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High passage numbers induce resistance to apoptosis in C2C12muscle cells

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BIOCELL 2013年第1期37卷 1-9页

作者： LUCIA PRONSATO ANABELA LA COLLA ANA carolina RONDA LORENA MILANESI RICARDOBOLAND ANDREA VASCONSUELO Departamento de Biología Bioquímica y FarmaciaUniversidad Nacional del Sur.San Juan 6708000 Bahía BlancaArgentina

Cell lines with high passage numbers exhibit alterations in cell morphology and *** thepresent work,C2C12 skeletal muscle cells with either low(60)passage numbers(identified as l-C2C12 or h-C2C12,respectively)were used to investigate the apoptotic response to H2O2 as a function ofculture age *** found that older cultures(h-C2C12 group)were depleted of mitochondrial DNA(mtDNA).When we analyzed the behavior of Bad,Bax,caspase-3 and mitochondrial transmembrane potential,we observed that cells in the h-C2C12 group were resistant to H2O2 induction of *** propose seriallycultured C2C12 cells as a refractory model to H2O2-induced *** addition,the data obtained in thiswork suggest that mtDNA is required for apoptotic cell death in skeletal muscle C2C12 cells.

关键词： over-subculturing changes aged muscle cultures mitochondrial DNA

Morphometric evaluation of wound healing in burns treated with Ulmo (Eucryphia cordifolia) honey alone and supplemented with ascorbic acid in guinea pig (Cavia porcellus)

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Burns & Trauma 2016年第4期4卷 264-272页

作者： carolina Schencke Adriana Vasconcellos Cristian Sandoval Paulina Torres Francisca Acevedo Mariano del Sol Doctoral Program in Morphological Sciences Universidad de La FronteraTemucoChile CONICYT-PCHA/National Doctorate Programme/2014-21141130 SantiagoChile Facultad de Medicina Universidad de La FronteraTemucoChile Doctoral Program in Morphological Sciences Universidad de La FronteraTemucoChile CIMA Research Group Facultad de OdontologíaUniversidad de La FronteraTemucoChile CONICYT-PCHA/Doctorado Nacional/2015-21150991 SantiagoChile Scientific and Technological Bioresource Nucleus Universidad de La FronteraTemucoChile Facultad de Medicina Universidad de La FronteraTemucoChile Centro de Excelencia en Estudios Morfológicos y Quirúrgicos(CEMyQ) Universidad de La FronteraTemucoChile Centro de Investigación en Ciencias Biomédicas Universidad Autónoma de ChileTemucoChile

Background:In the context of the search for cost-efficient treatments,Ulmo(Eurcyphia cordifolia)honey is an excellent alternative for treating burn wounds and could have a profound medical,social,and economic *** acid is an enzymatic co-factor necessary for the synthesis of collagen and the proliferation of fibroblasts and has been proposed as a coadjuvant to strengthen the healing effects of *** aim of this work was to evaluate by morphometric studies the healing wounds caused by burns treated with Ulmo honey alone and supplemented with ascorbic acid in guinea pig(Cavia porcellus).Methods:Fifteen guinea pigs were used and divided randomly into three groups:positive control(C+),experimental with unsupplemented honey(H),and experimental with supplemented honey(SH).A uniform deep burn covering 1 cm2of the back skin was *** following indices were calculated for the morphometric study:superficial contraction index of the wound,deep contraction index of the wound,wound severity index,global healing index,global contraction index,and dermal proliferation ***:The superficial contraction index of the wound,global healing index,global contraction,and dermal proliferation area values of the experimental with supplemented honey group were higher than the other groups(P<0.05).Conclusions:According to these results,the combination of honey with an antioxidant(ascorbic acid)promotes an appropriate action to support the healing *** study showed that by supplementing the Ulmo honey with ascorbic acid,the healing and contraction effects can be strengthened in burn wounds compared to unsupplemented *** results were proof of the synergy between honey and ascorbic acid in healing burn wounds.

