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Health 2014年第12期6卷 1503-1511页

作者： David Martins Yuan-Xiang Meng Naureen Tareen Jorge Artaza Jae Eun Lee caroline farodolu Gary Gibbons Keith Norris Charles R. Drew University Los Angeles USA Jackson State University Jackson USA Morehouse School of Medicine Atlanta USA National Heart Lung and Blood Institute Bethesda USA University of California Los Angeles Los Angeles USA

Background: Vitamin D deficiency has been implicated as a potential risk factor for cardiovascular disease. The high rate of vitamin D deficiency ( 25) African Americans with elevated blood pressure (130 - 150/85 - 100 mmHg) and low serum vitamin D level (10 - 25 ng/ml). Results: There was a significant increase in the serum 25(OH)D levels to a mean level of 34.5 ng/ml (SD = 7.1) with the intervention (p < 0.001). The increase in 25(OH)D levels was associated with a significant decrease in the serum level of intact PTH (p = 0.02), mean urinary isoprostane (p = 0.02) and adipocyte cytokine expression. Although the increase in the 25(OH)D levels was not associated with any significant change in the Pulse Wave Velocity (PWV) in the overall study sample, it was associated with a significant decrease in the augmentation index among the participants with the highest tertile of urinary isoprostane (p = 0.007). Conclusion: We concluded that vitamin D supplementation increased serum 25(OH)D levels, decreased intact PTH level and the levels of select inflammatory and oxidative stress mediators of arterial stiffness. Longer term prospective studies are warranted to evaluate the effect of high dose vitamin D supplementation on arterial stiffness.

关键词： Vitamin D Overweight Hypovitaminosis D

On the Stability of Racing Sailing Boats with Foils

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Chinese Annals of Mathematics,Series B 2018年第3期39卷 427-450页

作者： Philippe DESTUYNDER caroline FABRE Département d'ingénierie Mathématique Laboratoire M2N Conservatoire National des Arts et Métiers 292rue saint Martin75003 ParisFrance Laboratoire de Mathématiques d'Orsay Univ.Paris-SudCNRSUniversitéParis-Saclay 91405 OrsayFrance

The development of foils for racing boats has changed the strategy of sailing. Recently, the America＇s cup held in San Francisco, has been the theatre of a tragicomic history due to the foils. During the last round, the New-Zealand boat was winning by 8 to 1 against the defender USA. The winner is the first with 9 victories. USA team understood suddenly （may be） how to use the control of the pitching of the inain foils by adjusting the rake in order to stabilize the ship. And USA won by 9 victories against 8 to the challenger NZ. The goal in this paper is to point out few aspects which could be taken into account in order to improve this mysterious control law which is known as the key of the victory of the USA team. There are certainly many reasons and in particular the cleverness of the sailors and of all the engineering team behind this project. But it appears interesting to have a mathematical discussion, even if it is a partial one, on the mechanical behaviour of these extraordinary sailing boats. The nunlerical exanlples given here are not the true ones. They have just been invented in order to explain the theoretical developments concerning three points： The possibility of tacking on the foils for sailing upwind, the nature of foiling instabilities, if there are, when the boat is flying and the control laws.

关键词： Hydrodynamics of foils Mathematical analysis Stability

Old dog,new trick:The PHR-SPX system regulates arbuscular mycorrhizal symbiosis

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Molecular Plant 2022年第2期15卷 225-227页

作者： Debatosh Das caroline Gutjahr CUHK Shenzhen Research Institute No.10 Yuexing 2nd RoadNanshanShenzhenChina Plant Genetics TUM School of Life SciencesTechnical University of Munich(TUM)Emil Ramann Strasse 485354 FreisingGermany

Plant growth depends on the continuous availability of the macro-nutrient phosphate(Pi).However,in most soils,Pi is only poorly accessible to plants,resulting in Pi deficiency and triggering a number of Pi starvation *** strategy of plants to over-come Pi limitation is to form a symbiosis with arbuscular mycor-rhizal(AM)fungi(Smith et al.,2011),which occurs with approximately 80%of land *** fungi improve the uptake of Pi and other mineral nutrients and thereby increase plant performance and stress *** collect these minerals with an extraradical hyphal network from the soil and release them from highly branched structures,called arbuscules,into root cortex ***,Pi sufficiency causes inhibition of internal root colonization(Balzergue et al.,2011;Breuillin et al.,2010).The mechanistic basis for this has long remained *** studies have now solved this long-standing mystery and demonstrated that a canonical Pi-response regulatory module regulates AM symbiosis in accordance with the plant Pi status(Shi et al.,2021;Das et al.,2022).

