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Plant Communications 2024年第4期5卷 129-132页

作者： Enzo Lezin Ines Carqueijeiro Clement Cuello Mickael Durand Hans JJansen Valentin Verges caroline birer williams Audrey Oudin Thomas Duge de Bernonville Julien Petrignet Noemie Celton Benoit St-Pierre Nicolas Papon Chao Sun Ron P.Dirks Sarah Ellen O’Connor Michael Krogh Jensen Sebastien Besseau Vincent Courdavault Biomole´cules et Biotechnologies Vegetales EA2106Universite´de Tours37200 ToursFrance Future Genomics Technologies 2333 BE Leidenthe Netherlands Laboratoire Synthe se et Isolement de Molecules BioActives(SIMBA EA 7502)Universitede Tours37200 ToursFrance Laboratoire de Cytoge´netique Constitutionnelle CHRU de Tours-Hopital Bretonneau37044 ToursFrance University Angers University BrestIRFSFR ICAT49000 AngersFrance Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 2800China Department of Natural Product Biosynthesis Max Planck Institute for Chemical Ecology07745 JenaGermany Novo Nordisk Foundation Center for Biosustainability Technical University of Denmark100193 Kgs LyngbyDenmark Present address:Limagrain Center de RechercheRoute d’EnnezatChappesFrance These authors contributed equally to this article

Dear Editor,Rauvolfia tetraphylla(aka the Devil pepper)(Supplemental Figure 1)is a well-known medicinal plant that produces monoterpenoid indole alkaloids(MIAs).This MIA biosynthesis occurs in several organs,including leaves,stems,fruit,and roots,which accumulate the famous antiarrhythmic ajmaline(Kumar et al.2016a,2016b;Kumara et al.,2019).MIAs are natural products notably involved in plant adaptation to the environment and defense against *** mainly results from their high biological activities,which also explain their pharmacological properties.

关键词： properties. Figure roots

Cold adaptation does not alter ATP homeostasis during cold exposure in Drosophila melanogaster

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Integrative Zoology 2018年第4期13卷 471-481页

作者： caroline M.williams James R.ROCCA Arthur S.EDISON David B.ALLISON Theodore J.MORGAN Daniel A.HAHN Department of Integrative Biology University of CaliforniaBerkeleyCaliforniaUSA Departments of Entomology and Nematology University of FloridaGainesvilleFloridaUSA Biochemistry University of FloridaGainesvilleFloridaUSA Advanced Magnetic Resonance Imaging and Spectroscopy Facility McKnight Brain InstituteUniversity of FloridaGainesvilleFloridaUSA Departments of Genetics and Biochemistry Complex Carbohydrate Research CenterUniversity of GeorgiaAthensGeorgiaUSA Department of Epidemiology and Biostatistics School of Public HealthIndiana University BloomingtonBloomingtonIndianaUSA Division of Biology Kansas State UniversityManhattanKansasUSA

In insects and other ectotherms,cold temperatures cause a coma resulting from loss of neuromuscular function,during which ionic and metabolic homeostasis are progressively *** adaptation improves homeostasis during cold exposure,but the ultimate targets of selection are still an open *** acclimation and adaptation remodels mitochondrial metabolism in insects,suggesting that aerobic energy production during cold exposure could be a target of ***,we test the hypothesis that cold adaptation improves the ability to maintain rates of aerobic energy production during cold exposure by using^(31)P NMR on live *** lines of Drosophila melanogaster artificially selected for fast and slow recovery from a cold coma,we show that cold exposure does not lower ATP levels and that cold adaptation does not alter aerobic ATP production during cold ***-hardy and cold-susceptible lines both experienced a brief transition to anaerobic metabolism during cooling,but this was rapidly reversed during cold exposure,suggesting that oxidative phosphorylation was sufficient to meet energy demands below the critical thermal minimum,even in cold-susceptible *** thus reject the hypothesis that performance under mild low temperatures is set by aerobic ATP supply limitations in ***,excluding oxygen and capacity limitation as a weak link in energy *** work suggests that the modulations to mitochondrial metabolism resulting from cold acclimation or adaptation may arise from selection on a biosynthetic product(s)of those pathways rather than selection on ATP supply during cold exposure.

