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Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity

Bone Research 2024年第1期12卷 180-198页

作者： morten S.Hansen Kaja madsen maria Price Kent Søe Yasunori Omata mario m.Zaiss caroline m.gorvin morten Frost Alexander Rauch molecular Endocrinology Laboratory(KmEB) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark Department of Clinical Research Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark Clinical Cell Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute of metabolism and Systems Research(ImSR)and Centre for Diabetes Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK Centre for membrane Proteins and Receptors(COmPARE) Universities of Birmingham and NottinghamBirmingham B152TTUK Department of molecular medicine University of Southern DenmarkDK-5000 Odense CDenmark Department of Orthopedic Surgery Faculty of MedicineThe University of TokyoTokyo 113-8655Japan Department of Internal medicine 3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany Deutsches Zentrum Immuntherapie(DZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany Steno Diabetes Center Odense Odense University HospitalDK-5000 Odense CDenmark

Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis,which is characterized by increased bone resorption and inadequate bone *** novel antiosteoporotic therapeutics are needed,understanding the genetic regulation of human osteoclastogenesis could help identify potential treatment *** study aimed to provide an overview of transcriptional reprogramming during human osteoclast *** were differentiated from CD14+monocytes from eight female *** sequencing during differentiation revealed 8980 differentially expressed genes grouped into eight temporal patterns conserved across *** patterns revealed distinct molecular functions associated with postmenopausal osteoporosis susceptibility genes based on RNA from iliac crest biopsies and bone mineral density *** analyses revealed mutual dependencies between temporal expression patterns and provided insight into subtype-specific transcriptional *** donor-specific expression patterns revealed genes at the monocyte stage,such as filamin B(FLNB)and oxidized low-density lipoprotein receptor 1(OLR1,encoding LOX-1),that are predictive of the resorptive activity of mature *** expression of differentially expressed G-protein coupled receptors was strong during osteoclast differentiation,and these receptors are associated with bone mineral density SNPs,suggesting that they play a pivotal role in osteoclast differentiation and *** regulatory effects of three differentially expressed G-protein coupled receptors were exemplified by in vitro pharmacological modulation of complement 5 A receptor 1(C5AR1),somatostatin receptor 2(SSTR2),and free fatty acid receptor 4(FFAR4/GPR120).Activating C5AR1 enhanced osteoclast formation,while activating SSTR2 decreased the resorptive activity of mature osteoclasts,and activating FFAR4 decreased both the number and resorptive activity of mature *** conclus

关键词： osteoclast programming identif

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The influence of resistance exercise training prescription variables on skeletal muscle mass,strength,and physical function in healthy adults:An umbrella review

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Journal of Sport and Health Science 2024年第1期13卷 47-60页

作者： Jonathan C.mcleod Brad S.Currier caroline V.Lowisz Stuart m.Phillips Department of Kinesiology Faculty of ScienceMcMaster UniversityHamilton L8S4L8Canada

Purpose:The aim of this umbrella review was to determine the impact of resistance training(RT)and individual RT prescription variables on muscle mass,strength,and physical function in healthy ***:Following Preferred Reporting Items for Systematic Reviews and meta-Analyses(PRISmA)guidelines,we systematically searched and screened eligible systematic reviews reporting the effects of differing RT prescription variables on muscle mass(or its proxies),strength,and/or physical function in healthy adults aged>18 ***:We identified 44 systematic reviews that met our inclusion *** methodological quality of these reviews was assessed using A measurement Tool to Assess Systematic Reviews;standardized effectiveness statements were *** found that RT was consistently a potent stimulus for increasing skeletal muscle mass(4/4 reviews provide some or sufficient evidence),strength(4/6 reviews provided some or sufficient evidence),and physical function(1/1 review provided some evidence).RT load(6/8 reviews provided some or sufficient evidence),weekly frequency(2/4 reviews provided some or sufficient evidence),volume(3/7 reviews provided some or sufficient evidence),and exercise order(1/1 review provided some evidence)impacted RT-induced increases in muscular *** discovered that 2/3 reviews provided some or sufficient evidence that RT volume and contraction velocity influenced skeletal muscle mass,while 4/7 reviews provided insufficient evidence in favor of RT load impacting skeletal muscle *** was insufficient evidence to conclude that time of day,periodization,inter-set rest,set configuration,set end point,contraction velocity/time under tension,or exercise order(only pertaining to hypertrophy)influenced skeletal muscle adaptations.A paucity of data limited insights into the impact of RT prescription variables on physical ***:Overall,RT increased muscle mass,strength,and physical function compared to no ***