关键词： thereby symbiosis release

RNA therapeutics:updates and future potential

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Science China(Life Sciences) 2023年第1期66卷 12-30页

作者： caroline Zhang Biliang Zhang State Key Laboratory of Respiratory Disease Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China Guangzhou RiboBio Co. LtdGuangzhou 510663China Argorna Pharmaceuticals Co. Guangzhou 510530China

Recent advancements in the production,modification,and cellular delivery of RNA molecules facilitated the expansion of RNAbased *** increasing understanding of RNA biology initiated a corresponding growth in RNA *** this review,the general concepts of five classes of RNA-based therapeutics,including RNA interference-based therapies,antisense oligonucleotides,small activating RNA therapies,circular RNA therapies,and messenger RNA-based therapeutics,will be ***,we also provide an overview of RNA-based therapeutics that have already received regulatory approval or are currently being evaluated in clinical trials,along with challenges faced by these ***-based drugs demonstrated positive clinical trial results and have the ability to address previously“undruggable”targets,which delivers great promise as a disruptive therapeutic technology to fulfill its full clinical potentiality.

关键词： RNA RNA therapeutics mRNA vaccine RNAi

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Frequency-selective Optimization of Periodic Gate Control Signals in DC/DC Converters for EMI-reduction

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Chinese Journal of Electrical Engineering 2022年第4期8卷 11-18页

作者： caroline Krause Stephan Frei On-board Systems Lab TU Dortmund UniversityDortmund 44227Germany

High-frequency switching of power transistors in power electronic systems can cause electromagnetic *** approaches for reducing high-frequency disturbances,such as inserting an additional gate resistor,lead to increased power *** makes achieving both electromagnetic compatibility and power efficiency *** gate drivers help to find a trade-off between these ***,only narrow-band disturbances must be ***,a target signal with a spectrum notched at some frequencies can be *** target signal can be reached by a target-signal-oriented control of the transistor’s *** leads to steeper switching slopes,such that the power losses are less *** arbitrary target signals is *** transistor signal exhibits some physical limitations.A constraint satisfaction problem must be solved,and the gate drive signal must be optimized by applying a residual and Newton’s *** proposed optimization process in the frequency domain is based on the circuit simulation method named“harmonic balance”.Measurements on a DC/DC converter exhibit the benefits of this method.

关键词： Power electronics active gate driving electromagnetic compatibility Newton’s method

INTEGRATED DESIGN CONSIDERATIONS FOR SOLAR COMMUNITIES

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Journal of Green Building 2015年第2期10卷 134-156页

作者： caroline Hachem-Vermette Faculty of Environmental Design Professional Faculties 3170 University of Calgary2500 University Drive NWCalgary AB T2N 1N4

This paper presents design considerations for an integrated design of solar commu-nities highlighting the interactive nature of various design parameters to improve the energy performance of these *** considerations are illus-trated through practical design examples of different neighborhood scenarios and individual buildings,based on extensive studies and analysis of energy performance of a wide spectrum of buildings and *** examples fall under two general categories-design at the neighborhood level,and design at the individ-ual building *** design is illustrated by examples of homogeneous residential neighborhoods consisting of 2-storied housing units and of a mixed-rise *** of individual buildings focuses primarily on design of the envelope-consisting of roof and façades-for maximizing energy generation poten-tial,as a function of height and relative position to adjacent *** addition to examples of application of the design considerations,the paper outlines the process of design of solar communities and the role of simulations in the design process.

