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Appropriate search techniques to estimate Weibull function parameters in a Pinus ***

Journal of Forestry Research 2021年第6期32卷 2423-2435页

作者： Lais Almeida Araujo Rafael Menali Oliveira Mario Dobner Jr carolina souza jarochinskie silva Lucas Rezende Gomide Department of Forest Sciences Federal University of LavrasLavrasMinas GeraisBrazil Department of Agriculture Biodiversity and ForestsFederal University of Santa CatarinaCuritibanosSanta CatarinaBrazil

The Weibull function,a continuous probability distribution,is widely used for diameter distribution modelling,in which parameter estimation performance is affected by stand attributes and fitting *** Weibull cumulative distribution function is nonlinear,and classical fitting methods may provide a not optimal *** the use of artificial intelligence by metaheuristics is reasonable for this optimisation ***,aimed and compared(1)the metaheuristics genetic algorithm and simulated annealing performance over the moment and percentile methods;(2)the hybrid strategy merging the metaheuristics tested and the percentile method and,(3)the metaheuristics fitness functions under basal area and density errors.A long-term experiment in a Pinus taeda stand subjected to crown thinning was *** to our findings,all methods have a similar performance,independent of the thinning regimes and *** pattern of the estimated parameters tends to be acceptable,as b increases over time and c increases after ***,our findings suggest that methods based on metaheuristics have a higher precision than classical methods for estimating Weibull *** to the classification test,the methods that involved simulated annealing stood *** hybrid method involving this metaheuristic also stood out,with accurate *** methods showed the poorest performance,and we therefore suggest the use of simulated annealing due to its faster processing time and high-quality solution.

关键词： Forest management Diameters distribution Weibull function Genetic algorithm Simulated annealing

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Tropical dendrochronology applied to invasive tree species in the Brazilian Atlantic Forest

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Journal of Forestry Research 2021年第1期32卷 91-101页

作者： carolina Nogueira Xavier Daniela Granato-souza Ana carolina M.C.Barbosa JoséReinaldo Moreira da silva Forest Sciences Department Federal University of Lavras(UFLA)C.P.3037Lavras 37200-000Brazil Department of Geosciences University of ArkansasFayettevilleAR 72701USA

The Atlantic Forest is one of the largest and most biodiverse rainforests of South America but anthropogenic activities are drastically changing these *** invasion of alien or exotic species is one of the greatest threats to *** are few studies of invasive species in tropical Brazilian *** research examines growth and ecological aspects of Syzygium cumini and Clitoria fairchildiana,two invasive tree species in the Pedra Branca State Park,an Atlantic Forest remnant in southeastern *** species were successfully dated,indicating an average age of 58 and 31 years,respectively.A positive relationship between growth and precipitation of the previous growing season suggests an ecological adaptive strategy,which could be facilitating their invasion into the *** growth diameter curves indicate slow and fast growth rates for *** and ***,*** release episodes detected in the tree rings indicate increased anthropogenic disturbances over the last 50 years.

关键词： Atlantic Forest biome Invasive species Protected areas Tree rings

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Crop residues: applications of lignocellulosic biomass in the context of a biorefinery

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Frontiers in Energy 2022年第2期16卷 224-245页

作者： Maria carolina ANDRADE Caio de Oliveira GORGULHO silva Leonora Rios de souza MOREIRA Edivaldo Ximenes FERREIRA FILHO Laboratory of Enzymology Department of Cellular BiologyUniversity of BrasiliaBrasiliaDFBrazil

Interest in lignocellulosic biomass conversion technologies has increased recently because of their potential to reduce the dependency on non-renewable feedstocks. Residues from a variety of crops are the major source of lignocellulose, which is being produced in increasingly large quantities worldwide. The commercial exploitation of crop residues as feedstocks for biorefineries which could be used to produce a variety of goods such as biofuels, biochemicals, bioplastics, and enzymes is an attractive approach not only for adding value to residues but also for providing renewable products required by the expanding bioeconomy market. Moreover, the implementation of biorefineries in different regions has the potential to add value to the specific crop residues produced in the region. In this review, several aspects of crop residue application in biorefineries are discussed, including the role of crop residues in the bioeconomy and circular economy concepts, the main technical aspects of crop residue conversion in biorefineries, the main crop residues generated in different regions of the world and their availability, the potential value-added bioproducts that can be extracted or produced from each crop residue, and the major advantages and challenges associated with crop residue utilization in biorefineries. Despite their potential, most biomass refining technologies are not sufficiently advanced or financially viable. Several technical obstacles, especially with regard to crop residue collection, handling, and pre-treatment, prevent the implementation of biorefineries on a commercial scale. Further research is needed to resolve these scale-up-related challenges. Increased governmental incentives and bioeconomic strategies are expected to boost the biorefinery market and the cost competitiveness of biorefinery products.