关键词： Hypertrophy Resistance training Resistance training prescription variables Strength Umbrella review

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Chitin-glucan improves important pathophysiological features of irritable bowel syndrome

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World Journal of Gastroenterology 2024年第16期30卷 2258-2271页

作者： caroline Valibouze caroline Dubuquoy Philippe Chavatte michaël Genin Veronique maquet Salvatore modica Pierre Desreumaux Christel Rousseaux Department of Digestive Surgery and Transplantation Lille UniversityLille 59037France Intestinal Biotech Development Facultéde MédicineLille 59045France U1286-INFINITE-Institute for Translational Research in Inflammation Universitéde LilleLille 59000France ULR 2694-mETRICS Évaluation des Technologies de santéet des Pratiques MédicalesUniversity of LilleLille 59000France KitoZyme SA Institution SociétéAnonymeZone 2Parc des Hauts SartsRue de MilmortHerstal 4040Belgium Hepato-Gastroenterology Department Lille University HospitalLille 59037France

BACKGROUND Irritable bowel syndrome(IBS)is one of the most frequent and debilitating conditions leading to gastroenterological ***,recommended treatments remain limited,yielding only limited therapeutic ***-glucan(CG)is a novel dietary prebiotic classically used in humans at a dosage of 1.5-3.0 g/d and is considered a safe food ingredient by the European Food Safety *** provide an alternative approach to managing patients with IBS,we performed preclinical molecular,cellular,and animal studies to evaluate the role of chitin-glucan in the main pathophysiological mechanisms involved in *** To evaluate the roles of CG in visceral analgesia,intestinal inflammation,barrier function,and to develop computational molecular *** Visceral pain was recorded through colorectal distension(CRD)in a model of long-lasting colon hypersensitivity induced by an intra-rectal administration of TNBS[15 milligrams(mg)/kilogram(kg)]in 33 Sprague-Dawley *** pressure was regularly assessed during the 9 wk-experiment(weeks 0,3,5,and 7)in animals receiving CG(n=14)at a human equivalent dose(HED)of 1.5 g/d or 3.0 g/d and compared to negative control(tap water,n=11)and positive control(phloroglucinol at 1.5 g/d HED,n=8)*** anti-inflammatory effect of CG was evaluated using clinical and histological scores in 30 C57bl6 male mice with colitis induced by dextran sodium sulfate(DSS)administered in their drinking water during 14 ***-29 cells under basal conditions and after stimulation with lipopolysaccharide(LPS)were treated with CG to evaluate changes in pathways related to analgesia μ-opioid receptor(mOR),cannabinoid receptor 2(CB2),peroxisome proliferator-activated receptor alpha,inflammation[interleukin(IL)-10,IL-1b,and IL-8]and barrier function[mucin 2-5AC,claudin-2,zonula occludens(ZO)-1,ZO-2]using the real-time PCR *** modelling of CG,LPS,lipoteichoic acid(LTA),and phospholipomannan(PLm)was developed,and the abili

关键词： Chitin-glucan Irritable bowel syndrome Abdominal pain Inflammation Intestinal barrier molecular modelling microbial cell walls chelation

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Impact of multifocal gas-permeable lens designs on short-term choroidal response, axial length, and retinal defocus profile

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 247-256页

作者： muteb Alanazi Patrick caroline Amane Alshamrani maria Liu Optometry Department College of Applied Medical SciencesKing Saud UniversityRiyadh 14813Saudi Arabia College of Optometry Pacific UniversityForest GroveOregon 97116-1756United States Optometry School University of California at BerkeleyCalifornia 94720United States

