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Preservation of platelet function in patients with cirrhosis and thrombocytopenia undergoing esophageal variceal ligation

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Hepatobiliary & Pancreatic Diseases International 2020年第6期19卷 555-560页

作者： Evandro de Oliveira souza Elbio Antonio D’Amico Tania Rubia Flores da Rocha caroline marcond.s ferreira Juliana Medeiros Batista Luiz Augusto CarneiroD’Albuquerque Flair Jose Carrilho Alberto Queiroz Farias Division of Gastroenterology and Hepatology University of Sao Paulo School of MedicineAv.Dr.Eneas Carvalho de Aguiar2559th flooroffice 9159Sao PauloSP 05403-000Brazil Hemostasis Laboratory Hematology ServiceUniversity of Sao Paulo School of MedicineAv.Dr.Eneas Carvalho de Aguiar2552nd floorSao PauloSP 05403-000Brazil

Background:Thrombocytopenia is a possible risk factor for bleeding after band ligation of esophageal ***,elevated von Willebrand factor(VWF)in cirrhosis improves platelet function and could decrease this *** objective was to assess platelet function in patients with cirrhosis undergoing esophageal variceal ligation(EVL).Methods:The assessment consisted of platelet count,antigen and activity of VWF and VWF-cleaving protease ADAMTs-13 activity,and a platelet adhesion and aggregation test simulating vascular flow in vivo(Impact-RR)prior to ***:Totally 111 patients were divided into three groups according to platelet count:(1)100×109/L(n=26,23.4%).No statistically significant difference was found in the aggregate size of platelets[group 1:41.0(31.8–67.3)μm 2;group 2:47.0(33.8–71.3)μm 2;and group 3:47.0(34.0–66.0)μm 2;P=0.60]and no significant correlation was found between aggregate size and platelet count(spearman r=0.07;P=0.47).surface coverage was 4.1%(2.8%–6.7%),8.5%(4.0%–10.0%),and 9.0%(7.1%–12.0%)(Ps 1,2 and 3,respectively and correlated with platelet count(spearman r=0.39;Ps no significant difference between groups in VWF or ***-EVL bleeding occurred in six(5.4%)patients(n=2 in group 1,n=1 in group 2,and n=3 in group 3;P=0.32).Patients with bleeding had higher MELD scores[15.0(11.3–20.3)versus 12.0(10.0–15.0);P=0.025],but no difference was demonstrated for platelet function ***:Platelet function is preserved even in the presence of thrombocytopenia,including in the patients with post-EVL bleeding.

关键词： Cirrhosis Hemostasis Thrombocytopenia Platelet aggregation Endoscopy Hemorrage

Association of TNFA(-308G/A),IFNG(+874 A/T)and IL-10(-819 C/T)polymorphisms with protection and susceptibility to dengue in Brazilian population

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Asian Pacific Journal of Tropical Medicine 2017年第11期10卷 1065-1071页

作者： Ana caroline Melo dos santos Edilson Leite de Moura Jean Moises ferreira Alexandre Wendell Araujo de Moura Ailson Darlan sales ferreira Rubens Pereira Bezerra Diego de siqueira Figueiredo Karol Fireman de Farias Tiago Gomes de Andrade Elaine Virginia Martins de souza Figueiredo Molecular Biology and Gene Expression Laboratory Federal University of AlagoasCampus ArapiracaAv Manoel Severino BarbosaBom SucessoArapiracaAL57309-005Brazil Faculty of Medicine Federal University of AlagoasCampus AC SimoesTabuleiro dos MartinsMaceioAlagoasBrazil

Objective: To evaluate gene polymorphisms and their association with susceptibility to ***: A retrospective case-control study was performed with 262 subjects,comprising 78 dengue fever(DF) patients, 49 dengue hemorrhagic fever(DHF) patients and 135 healthy controls. Genotypic and allelic profiles were identified using polymerase chain reaction based in real time and amplification-refractory mutation ***: We observed a protective association of IL-10(-819 C/T) C allele(P = 0.028,OR = 0.56, CI = 0.34–0.91) against DHF, while the C/T(P = 0.047, OR = 2.10,CI = 1.01–4.38) and T/T(P = 0.008, OR = 3.82, CI = 1.38–10.59) genotypes were associated with DHF and DF, respectively. The dominant model TNFA-308 GA + AA(P = 0.043, OR = 0.45, CI = 0.20–1.00) genotypes were found to have protective effect against dengue infection. A protective association among the IFNG(+874 A/T) A/T genotype against DF(P = 0.02, OR = 0.46, CI = 0.24–0.89) and DHF(P = 0.034,OR = 0.43, CI = 0.19–0.95) was observed. When the studied single-nucleotide polymorphism was analyzed in combination, the combination GTA(P = 0.022, OR = 2.95,CI = 1.18–7.41) was statistically significantly associated with susceptibility to DF and the combination GCT(P = 0.035, OR = 0.28, CI = 0.08–0.90) with protection against the development of ***: This research identifies the association of the IFNG(+874 A/T), TNFA(-308 G/A), IL-10(-819 C/T) genotypes as a factor for protection, susceptibility and severity to dengue.

