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Ornithine aspartate effects on bacterial composition and metabolic pathways in a rat model of steatotic liver disease

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World Journal of Hepatology 2024年第5期16卷 832-842页

作者： Elisa carolina Lange Pabulo Henrique Rampelotto Larisse Longo Laura Bainy Rodrigues de Freitas carolina Uribe-Cruz Mario reis Alvares-da-Silva Experimental Laboratory of Hepatology and gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil graduate Program in gastroenterology and Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-007Brazil Bioinformatics and Biostatistics Core Facility Universidade Federal do Rio Grande do SulPorto Alegre 91501-970Brazil graduate Program in Biological Sciences:Pharmacology and Therapeutics Universidade Federal do Rio Grande do SulPorto Alegre 90035-007Brazil Facultad de Ciencias de la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Division of gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007RSBrazil Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)researcher Brasília 71605-001Brazil

BACKgROUND Metabolic-dysfunction associated steatotic liver disease(MASLD)is a hepatic manifestation of metabolic *** suggest ornithine aspartate(LOLA)as drug *** To analyze the influence of LOLA intake on gut microbiota using a nutritional model of *** Adult male Sprague Dawley rats were randomized into three groups:Control(10 rats fed with a standard diet),MASLD(10 rats fed with a high-fat and choline-deficient diet),and LOLA(10 rats receiving 200 mg/kg/d LOLA,after the 16th week receiving high-fat and choline-deficient diet).After 28 wk of the experiment,animals were euthanized,and feces present in the intestine were *** fecal DNA extraction,the V4 region of the 16S rRNA gene was amplified followed by sequencing in an Ion S5™*** Alpha and beta diversity metrics were comparable between MASLD and LOLA.3 OTUs were differentially abundant between MASLD and LOLA,which belong to the species Helicobacter rodentium,Parabacteroides goldsteinii,and Parabacteroides *** functional prediction provided two different metabolic profiles between MASLD and *** 9 pathways differentially abundant in MASLD are related to a change in energy source,adenosine/purine nucleotides degradation as well as guanosine and adenosine deoxyribonucleotides *** 14 pathways differentially abundant in LOLA are associated with four major metabolic functions primarily influenced by L-aspartate,including tricarboxylic acid cycle pathways,purine/guanosine nucleotides biosynthesis,pyrimidine ribonucleotides biosynthesis and salvage as well as lipid IVA *** Although LOLA had no influence on alpha and beta diversity in this nutritional model of MASLD,it was associated with changes in specific gut microbes and their related metabolic pathways.

关键词： Animal model gut microbiota Metabolic-associated steatotic liver disease Metabolic prediction Ornithine aspartate

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Effect of Turbidity on Semi-Automatic Analysis of Copepod Size and Abundance Distribution in the Water Column

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Advances in Bioscience and Biotechnology 2024年第6期15卷 380-395页

作者： Thiago da Silva Matos carolina Siqueira dos reis Laura de Andrade Moura Márcio Abreu Ricardo Coutinho Lohengrin Fernandes IEAPM/UFF Marine Biotechnology Post-graduate Program Arraial do Cabo Brazil Instituto de Estudos do Mar Almirante Paulo Moreira Arraial do Cabo Brazil

Automated image systems to characterize aquatic organisms improve research and enable fast response to environmental risk situations. In November 2015, a dam in Mariana City-Mg (Brazil) collapsed and led to the disposal of mud tailings from the mining process to the Doce River. The accident resulted in several casualties and incalculable damage to surrounding communities and the environment. The mud increased water turbidity, an essential condition to the functioning of the image analysis systems, and directly affected the characterization of the organisms, making it impossible to distinguish copepods in the mud, due to the blurred outline. To get a quick response evaluating environmental situations, this work aimed to develop and test different algorithms characterizing and classifying copepods by their size (length and area) using in situ images acquired by the Lightframe On-Sight Keyspecies Investigation device. Field tests were carried out under different turbidity levels throughout the gradient observed in the coastal zone adjacent to the Doce River. The best algorithm reduced nearly 50% of the noise in some images when compared with manual treatment and led to 96% accuracy in measurement and counting. Semi-automated devices that perform post-processing corrections are suitable for fast environmental evaluation under high turbidity scenarios.