AIm:To investigate the impact of multifocal gas permeable contact lens(mFGPCL)in various add power and distance/near area allocation on short-term changes of choroidal thickness(ChT),axial length(AL),and retinal defocus profile in young ***:Seventeen young adults(2 males and 15 females;age 23.17±4.48y)were randomly assigned to wear two designs binocularly with a one-week washout period in *** of four mFGPCL designs were *** designs were distance-center that varied in two add power(+1.50 and 3.00 D)and/or two distance zone(DZ)diameters(1.50 and 3.00 mm;design A:DZ 1.5/add 3.0,B:DZ 1.5/add 1.5,C:DZ 3.0/add 3.0,D:DZ 3.0/add 1.5).ChT,AL,and peripheral refraction data were collected on each subject at baseline,on days 1 and 7 of mFGPCL daily *** was assessed in four quadrants using a spectraldomain optical coherence ***:AL was shortened by-26±44μm with lens C,-18±27μm with lens D,-13±29μm with lens A,and-8±30μm with lens B(all Pm,B:+3±7μm,C:+8±7μm,and D:+8±7μm).Temporal and superior choroid exhibited more choroidal thickening associated with *** designs induced significant relative peripheral myopia(RPm)beyond the central 20o across the horizontal meridian in both nasal and temporal fields(PmFGPCLs show a significant influence on ChT and AL,which are associated with significant increase in RPm after short-term *** reliability and feasibility of quantifying short-term changes in ChT support its use as a promising marker for the long-term efficacy of myopia-controlling treatments.

关键词： choroid gas-permeable contact lens retinal defocus axial length myopia

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Near Infrared Spectroscopy (NIRS) model-Based Prediction for Protein Content in Cowpea

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American Journal of Plant Sciences 2024年第3期15卷 145-160页

作者： Kavera Biradar Waltram Ravelombola Aurora manley caroline Ruhl Texas A&m AgriLife Research Vernon TX USA University of Agricultural Sciences Dharwad India Department of Soil and Crop Sciences Texas A&M University College Station TX USA

Cowpea (Vigna unguiculata L. Walp) is a multi-purpose legume with high quality protein for human consumption and livestock. The objective of this work was to develop near-infrared spectroscopy (NIRS) prediction models to estimate protein content in cowpea. A total of 116 cowpea breeding lines with a wide range of protein contents (19.28 % to 32.04%) were selected to build the model using whole seed and ground seed samples. Partial least-squares discriminant analysis (PLS-DA) regression technique with different pre-treatments (derivatives, standard normal variate, and multiplicative scatter correction) were carried out to develop the protein prediction model. Results showed: 1) spectral plots of both the whole seed and ground seed showed higher spectral scatter at higher wavelengths (>1450 nm), 2) data pre-processing affects prediction accuracy for bot whole seed and ground seed samples, 3) prediction using ground seed samples (0.64 R2 0.85) is better than the whole seed (0.33 R2 0.78), and 4) the data pre-processing second derivative with standard normal variate has the best prediction (R2_whole seed = 0.78, R2_ground seed = 0.85). The results will be of interest in cowpea breeding programs aimed at improving total seed protein content.

关键词： Cowpea Germplasm Protein Near-Infrared Spectroscopy (NIRS) Partial Least Squares (PLS)

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How completely are randomized controlled trials of non-pharmacological interventions following concussion reported? A systematic review

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Journal of Sport and Health Science 2024年第4期13卷 537-547页

作者： Jacqueline Josee van Ierssel Olivia Galea Kirsten Holte caroline Luszawski Elizabeth Jenkins Jennifer O’Neil Carolyn A Emery Rebekah mannix Kathryn Schneider Keith Owen Yeates Roger Zemek Children’s Hospital of Eastern Ontario Research Institute OttawaON K1H 8L1Canada The Centre for Health Activity and Rehabilitation ResearchUniversity of OtagoDunedin 9016New Zealand Sport Injury Prevention Research Centre Faculty of KinesiologyUniversity of CalgaryCalgaryAB T2N 1N4Canada Alberta Children’s Hospital Research Institute University of Calgary CalgaryAB T2N 1N4Canada Hotchkiss Brain Institute University of CalgaryCalgaryAB T2N 4N1Canada Department of Psychology University of CalgaryCalgaryAB T2N 1N4Canada g Faculty of MedicineUniversity of OttawaOttawaON K1H 8M5Canada School of Rehabilitation Sciences University of OttawaOttawaON K1H 8M5Canada Bruyere Research Institute OttawaON K1N 5C8Canada Departments of Pediatrics and Emergency medicine Harvard Medical SchoolBostonMA 02115USA Departments of Pediatrics and Emergency medicine University of OttawaOttawaON K1H 8M5Canada

