检索结果-南通市图书馆

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

引用

Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-Segura Aleksandra Polishchuk Laura Nadal Marta Tomàs carolina Silvera-Simón Manel M.Santafé Maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chemical and spectroscopic characterization of humic substances from sediment and riparian soil of a highly polluted urban river(Suquía River,Córdoba,Argentina)

引用

International Journal of Sediment Research 2020年第3期35卷 287-294页

作者： carolina Merlo carolina v.zquez Ana Graciela Iriarte Carlos Matías Romero Instituto Multidisciplinario de Biologia vegetal (CONICET) Facultad de Ciencias Agropecuarias Universidad Nacional de Cordoba INFIQC Departament of FisicoquimicaFacultad de Ciencias QuimicasUniversidad Nacional de Cordoba Agriculture and Agri-Food Canada Lethbridge Research and Development Centre Department of Biological Sciences University of Lethbridge

The Suquia River,the largest urban river in Cordoba(Argentina),has been severely polluted for *** must be taken to restore its environmental quality by managing riparian zones for increased water-self *** current study aimed to characterize organic matter(OM) dynamics and humic substances(HS) spectrochemical properties along the lower-middle basin of the Suquia *** soil(0-20 cm) and sediment(0-10 cm) samples were collected from a reference location(S1)and four polluted sites(S2-S5) during a low-flow *** contents of soil and sedimentary OM and HS fractions were analyzed by wet oxidation,as well as HS Fourier transform infrared(FT-IR) and ultraviolet-visible(Uv-vis) spectrochemical *** OM and HS fractions from riparian soil were high upstream of Cordoba City(S1 and S2,50.2-50.4 g/kg OM) and within a 50 km downstream location(S5,30.9 g/kg OM) owing to a surplus of fresh plant biomass-carbon(C) *** heterogeneous sediment samples did not show any significant differences among sites(P> 0.05).The lowest values of the ratio of absorbances at 465 and 665 nm(E4/E6)(1.78) and the Δ log K(0.15) coefficient(a measure of HS maturity degree) were obtained downstream of Cordoba City,for both riparian soil and sediment,indicating that HS were enriched by more condensed aromatic structures within highly degraded portions of the *** samples exhibited similar IR spectra,implying overlapping recalcitrant-C structures at the functional group level,but with different absorbance *** from the current study constitute a baseline for understanding the chemical nature of HS from sediment and riparian soil along the Suquia River and can be used as a reference for future studies tracking OM compositional changes over time.

关键词： Lotic ecosystems Organic matter Humic acids FT-IR spectroscopy Uv-vis spectroscopy

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Hypothalamic circuits and aging:keeping the circadian clock updated

引用

Neural Regeneration Research 2024年第9期19卷 1919-1928页

作者： Rosa v.zquez-Lizarraga Lucia Mendoza-viveros carolina Cid-Castro Sareni Ruiz-Montoya Erick Carreño-v.zquez Ricardo Orozco-Solis Instituto Nacional de Medicina Genómica(INMEGEN) México CityMéxico Centro de Investigacíon sobre el Envejecimiento Centro de Investigacíon y de Estudios Avanzados(CIE-CINVESTAV)México CityMéxico Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México UNAMMéxico CityMéxico

Over the past century,age-related diseases,such as cancer,type-2 diabetes,obesity,and mental illness,have shown a significant increase,negatively impacting overall quality of *** on aged animal models have unveiled a progressive discoordination at multiple regulatory levels,including transcriptional,translational,and post-translational processes,resulting from cellular stress and circadian *** circadian clock emerges as a key regulator,sustaining physiological homeostasis and promoting healthy aging through timely molecular coordination of pivotal cellular processes,such as stem-cell function,cellular stress responses,and inter-tissue communication,which become disrupted during *** the crucial role of hypothalamic circuits in regulating organismal physiology,metabolic control,sleep homeostasis,and circadian rhythms,and their dependence on these processes,strategies aimed at enhancing hypothalamic and circadian function,including pharmacological and non-pharmacological approaches,offer systemic benefits for healthy *** brain-directed drug administration represents a promising avenue for effectively targeting specific brain regions,like the hypothalamus,while reducing side effects associated with systemic drug delivery,thereby presenting new therapeutic possibilities for diverse age-related conditions.