关键词： Immune system IFNG TNFA IL-10 Dengue Polymorphism

Method for Estimating of Construction Cost of a Building Based on Previous Experiences

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Open Journal of Civil Engineering 2016年第5期6卷 749-763页

作者： Cláudio Ricardo Bettini Orlando Celso Longo Luciane ferreira Alcoforado Alana caroline Gamba Maia Escola de Engenharia Universidade Federal Fluminense Niter&oacute i Brazil

In a real estate project, the estimated cost of construction and the revenues generally represent together the most important values of its feasibility study. When a decision of undertaking a project is made, often there are few definitions of what is about to be constructed, and frequently not enough to ensure the accuracy of the estimated costs. Considering a global tendency on reducing margins of return over the real estate markets, slight variations of the construction cost can jeopardize the success of the whole real estate enterprise and even the financial stability of the builder or of the developer. This article aims at presenting a method of estimating the building construction costs applicable at the stage of feasibility studies, being able to provide acceptable errors.

关键词： Real Estate Development Construction Cost Estimation Cost Forecast Cost Estimation Error

Acute heart failure as an adverse event of tumor necrosis factor inhibitor therapy in inflammatory bowel disease:A review of the literature

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World Journal of Cardiology 2023年第5期15卷 217-228页

作者： Thais Gagno Grillo caroline ferreira da silva Mazeto Pupo silveira Ana Elisa Valencise Quaglio Renata de Medeiros Dutra Julio Pinheiro Baima silmeia Garcia Zanati Bazan Ligia Yukie sassaki Department of Internal Medicine Medical SchoolSão Paulo State UniversityBotucatuBotucatu 18618686Brazil Department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State UniversityBotucatuBotucatu 18618689Brazil

Tumor necrosis factor inhibitors(anti-TNFs)are widely used therapies for the treatment of inflammatory bowel diseases(IBD);however,their administration is not *** failure(HF),although rare,is a potential adverse event related to administration of these ***,the exact mechanism of development of HF remains ***αis found in both healthy and damaged *** effects are concentration-and receptor-dependent,promoting either cardio-protection or cardiomyocyte *** rat models with TNFαreceptor knockout showed increased survival rates,less reactive oxygen species formation,and improved diastolic left ventricle ***,clinical trials employing anti-TNF therapy to treat HF had disappointing results,suggesting abolishment of the cardioprotective properties of TNFα,making cardiomyocytes susceptible to apoptosis and ***,patients with IBD who have risk factors should be screened for HF before initiating anti-TNF *** review aims to discuss adverse events associated with the administration of anti-TNF therapy,with a focus on HF,and propose some approaches to avoid cardiac adverse events in patients with IBD.

关键词： Tumor necrosis factor inhibitors Inflammatory bowel disease Heart failure Adverse event TNFαreceptor

Prevalence of Methicillin-Resistant <i>staphylococcus aureus</i>in Raw Hamburgers and Ready-to-Eat sandwiches Commercialized in supermarkets and Fast Food Outlets in Brazil

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Food and Nutrition sciences 2015年第14期6卷 1324-1331页

作者： Claudia Patrícia álvarez Contreras Lis Nery Nunes da silva Dilza caroline Gomes ferreira Jeane dos santos ferreira Rogeria Comastri de Castro Almeida Department of Food science Nutrition School Federal University of Bahia Salvador Brazil

Although well known, staphylococcus aureus is a bacterium that remains widely studied because of its high pathogenic potential and its ability to develop resistance to antibiotics routinely used in clinical practice. The present study investigated the occurrence of methicillin-resistant staphylococcus aureus (MRsA) in hamburgers and sandwiches sold in supermarkets and fast food outlets in salvador, BA, Brazil. Fifty samples of frozen raw hamburgers (25: beef and 25: chicken) and 50 samples of ready-to-eat sandwiches (25: beef and 25: chicken) were collected and investigated for the presence of MRsA. MRsA was present in 32% of the hamburgers and 8% of the sandwiches. The frequency of MRsA was higher in the samples containing chicken meat. However, the statistical analysis showed no association between MRsA presence and the type of meat investigated (P > 0.05). The high prevalence of MRsA in hamburgers and the presence of the microorganism in ready-to-eat sandwiches are worrying and indicate the need for better control during food preparation to prevent the spread of bacteria.

