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The apple REFPOP—a reference population for genomics-assisted breeding in apple

Horticulture Research 2020年第1期7卷 364-379页

作者： Michaela Jung Morgane Roth Maria JoséAranzana Annemarie Auwerkerken Marco Bink Caroline Denancé Christian Dujak Charles-Eric Durel carolina font i forcada Celia M.Cantin Walter Guerra Nicholas P.Howard Beat Keller Mariusz Lewandowski Matthew Ordidge Marijn Rymenants Nadia Sanin Bruno Studer Edward Zurawicz François Laurens Andrea Patocchi Hélène Muranty Molecular Plant Breeding Institute of Agricultural SciencesETH Zurich8092 ZurichSwitzerland Breeding Research group Agroscope 8820 WädenswilSwitzerland iRTA(institut de Recerca i Tecnologia Agroalimentàries) 08140 Caldes de MontbuiBarcelonaSpain Centre for Research in Agricultural Genomics(CRAG)CSiC-iRTA-UAB-UB Campus UAB08193 BellaterraBarcelonaSpain Better3fruit N.V. 3202 RillaarBelgium Biometris Wageningen University and Research6708 PB WageningenThe Netherlands Hendrix Genetics Research Technology and Services B.V.PO Box 1145830AC BoxmeerThe Netherlands iRHS Universitéd’AngersINRAEInstitut AgroSFR 4207 QuaSaV49071 BeaucouzéFrance ARAiD(Fundación Aragonesa para la investigación y el Desarrollo) 50018 ZaragozaSpain Research Centre Laimburg 39040 AuerItaly Department of Horticultural Science University of MinnesotaSt.PaulMN 55108USA institute of Biology and Environmental Sciences University of Oldenburg26129 OldenburgGermany Research institute of Horticulture 96-100 SkierniewicePoland School of Agriculture Policy and DevelopmentUniversity of ReadingWhiteknights RG66AR ReadingUK Laboratory for Plant Genetics and Crop improvement KU Leuven B-3001 LeuvenBelgium GAFL INRAE84140 MontfavetFrance

Breeding of apple is a long-term and costly process due to the time and space requirements for screening selection ***-assisted breeding utilizes genomic and phenotypic information to increase the selection efficiency in breeding programs,and measurements of phenotypes in different environments can facilitate the application of the approach under various climatic *** we present an apple reference population:the apple REFPOP,a large collection formed of 534 genotypes planted in six European countries,as a unique tool to accelerate apple *** population consisted of 269 accessions and 265 progeny from 27 parental combinations,representing the diversity in cultivated apple and current European breeding material,respectively.A high-density genome-wide dataset of 303,239 SNPs was produced as a combined output of two SNP arrays of different densities using marker imputation with an imputation accuracy of *** on the genotypic data,linkage disequilibrium was low and population structure was *** well-studied phenological traits of horticultural importance were *** found marker–trait associations in several previously identified genomic regions and maximum predictive abilities of 0.57 and 0.75 for floral emergence and harvest date,*** decreasing SNP density,the detection of significant marker–trait associations varied depending on trait *** of the trait,10,000 SNPs sufficed to maximize genomic prediction *** confirm the suitability of the apple REFPOP design for genomics-assisted breeding,especially for breeding programs using related germplasm,and emphasize the advantages of a coordinated and multinational effort for customizing apple breeding methods in the genomics era.

关键词： breeding planted utilize

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Local administration of porcine immunomodulatory,chemotactic and angiogenic extracellular vesicles using engineered cardiac scaffolds for myocardial infarction

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Bioactive Materials 2021年第10期6卷 3314-3327页

作者： Marta Monguió-Tortajada Cristina Prat-Vidal Miriam Moron-font Marta Clos-Sansalvador Alexandra Calle Paloma Gastelurrutia Adriana Cserkoova Anna Morancho Miguel Angel Ramírez Anna Rosell Antoni Bayes-Genis carolina Gàlvez-Montón Francesc E.Borràs Santiago Roura iCREC Research Program Health Science Research Institute Germans Trias i Pujol(IGTP)Can Ruti CampusBadalonaSpain REMAR-iVECAT Group Health Science Research Institute Germans Trias i Pujol(IGTP)Can Ruti CampusBadalonaSpain Department of Cell Biology Physiology and ImmunologyUniversitat Autónoma de Barcelona(UAB)BellaterraSpain CiBERCV Instituto de Salud Carlos IIIMadridSpain institut d’investigacióBiomèdica de Bellvitge-iDiBELL L’Hospitalet de LlobregatSpain Departamento de Reproducción Animal Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA)MadridSpain Neurovascular Research Laboratory Vall d’Hebron Research Institute(VHIR)UABBarcelonaSpain Cardiology Service Germans Trias i Pujol University HospitalBadalonaSpain Department of Medicine UABBarcelonaSpain Nephrology Service Germans Trias i Pujol University HospitalBadalonaSpain Faculty of Medicine University of Vic-Central University of Catalonia(UVic-UCC)VicBarcelona08500Spain

The administration of extracellular vesicles(EV)from mesenchymal stromal cells(MSC)is a promising cell-free nanotherapy for tissue repair after myocardial infarction(Mi).However,the optimal EV delivery strategy remains ***,we designed a novel MSC-EV delivery,using 3D scaffolds engineered from decellularised cardiac tissue as a cell-free product for cardiac *** from porcine cardiac adipose tissue-derived MSC(cATMSC)were purified by size exclusion chromatography(SEC),functionally analysed and loaded to ***-EV markedly reduced polyclonal proliferation and pro-inflammatory cytokines production(iFNγ,TNFα,iL12p40)of allogeneic ***,cATMSC-EV recruited outgrowth endothelial cells(OEC)and allogeneic MSC,and promoted *** labelled cATMSC-EV were mixed with peptide hydrogel,and were successfully retained in decellularised ***,cATMSC-EV-embedded pericardial scaffolds were administered in vivo over the ischemic myocardium in a pig model of *** days from implantation,the engineered scaffold efficiently integrated into the post-infarcted ***-EV were detected within the construct and Mi core,and promoted an increase in vascular density and reduction in macrophage and T cell infiltration within the damaged *** confined administration of multifunctional MSC-EV within an engineered pericardial scaffold ensures local EV dosage and release,and generates a vascularised bioactive niche for cell recruitment,engraftment and modulation of short-term post-ischemic inflammation.

关键词： Exosomes Mesenchymal stem/stromal cells Migration infiltration Cardiac tissue engineering

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