关键词： Imaging Zooplankton Doce River LOKI Copepod

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Risk Stratification in Obstetrics: An Integrated Approach to Maternal Health

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Open Journal of Obstetrics and gynecology 2024年第6期14卷 903-910页

作者： Taina Crespo Mendonca Bianca Beatriz Soares dos reis Júlia Cruz Coelho Antônio de Oliveira Battistini Pestana Vitória carolina Barreto Negri Alvaro Augusto Trigo Department of Medicine University of Franca Franca Brazil

Introduction: Prenatal care is crucial for maternal and fetal health, highlighting the importance of obstetric risk stratification. This enables personalized care, avoiding unnecessary interventions and reducing costs. Conditions such as first trimester bleeding, spontaneous abortion, gestational trophoblastic disease, and ectopic pregnancy require specific approaches. Early identification of these complications is vital, especially in urgent and emergency obstetric cases, which demand immediate hospital attention. Objective: Comprehensive review of first trimester pathologies and gestational hypertension, focusing on obstetric risks and personalized prenatal management. Methods: Literature review on bleeding and gestational hypertension. Results: The study provides a detailed analysis of pathologies associated with first trimester uterine bleeding and hypertensive disorders, focusing on obstetric risk stratification. The main causes of maternal and fetal mortality are hypertensive disorders, hemorrhages, infections, childbirth complications, and abortion. Spontaneous abortion is common, with different classifications, ranging from threatened to missed abortion. Infected abortion is a severe complication. Brazil has restrictive abortion laws, but many unsafe abortions occur, resulting in high public health costs. Pharmacological treatment with misoprostol is a safe option. Other pathologies include gestational trophoblastic disease, ectopic pregnancy, and placenta previa. Preeclampsia and eclampsia are severe conditions requiring immediate treatment to avoid complications. Conclusion: Early identification and management of obstetric risk factors, such as uterine bleeding, are essential for positive maternal and fetal outcomes. A multidisciplinary approach is fundamental.

关键词： Obstetrics Emergencies Hypertension Pregnancy-Induced Uterine Hemorrhage Pregnancy Trimester First

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Rifaximin on epigenetics and autophagy in animal model of hepatocellular carcinoma secondary to metabolic-dysfunction associated steatotic liver disease

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World Journal of Hepatology 2024年第1期16卷 75-90页

作者： Matheus Truccolo Michalczuk Larisse Longo Melina Belén Keingeski Bruno de Souza Basso gabriel Tayguara Silveira guerreiro Jessica T Ferrari JoséEduardo Vargas Cláudia P Oliveira carolina Uribe-Cruz Carlos Thadeu Schmidt Cerski Eduardo Filippi-Chiela Mário reisÁlvares-da-Silva Division of gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil graduate Program in gastroenterology and Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Experimental Laboratory of Hepatology and gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Laboratory of Inflammatory and Neoplastic Cells Universidade Federal do ParanáParaná81530900Brazil Department of gastroenterology(LIM07) Faculdade de Medicina da Universidade de São PauloSão Paulo 01246903Brazil Facultad de Ciencias de la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Unit of Surgical Pathology Hospital de Clinicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Center of Biotechnology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Department of Morphological Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90.050-170Rio Grande do SulBrazil Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)ResearcherBrasília 71.605-001Brazil