关键词： Honey Ascorbic acid Burn Morphometry Wound healing

road to stemness in hepatocellular carcinoma

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World Journal of Gastroenterology 2017年第37期23卷 6750-6776页

作者： Teresita NJ Flores-Téllez Saúl Villa-Trevino carolina Pina-Vázquez Departam ento de Biología Celular Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional(CINVESTAV-IPN) Av.IPN No.2508 Col

Carcinogenic process has been proposed to relay on the capacity to induce local tissue damage and proliferative repair. Liver has a great regeneration capacity and currently, most studies point towards the dominant role of hepatocytes in regeneration at all levels of liver damage. The most frequent liver cancer is hepatocellular carcinoma(HCC). Historical findings originally led to the idea that the cell of origin of HCC might be a progenitor cell. However, current linage tracing studies put the progenitor hypothesis of HCC origin into question. In agreement with their dominant role in liver regeneration, mature hepatocytes are emerging as the cell of origin of HCC, although, the specific hepatocyte subpopulation of origin is yet to be determined. The relationship between the cancer cell of origin(CCO) and cancer-propagating cells, known as hepatic cancer stem cell(HCSC) is unknown. It has been challenging to identify the definitive phenotypic marker of HCSC, probably due to the existence of different cancer stem cells(CSC) subpopulations with different functions within HCC. There is a dynamic interconversion among different CSCs, and between CSC and non-CSCs. Because of that, CSC-state is currently defined as a description of a highly adaptable and dynamic intrinsic property of tumor cells, instead of a static subpopulation of a tumor. Altered conditions could trigger the gain of stemness, some of them include: EMT-MET, epigenetics, microenvironment and selective stimulus such as chemotherapy. This CSC heterogeneity and dynamism makes them out reach from therapeutic protocols directed to a single target. A further avenue of research in this line will be to uncover mechanisms that trigger this interconversion of cell populations within tumors and target it.

关键词： Cancer stem cell Liver progenitor cell Liver stem progenitor cell Stemness Plasticity Cancer cell of origin Cancer stem cells subpopulations

Diabetes remission after bariatric surgery

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World Journal of Diabetes 2021年第7期12卷 1093-1101页

作者： Maryna Chumakova-Orin carolina Vanetta Dimitrios P Moris Alfredo D Guerron Department of Surgery Duke UniversityDurhamNC 27705United States

Over the last decade,obesity rates have continued to rise in the United States as well as worldwide and are showing no signs of slowing *** rise is in parallel with the increasing rates of type 2 diabetes mellitus(T2DM).Given the association between obesity and T2DM and their strong correlation with increased morbidity and mortality in addition to healthcare expenditure,it is important to recognize the most effective ways to combat ***,we performed a review of literature that focused on assessing the outcomes of T2DM following bariatric *** evidence suggests that bariatric surgery provides better T2DM resolution in obese patients when compared to best medical management ***,Biliopancreatic diversion with duodenal switch as well as Roux-en-Y gastric bypass have demonstrated higher rates of T2DM resolution when compared with other bariatric procedures.

关键词： Bariatric surgery Diabetes Remission Gastric Bypass Obesity

Chemical characterisation of particulate matter in urban transport modes

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Journal of Environmental Sciences 2021年第2期33卷 51-61页

作者： Vania Martins carolina Correia Ines Cunha-Lopes Tiago Faria Evangelia Diapouli Manousos Ioannis Manousakas Konstantinos Eleftheriadis Susana Marta Almeida Centro de Ciencias e Tecnologias N ucleares Instituto Superior TecnicoLisbonPortugal Institute of Nuclear and Radiological Sciences and Technology Energy and SafetyN.C.S.R.'Demokritos'AthensGreece