关键词： Methicillin-Resistant staphylococcus aureus Hamburgers sandwiches Food safety

Lafoensia pacari alleviates intestinal damage by modulating cyclooxygenase-2:In silico and in vivo evaluation in a colitis model

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World Journal of Gastroenterology 2023年第17期29卷 2628-2641页

作者： Gabrielle caroline Peiter Thayene Kamyli Moesch Queiroz Edson Luiz Michalkiewicz Jr Raphael Henrique Chappuis Jennefer sousa Luz Luiz Henrique Casagrande Piovezani Cleison ferreira silva Matheus Nozomi Tsutumi Augusto Fernandes Chaves Rafael Messias Luiz Cinthia Façanha Wendel Ana Carla Zarpelon-schutz Kádima Nayara Teixeira Programa Multicêntrico de Pós-graduação em Biquímica e Biologia Molecular-setor Palotina Universidade Federal do ParanáPalotina 85.950-000ParanáBrazil Programa de Pós-graduação em Biotecnologia-setor Palotina Universidade Federal do ParanáPalotina 85.950-000ParanáBrazil Campus Toledo Universidade Federal do ParanáToledo 85.919-899ParanáBrazil

BACKGROUND Inflammatory bowel diseases(IBD)are a worldwide health problem and mainly affect young people,consequently affecting the *** treatments are often associated with side effects,and new therapeutic options are *** centuries,plants have represented important substrates in the field of drug *** pacari(***)is a plant whose pharmaceutical potential has been described,and may have biological activity relevant to the treatment of IBD *** To investigate the activity of keto-alcoholic extracts of *** with respect to ameliorating the inflammatory and nociceptive symptoms of acute experimental colitis in *** Keto-alcoholic extracts of *** leaves and bark were administered to male andfemale swiss mice weighing 25 g to 30 g(n=8 male mice and n=8 female mice).The effect of these extracts was observed in an acetic acid-induced acute experimental model of colitis with regard to antinociception/analgesia and inflammatory tissue *** macroscopic indices included the Wallace score and the colon weight obtained using a precision *** hyperalgesia was determined using an electronic *** related to overt pain was determined by quantifying the number of writhing instances within 20 min of administration of acetic *** docking was performed using human and murine cyclooxygenase-2(COX-2)with 3 flavonoids(ellagic acid,kaempferol,and quercetin)on the AutoDock Vina *** of variance followed by Tukey’s posttest was used with Ps murine model of colitis,administration of extracts from *** ameliorated acetic acidinduced writhing and colitis-associated inflammatory *** improvements may be attributable to the reduction in edema,inflammation(e.g.,ulcers,hyperemia,and bowel wall damage),and the intensity of abdominal *** keto-alcoholic extracts of *** leaves and bark administered at a

关键词： Antinociceptive activity Anti-inflammatory activity Cyclooxygenase-2 Flavonoids Inflammatory bowel disease Lafoensia pacari

Production of Enzymes and Biotransformation of Orange Waste by Oyster Mushroom, <i>Pleurotus pulmonarius</i>(Fr.) Quél.

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Advances in Microbiology 2015年第1期5卷 1-8页

作者： Fabíola Dorneles Inácio Roselene Oliveira ferreira caroline Aparecida Vaz de Araujo Rosane Marina Peralta Cristina Giatti Marques de souza Federal Institute of Paraná-Campus Jacarezinho Jacarezinho Brazil Post-Graduation Program of Biological sciences State University of Maringá Maringá Brazil Departament of Biochemistry State University of Maringá Maringá Brazil

The wood-decay fungi are able to bioconvert a wide variety of lignocellulosic residues due to the secretion of extracellular enzymes. The use of agricultural wastes as substrate for mushroom cultivation or enzymes production can help to solve environmental problems caused by inadequate discharge in the nature. The production of hydrolytic and oxidative enzymes by Pleurotus pulmonarius developed in solid state system using orange waste as substrate was evaluated in this work. Among the hydrolytic enzymes, pectinase was the main enzyme produced by the fungus, presenting the highest enzymatic activity of 9.4 U/mL after 35 days of cultivation. Considering the oxidative enzymes, laccase was the main enzyme produced with maximal activity of 12.2 U/mL obtained after 20 days of cultivation. Low enzyme levels of manganese peroxidase, β-glucosidase and β-xy-losidase were detected with activity peaks at the end of the cultivation. The enzymatic levels of amylase, carboxymethyl cellulase and xylanase were similar and less than 1.5 U/mL. No aryl-alcohol oxidase activity was detected. NDF, ADF and cellulose values increased during 45 days of cultivation. There was no lignin degradation during the study period and the fungus culture in orange solid waste caused protein enrichment in the substrate. Our results demonstrate that P. pulmonarius was an efficient producer of two important industrial enzymes, pectinase and laccase in a cheap solid state system using orange waste as substrate.