关键词： crop residue biorefinery bioproduct biomass circular bioeconomy enzyme

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Effect of solvent mixtures on the ultrasound-assisted extraction of compounds from pineapple by-product

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Food Bioscience 2022年第6期50卷 1217-1224页

作者： Gabriella Giovana Zampar Isabella carolina Zampar Sandra Beserra da silva de souza Camila da silva Beatriz Cervejeira Bolanho Barros Department of Agricultural Science Maringá State UniversityUmuarama87500-000Brazil Department of Technology Maringá State UniversityUmuarama87506-370Brazil

Extraction of compounds from pineapple by-products can be affected by operational conditions and *** study aimed to(i)carry out the ultrasound-assisted extraction of phenolic compounds from pineapple peels using different types of solvents and operating conditions and(ii)characterize the extracts *** solvents with the highest efficiency in extracting total phenolic compounds(TPC),namely water,ethanol,and acid solution(1 mol L−1 HCl),were tested in different proportions using a simplex-centroid mixture *** effects of time(5–45 min),temperature(30–60°C),and ultrasonic power(0–100 W)were also *** were assessed for antioxidant potential,phenolic profile,and sugar *** contents ranged from 219.75 to 405.06 mg GAE 100 g−1,with the highest value obtained in the mixture of ethanol(0.50)and acid solution(0.50).The extract with the highest TPC content and antioxidant activity was obtained at 60°C,50 W of ultrasonic power and 30 *** extract obtained under these conditions contained fructose(7.17 g 100 g−1)and glucose(8.29 g 100 g−1)as major soluble sugars and caffeic acid(217.65 mg 100 g−1)as the major phenolic ***,the extraction of compounds under the conditions studied is an alternative to the valorization of pineapple waste.

关键词： Ananas comosus Fruit waste Phenolic compounds Soluble sugars Solid–liquid extraction

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Multi-objective forest harvesting under sustainable and economic principles

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Journal of Forestry Research 2023年第5期34卷 1379-1394页

作者： Talles Hudson souza Lacerda Luciano Cavalcante de Jesus Franca Isáira Leite e Lopes Sammilly Lorrayne souza Lacerda Evandro OrfanóFigueiredo Bruno Henrique Groenner Barbosa carolina souza Jarochinski e silva Lucas Rezende Gomide Suzano SA Sao JoséDos CamposSao PauloBrazil Institute of Agricultural Sciences Federal University of Uberlandia–UFUMonte CarmeloMinas GeraisBrazil Department of Forest Sciences Federal University of Lavras–UFLALavrasMinas GeraisBrazil Brazilian Agricultural Research Corporation–EMBRAPA Rio BrancoAcreBrazil Department of Systems and Automation Federal University of Lavras–UFLALavrasMinas GeraisBrazil

Selective logging is well-recognized as an effective practice in sustainable forest ***,the ecological efficiency or resilience of the residual stand is often in *** time depends on operational variables,diversity,and forest *** logging is excellent but is open to *** may be resolved by mathematical programming and this study integrates the economic-ecological aspects in multi-objective function by applying two evolutionary *** function maximizes remaining stand diversity,merchantable logs,and the inverse of distance between trees for harvesting and log landings *** Brazilian rainforest database(566 trees)was used to simulate our 216-ha *** log landing design has a maximum volume limit of 500 *** nondominated sorting genetic algorithm was applied to solve the main optimization *** parallel,a sub-problem(p-facility allocation)was solved for landing allocation by a genetic *** frontier analysis was applied to distinguish the gradientsα-economic,β-ecological,andγ-*** expected,the solutions have high diameter changes in the residual stand(average removal of approximately 16 m^(3) ha^(-1)).All solutions showed a grouping of trees selected for harvesting,although there was no formation of large clearings(percentage of canopy removal<7%,with an average of 2.5 ind ha^(-1)).There were no differences in floristic composition by preferentially selecting species with greater frequency in the initial stand for *** implies a lower impact on the demographic rates of the remaining *** methodology should support projects of reduced impact logging by using spatial-diversity information to guide better practices in tropical forests.