BACKgROUND Prevalence of hepatocellular carcinoma(HCC)is increasing,especially in patients with metabolic dysfunctionassociated steatotic liver disease(MASLD).AIM To investigate rifaximin(RIF)effects on epigenetic/autophagy markers in *** Adult Sprague-Dawley rats were randomly assigned(n=8,each)and treated from 5-16 wk:Control[standard diet,water plus gavage with vehicle(Veh)],HCC[high-fat choline deficient diet(HFCD),diethylnitrosamine(DEN)in drinking water and Veh gavage],and RIF[HFCD,DEN and RIF(50 mg/kg/d)gavage].gene expression of epigenetic/autophagy markers and circulating miRNAs were *** All HCC and RIF animals developed metabolic-dysfunction associated steatohepatitis fibrosis,and cirrhosis,but three RIF-group did not develop *** animals who developed HCC with those who did not,miR-122,miR-34a,tubulin alpha-1c(Tuba-1c),metalloproteinases-2(Mmp2),and metalloproteinases-9(Mmp9)were significantly higher in the *** opposite occurred with Becn1,coactivator associated arginine methyltransferase-1(Carm1),enhancer of zeste homolog-2(Ezh2),autophagy-related factor LC3A/B(Map1 Lc3b),and p62/sequestosome-1(p62/SQSTM1)-*** with controls,Map1 Lc3b,Becn1 and Ezh2 were lower in HCC and RIF-groups(Pgher in HCC in relation to the control;the opposite was observed for p62/Sqstm1(Pgroup compared to the control(P=0.024).There was no difference among groups for Tuba-1c,Aldolase-B,alpha-fetoprotein,and Mmp2(P>0.05).miR-122 was higher in HCC,and miR-34a in RIF compared to controls(Pg groups regarding miR-33a,miR-143,miR-155,miR-375 and miR-21(P>0.05).CONCLUSION RIF might have a possible beneficial effect on preventing/delaying liver carcinogenesis throu

关键词： Animal model Autophagy Epigenetic Hepatocellular carcinoma Metabolic dysfunction-associated steatotic liver disease Rifaximin

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Prevalence of sarcopenia using different methods in patients with non-alcoholic fatty liver disease

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World Journal of Hepatology 2022年第8期14卷 1643-1651页

作者： Naiade Silveira Almeida Raquel Rocha Claudineia Almeida de Souza Ana carolina Sirelli da Cruz Bruna dos reis Ribeiro Luiza Valois Vieira Carla Daltro Rafael Silva Manoel Sarno Helma Pinchemel Cotrim Programa de Pós-graduação em Medicina e Saúde Universidade Federal da BahiaSalvador 40110-060BABrazil Departamento de Ciência da Nutrição Escola de NutriçãoUniversidade Federal da BahiaSalvador 40110-060Brazil Caliper Clínica e Escola de Imagem Salvador 41810-012Brazil

BACKgROUND Sarcopenia is a clinical condition associated with several liver diseases and it includes non-alcoholic fatty liver disease(NAFLD)in its broad spectrum as steatosis,steatohepatitis and ***,the criteria to define sarcopenia are diverse,and even those established in consensus have been discussed regarding their performance in making an accurate *** To evaluate the prevalence of sarcopenia,using different methods,in patients with NAFLD,and its association with clinical-anthropometric *** This was an observational study of outpatients with *** was defined by the European Working group Consensus on Sarcopenia in Older People of 2010(EWgSOP1)and 2018(EWgSOP2).The skeletal muscle index was used to estimate muscle mass,handgrip strength was assessed using the dynamometer and physical performance by walking a distance of four meters at usual walking *** non-invasive fibrosis scores,fibrosis-4(FIB-4)index and Aspartate aminotransferase to platelet ratio index(APRI),were used to assess the absence and presence of *** Fifty-seven individuals with NAFLD were evaluated,the mean age(SD)was 52.7(11.3)years and 75.4%were *** assessed by FIB-4 and APRI was observed in 3.7%and 16.6%of patients with NAFLD,*** diagnosis of sarcopenia was identified only by EWgSOP1 in 3.5%of NAFLD patients,and the prevalence of probable/pre-sarcopenia was higher using the EWgSOP2 consensus at 26.3%,when compared to 1.8%with *** defined by EWgSOP1,was associated with grade I steatosis,but without overweight(P0.05).EWgSOP2 showed a greater number of patients with probable sarcopenia,and who were overweight(12(80.0%)),with a higher degree of steatosis[11(73.3%)and presence of fibrosis(1(6.7%),FIB-4 and 3(20.0%),APRI]compared to EWgSOP1[1(100%),0(0.0%),0(0.0%),FIB-4 and 0(0.0%),APRI,respectively].CONCLUSION The presen