关键词： Integrated Design Process Solar Potential Passive solar design Building integrated photovoltaic Solar neighbourhood design

Matrin-3 dysfunction in myopathy and motor neuron degeneration

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Neural Regeneration Research 2022年第3期17卷 575-576页

作者： caroline Ward Udai Bhan Pandey Department of Pediatrics Division of Child NeurologyChildren’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA Department of Human Genetics School of Public HealthSchool of Public HealthUniversity of Pittsburgh Center for Neuroscience Institute Children’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA

The MATR3 protein was first identified comprising the nuclear matrix,an essential part of preserving the skeletal framework of the nucleus,amongst other nuclear *** mainly of intrinsically disordered regions,the prote... 详细信息

关键词： domains. preserving disordered

Spawning ascent durations of pelagic spawning reef fishes

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Current Zoology 2012年第1期58卷 95-102页

作者： Habrun, caroline A. Sancho, Gorka College of Charleston Department of Biology Grice Marine Laboratory 205 Fort Johnson Road Charleston SC 29412 USA

Predation risks have been hypothesized to influence spawning behaviors of coral reef fishes that broadcast gametes pelagically. The duration of spawning ascents of 13 species were measured from video footage at a single spawning site for mul- tiple coral reef fishes to investigate ff this behavior was influenced by varying risks of predation. Fishes that spawned in pairs had as- cents of longer duration than group-spawning species. Duration of spawning ascents did not vary between fishes spawning at daytime and dusk, nor between group-spawning species with specific anti-predatory morphological adaptations. These results indicate that risk of predation may not significantly influence the duration of spawning ascents of pair spawning reef fishes at our study site, while group-spawning behaviors are influenced by predation. Avoidance of egg predation by benthic organisms and female mate choice are more likely to influence the pelagic spawning behaviors of all fishes observed [Current Zoology 58 （1）： 95-102, 2012].

关键词： Reef fishes Behavior Spawning Predation Mate selection

The pathology behind glaucoma:what we already know using omics technologies

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Neural Regeneration Research 2023年第12期18卷 2701-2702页

作者： caroline May Sabrina Reinehr Department Functional Proteomics Medizinisches Proteom-CenterRuhr-University BochumBochumGermany Experimental Eye Research Institute University Eye HospitalRuhr-University BochumBochumGermany

The term glaucoma encompasses a spectrum of eye diseases pathologically characterized by an irreversible loss of retinal ganglion cells and their associated axons. Patients initially suffer from gaps in their visual field, the part of the visual range that can be perceived without eye movement. In the early stages of the disease, this damage can be compensated very well by eye movements. This, in turn, means that glaucoma is often not diagnosed until the disease is more advanced.

关键词： visual irreversible initially

Classification of natural products as sources of drugs according to the biopharmaceutics drug disposition classification system(BDDCS)

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Chinese Journal of Natural Medicines 2016年第12期14卷 888-897页

作者： LI Ji caroline A.Larregieu Leslie *** Department of Clinical Pharmacy School of Basic Medicine and Clinical Pharmacy China Pharmaceutical University Department of Bioengineering & Therapeutic Science University of California

Natural products(NPs) are compounds that are derived from natural sources such as plants, animals, and microisms. Therapeutics has benefited from numerous drug classes derived from natural product sources. The Biopharmaceutics Drug position Classification System(BDDCS) was proposed to serve as a basis for predicting the importance of transporters and enzymes in determining drug bioavailability and disposition. It categorizes drugs into one of four biopharmaceutical classes according to their water solubility and extent of metabolism. The present paper reviews 109 drugs from natural product sources: 29% belong to class 1(high solubility, extensive metabolism), 22% to class 2(low solubility, extensive metabolism), 40% to class 3(high solubility, poor metabolism), and 9% to class 4(low solubility, poor metabolism). Herein we evaluated the characteristics of NPs in terms of BDDCS class for all 109 drugs as wells as for subsets of NPs drugs derived from plant sources as antibiotics. In the 109 NPs drugs, we piled 32 drugs from plants, 50%(16) of total in class 1, 22%(7) in class 2 and 28%(9) in class 3, none found in class 4; Meantime, the antibiotics were found 5(16%) in class 2, 22(71%) in class 3, and 4(13%) in class 4; no drug was found in class 1. Based on this classification, we anticipate BDDCS to serve as a useful adjunct in evaluating the potential characteristics of new natural products.

关键词： Biopharmaceutics Drug Disposition Classification System(BDDCS) Natural products(NPs) Dose number Solubility and extent of metabolism