Purpose:The study aimed to examine the reporting completeness of randomized controlled trials(RCTs)of non-pharmacological interventions following ***:We searched mEDLINE,Embase,PsycInfo,CINAHL,and Web of Science up to may *** reviewers independently screened studies and assessed reporting completeness using the Template for Intervention Description and Replication(TIDieR),Consensus on Exercise Reporting Template(CERT),and international Consensus on Therapeutic Exercise aNd Training(i-CONTENT)*** information was sought my study authors where reporting was *** of bias(ROB)was assessed with the Cochrane ROB-2 *** examining non-pharmacological interventions following ***:We included 89 RCTs(n=53 high ROB)examining 11 different interventions for concussion:sub-symptom threshold aerobic exercise,cervicovestibular therapy,physical/cognitive rest,vision therapy,education,psychotherapy,hyperbaric oxygen therapy,transcranial magnetic stimulation,blue light therapy,osteopathic manipulation,and head/neck *** scores were:TIDieR 9/12(75%;interquartile range(IQR)=5;range:5-12),CERT 17/19(89%;IQR=2;range:10-19),and i-CONTENT 6/7(86%;IQR=1;range:5-7).Percentage of studies completely reporting all items was TIDieR 35%(31/89),CERT 24%(5/21),and i-CONTENT 10%(2/21).Studies were more completely reported after publication of TIDieR(t_(87)=2.08;p=0.04)and CERT(t_(19)=2.72;p=0.01).Reporting completeness was not strongly associated with journal impact factor(TIDieR:rs=0.27;p=0.01;CERT:r_(s)=-0.44;p=0.06;i-CONTENT:r_(s)=-0.17;p=0.48)or ROB(TIDieR:rs=0.11;p=0.31;CERT:rs=0.04;p=0.86;i-CONTENT:rs=0.12;p=0.60).Conclusion:RCTs of non-pharmacological interventions following concussion demonstrate moderate to good reporting completeness,but are often missing key components,particularly modifications,motivational strategies,and qualified *** completeness improved after TIDieR and CERT publication,but p

关键词： Concussion Intervention Randomized controlled trial Systematic review

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Typology and Agroecology of Agroecosystems in Vegetation Dynamics in the Ecotones of the mbam and Inoubou

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Open Journal of Forestry 2024年第1期14卷 42-66页

作者： Alex Bruno Dong Etchike Lucie Félicité Temgoua Bertine Tiokeng marie caroline momo Solefack martin Benoit Ngassoum Pierre marie mapongmetsem Laboratory of Applied Botany Faculty of Sciences of the University of Dschang Dschang Cameroon Department of Forestry Faculty of Agronomy and Agricultural Sciences University of Dschang Dschang Cameroon National School of Agro-Industrial Sciences of the University of Ngaoundéré Ngaoundéré Cameroon Laboratory of Biodiversity and Sustainable Development of the University of Ngaoundéré Ngaoundéré Cameroon