关键词： aging astrocytes cellular stress responses circadian clock hypothalamus intranasal drug administration metabolic control nutrient sensor SIRT1 sleep homeostasis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

road to stemness in hepatocellular carcinoma

引用

World Journal of Gastroenterology 2017年第37期23卷 6750-6776页

作者： Teresita NJ Flores-Téllez Saúl villa-Trevino carolina Pina-v.zquez Departam ento de Biología Celular Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional(CINVESTAV-IPN) Av.IPN No.2508 Col

Carcinogenic process has been proposed to relay on the capacity to induce local tissue damage and proliferative repair. Liver has a great regeneration capacity and currently, most studies point towards the dominant role of hepatocytes in regeneration at all levels of liver damage. The most frequent liver cancer is hepatocellular carcinoma(HCC). Historical findings originally led to the idea that the cell of origin of HCC might be a progenitor cell. However, current linage tracing studies put the progenitor hypothesis of HCC origin into question. In agreement with their dominant role in liver regeneration, mature hepatocytes are emerging as the cell of origin of HCC, although, the specific hepatocyte subpopulation of origin is yet to be determined. The relationship between the cancer cell of origin(CCO) and cancer-propagating cells, known as hepatic cancer stem cell(HCSC) is unknown. It has been challenging to identify the definitive phenotypic marker of HCSC, probably due to the existence of different cancer stem cells(CSC) subpopulations with different functions within HCC. There is a dynamic interconversion among different CSCs, and between CSC and non-CSCs. Because of that, CSC-state is currently defined as a description of a highly adaptable and dynamic intrinsic property of tumor cells, instead of a static subpopulation of a tumor. Altered conditions could trigger the gain of stemness, some of them include: EMT-MET, epigenetics, microenvironment and selective stimulus such as chemotherapy. This CSC heterogeneity and dynamism makes them out reach from therapeutic protocols directed to a single target. A further avenue of research in this line will be to uncover mechanisms that trigger this interconversion of cell populations within tumors and target it.

关键词： Cancer stem cell Liver progenitor cell Liver stem progenitor cell Stemness Plasticity Cancer cell of origin Cancer stem cells subpopulations

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Q-switching of waveguide lasers based on graphene/WS_2 van der Waals heterostructure

引用

Photonics Research 2017年第5期5卷 406-410页

作者： ZIQI LI CHEN CHENG NINGNING DONG carolina ROMERO QINGMING LU JUN WANG JAvIER RODRíGUEZ v.zquez DE ALDANA YANG TAN FENG CHEN School of Physics State Key Laboratory of Crystal Materials Shandong University Key Laboratory of Materials for High-Power Laser Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences Laser Microprocessing Group Facultad Ciencias Universidad de Salamanca School of Chemistry and Chemical Engineering Shandong University

We report on the operation of passively Q-switched waveguide lasers at 1 μm wavelength based on a graphene∕WS_2 heterostructure as a saturable absorber(SA). The gain medium is a crystalline Nd:YvO_4 cladding waveguide produced by femtosecond laser writing. The nanosecond waveguide laser operation at 1064 nm has been realized with the maximum average output power of 275 m W and slope efficiency of 37%. In comparison with the systems based on single WS_2 or graphene SA, the lasing Q-switched by a graphene∕WS_2 heterostructure SA possesses advantages of a higher pulse energy and enhanced slope efficiency, indicating the promisingapplications of van der Waals heterostructures for ultrafast photonic devices.

关键词： WS Q-switching of waveguide lasers based on graphene/WS2 van der Waals heterostructure der

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Diagnostic tests for hepatitis C: Recent trends in electrochemical immunosensor and genosensor analysis

引用

World Journal of Gastroenterology 2014年第42期20卷 15476-15491页

作者： carolina v Uliana Carla S Riccardi Hideko Yamanaka Department of Chemistry Federal University of Sao Carlos Department of Physical Chemistry Institute of Chemistry Sao Paulo State University Department of Analytical Chemistry Institute of Chemistry of Araraquara Sao Paulo State University (UNESP)