关键词： Amazon rainforest management Computational intelligence Multi-objective functions Evolutionary computing

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Innate and adaptive immune responses that control lymph-borne viruses in the draining lymph node

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Cellular & Molecular Immunology 2024年第9期21卷 999-1007页

作者： carolina R.Melo-silva Luis J.Sigal Department of Microbiology and Immunology Thomas Jefferson UniversityBluemle Life Sciences Building Room 709233 South 10th StreetPhiladelphiaPA19107USA

The interstitial fluids in tissues are constantly drained into the lymph nodes(LNs)as lymph through afferent lymphatic vessels and from LNs into the blood through efferent *** are strategically positioned and have the appropriate cellular composition to serve as sites of adaptive immune initiation against invading ***,for lymph-borne viruses,which disseminate from the entry site to other tissues through the lymphatic system,immune cells in the draining LN(dLN)also play critical roles in curbing systemic viral dissemination during primary and secondary ***-borne viruses in tissues can be transported to dLNs as free virions in the lymph or within infected *** of the entry mechanism,infected myeloid antigen-presenting cells,including various subtypes of dendritic cells,inflammatory monocytes,and macrophages,play a critical role in initiating the innate immune response within the *** innate immune response involves cellular crosstalk between infected and bystander innate immune cells that ultimately produce type I interferons(IFN-Is)and other cytokines and recruit inflammatory monocytes and natural killer(NK)***-I and NK cell cytotoxicity can restrict systemic viral spread during primary infections and prevent serious ***,the memory CD8+T-cells that reside or rapidly migrate to the dLN can contribute to disease prevention during secondary viral *** review explores the intricate innate immune responses orchestrated within dLNs that contain primary viral infections and the role of memory CD8+T-cells following secondary infection or CD8+T-cell vaccination.

关键词： Virus infection lymph borne virus lymph node virus control innate immunity adaptive immunity dendritic cells Langerhans cells macrophages inflammatory monocytes natural killer cells CD8+T-cells

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Association between Helicobacterpylori, Epstein-Barr virus, human papillomavirus and gastric adenocarcinomas

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World Journal of Gastroenterology 2018年第43期24卷 4928-4938页

作者： carolina Rosal Teixeira de souza Marcelli Carolini Alves Almeida Andre Salim Khayat Emerson Lucena da silva Paulo Cardoso Soares Luiz Claudio Chaves Rommel Mario Rodriguez Burbano Laboratory of Human Cytogenetics Institute of Biological Sciences Federal University of Para Belem Para 66075-110 Brazil Oncology Research Center Federal University of Para Joao deBarros Barreto University Hospital Belem Para 66073-000Brazil Ophir Loyola Hospital Belem Para 66060-281 Brazil

AIM TO correlate Helicobacter pylori （H. pylorli）, EpsteinBarr virus （EBV） and human papillomavirus （HPV） with gastric cancer （GC） cases in Para State, *** Tissue samples were obtained from 302 gastric adenocarcinomas. A rapid urease test was used to detect the presence of H. pylori, and the presence of the cagA gene in the HP-positive samples was confirmed by PCR. An RNA in situ hybridization test designed to complement Eberl RNA was used to detect the presence of EBV in the samples, and the L1 region of HPV was detected using nested PCR. Positive HPV samples were genotyped and analyzed for E6 and E7 viral gene expression. Infections were also correlated with the clinical and pathological characteristics of the *** The majority of the 302 samples analyzed were obtained from men （65%） aged 55 years or older （67%） and were classified as the intestinal subtype （55%）. All three pathogens were found in the samples analyzed in the present study （H. pylori： 87%, EBV： 20%, HPV： 3%）. Overall, 78% of the H. pylori-positive （H. pylorl＋） samples were cagA＋（H. pylori-cagA＋）, and there was an association between the cytotoxic product of this gene and EBV. Coinfections of H. pylori-cagA＋ and EBV were correlated with the most advanced tumor stages. Although only 20% of the tumors were positive for EBV, infection with this virus was associated with distant metastasis. Only the HPV 16 and 18 strains were found in the samples, although no expression of the E6 and E7 oncoproteins was detected. The fundus of the stomach was the region least affected by the *** HPV was not involved in gastric tumorigenesis. Prophy- lactic and therapeutic measures against H. pylori and EBV may prevent the development of GC, especially the more aggressive forms.

