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Increased virulence of the oral microbiome in oral squamous cell carcinoma revealed by metatranscriptome analyses

International Journal of Oral Science 2018年第4期10卷 263-272页

作者： Susan Yost Philip Stashenko Yoonhee Choi Maria Kukuruzinska caroline a.genco Andrew Salama Ellen O.Weinberg Carolyn D.Kramer Jorge Frias-Lopez Forsyth Institute 245 First StreetCambridgeMA 02142USA Boston University Henry M.Goldman School of Dental Medicine 100 East Newton StreetBostonMA 02118USA Department of Integrative Physiology and Pathobiology Tufts University School of Medicine136 Harrison AvenueBostonMA 02111USA Department of Oral Biology College of DentistryUniversity of Florida1395 Center DriveGainesvilleFL 32610-0424USA

Oral squamous cell carcinoma(OSCC) is the most prevalent and most commonly studied oral cancer. However, there is a void regarding the role that the oral microbiome may play in OSCC. Although the relationship between microbial community composition and OSCC has been thoroughly investigated, microbial profiles of the human microbiome in cancer are understudied. Here we performed a small pilot study of community-wide metatranscriptome analysis to profile mRNA expression in the entire oral microbiome in OSCC to reveal molecular functions associated with this disease. Fusobacteria showed a statistically significantly higher number of transcripts at tumour sites and tumour-adjacent sites of cancer patients compared to the healthy controls analysed. Regardless of the community composition, specific metabolic signatures were consistently found in disease. Activities such as iron ion transport, tryptophanase activity, peptidase activities and superoxide dismutase were over-represented in tumour and tumour-adjacent samples when compared to the healthy controls. The expression of putative virulence factors in the oral communities associated with OSCC showed that activities related to capsule biosynthesis, flagellum synthesis and assembly, chemotaxis, iron transport, haemolysins and adhesins were upregulated at tumour sites. Moreover, activities associated with protection against reactive nitrogen intermediates, chemotaxis, flagellar and capsule biosynthesis were also upregulated in non-tumour sites of cancer patients. Although they are preliminary, our results further suggest that Fusobacteria may be the leading phylogenetic group responsible for the increase in expression of virulence factors in the oral microbiome of OSCC patients.

关键词： profiles analyses

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Optical nonlinearity goes ultrafast in 2D semiconductor-based nanocavities

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Light(Science & Applications) 2022年第6期11卷 1016-1018页

作者： Armando genco Giulio Cerullo Dipartimento di Fisica Politecnico di MilanoPiazza Leonardo da Vinci 3220133 MilanoItaly

Hybrid systems of silver nanodisks strongly coupled to monolayer tungsten-disulfide(WS_(2))show giant room-temperature nonlinearity due to their deeply sub-wavelength localized nature,resulting in ultrafast modificati... 详细信息

关键词： nonlinearity silver disulfide

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Incidence of Gonorrhea and Chlamydia in Urban Settings: The Case for Neighborhood Level Analysis in Boston

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Advances in Infectious Diseases 2015年第4期5卷 162-166页

作者： Catherine Cattley Paola Massari caroline A. genco Department of Medicine Section of Infectious Diseases Boston University School of Medicine Boston USA Department of Microbiology Boston University School of Medicine Boston USA

The sexually transmitted infections (STIs) gonorrhea and chlamydia are known to disproportionately affect impoverished communities and communities of color, especially in urban areas. Moreover, socioeconomic and demographic factors such as poverty and race/ethnicity may contribute to a difference in treatment setting choice as well as a delay in care seeking. In an urban metropolitan area such as Boston, the overall gonorrhea and chlamydia rates are higher than national rates, and such differences are even more marked in certain neighborhoods with greater proportions of individuals who are impoverished, young, and of color. Using a retrospective analysis of city wide data, we highlight the effects of socioeconomic and demographic variables on urban STI prevalence. High poverty rates, race/ethnicity and younger adult populations are linked to disproportionately high STI rates. Interestingly, STI rates do not appear to be influenced by the universal health care coverage offered to the whole Massachusetts’ resident populations. We examine the effects of these variables in Boston neighborhoods in conjunction to STI rates and hypothesize that the observed rates are underestimates of the true prevalence of infection. Future studies will investigate how these same socioeconomic and demographic factors influence which treatment settings are chosen and subsequently lead to a delay in treatment.

