检索结果-南通市图书馆

Liver transplantation: current status and challenges

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第18期22卷 4438-4445页

作者： caroline c Jadlowiec timucin taner William J. von Liebig transplantation center Division of Transplant Surgery Department of SurgeryMayo Clinic

Great progress has been made in the field of liver transplantation over the past two decades. this progress, however, also brings up the next set of challenges: First, organ shortage remains a major limitation, and accounts for a large proportion of wait list mortality. While living donation has successfully increased the total number of liver transplants done in Asian countries, the total number of such transplants has been stagnant in the western hemisphere. As such, there has been a significant effort over the past decade to increase the existing deceased donor pool. this effort has resulted in a greater use of liver allografts following donation after cardiac death(DcD) along with marginal and extended criteria donors. Improved understanding of the pathophysiology of liver allografts procured after circulatory arrest has not only resulted in better selection and management of DcD donors, but has also helped in the development of mechanical perfusion strategies. Early outcomes demonstrating the clinical applicability of both hypothermic and normothermic perfusion and its potential to impact patient survival and allograft function have generated much interest. Second, long-term outcomes of liver transplant recipients have not improved significantly, as recipients continue to succumb to complications of long-term immunosuppression, such as infection, malignancy and renal failure. Furthermore, recent evidence suggests that chronic immune-mediated injury to the liver may also impact graft function.

关键词： Donation after cardiac death Mechanical perfusion Renal-sparing immunosuppression Antibody-mediated rejection

Revisiting the liver’s role in transplant alloimmunity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2019年第25期25卷 3123-3135页

作者： Nitin Abrol caroline c Jadlowiec timucin taner William J.von Liebig center for transplantation and clinical Regeneration Massyo ClinicRochesterMN 55905United States transplant center Mayo ClinicPhoenixAZ 85259United States

the transplanted liver can modulate the recipient immune system to induce tolerance after *** phenomenon was observed nearly five decades ***,the liver’s role in multivisceral transplantation was recognized,as it has a protective role in preventing rejection of simultaneously transplanted solid organs such as kidney and *** liver has a unique architecture and is home to many cells involved in immunity and *** transplantation,these cells migrate from the liver into the *** studies identified chimerism as an important mechanism by which the liver modulates the human immune *** studies on human t-cell subtypes,cytokine expression,and gene expression in the allograft have expanded our knowledge on the potential mechanisms underlying *** this article,we discuss the privileged state of liver transplantation compared to other solid organ transplantation,the liver allograft’s role in multivisceral transplantation,various cells in the liver involved in immune responses,and the potential mechanisms underlying immunomodulation of host alloresponses.

关键词： Liver transplantation Alloimmunity Liver-kidney transplant tolerance Rejection

Like or dislike:Response of rodents to the odor of plant secondary metabolites

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrative Zoology 2017年第5期12卷 428-436页

作者： Sabine c.HANSEN caroline StOLtER christian IMHOLt Jens JAcOB Julius-Kühn Institute for Plant Protection in Horticulture and Forests Vertebrate ResearchMünsterGermany University Hamburg Biocenter Grindel and Zoological MuseumHamburgGermany

Rodents,including common voles(Microtus arvalis)and house mice(Mus musculus)cause immense pre-harvest and post-harvest ***,developing methods that mitigate these losses while maintaining their role in ecosystems is a *** plant secondary metabolites(PSM)which significantly reduce food intake of both species under laboratory conditions have been ***,before these can be used in rodent pest management,they must be tested under more natural conditions where other food sources are *** this study,the odors of 4 PSMs were evaluated for their repellent effects in experiments conducted in semi-natural *** treated with PSMs or untreated soil(experimental control)was placed in an underground box containing food(rolled oats).We quantified the number of visits to each box and could demonstrate that all 4 PSMs reduced the number of visits to treatment boxes in both rodent *** common voles the combination of methyl nonyl ketone+black pepper oil was the most repellent *** mice made fewer visits to all PSM boxes;boxes with the anthraquinone were visited ***,house mice consumed less food from boxes containing soil treated with all 4 *** results suggest that PSMs are repellent in murid and microtine rodents under semi-field *** addition,the future use of PSM odors for repelling both pest species,especially house mice,seems *** investigations with other PSMs,different concentrations as well as alternative application methods are needed to repel common voles from attractive crops.