关键词： Gastric cancer Gastric adenocarcinomas Microorganisms Helicobacter pylori cagA Epstein-Barr virus Human papillomavirus

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The peptide fraction of Bothrops jararaca snake venom induces toxicological effects on the male reproductive system after local envenomation in mice

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BIOCELL 2023年第2期47卷 289-295页

作者： CARLOS ALBERTO-silva ANA carolina DE ARAUJO RODRIGO SIMÃO BONFIM JOYCE MEIRE GILIO Natural and Humanities Sciences Center Experimental Morphophysiology LaboratoryFederal University of ABC(UFABC)São Bernardo do Campo09606-070Brazil Departamento de Biofísica Universidade Federal de São PauloSão Paulo04023-062Brazil

Bothrops envenomation is complex and provokes prominent local tissue damage and systemic disturbances,but little is known about their effects on the male reproductive *** intratesticular injection,the bioactive peptide fraction(Bj-PF)obtained from Bothrops jararaca snake venom changes the structure of different stages of the seminiferous epithelium cycle in adult *** the first time,we investigated whether local envenomation of Bj-PF induces toxicological effects on the male reproductive system,particularly on the seminiferous epithelium and Sertoli *** adult mice were treated with 0.24 ***^(-1) by intramuscular(i.m.)injection for 24 *** testes samples were collected for morphological and morphometric *** toxicological effects of Bj-PF were also analyzed on mitochondrial metabolism and nitrite(NO2)production in 15P-1 Sertoli cell ***-PF changed the structure and function of the seminiferous epithelium,particularly the disruption of the epithelium and the presence of degenerated germ cells in the adluminal compartment,but there were no alterations in the basal ***-PF increased the thickness of the seminiferous epithelium and decreased the lumen diameter of the *** histological assessment of the degree of tubule degeneration revealed that Bj-PF also increased the number of hypospermatogenic tubules compared to ***-PF reduced NO2 levels in 15P-1 Sertoli cells without changing the mitochondrial ***,the fact that Bj-PF alters the structure and function of the seminiferous epithelium suggests that bioactive peptides found in *** snake venom can have toxicological effects on the reproductive systems of affected male mice,providing new insight into the biological characteristics of snake venom and therapeutic strategies for envenomation inflammation.

关键词： Snake venom Bothrops jararaca Reproductive toxicology Seminiferous epithelium

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Co-expression of HBZ,TAX and FOXp3 and HTLV-1-associated myelopathy/tropical spastic paraparesis development in HTLV-1-infected individuals:A systematic review

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Asian Pacific Journal of Tropical Medicine 2021年第8期14卷 333-340页

作者： Ana carolina Marinho Monteiro Lima Greice carolina Santos da silva Fernanda Khouri Barreto Filipe Ferreira de Almeida Rego Luana Leandro Gois Luciane Amorim Santos Catholic University of Salvador SalvadorBahiaBrazil Multidisciplinary Institute in Health Federal University of BahiaVitoria da ConquistaBahiaBrazil Bahia School of Medicine and Public Health SalvadorBahiaBrazil Postgraduate Program in Health Sciences Faculty of Medicine of BahiaFederal University of BahiaSalvadorBahiaBrazil