关键词： Gonorrhea Chlamydia Social Determinants of Health Poverty Boston

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High-speed flow of interacting organic polaritons

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Light(Science & Applications) 2016年第1期5卷 235-240页

作者： Giovanni Lerario Dario Ballarini Antonio Fieramosca Alessandro Cannavale Armando genco Federica Mangione Salvatore Gambino Lorenzo Dominici Milena De Giorgi Giuseppe Gigli Daniele Sanvitto CNR NANOTEC-Istituto di Nanotecnologia Via Monteroni73100 LecceItaly Dipartimento di matematica e fisica‘Ennio De Giorgi’ Universitàdel Salento73100 LecceItaly

The strong coupling of an excitonic transition with an electromagnetic mode results in composite quasi-particles called exciton polaritons,which have been shown to combine the best properties of their individual components in semiconductor ***,the physics and applications of polariton flows in organic materials and at room temperature are still unexplored because of the poor photon confinement in such ***,we demonstrate that polaritons formed by the hybridization of organic excitons with a Bloch surface wave are able to propagate for hundreds of microns showing remarkable third-order nonlinear interactions upon high injection *** findings pave the way for the study of organic nonlinear light–matter fluxes and for a technologically promising route of the realization of dissipation-less on-chip polariton devices operating at room temperature.

关键词： optical nonlinearity organic materials polaritons surface waves 2D optics

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Histopathological evaluation of long-term tenofovir disoproxil fumarate treatment in patients with hepatitis be antigen-negative chronic hepatitis B

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2021年第2期12卷 32-39页

作者： Bahri Abayli Cansu Abaylı genco Gencdal Seyhan Devlet Hastanesi Adana 090Turkey Department of Gastroenterology Hepatology and Liver TransplantationKoc UniversitySchool of Medicineİstanbul 34300Turkey

BACKGROUND Hepatitis B virus is a universal health *** are approximately 250 million people living with hepatitis B worldwide,and approximately 600000 of these people die every year due to the *** To compare the pretreatment and post-treatment histopathological results of patients with hepatitis be antigen(HBeAg)-negative chronic hepatitis B(CHB)who had been receiving tenofovir disoproxil fumarate(TDF)treatment at our clinic for at least 5 *** Patients with HBeAg-negative CHB who were being treated with TDF(245 mg/d)were included in the *** biopsies of patients before TDF treatment and liver biopsies after 5 years of TDF treatment were retrospectively *** A total of 50 HBeAg-negative CHB patients were included in the study(mean age:47.9±10.4 years,men:27.54%).Histological improvement was observed in 78%(39)of the patients after 5 years of *** the 5 years of treatment,the mean Ishak score of the patients was 1.3±1.3,and the mean histologic activity index score was 4.1±2.8.A 1.53 point reduction in Ishak fibrosis score was detected after long-term TDF *** Liver biopsies after 5 years of TDF treatment revealed a significant histological response and a regression of the necroinflammatory score compared to pretreatment liver *** better understand the effects of antiviral treatments on the improvement of liver histology,long-term studies involving larger numbers of patients are needed.

关键词： Hepatitis B Tenofovir Chronic hepatitis Biopsy Liver Fibrosis

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Natural history of untreatable hepatocellular carcinoma:A retrospective cohort study

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World Journal of Hepatology 2012年第9期4卷 256-261页

作者： Giuseppe Cabibbo Marcello Maida Chiara.genco Pietro Parisi Marco Peralta Michela Antonucci Giuseppe Brancatelli Calogero Cammà Antonio Craxì Vito Di Marco Section of Gastroenterology Department of Internal Medicine and Biomedical SpecialistUniversity of PalermoPalermo 90127Italy Department of Biopathology and Biomedical Methodologies University of PalermoPalermo 90127Italy Department of Oncology Division of General Surgery and OncologyUniversity of PalermoPalermo 90127Italy Department of Radiology DIBIMEFUniversity of PalermoPalermo 90127Italy