关键词： Non-alcoholic fatty liver disease Sarcopenia Muscle strength Physical performance Liver fibrosis

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Associations between sociodemographic factors and physical activity and sedentary behaviors in adults with chronic diseases during COVID-19 pandemic

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Sports Medicine and Health Science 2020年第4期2卷 216-220页

作者： Jean Marinho da Silva Rozangela Verlengia JoséJonas de Oliveira Anna g.briela Silva Vilela Ribeiro carolina g.briela reis barbosa Uliana Sbeguen Stotzer Alex Harley Crisp Post-graduate Program in Human Movement Sciences Methodist University of Piracicaba(UNIMEP)PiracicabaSPBrazil Physical Education Department Faculty of S~ao Lourenço(UNISEPE)S~ao LourençoMinas GeraisBrazil Physical Education Department University Centre of Itajubá(FEPI)ItajubáMinas GeraisBrazil

The pandemic of the new coronavirus(COVID-19)may be affecting the physical activity(PA)level in much of the *** study aimed to investigate the prevalence of physical inactivity and sedentary behavior(SB)among adults with chronic diseases and their associations with sociodemographic factors during the COVID-19 *** cross-sectional study included 249 participants(age:18-91 years;61.4%female)with chronic conditions and attended the Family Health Strategy program in a small town in *** were collected between 2020-07-13 and 2020-07-24 by face-to-face ***-reported PA,sitting time,chronic diseases,medication use,sociodemographic data,and self-isolation adherence were obtained by *** this specific time point of the COVID-19 pandemic,71.5%of participants did not meet the PA recommendations(≥500 METs-min/week),and the prevalence of SB risk(≥4 h sitting)was 62.7%.Adjusted logistic regression indicated that male participants(odds ratio[OR]:1.89[95%CI 1.02-3.53]),living alone(OR:2.92[95%CI 1.03-8.30])or in a two-person household(OR:2.32[95%CI 1.16-4.63]),and those who reported sometimes performing self-isolation(OR:3.07[95%CI 1.47-6.40])were more likely to meet the minimum PA *** smokers had a lower odds(OR:0.36[95%CI 0.14-0.95])of meeting the PA *** participants(OR:2.18[95%CI 1.06-4.50])and those who had multimorbidity(OR:1.92[95%CI 1.07-3.44])were more likely to have a higher degree of *** is an urgent need to mitigate physical inactivity and SB,and public health interventions must take into account sociodemographic status.

关键词： Moderate-to-vigorous physical activity Sitting time Morbidity Coronavirus Quarantine

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gripper Design for Radio Base Station Autonomous Maintenance System

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International Journal of Automation and computing 2021年第4期18卷 645-653页

作者： gabriel reis Marrone Dantas Daniel Bezerra gibson Nunes Pedro Dreyer carolina Ledebour Judith Kelner Djamel Sadok Ricardo Souza Silvia Lins Maria Marquezini Networking and Telecommunications Research group Informatics CenterFederal University of PernambucoRecife 50730-120Brazil Ericsson Research Indaiatuba 13337-300Brazil

For an autonomous system to perform maintenance tasks in a networking device or a radio base station(RBS), it has to deal with a series of technological challenges ranging from identifying hardware-related problems to manipulating connectors. This paper describes the development of a robot maintenance system dedicated to detect and resolve faulty links caused by unplugged or poorly connected cables. Although the maintenance system relies on four subsystems, we significantly focus on our low-cost and efficient custom gripper solution developed to handle RJ45 Ethernet connectors. To examine our gripper, we conducted three experiments. First, a qualitative questionnaire was submitted to 30 users in the case of the teleoperated scenario of the gripper attached to a robotic arm. Similarly, we also tested the automatic operation mode. The results showed that our system is reliable and delivers a highly efficient maintenance tool in both teleoperated and autonomous operation modes. The practical experiment containing the removal or unplugging of connectors demonstrated our gripper′s ability to adequately handle these, whereas the feedback from the questionnaire pointed to a positive user experience. The automatic test assessed the gripper′s robustness against the continuous operation.