Human T-cell lymphotropic virus type 1(HTLV-1)is associated with the development of HTLV-1-associated myelopathy/tropical spastic paraparesis(HAM/TSP).It has been reported that the HTLV-1 proteins(specifically TAX and HBZ)can modulate FOXp3,resulting in an immune imbalance that can favor the progression of HAM/*** review aims to summarize the literature in order to clarify the relationship between the expression of HTLV-1 m RNAs and/or viral proteins(TAX and HBZ)with the expression of mRNA and/or protein FOXp3 and their correlation with HAM/TSP *** systematic review was conducted according to the recommendations of the Preferred Reporting Items for Systematic Reviews and *** search strategy was performed on the Medical Literature Analysis and Retrieval System Online and Latin American and Caribbean Literature in Health Sciences Platform using subject *** screening,six articles were included in this *** studies suggested that TAX and HBZ have a directly proportional correlation with FOXp3 in individuals with HAM/TSP,which also presented an increased expression of FOXp3 compared to asymptomatic controls and/or healthy *** systematic review indicates that TAX and HBZ can interact with FOXp3 and that interaction may influence HAM/TSP development.

关键词： HTLV-1 HTLV-1-associated myelopathy/tropical spastic paraparesis(HAM/TSP) FOXp3 HBZ TAX

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Y-chromosome microdeletions in nonobstructive azoospermia and severe oligozoospermia

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Asian Journal of Andrology 2017年第3期19卷 338-345页

作者： carolina Goncalves Mariana Cunha Eduardo Rocha Susana Fernandess, Joaquina silva Luis Ferraz Cristiano Oliveira Alberto Barros Mairio Sousa Department of Biology ClCECO University of Aveiro Campus Universitario de Santiago 3810-193 Aveiro Portugal Department of Microscopy Laboratory of Cell Biology Institute of Biomedical Sciences Abel Salazar University of Porto (ICBAS-UP) Rua Jorge Viterbo Ferreira 228 4050-313 Porto Portugal and Multidisciplinary Unit for Biomedical Research ICBAS-UP Portugal Centre for Reproductive Genetics Prof. Alberto Barros Av. do Bessa 240 1° Dto. Frente 4100-009 Porto Portugal Department of Microscopy Laboratory of Histology and Embryology ICBAS-UP Rua Jorge Viterbo Ferreira 228 4050-313 Porto Portugal Department of Genetics Faculty of Medicine University of Porto Alameda Prof. Hernani Monteiro 4200-319 Porto Portugal and Institute for Innovation and Health Research (13S) University of Porto Portugal Department of Urology Hospital Center of Vila Nova de Gala Rua Conceicao Fernandes 4430-502 Vila Nova de Gala Portugal.

The aim of the present work was to present the outcomes of the patients with Y-chromosome microdeletions treated by intracytoplasmic sperm injection （ICSI）, either using fresh （TESE） or frozen-thawed （TESE-C） testicular sperm and ejaculated sperm （EJAC）. The originality of this work resides in the comparisons between the different types of Y-microdeletions （AZFa, AZFb, and AZFc） and treatments, with detailed demographic, stimulation, embryological, clinical, and newborn （NB） outcomes. Of 125 patients with Y-microdeletions, 33 patients presented severe oligozoospermia （18 performed ICSI with ejaculated sperm） and 92 secretory azoospermia （65 went for TESE with 40 having successful sperm retrieval and performed ICSI）. There were 51 TESE treatment cycles and 43 TESE-C treatment cycles, with a birth of 19 NB （2 in AZFa/TESE-C, 12 in AZFc/TESE, and 5 in AZFc/TESE-C）. Of the 29 EJAC cycles, there was a birth of 8 NB （in AZFc）. In TESE and EJAC cycles, there were no significant differences in embryological and clinical parameters. In TESE-C cycles, there was a significant lower oocyte maturity rate, embryo cleavage rate and mean number of embryos transferred in AZFb, and a higher mean number of oocytes and lower fertilization rate in AZFc. In conclusion, although patients with AZFc microdeletions presented a high testicular sperm recovery rate and acceptable clinical outcomes, cases with AZFa and AZFb microdeletions presented a poor prognosis. Due to the reported heredity of microdeletions, patients should be informed about the infertile consequences on NB and the possibility of using preimplantation genetic diagnosis for female sex selection.

关键词： intracytoplasmic sperm injection newborn outcomes nonobstructive azoospermia severe oligozoospermia testicularsperm extraction Y-chromosome microdeletions

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