Hepatitis C is a liver disease that is transmitted through contact with the blood of an infected person. An estimated 150 million individuals worldwide have been chronically infected with the hepatitis C virus(HCv). Hepatitis C shows significant genetic variation in the global population, due to the high rate of viral RNA mutation. There are six variants of the virus(HCv genotypes 1, 2, 3, 4, 5, and 6), with 15 recorded subtypes that vary in prevalence across different regions of the world. A variety of devices are used to diagnose hepatitis C, including HCv antibody test, HCv viral load test, HCv genotype test and liver biopsy. Rapid, inexpensive, sensitive, and robust analytical devices are therefore essential for effective diagnosis and monitoring of disease treatment. This review provides an overview of current electrochemical immunosensor and genosensortechnologies employed in HCv *** are a limited number of publications showing electrochemical biosensors being used for the detection of *** to their simplicity,specificity,and reliability,electrochemical biosensor devices have potential clinical applications in several viral infections.

关键词： Hepatitis C virus Immunosensors Genosensors Electrochemical detection Diagnostic tests

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

飞秒激光烧蚀氟化钙晶体表面特性

引用

光学学报 2019年第1期39卷 271-277页

作者：郭太勇张立木任莹莹蔡阳健 carolina Romero Javier R.v.zquez de Aldana 山东师范大学物理与电子科学学院光场调控及应用中心山东省光学与光子器件技术重点实验室山东济南250014 萨拉曼卡大学应用物理系激光微加工组西班牙萨拉曼卡37008

采用飞秒激光对氟化钙晶体表面进行加工。通过调控激光参数,采用静止聚焦和动态扫描两种方式在晶体表面加工出一系列微结构(烧蚀孔和烧蚀线)。分别对两种加工方式烧蚀后的氟化钙晶体表面微结构进行系统研究,包括参数依赖关系、材料表面... 详细信息

采用飞秒激光对氟化钙晶体表面进行加工。通过调控激光参数,采用静止聚焦和动态扫描两种方式在晶体表面加工出一系列微结构(烧蚀孔和烧蚀线)。分别对两种加工方式烧蚀后的氟化钙晶体表面微结构进行系统研究,包括参数依赖关系、材料表面烧蚀阈值等。计算结果表明:在静止聚焦情况下,累积因子为0.0033;在动态扫描情况下,当扫描方向与激光偏振方向垂直或平行时,累积因子分别为0.0043和0.0052。飞秒激光加工过程中的脉冲累积效应能够对晶体的烧蚀产生重要影响。

关键词：物理光学飞秒激光烧蚀微结构累积效应氟化钙晶体

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multi-gigahertz mode-locked femtosecond Yb:KLuW waveguide lasers

引用

Photonics Research 2022年第11期10卷 2584-2589页

作者： JI EUN BAE XAvIER MATEOS MAGDALENA AGUILÓ FRANCESC DÍAZ JAvIER GARCÍA AJATES carolina ROMERO JAvIER RODRÍGUEZ v.zquez DE ALDANA FABIAN ROTERMUND Department of Physics Korea Advanced Institute of Science and Technology(KAIST)34141 DaejeonRepublic of Korea Universitat Rovira i virgili(URv) Fı´sica i Cristal·lografia de Materials i Nanomaterials(FiCMA)43007 TarragonaSpain Grupo de Investigación en Aplicaciones del Láser y Fotónica University of Salamanca37008 SalamancaSpain

We demonstrate multi-gigahertz continuous-wave mode-locking of a Yb:KLuW waveguide laser. A femtosecondlaser-inscribed Yb:KLuW channel waveguide in an extended laser cavity delivers a fundamentally mode-locked laser near 1030 nm. A tunable few-centimeter-long cavity containing a single-walled carbon nanotube saturable absorber as mode-locker generates self-starting femtosecond pulses with average output powers exceeding210 mW at repetition rates of 2.27, 2.69, and 3.55 GHz. The laser cavity, which includes a wedged waveguide,is extended by using a lens pair that controls the laser fluence on the saturable absorber for reliable mode-locked operation without instability. The presented laser performance, mode-locked up to 3.55 GHz, highly suggests the potential of crystalline Yb:KLuW waveguides for realizing high-power ultrafast lasers with higher GHz repetition rates in a quasi-monolithic cavity.