Agroforestry systems strongly characterize the Cameroonian agrarian landscape. Agroforests are among those structuring the ecotones of mbam and Inoubou in the Central Cameroon region. Numerous works on agroecosystems of Central and South Cameroon, few have come out contribution of the structure of these traditional systems in the dynamics of the vegetation of these forest-savannah ecotones. The present contribution has the overall objective of demonstrating the structural efficiency of agroforests the dynamics of ecotone vegetation, but also in the conservation of biodiversity. To do this, a participatory analysis was carried out with 56 farmers distributed in the five villages of makénéné. Botanical inventories supplemented socio-economic household surveys. The data collected was subjected to various analyzes (univariate test, analysis of variance, multivariate test, PCA, CAH). The results reveal that 55.2% of agroforests are less than 15 years old and those with an area greater than 1500 m2 predominate (33%). They are mainly young with generally small surface areas. The horizontal structure reveals that the largest diameter classes are those of [20 - 30 cm[ and [10 - 20 cm[ with a very low rate of basal area. Agroforests with trees over 10 m high are dominant in five villages of makénéné. Two types of structural profiles characterize the agroforestry flora of the area, namely intensive pluristratified home gardens on savannah and intensive pluristratified agroforests under forest-savannah transition vegetation. Principal Component Analysis (PCA) and Ascending Hierarchical Clustering (HAC) show three Agroforest Clusters each. The PCA distribution reveals that woody biomass (Y) is strongly correlated with tree diameter (DBH) and significantly with height (Cluster 2). The age (AAG) (Cluster 1) of these agroforests, on the other hand, remains independent of the density (DST) of these trees (Cluster 3). The agroforests in the Nyokon, Carrière and mocksud vil

关键词： Agroforests Agroecosystem Center Cameroon Dynamics Agroecology Typology

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Floristic Diversity, Stand Structure and Plant Life Traits in the Forest-Savanna mosaic at Ndjole (Centre Cameroon)

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Open Journal of Ecology 2024年第4期14卷 309-330页

作者： Djeuguen Vanessa Tchaleu Solefack marie caroline momo mateso Aimé Kambale Ndondjeu Charles Tafen Yanick Borel Kamga Victor François Nguetsop Research Unit of Applied Botany (URBOA) Department of Plant Biology Faculty of Science University of Dschang Dschang Cameroon

With the aim of assessing floristic diversity, stand structure and vegetation ecology, the present work was carried out in the savanna mosaic forest of the locality of Ndjole (Centre Cameroon). A total of 30 floristic plots of 40 m × 40 m (1600 m2) were delineated in the different ecosystems (forest, forest-savanna contact zone and the savanna). Within each plot, all individuals with a diameter at breast height ≥ 10 cm at 1.30 m were taken into account. ANOVA was used to compare the means of the diversity indices of the different ecosystems, and the DUNCAN test at 5% significance level (XLSTAT 2016) to separate these means. A total of 85 species belonging to 67 genera and 33 families were recorded. That is, 68 species in semi-caducifolia forest, 45 in forest-savanna contact zone and 18 in savanna. Urticaceae, Combretaceae, Apocynaceae, myristicaceae and Euphorbiaceae are the most diverse families in the forest. On the other hand, in contact zones, the Euphorbiaceae, Fabaceae, Annonaceae and moraceae families are the most diversified, while in the savannas, the Combretaceae, Fabaceae and Annonaceae families are the most diversified. Shannon’s diversity index values (1.7 to 2.37 bits) reflect low specific diversity;Piélou’s equitability (0.86 to 0.9) shows good distribution of individuals within species. The diametric structure of woody species shows an inverted “J” shape in all plant communities. This indicates a high regeneration potential characterized by a greater number of small trees than large trees. mesophanerophytes and megaphanerophytes are dominant in forests and forest-savanna contact zones, and microphanerophytes in the savannas. Endozoochory is the main mode of diaspore dissemination. As regards the distribution of phytogeographical types, it shows the overall dominance of Guineo-Congolese species in all plant communities. Our study provides detailed data on forest-savanna floristic and plant life traits in the mosaic and recommends further st

关键词： mosaic Communities Dissemination Regeneration Diversity

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How well does XAD resin extraction recover halogenated disinfection byproducts for comprehensive identification and toxicity testing?

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Journal of Environmental Sciences 2022年第7期34卷 264-275页

作者： Xiaobin Liao Joshua m.Allen caroline O.Granger Susan D.Richardson Department of Chemistry and Biochemistry University of South CarolinaColumbiaSouth Carolina 29208USA Institute of municipal and Environmental Engineering College of Civil EngineeringHuaqiao UniversityFujian 361021China Currently at LanzaTech 535 Commerce DriveSopertonGeorgia 30457USA

