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Corrosion in Mg-alloy biomedical implants-the strategies to reduce the impact of the corrosion inflammatory reaction and microbial activity

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Journal of Magnesium and Alloys 2022年第12期10卷 3306-3326页

作者： Soumya Saha Widya Lestari caroline dini Murni Nazira Sarian Hendra Hermawan Valentim A.R.Barão Cortino Sukotjo Christos Takoudis Department of Biomedical Engineering University of Illinois at ChicagoChicagoUnited States Fundamental Dental and Medical Sciences Department Kulliyyah of DentistryInternational Islamic University MalaysiaKuantanMalaysia Department of Prosthodontics and Periodontology Piracicaba Dental SchoolUniversity of Campinas(UNICAMP)PiracicabaBrazil Institute of Systems Biology(INBIOSIS) Universiti Kebangsaan MalaysiaBandar Baru BangiSelangor 43600Malaysia Department of Mining Metallurgical and Materials EngineeringLaval UniversityQuebec CityQC G1V 0A6Canada Department of Restorative Dentistry University of Illinois at Chicago College of DentistryChicagoUnited States Department of Chemical Engineering University of Illinois at ChicagoChicagoUnited States

The most common complication of orthopedic surgery is implant failure, which can result in catastrophic injury and a significant financial burden for patients. Implant failure can be caused by a variety of factors, the most common of which are peri–implant infection(or implantrelated infection), excessive inflammatory response which caused pain and aseptic loosening. Orthopedic surgeons now have a variety of options for treating these issues, including revision surgery, which has demonstrated to be effective. If excessive inflammatory reaction caused by the corrosion and peri–implant infection can be avoided, it will be of enormous social benefits. This review will provide a summary of corrosion and the inflammation reactions due to the corrosion and antimicrobial properties of Mg alloy-based implants covering both in vitro and in vivo studies. The strategies on hindering/overcoming the excessive inflammatory response and enhancing the antimicrobial activity are discussed in this review.

关键词： Mg-alloy implants review Corrosion and inflammation Microbial infection

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