Traffic is a main source of air pollutants in urban areas and consequently daily peak exposures tend to occur during *** exposure to particulate matter(PM)was monitored while cycling and travelling by bus,car and metro along an assigned route in Lisbon(Portugal),focusing on PM_(2.5) and PM_(1)0(PM with aerodynamic diameter<2.5 and 10μm,respectively)mass concentrations and their chemical *** vehicles,the indoor-outdoor interplay was also *** PM_(2.5) mean concentrations were 28±5,31±9,34±9 and 38±21μg/m 3 for bus,bicycle,car and metro modes,*** carbon concentrations when travelling by car were 1.4 to 2.0 times higher than in the other transport modes due to the closer proximity to exhaust *** are marked differences in PM chemical composition depending on transport *** particular,Fe was the most abundant component of metro PM,derived from abrasion of rail-wheel-brake *** concentrations of Zn and Cu in cars and buses were related with brake and tyre wear particles,which can penetrate into the *** the motorised transport modes,Fe,Zn,Cu,Ni and K were correlated,evidencing their common traffic-related *** average,the highest inhaled dose of PM_(2.5) was observed while cycling(55μg),and the lowest in car travels(17μg).Cyclists inhaled higher doses of PM_(2.5) due to both higher inhalation rates and longer journey times,with a clear enrichment in mineral *** presented results evidence the importance of considering the transport mode in exposure assessment studies.

关键词： Traffic Commuting Air pollution Particle chemistry Indoor-outdoor interplay Inhaled dose

Survey on Simulation for Mobile Ad-Hoc Communication for Disaster Scenarios

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Journal of Computer Science & Technology 2016年第2期31卷 326-349页

作者： Erika Rosas Nicolas Hidalgo Veronica Gil-Costa carolina Bonacic Mauricio Marin Hermes Senger Luciana Arantes CesarMarcondes Olivier Marin Department of Informatics Engineering University of Santiago Santiago 9170022 Chile National Council of Scientific and Technical Research National University of San Luis San Luis 5700 Argentina Department of Computer Science Federal University of Sao Carlos Sao Carlos 13565-905 Brazil Laboratoire d'Informaique de Paris 6 University of Pierre and Marie C'urrie Sorbonne Universitds UIVttS 11VRIA Paris 75005 France Engineering and Computer Science New York University Shanghai Shanghai 200122 China

Mobile ad-hoc communication is a demonstrated solution to mitigate the impact of infrastructure failures during large-scale disasters. A very complex issue in this domain is the design validation of software applications that support decision-making and communication during natural disasters. Such disasters are irreproducible, highly unpredictable, and impossible to scale down, and thus extensive assessments cannot be led in situ. In this context, simulation constitutes the best approach towards the testing of software solutions for natural disaster responses. The present survey reviews mobility models, ad-hoc network architectures, routing protocols and network simulators. Our aim is to provide guidelines for software developers with regards to the performance evaluation of their applications by means of simulation.

关键词： mobile ad-hoc communication simulation disaster scenario mobility model

A wheat chromosome 5AL region confers seedling resistance to both tan spot and Septoria nodorum blotch in two mapping populations

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The Crop Journal 2019年第6期7卷 809-818页

作者： Wenjing Hu Xinyao He Susanne Dreisigacker carolina P.Sansaloni Philomin Juliana Pawan K.Singh Key Laboratory of Wheat Biology and Genetic Improvement for Low&Middle Yangtze Valley Ministry of AgricultureLixiahe Region Institute of Agricultural Sciences of Jiangsu ProvinceYangzhou 225007JiangsuChina International Maize and Wheat Improvement Center(CIMMYT) Apdo.Postal 6-64a06600 Mexico D.F.Mexico