关键词： Orange Waste Biotransformation Pleurotus pulmonarius Basidiomycetes

Comparison of Three Experimental Models for Rat Osteoarthritis Induction

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Journal of Biosciences and Medicines 2016年第12期4卷 62-69页

作者： Henrique Ribeiro Rodrigues-Neto Edilson ferreira Andrade-Junior Denilson Jose silva Feitosa-Junior André Lopes Valente Thiago Cesar Xavier Bianca caroline do Nascimento Alho Renan Kleber Costa Teixeira Fabio Vidal Moriya Rui sérgio Monteiro de Barros Department of Orthopaedics and Traumatology Porto Dias Hospital Bel&eacute m Brazil Experimental surgery Laboratory Par&aacute state University Bel&eacute m Brazil

Background: Osteoarthritis is a slowly progressive and debilitating disease with high prevalence in adult population. Knee is one of the joints most affected by this disorder. There are several models for animals’ osteoarthritis induction, however it is not identified any paper that compares these techniques. The present study was aimed to define the most appropriate model for rats osteoarthritis induction. Material and Methods: 40 Wistar rats were distributed into 4 groups of 10 animals each: normality group (NG);meniscectomy group (MG);quinolone group (QG) and iodoacetate group (IG). Radiographic images of the rat’s knees were analyzed as well as the amount of chondrocytes in the epiphyseal and articular cartilage. Results: In the radiographic analysis, there was a low correlation between the raters. Regarding the amount of chondrocytes in the epiphyseal cartilage, it was noticed that the IG and QG groups had fewer chondrocytes than NG, in contrast to MG that reported similar results to normality (p > 0.05). There was no significant difference between IG and QG groups (p > 0.05). Regarding the amount of chondrocytes in articular cartilage, it was noticed that the IG group showed fewer chondrocytes than NG (p 0.05). There was no significant difference between QG and MG groups (p > 0.05). Conclusion: Intraarticular injection of iodoacetate in rats is the model with greatest effect on reduction of chondrocytes amount.

关键词： Osteoarthritis Knee Joint Experimental Arthritis Animal Disease Models Rats

Antimicrobial Activity of the Essential Oil from Hyptis carpinifolia Benth

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American Journal of Plant sciences 2017年第11期8卷 2871-2877页

作者： Karen caroline Camargo Luís Roberto Batista Paulo Estevao de souza Maria Luisa Teixeira Thaís Aparecida sales Vanuzia Rodrigues Fernandes ferreira Jéssica Oliveira e Nogueira Maísa Lamounier Magalh?es Alex Rodrigues silva Caetano David Lee Nelson Maria das Gra?as Cardoso Department of Chemistry Federal University of Lavras Lavras Brazil Department of Food science Federal University of Lavras Lavras Brazil Department of Phytopathology Federal University of Lavras Lavras Brazil Pro-Rectory of Research and Graduate studies Federal University of the Jequitinhonha and Mucuri Valleys Diamantina Brazil

Essential oils are secondary metabolites whose biological properties have been studied with emphasis on antimicrobial activity. Hyptis carpinifolia Benth (Rosmaninho) is used in folk medicine in the fight against colds and rheumatism. The objective of this study was to evaluate the antimicrobial activity of the essential oil from H. carpinifolia. The essential oil was extracted by hydrodistillation using a modified Clevenger apparatus. The biological activity was determined using the Agar Cavity Diffusion technique to evaluate the effect of concentrations of 500, 250, 125, 62.5, 31.25, 15.62, 7.81 and 3.9 μg·mL-1 on the bacteria Escherichia coli, Listeria monocytogenes, salmonella Choleraesuis, staphylococcus aureus and Pseudomonas aeruginosa. The fungicidal potential was evaluated by the method of dilution in agar, and the percentage inhibition of mycelial growth of Alternaria alternata, Botrytis cinerea and Fusarium oxysporum was evaluated. The dilutions tested were 1000, 750, 500, 250 and 100 μL·L-1. The minimum inhibitory concentrations (MIC) of the essential oil for L. monocytogenes, s. aureus and E. coli were 31.25;15.62 and 62.5 μg·mL-1, respectively. The MIC was 500 μg·mL-1 for salmonella Choleraesuis and P. aeruginosa. The percentage inhibitions of mycelial growth of B. cinerea and A. alternate were 67% and 33%, respectively, at the dilution of 750 μL·L-1. The essential oil inhibited about 48% of the mycelial growth of F. oxysporum, at the dilution of 1000 μL·L-1. The essential oil of H. carpinifolia presented biological activity against all the microorganisms evaluated.

关键词： Essential Oils Antimicrobial Activity