关键词： Robotic gripper maintenance system gripper design 3D print product development

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A large epeiric methanogenic Bambuí sea in the core of gondwana supercontinent?

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geoscience Frontiers 2021年第1期12卷 203-218页

作者： Sergio Caetano-Filho Pierre Sansjofre Magali Ader gustavo M.Paula-Santos Cristian guacaneme Marly Babinski carolina Bedoya-Rueda Matheus Kuchenbecker Humberto L.S.reis Ricardo I.F.Trindade Universidade de Sao Paulo Instituto de GeocienciasRua do Lago562-Sao Paulo05508-080Brazil MNHN Sorbonne UniversiteCNRS UMR 7590Institut de Mineralogiede Physique des Materiaux et de Cosmochimie75005ParisFrance Universite de Paris Institut de Physique du Globe de ParisCNRSF-75005ParisFrance Universidade Estadual de Campinas Instituto de GeocienciasRua Carlos Gomes250-Campinas13083-855Brazil Universidade Federal dos Vales do Jequitinhonha e Mucuri Instituto de Ciencia e TecnologiaLaboratorio de Estudos TectonicosRodovia MGT 367Km 583-Diamantina39100-000Brazil Universidade Federal de Ouro Preto Departamento de Geologia-Escola de MinasLaboratiorio de Modelagem TectonicaCampus Morro do Cruzeiro-Ouro Preto35400-000Brazil Universidade de Sao Paulo Instituto de AstronomiaGeofísica e Ciencias AtmosfericasRua do Matao1226-Sao Paulo05508-090Brazil

Carbon isotope compositions of both sedimentary carbonate and organic matter can be used as key proxies of the global carbon cycle and of its evolution through time,as long as they are acquired from waters where the dissolved inorganic carbon(DIC)is in isotope equilibrium with the atmospheric ***,in shallow water platforms and epeiric settings,the influence of local to regional parameters on carbon cycling may lead to DIg isotope variations unrelated to the global carbon *** may be especially true for the terminal Neoproterozoic,when gondwana assembly isolated waters masses from the global ocean,and extreme positive and negative carbon isotope excursions are recorded,potentially decoupled from global *** improve our understanding on the type of information recorded by these excursions,we investigate the pairedδ^13Ccarb andδ^13Corg evolution for an increasingly restricted late Ediacaran-Cambrian foreland system in the West gondwana interior:the basal Bambui *** succession represents a 1~(st)-order sedimentary sequence and records two majorδ^13Ccarb excursions in its two lowermost lower-rank *** basal cap carbonate interval at the base of the first sequence,deposited when the basin was connected to the ocean,hosts antithetical negative and positive excursions forδ^13Ccarb andδ^13Corg,respectively,resulting inΔ^13C values lower than 25‰.From the top of the basal sequence upwards,an extremely positiveδ^13Ccarb excursion is coupled toδ^13Corg,reaching values of+14‰and-14‰,*** positive excursion represents a remarkable basin-wide carbon isotope feature of the Bambui group that occurs with only minor changes inΔ^13C values,suggesting change in the DIC isotope *** argue that this regional isotopic excursion is related to a disconnection between the intrabasinal and the global carbon *** extreme carbon isotope excursion may have been a product of a disequilibria between the basin DIC and atmospheric CO2

关键词： Methanogenesis Ediacaran Cambrian Carbon isotopes Sao Francisco Basin Bambui group

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Chronic exposure to ethanol causes steatosis and inflammation in zebrafish liver

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World Journal of Hepatology 2017年第8期9卷 418-426页

作者： Ana Claudia reis Schneider Cleandra gregório carolina Uribe-Cruz Ranieli guizzo Tais Malysz Maria Cristina Faccioni-Heuser Larisse Longo Themis Reverbel da Silveira La-boratório Experimental de Hepatologia e gastroenterologia Hospital de Clínicas de Porto Alegre Programa de Pós- graduacao em Ciências Médicas Gastroenterologia e HepatologiaUniversidade Federal do Rio Grande do Sul Programa de Pós-graduacao em genética e Biologia Molecular(UFRgS) Instituto de Ciências Básicas da Saúde(UFRgS) Departamento de Ciências Morfológicas(UFRgS) Centro de Microscopia Eletronica(UFRgS)