Tan spot(TS) and Septoria nodorum blotch(SNB), caused by Pyrenophora tritici-repentis and Parastagonospora nodorum, respectively, are important fungal leaf-spotting diseases of wheat that cause significant losses in grain yield. In this study, two recombinant inbred line populations, ‘Bartai’ × ‘Ciano T79’(referred to as B × C) and ‘Cascabel’ × ‘Ciano T79’(C × C) were tested for TS and SNB response in order to determine the genetic basis of seedling resistance. Genotyping was performed with the DAr Tseq genotypingby-sequencing(GBS) platform. A chromosome region on 5 AL conferred resistance to TS and SNB in both populations, but the effects were larger in B × C(R^2= 11.2%–16.8%) than in C × C(R^2= 2.5%–9.7%). Additionally, the chromosome region on 5BL(presumably Tsn1)was significant for both TS and SNB in B × C but not in C × C. Quantitative trait loci(QTL)with minor effects were identified on chromosomes 1B, 2A, 2B, 3A, 3B, 4D, 5A, 5B, 5D, 6B,and 6D. The two CIMMYT breeding lines ‘Bartai’ and ‘Cascabel’ contributed resistance alleles at both 5AL and 5BL QTL mentioned above. The QTL on 5AL showed linkage with the Vrn-A1 locus, whereas the vrn-A1 allele conferring lateness was associated with resistance to TS and SNB.

关键词： Parastagonospora nodorum Pyrenophora tritici-repentis QTL mapping Resistance breeding Triticum aestivum

Influence of obesity and bariatric surgery on gastric cancer

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Cancer Biology & Medicine 2016年第2期13卷 269-276页

作者： Anna carolina Batista Dantas Marco Aurelio Santo Roberto de Cleva Rubens Antonio Aissar Sallum Ivan Cecconello Department of Digestive Surgery University of Sao Paulo School of Medicine Sao Paulo-SP 05403-000 Brazil

Esophageal and gastric cancer(GC) are related to obesity and bariatric surgery. Risk factors, such as gastroesophageal reflux and Helicobacter pylori, must be investigated and treated in obese population. After surgery, GC reports are anecdotal and treatment is not standardized. This review aims to discuss GC related to obesity before and after bariatric surgery.

关键词： Obesity bariatric surgery stomach neoplasms esophageal neoplasms

Mass transfer and loss of the massive semi-detached binary AI Crucis

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Research in Astronomy and Astrophysics 2010年第5期10卷 438-444页

作者： Er-Gang Zhao Sheng-Bang Qian E. Femanindez Lajus carolina von Essen Li-Ying Zhu National Astronomical Observatories / Yunnan Observatory Chinese Academy of SciencesKunming 650011 China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy ofSciences Kunming 650011 China Graduate University of Chinese Academy of Sciences Beijing 100049 China Facultad de Ciencias Astron6micas y Geoffsicas Universidad Nacional de La Plata 1900 LaPlata Buenos Aires Argentina

AI Crucis is a short-period semi-detached massive close binary （P = 1.41771d, Sp.=B1.5） in the open cluster NGC 4103. It is a good astrophysical laboratory for investigating the formation and evolution of massive close binary stars via case A mass transfer. Orbital period variations of the system were analyzed based on one newly determined eclipse time and the others compiled from the literature. It is discovered that the orbital period of the binary is continuously increasing at a rate of dP/dt = ＋1.00（±0.04） × 10-7 d yr-1. After the long-term increase is subtracted from the O - C diagram, weak evidence indicates the presence of a cyclic oscillation with a period of 30.1yr, which may reveal a very cool stellar companion in the system. The long-term period increase can be explained by mass transfer from the less massive component to the more massive one. This is in agreement with the semidetached configuration of the binary, indicating that the system is undergoing a slow mass-transfer stage on the nuclear time scale of the secondary. However, it is found that the slow mass transfer is insufficient to cause the observed period increase, which suggests that the stellar wind from the hot component should contribute to the amount of period increase dP/dt = ＋0.54× 10-7 d yr-1 that corresponds to a mass loss rate of M˙1 = 2.72 × 10-7 M yr-1. It is estimated that the hot component lost a total mass of 4.1M during the slow mass-transfer stage and, thus, the evolution of the binary system should be changed greatly by the mass loss.

关键词： stars: binaries: close — stars: binaries: eclipsing — stars: individual (AI Crucis) — stars: early-type — stars: evolution