关键词： enclosure trials odor plant secondary metabolites repellents rodents

Novel heart valve leaflet designs with stiff polymeric materials and biomimetic kinematics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bio-Design and Manufacturing 2024年第6期7卷 1018-1034页

作者： caroline c.Smid Georgios A.Pappas Nikola cesarovic Volkmar Falk Paolo Ermanni Laboratory of composite Materials and Adaptive Structures ETH ZürichLeonhardstrasse 218092 ZürichSwitzerland translational cardiovascular technologies ETH ZürichLeopold-Ruzicka-Weg 48093 ZürichSwitzerland Department for cardiothoracic and Vascular Surgery Deutsches Herzzentrum der CharitéCharitéUniversitätsmedizin BerlinAugustenburger Pl.113353 BerlinGermany German center for cardiovascular Research(DZHK) Partner Site BerlinAugustenburger Pl.113353 BerlinGermany

Despite continuous efforts to improve the robustness of cardiac valve implants,neither bioprosthetic nor mechanical valves fulfill both hemodynamic and durability *** study discussed novel flexible leaflet designs,focusing on polymeric materials with proven hemocompatibility,such as polyether ether ketone,of much higher stiffness than native tissue,aiming at optimal valve implants.A biomimetic valve with a single-curvature belly-curve(B-c)was used as a reference for new design variants with a double-curvature B-c with varying ***(13.2 MPa)and stiff(2.4 GPa)leaflet materials and different thicknesses were studied using lean simulations and in vitro experiments under physiologic hemodynamic *** performance was assessed using opening pressure(OP)and orifice area(OA).the latter was determined by a newly developed automatized image processing *** trends are in agreement with simulations and demonstrated that a buckling-inspired double-curvature leaflet design significantly enhances the trileaflet valve opening behavior,which is particularly advantageous for stiffer leaflet *** to the reference,the best-performing variant showed an OP improvement of 47%and 44%based on simulations and experiments,*** contrast,the achieved mean pressure differential was directly comparable to state-of-the-art bioprosthetic *** OA was slightly reduced for new variants but still in the satisfying range.

关键词： Fully polymeric heart valve Parametric leaflet design Finite element analysis Leaflet kinematics In vitro testing

Effect of natural organic matter on thallium and silver speciation

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2020年第7期32卷 185-192页

作者： Loïc A.Martin caroline Simonucci Sétareh Rad Marc F.Benedetti Universitéde Paris Institut de physique du globe de ParisCNRSF-75005 ParisFrance IRSN PSE-ENV/SIRSE/LER-NordBP 1792262 Fontenay-aux-Roses CedexFrance catchment and Eco-Hydrology Research Group Luxembourg Institute of Science and TechnologyL-4422 BelvauxLuxembourg BRGM Unitéde Géomicrobiologie et Monitoring Environnemental45060 Orléans Cedex 2France

Natural organic matter(NOM)is known to play an important role in the transport and binding of trace metal elements in aquatic and soil *** is a pollutant for which the extent of the role played by NOM is poorly ***,this study investigates thallium(Ⅰ)and its complexation to a purified humic substance as proxy for *** were performed with the Donnan Membrane technique to separate,for the first time,the free tl^+ion from its complexed form in the bulk *** pH and concentrations were investigated at constant ionic strength and constant NOM proxy concentrations in *** results were described with NIcA-Donnan *** complexation was compared to silver complexation using literature data and using the same NIcA-Donnan *** for these two cations(tl^+and Ag^+)are reported in this article,for the first *** display low thallium complexation to the NOM proxy while silver competes with divalent cations for the NOM binding *** speciation for dissolved thallium highlights the dominance of free thallium(tl^+)in solution whereas tl-NOM complexes contribute roughly 15%to total tl(Ⅰ)species in river and lake type *** results are obtained for soil solutions,tl-bound to NOMtotal,from UK soils with different land use and geochemistry.

关键词： thallium Organic matter Speciation NIcA-Donnan model Soil Water

Shifts in phenology of autumn migration and wing length among reedbed passerines along the East Asian–Australasian Flyway

在线全文

学校读者我要写书评

暂无评论

Avian Research 2022年第3期13卷 275-284页

作者： John A.Allcock timothy c.Bonebrake Yik Hei Sung caroline Dingle School of Biological Sciences Kadoorie Biological Sciences BuildingThe University of Hong KongPok Fu LamHong Kong SARChina Science Unit Lingnan UniversityHong Kong SARChina

climate change impacts bird migration phenology,causing changes in departure and arrival dates,leading to potential mismatches between migration and other key seasonal *** the impacts of climate change on arrival at breeding grounds have been relatively well documented,little is known about the impacts of climate change on post-breeding migration,especially at stopover *** we use long-term(11 years)banding data(11,118 captures)from 7 species at Mai Po Marshes Nature Reserve in Hong Kong,a key stopover site for migratory birds along the East Asian–Australasian Flyway,to describe long-term changes in migration phenology and to compare observed changes to annual weather *** also examine changes in wing length over a longer time period(1985–2020)as wing length often correlates positively with migration *** found that observed changes in migratory phenology vary by species;three species had later estimated arrival(by 1.8 days per year),peak(by 2.6 days per year)or departure(by 2.5 days per year),one showed an earlier peak date(by 1.8days per year)and two showed longer duration of passage(2.7 days longer and 3.2 days longer per year).three species exhibited no long-term change in migration *** two of the four species with shifting phenology,temperature was an important predictor of changing peak date,departure dates and duration of *** length was shorter in three species and longer in two species,but these changes did not correlate with observed phenological *** complex changes observed here are indicative of the challenges concerning the detection of climate change in migratory stopover *** monitoring and a better understanding of the dynamics of all sites in the migratory pathway will aid conservation of these species under global change.