Halogenated disinfection byproducts(DBPs) are an unintended consequence of drinking water disinfection, and can have significant toxicity. XAD resins are commonly used to extract and enrich trace levels of DBPs for comprehensive, nontarget identification of DBPs and also for in vitro toxicity studies. However, XAD resin recoveries for complete classes of halogenated DBPs have not been evaluated, particularly for low, environmentally relevant levels(ng/L to low μg/L). Thus, it is not known whether levels of DBPs or the toxicity of drinking water might be underestimated. In this study, DAX-8/XAD-2 layered resins were evaluated, considering both adsorption and elution from the resins, for extracting 66 DBPs from water. Results demonstrate that among the 7 classes of DBPs investigated, trihalomethanes(THms), including iodo-THms, were the most efficiently adsorbed, with recovery of most THms ranging from 50%-96%, followed by halonitromethanes(40%-90%). The adsorption ability of XAD resins for haloacetonitriles, haloacetamides, and haloacetaldehydes was highly dependent on the individual species. The adsorption capacity of XAD resins for haloacetic acids was lower(5%-48%), even after adjusting to p H 1 before extraction. Recovery efficiency for most DBPs was comparable with their adsorption, as most were eluted effectively from XAD resins by ethyl acetate. DBP polarity and molecular weight were the two most important factors that determine their recovery. Recovery of trichloromethane, iodoacetic acid, chloro-and iodo-acetonitrile, and chloroacetamide were among the lowest, which could lead to underestimation of toxicity, particularly for iodoacetic acid and iodo-acetonitrile, which are highly toxic.

关键词： XAD resins Disinfection byproducts DBPs Recovery Toxicity

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全球日晒行为调查研究

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中华皮肤科杂志 2024年第7期57卷 672-673页

作者： Thierry Passeron Henry W. Lim Chee Leok Goh Hee Young Kang Fatimata Ly Akimichi morita Jorge Ocampo-Candiani Susana Puig Sergio Schalka Wei Liu Anne-Laure Demessant-Flavigny caroline Le Floc’h Delphine Kerob Brigitte Dreno Jean Krutmann Department of Dermatology Côte d'Azur University Nice University Hospital Center Nice France INSERm U1065 C3M Côte d'Azur University Nice France Department of Dermatology Henry Ford Health Detroit Michigan USA National Skin Centre Singapore City Singapore Department of Dermatology Ajou University School of Medicine Suwon South Korea Department of Dermatology Cheikh Anta Diop Dakar University EPS Institute of Social Hygiene Dakar Senegal Department of Geriatric and Environmental Dermatology Nagoya City University Graduate School of Medical Sciences Nagoya Japan Universidad Autonoma de Nuevo León Facultad de Medicina University Hospital “Dr. Jose E. González” Monterrey Mexico Dermatology Department Hospital Clinic de Barcelona Barcelona University Barcelona Spain medcin Skin Research Center and Biochemistry Department Chemistry Institute of Sao Paulo University Sao Paulo Brazil Department of Dermatology The General Hospital of Air Force PLA Beijing China La Roche-Posay International Levallois-Perret France Nantes University Univ Angers INSERM Immunology and New Concepts in ImmunoTherapy INCIT UMR 1302 Nantes France IUF Leibniz Research Institute for Environmental medicine Duesseldorf Germany medical Faculty Heinrich-Heine-University Duesseldorf Germany

适量的日光照射有益于维生素D合成和情绪调节,但日光中的紫外线可能引发多种机体损伤,包括红斑、晒伤、光免疫抑制和光变态反应等急性损伤,以及皮肤癌、黄褐斑、炎症后色素沉着和光老化等慢性损伤。近期研究还显示,可见光(紫色至红色,40... 详细信息

适量的日光照射有益于维生素D合成和情绪调节,但日光中的紫外线可能引发多种机体损伤,包括红斑、晒伤、光免疫抑制和光变态反应等急性损伤,以及皮肤癌、黄褐斑、炎症后色素沉着和光老化等慢性损伤。近期研究还显示,可见光(紫色至红色,400~700nm)和红外线(700nm~1mm)也是皮肤光老化和光损伤的影响因素,可见光会导致黄褐斑等色素性疾病加重。

关键词：色素性疾病皮肤光老化光变态反应慢性损伤日光照射黄褐斑机体损伤维生素D

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