AIM To evaluate the effects of chronic exposure to ethanol in the liver and the expression of inflammatory genesin *** Zebrafish(n = 104),wild type,adult,male and female,were divided into two groups:Control and ethanol(0.05 v/v).The ethanol was directly added into water;tanks water were changed every two days and the ethanol *** animals were fed twice a day with fish food until *** two and four weeks of trial,livers were dissected,histological analysis(hematoxilineosin and Oil Red staining) and gene expression assessment of adiponectin,adiponectin receptor 2(adipor2),sirtuin-1(sirt-1),tumor necrosis factor-alpha(tnf-a),interleukin-1b(il-1b) and interleukin-10(il-10) were *** evaluations were conducted at fourth *** Exposing zebrafish to 0.5% ethanol developed intense liver steatosis after four weeks,as demonstrated by oil red *** ethanol-treated animals,the main ultrastructural changes were related to cytoplasmic lipid particles and droplets,increased number of rough endoplasmic reticulum cisterns and glycogen *** two and four weeks,hepatic mR NA expression of il-1b,sirt-1 and adipor2 were upregulated,indicating that ethanol triggered signaling molecules which are key elements in both hepatic inflammatory and protective *** was not detected in the liver of animals exposed and not exposed to ethanol,and il-10 did not show significant *** Data suggest that inflammatory signaling and ultrastructural alterations play a significant role during hepatic steatosis in zebrafish chronically exposed to ethanol.

关键词： Ethanol Hepatic steatosis Inflammation Zebrafish Alcoholic fatty liver

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Role of genetic Ancestry in Oropharyngeal Squamous-Cell Carcinoma: A Cross-Sectional Study in Brazil

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Journal of Biosciences and Medicines 2023年第1期11卷 150-161页

作者： Chrystiano De Campos Ferreira Ricardo Ribeiro gama Ana carolina De Carvalho Iara Santana Raiany S. Carvalho Debora S. De A. e Silva Lais M. De Jesus Rui M. reis Rozany Dufloth Department of Head and Neck Surgery Barretos Cancer Hospital S&atilde o Paulo Brazil Department of Medicine Federal University of Rond&ocirc nia Rond&ocirc nia Brazil Molecular Oncology Research Center Barretos Cancer Hospital S&atilde o Paulo Brazil Department of Pathology Barretos Cancer Hospital S&atilde o Paulo Brazil Life and Health Sciences Research Institute (ICVS) Medical School University of Minho Braga Portugal Institute of Anatomical Pathology Rede D’Or S&atilde o Luiz Hospitals Network S&atilde o Paulo Brazil

Background: HPV infection represents an important etiologic factor for Oropharyngeal Squamous Cell Carcinoma (OPSCC). The different ethnic backgrounds could be related to different susceptibility to Human Papillomavirus (HPV). The aim of our study was to assess the whole of genetic ancestry in HPV status in OPSCC patients. Methods: We conducted a cross-sectional study on patients with OPSCC admitted to the Barretos Cancer Hospital, Brazil from 2014 to 2019. Of these, DNA extraction was performed on 40 patients and genetic ancestry was assessed using a specific panel of 46 informative ancestry markers. Results: We observed a predominance of European ancestry (63%), followed by African (18%), Amerindian (9%) and Asian (8%) both in the OPSCC HPV-positive and HPV-negative group. We did not find any statistically significant differences between the HPV-positive and HPV-negative OPSCC groups in relation to European (p = 0.499), African (p = 0.448), Asian (p = 0.275) or Amerindian (p = 0.836) ancestry. Conclusions: We found a predominance of European ancestry, both in the HPV-positive and HPV-negative groups. In our study, we did not find statistically significant differences between HPV-positive or HPV-negative groups in relation to ancestry.

关键词： Oropharyngeal Neoplasms genetic Ancestry HPV Head and Neck Neoplasms P16

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