关键词： chill coma energetics insect oxygen limitation thermal tolerance

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惊人的认脸能力是怎么来的

方圆 2016年第3期 60-63页

作者： caroline williams 秦我不详

在最新开播的最强大脑第三季上，郭敬明与科学顾问Dr. 魏因为一个通过光点辨别韩国女子团子的身型而开撕。对于普通观众特别一些“脸盲症”患者来说，能够在眼花缭乱的舞步中记住几张类似的陌生面孔已经不易，更何况的还要对应上身型。... 详细信息

在最新开播的最强大脑第三季上，郭敬明与科学顾问Dr. 魏因为一个通过光点辨别韩国女子团子的身型而开撕。对于普通观众特别一些“脸盲症”患者来说，能够在眼花缭乱的舞步中记住几张类似的陌生面孔已经不易，更何况的还要对应上身型。事实上，一些人在人脸识别方面的特殊能力早就引起了国外科学家的注意。

关键词：特殊能力人脸识别科学家郭敬明顾问

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防扒手,你得懂点“诡骗术”

新东方英语（中英文版） 2015年第6期 39-43页

作者： caroline williams 祝莉丽

街头扒手让人烦不胜烦,却也是防不胜防。如今,小偷小摸靠的不仅仅是利落的手法,窃贼们还利用人们思维的漏洞,让你在不知不觉中被骗。俗话说,知己知彼,百战不殆。面对大家共同的敌人——小偷,如果你也能了解一些他们常用的计策,或许能让... 详细信息

街头扒手让人烦不胜烦,却也是防不胜防。如今,小偷小摸靠的不仅仅是利落的手法,窃贼们还利用人们思维的漏洞,让你在不知不觉中被骗。俗话说,知己知彼,百战不殆。面对大家共同的敌人——小偷,如果你也能了解一些他们常用的计策,或许能让自己避免上当,至少成为不易下手的对象,让窃贼对你避而远之。如果人人都能如此,"天下无贼"还会远吗?

关键词：天下无贼 straight Robbins everything something 特拉法尔加 e

Exploring salivary biomarkers and swallowing perceptions in Sjogren's syndrome:A case-control feasibility study

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Rheumatology & Autoimmunity 2022年第3期2卷 129-140页

作者： Veronica H.Letawsky Parker J.Holman caroline T.Nguyen Camilla Dawson Joanne Weinberg Lynne J.williams Stacey A.Skoretz Faculty of Medicine School of Audiology and Speech SciencesUniversity of British ColumbiaVancouverBCCanada Department of Cellular and Physiological Sciences University of British ColumbiaVancouverBCCanada Department of Oral Health Sciences University of British ColumbiaVancouverBCCanada National Dental Examining Board of Canada OttawaONCanada Department of Speech and Language Therapy University Hospitals Birmingham NHS Foundation TrustBirminghamUK BC Children's Hospital MRI Research Facility BC Children's Hospital Research InstituteVancouverBCCanada Department of Critical Care Medicine University of AlbertaEdmontonABCanada Centre for Heart Lung Innovation St.Paul's HospitalProvidence Health CareVancouverBCCanada

Background:The autoimmune disease Sjogren's syndrome(SS)is often characterized by salivary changes that may affect *** known study has investigated the association between salivary biomarkers and perceptions of swallowing in individuals with *** objectives were to explore:(1)the operational feasibility of investigating saliva volume and composition,along with perceptions of swallowing,in those with and without SS;and(2)the relationship between saliva composition and perceptions of oral dryness,swallowing,and quality of ***:We conducted a prospective,case–control feasibility study,collecting feasibility data(recruitment rate and optimal saliva collection methods)and whole mouth saliva samples(unstimulated and stimulated).We measured total protein content and conducted sialochemical(α-amylase,cortisol,C-reactive protein[CRP],and mucins),sialometric(flow rate),and perceptual(oral dryness and swallowing-related quality of life[SWAL-QOL])*** exploratory analyses focused on the main and fixed *** summarized all data descriptively,comparing:(a)outcomes between groups(t tests or Mann–Whitney U)and(b)salivary and perceptual data across participants(partial least-squares correlation[PLSC]).Results:We enrolled 12(N)participants(6 per group),all providing analyzable *** had lower flow rate(p=0.003)and higher total protein,cortisol,and CRP concentrations(p<0.02)than *** revealed inverse covariance between sialochemical and SWAL-QOL data across ***:Our study was feasible as *** explored novel relationships between salivary outcomes and participant-reported perceptions,distinguishing individuals with and without *** findings support further study of saliva's role in perceptions of swallowing,specifically analytes with lubricative properties.

关键词： deglutition feasibility studies quality of life saliva Sjogren's syndrome