关键词： Autumn migration climate change East Asian–Australasian flyway Passerines Phenology Reedbed

On the Stability of Racing Sailing Boats with Foils

在线全文

学校读者我要写书评

暂无评论

chinese Annals of Mathematics,Series B 2018年第3期39卷 427-450页

作者： Philippe DEStUYNDER caroline FABRE Département d'ingénierie Mathématique Laboratoire M2N Conservatoire National des Arts et Métiers 292rue saint Martin75003 ParisFrance Laboratoire de Mathématiques d'Orsay Univ.Paris-SudCNRSUniversitéParis-Saclay 91405 OrsayFrance

the development of foils for racing boats has changed the strategy of sailing. Recently, the America＇s cup held in San Francisco, has been the theatre of a tragicomic history due to the foils. During the last round, the New-Zealand boat was winning by 8 to 1 against the defender USA. the winner is the first with 9 victories. USA team understood suddenly （may be） how to use the control of the pitching of the inain foils by adjusting the rake in order to stabilize the ship. And USA won by 9 victories against 8 to the challenger NZ. the goal in this paper is to point out few aspects which could be taken into account in order to improve this mysterious control law which is known as the key of the victory of the USA team. there are certainly many reasons and in particular the cleverness of the sailors and of all the engineering team behind this project. But it appears interesting to have a mathematical discussion, even if it is a partial one, on the mechanical behaviour of these extraordinary sailing boats. the nunlerical exanlples given here are not the true ones. they have just been invented in order to explain the theoretical developments concerning three points： the possibility of tacking on the foils for sailing upwind, the nature of foiling instabilities, if there are, when the boat is flying and the control laws.

关键词： Hydrodynamics of foils Mathematical analysis Stability

Old dog,new trick:the PHR-SPX system regulates arbuscular mycorrhizal symbiosis

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2022年第2期15卷 225-227页

作者： Debatosh Das caroline Gutjahr cUHK Shenzhen Research Institute No.10 Yuexing 2nd RoadNanshanShenzhenChina Plant Genetics TUM School of Life SciencesTechnical University of Munich(TUM)Emil Ramann Strasse 485354 FreisingGermany

Plant growth depends on the continuous availability of the macro-nutrient phosphate(Pi).However,in most soils,Pi is only poorly accessible to plants,resulting in Pi deficiency and triggering a number of Pi starvation *** strategy of plants to over-come Pi limitation is to form a symbiosis with arbuscular mycor-rhizal(AM)fungi(Smith et al.,2011),which occurs with approximately 80%of land *** fungi improve the uptake of Pi and other mineral nutrients and thereby increase plant performance and stress *** collect these minerals with an extraradical hyphal network from the soil and release them from highly branched structures,called arbuscules,into root cortex ***,Pi sufficiency causes inhibition of internal root colonization(Balzergue et al.,2011;Breuillin et al.,2010).the mechanistic basis for this has long remained *** studies have now solved this long-standing mystery and demonstrated that a canonical Pi-response regulatory module regulates AM symbiosis in accordance with the plant Pi status(Shi et al.,2021;Das et al.,2022).

关键词： thereby symbiosis release

RNA therapeutics:updates and future potential

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science china(Life Sciences) 2023年第1期66卷 12-30页

作者： caroline Zhang Biliang Zhang State Key Laboratory of Respiratory Disease Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China Guangzhou RiboBio co. LtdGuangzhou 510663China Argorna Pharmaceuticals co. Guangzhou 510530China

Recent advancements in the production,modification,and cellular delivery of RNA molecules facilitated the expansion of RNAbased *** increasing understanding of RNA biology initiated a corresponding growth in RNA *** this review,the general concepts of five classes of RNA-based therapeutics,including RNA interference-based therapies,antisense oligonucleotides,small activating RNA therapies,circular RNA therapies,and messenger RNA-based therapeutics,will be ***,we also provide an overview of RNA-based therapeutics that have already received regulatory approval or are currently being evaluated in clinical trials,along with challenges faced by these ***-based drugs demonstrated positive clinical trial results and have the ability to address previously“undruggable”targets,which delivers great promise as a disruptive therapeutic technology to fulfill its full clinical potentiality.

关键词： RNA RNA therapeutics mRNA vaccine RNAi

同方期刊数据库