AIM: To investigate the clinical course of untreatable hepatocellular carcinoma (HCC) identified at any stage and to identify factors associated with mortality. METHODS: From January 1999 to December 2010, 320 out of 825 consecutive patients with a diagnosis of HCC and not appropriate for curative or palliative treatments were followed and managed with supportive therapy. Cirrhosis was diagnosed by histological or clinical features and liver function was evaluated according to Child-Pugh score. The diagnosis of HCC was performed by Ultra-Sound guided biopsy or by multiphasic contrast-enhanced computed tomography or gadolinium-enhanced magnetic resonance imaging. Data were collected for each patient including all clinical, laboratory and imaging variables necessary for the outcome prediction staging systems considered. HCC staging was performed according Barcelona Clinic Liver Cancer (BCLC) and Cancer of the Liver Italian Program scores. Follow-up time was defined as the number of months from the diagnosis of HCC to death. Prognostic baseline variables were analyzed by multivariate Cox analysis to identify the independent predictors of survival. RESULTS: Seventy-five per cent of patients had hepatitis C. Ascites was present in 169 patients (53%), while hepatic encephalopathy was present in 49 patients (15%). The Child-Pugh score was class A in 105 patients (33%), class B in 142 patients (44%), and class C in 73 patients (23%). One hundred patients (31%) had macroscopic vascular invasion and/or extra-hepatic spread of the tumor. A single lesion > 10 cm was observed in 34 patients (11%), while multinodular HCC was present in 189 patients (59%). Thirty nine patients (12%) were BCLC early (A) stage, 55 (17%) were BCLC intermediate (B) stage, 124 (39%) were BCLC advanced (C) stage, and 102 (32%) were end-stage BCLC (D). At the time of this analysis (July 2011), 28 (9%) patients were still alive. Six (2%) patients who were lost during follow-up were censored at the last vi

关键词： Hepatocellular carcinoma Liver Cancer Survival Prognosis Natural history

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莫干山翠域·木竹坞

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现代装饰 2016年第5期 38-49页

作者： genco Berk 余味 genco Berk-International Interiors 余味设计工作室德清云溪文化传播有限公司

本案位于浙江德清县莫干山一处名为木竹坞的美丽村庄,青山翠竹环绕,溪水潺潺,境地幽深静谧。上海的项目管理团队邀请来自奥地利的设计师genco Berk与中国的设计师们一起在这片翠绿之地打造了一处精品民宿群——翠域·木竹坞。项目共有4... 详细信息

本案位于浙江德清县莫干山一处名为木竹坞的美丽村庄,青山翠竹环绕,溪水潺潺,境地幽深静谧。上海的项目管理团队邀请来自奥地利的设计师genco Berk与中国的设计师们一起在这片翠绿之地打造了一处精品民宿群——翠域·木竹坞。项目共有4幢民宿,位于莫干山的西麓,路的尽头,于群山环抱、翠绿环绕的小山村中熠熠生辉。基地周边的环境尚未被大量开发,当地的农家淳朴热情。作为最里端的一个自然村,这里以前交通闭塞,路面坑坑洼洼,被称为＂断头路＂,进入村中要先过1公里的竹林。

关键词：竹坞莫干山青山翠竹断头路群山环抱项目管理团队村中浙江德清西麓天然石材

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用新型FCC催化剂降低汽油的硫含量

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石化译文 2001年第2期 36-38页

作者： Francesco genco 黄传军

意大利AgipPetroli公司的Priolo炼油厂，使用一种新型的FCC催化剂技术，使全馏程汽油的硫含量减少了35％。同时增加了装置生产汽油的选择性，并降低了气体和焦炭的产率。尽管必须对常压渣油进行脱金属处理，但Priolo炼油厂仍然使新鲜催... 详细信息

意大利AgipPetroli公司的Priolo炼油厂，使用一种新型的FCC催化剂技术，使全馏程汽油的硫含量减少了35％。同时增加了装置生产汽油的选择性，并降低了气体和焦炭的产率。尽管必须对常压渣油进行脱金属处理，但Priolo炼油厂仍然使新鲜催化剂的耗量降低了20％。Grace Davision公司的Kristal-243GFS催化剂具有这样的特性，它使Priolo炼油厂在满足严格的汽油硫含量环保法规要求的情况下降低生产成本，因而提高了炼油厂的经济效益。

关键词：催化裂化催化剂汽油硫含量性能

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