关键词： waveguide femtosecond mode

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Passively Q-switched femtosecond-laser-written thulium waveguide laser based on evanescent field interaction with carbon nanotubes

引用

Photonics Research 2018年第10期6卷 971-980页

作者： ESROM KIFLE PAvEL LOIKO JAvIER RODRíGUEZ v.zquez DE ALDANA carolina ROMERO AIRáN RóDENAS SUN YUNG CHOI JI EUN BAE FABIAN ROTERMUND vIKTOR ZAKHAROv ANDREY vENIAMINOv MAGDALENA AGUILó FRANCESC DíAZ UWE GRIEBNER vALENTIN PETROv XAvIER MATEOS Universitat Rovira i virgili Departament Quimica Fisica i Inorgànica Fisica i Cristal·lografia de Materials i Nanomaterials (FiCMA-FiCNA)-EMaS Campus Sescelades E-43007 Tarragona Spain ITMO University 49 Kronverkskiy pr. 197101 St. Petersburg Russia Aplicaciones del Láser y Fotónica University of Salamanca 37008 Salamanca Spain Istituto di Fotonica e Nanotecnologie Consiglio Nazionale delle Ricerche (IFN-CNR) Piazza Leonardo da Vinci 32 20133 Milano Italy Department of Physics KAIST 291 Daehak-ro Yuseong-gu 34141 Daejeon South Korea Max Born Institute for Nonlinear Optics and Short Pulse Spectroscopy Max-Bom-Str. 2a D-12489 Berlin Germany

Surface channel waveguides(WGs) were fabricated in a monoclinic Tm^(3+):KLu(WO_4)_2 crystal by femtosecond direct laser writing(fs-DLW). The WGs consisted of a half-ring cladding with diameters of 50 and 60 μm located just beneath the crystal surface. They were characterized by confocal laser microscopy and μ-Raman spectroscopy,indicating a reduced crystallinity and stress-induced birefringence of the WG cladding. In continuous-wave(CW)mode, under Ti:sapphire laser pumping at 802 nm, the maximum output power reached 171.1 mW at 1847.4 nm,corresponding to a slope efficiency η of 37.8% for the 60 μm diameter WG. The WG propagation loss was0.7 0.3 d B∕cm. The top surface of the WGs was spin-coated by a polymethyl methacrylate film containing randomly oriented(spaghetti-like) arc-discharge single-walled carbon nanotubes serving as a saturable absorber based on evanescent field coupling. Stable passively Q-switched(PQS) operation was achieved. The PQS60 μm diameter WG laser generated a record output power of 150 m W at 1846.8 nm with η = 34.6%. The conversion efficiency with respect to the CW mode was 87.6%. The best pulse characteristics(energy/duration)were 105.6 nJ/98 ns at a repetition rate of 1.42 MHz.

关键词：激光技术波导技术发展现状通讯技术

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Primary Polydipsia and sIDH Type D Due to Water-Electrolytic Disturbance in a Schizophrenic Patient: A Case Report and Systematic Review

引用

Open Journal of Psychiatry 2025年第1期15卷 1-15页

作者： Bianca F. Pires Júlia Maria de Oliveira Guilherme v. Kitayama vitória C. Tahan Flávia R. Darwin Luiz Antônio L. C. Saraiva carolina C. T. vilarinho Gabriela B. Dorilêo João Pedro F. Amaral Lucas P. B. de Santana Sarah P. Farid Tiago v. C. Albuquerque André B. villani Fernanda S. Nascimento Larissa D. G. Pelegrino Renato Augusto Tambelli álvaro Tavares de Figueiredo Department of Psychiatry Faculdade de Medicina de Marlia Marlia So Paulo Brazil

Introduction: Primary polydipsia, frequently observed in patients with schizophrenia, can cause severe hyponatremia, leading to serious complications. Objective: This study reviews the management and prevalence of psychogenic polydipsia, focusing on treatments and clinical outcomes. Methods: Following the PRISMA guidelines, studies on polydipsia in psychiatric patients were included. Data were extracted from databases such as PubMed and Scopus, and a meta-analysis was performed. Results: Fifteen studies were analyzed, totaling 586 patients. The use of urea was effective in correcting hyponatremia, while antipsychotics showed mixed results. Heterogeneity between studies was moderate (I2 = 56%). Conclusion: Psychogenic polydipsia is a severe condition in schizophrenic patients. The use of urea has shown promise, but further studies are needed to optimize treatments.

关键词： Schizophrenia Psychogenic Polydipsia Water intoxication Inappropriate ADH Syndrome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：