correlation with CRU data, with bias less than 1°C. The bias of temperature and precipitation in this simulation setup for the La Plata Basin is substantially reduced in comparison with previous literature using regional models. The climatic projections are shown in timeslices: 2011-2040, 2041-2070, and 2071-2099. In the three timeslices, the simulation project has a trend for an increase in precipitation during summer in Argentina, Uruguay, and southernmost Brazil. This increase is only projected in Southern Brazil during winter. The negative anomaly of precipitation appears in a large portion of the model domain during summer and is limited to some states in Southeast and Central-West Brazil in winter. The area with largest warming is projected in the northern portion of the domain. The projected increase in temperature reaches about 4°C in 2071-2099.

关键词： Regional Climate Model Climate Downscaling Climate Change Assessment La Plata Basin

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Analysis of Nursing Care Concept: Perspective of the Person Submitted to Care

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open Journal of Nursing 2016年第6期6卷 491-496页

作者： Camila Brasil Moreira Ana Fátima Carvalho Fernandes Míria Conceição Lavinas Santos Altamira Mendonça Félix Gomes Carla Monique Lopes mourão Rosy Denyse Pinheiro de oliveira Angelica Isabely de Morais Almeida Suzy Ramos Rocha Cláudia Rayanna Silva Mendes Sadrine Maria Eufrasino de Pinho Marinna Maria de Andrade Costa Jordana Prado Benevides caroline Batista de Queiroz Aquino Iarlla Silva Ferreira Raquel Vilanova Araujo Department of Nursing Federal University of Ceará Fortaleza Brazil

This study aimed to analyze the concept of nursing care to patients with breast cancer on chemotherapy treatment, according to the perspective of the person submitted to care. The study followed the conceptual analysis methodology proposed by Walker and Avant according to Waldow, and it was developed through consultation to SCoPUS and CINAHL databases. The selection was carried out by inclusion and exclusion criteria, constituting a sample of 7 articles. There have been identified the main uses of the risk concept, defining attributes, antecedents and consequences of the concept. The evaluation of the concept and nursing care to breast cancer patient on chemotherapy treatment allowed a broader understanding of the phenomenon, with emphasis on the skills and competencies in nursing care dispensed to woman on chemotherapy treatment for breast cancer.

关键词： Nursing Breast Neoplasms Analysis Research Nursing Care Chemotherapy

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