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Local Cutaneous Effects Associated with Chlorhexidine-Impregnated Gel Dressing in Hematopoietic Stem Cell Transplantation Patients

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Open Journal of Nursing 2018年第2期8卷 115-129页

作者： Bruna nogueira dos Santos Maria carolina de Oliveira Fernanda T. M. M. Braga Amanda Salles Margatho Laís C. C. Esparrachiari Renata C. de C. P. Silveira Department of General and Specialized Nursing Ribeir&#227 o Preto College of Nursing University of S&#227 o Paulo Ribeir&#227 o Preto Brazil Division of Clinical Immunology Ribeir&#227 o Preto Medical School University of S&#227 o Paulo Ribeir&#227 o Preto Brazil Department of Nursing State University of Londrina Londrina Brazil

Introduction: Hematopoietic stem cell transplantation (HSCT) often requires a central venous catheter (CVC) for quick and safe vascular access. Currently, new technologies are available to protect the catheter insertion site, such as chlorhexidine-impregnated gel dressings (CIGD). Objectives: To evaluate local cutaneous effects associated with CIGD in patients undergoing HSCT. Methods: In this cross-sectional, prospective study, we evaluated 25 HSCT patients who had a CVC inserted. Patients were visited daily to monitor the CIGD changing procedures and evaluate abnormalities of the underlying skin after dressing removal. Findings: Local erythema was the most frequently detected abnormality, although usually transient and considered secondary to the mechanical trauma of dressing removal. The most severe lesions, consisting of areas of skin loss, erythematous plaques and/or vesicles were classified as skin irritation and presented in 11 (44%) of the 25 patients. An association test showed that skin irritation was more frequent in patients who underwent allogeneic HSCT (p = 0.03). Skin irritation was most frequently observed in areas of contact with the non-woven polyester adhesive tape (n = 22;88%), which made up the adhesive margins of the dressing. The CIGD was discontinued in 6 (54%) of the 11 patients who presented severe skin injuries. Conclusion: In this study, we detected that skin irritation was more frequent in patients who underwent allogeneic HSCT. The most common skin manifestation was skin loss.

关键词： Bandages Catheterization Central Venous Catheters Hematopoietic Stem Cell Transplantation Skin Abnormalities

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Prognosis of Patients with Acute Coronary Syndromes and Bleeding—The Importance of Routine Use of a Bleeding Risk Score

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World Journal of Cardiovascular Diseases 2015年第12期5卷 327-334页

作者： Alexandre de Matos Soeiro Ricardo Cesar Campos Devezae Silva Aline Siqueira Bossa Cindel nogueira Zullino Tatiana de Carvalho Andreucci Torres Leal Maria carolina Feres de Almeida Soeiro Carlos V. Serrano Jr. Múcio Tavares Oliveira Jr. Emergency Unit-Heart Institute University of Sao Paulo Medical School Sao Paulo Brazil

Introduction: Recent studies showed relation between mortality and bleeding in acute coronary syndromes. Objective: The objective is to analyze the prognosis of patients with acute coronary syndromes with or without in-hospital major and/or minor bleedings. Methods: This was a pro-spective data bank analysis study with 546 patients (39 with bleeding (group I) and 507 without bleeding (group II)) with acute coronary syndromes included between May 2010 and May 2013. Besides, Mehran bleeding risk score was calculated to all patients. The primary endpoint was all causes of in-hospital death and combined events. Comparison between groups was made by Anova and Q-square. Multivariate analysis was determined by logistic regression and was considered significant when p p = 0.005) and combined events (35.9% vs 11.4%, p < 0.001). The same results were observed in multivariate and long-term analysis. Con-clusions: Almost half of patients with acute coronary syndromes had higher risk of bleeding, and that with major or minor bleedings had greater deaths and combined events.

关键词： Unstable Angina Bleeding Acute Myocardial Infarction

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Bredemeyera floribunda Wild Elemental Content and Comparison with Nutritional Recommendation for Adults:Medicinal Plant Used by the Brazilian Rural Population to Treat Fatigue and Exhaustion

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American Journal of Plant Sciences 2020年第3期11卷 323-343页

作者： Paula Fabiana Saldanha Tschinkel Elaine Silva de Padua Melo Daniela Granja Arakaki Valdir Aragao do Nascimento Melina Ribeiro Fernandes Nayara Vieira Lima Luana carolina Santos Leite Hugo Santos Pereira Kassia Roberta nogueira da Silva Francisco Jose Mendes dos Reis Valter Aragao do Nascimento Group of Spectroscopy and Bioinformatics Applied to Biodiversity and Health School of MedicinePostgraduation Program in Health and Development in the Midwest RegionFederal University of Mato Grosso do SulSchool of MedicineCampo GrandeBrazil Institute of Chemistry of the Federal University of Mato Grosso do Sul Campo GrandeBrazil

Bredemeyera floribunda Wild (Polygalaceae), also known as pau-de-ovo is a medicinal plant used to treat snakebites, as tonic and fortifiers to treat fatigue and exhaustion. The aim of the present study was to document the knowledge of herbal sellers in the preparation of the so-called “B. floribunda fortifier” and to compare the plant root content with the recommended nutritional values and the permitted limit for medicinal plants. The study revealed that, unlike other regions of Brazil, in the Midwest region, the root of the plant is used as food to treat fatigue and exhaustion. The contents in B. floribunda root decreased in the following order: Ca > K > P > Na > Fe > Mg > Si > Mn > Zn > Cu. Daily intake of 30 grams of B. floribunda roots are considered as an excellent source of Cr, Cu, Mn and Se for people 19 to 50 years of age according to the RDA. In addition, Cu and Fe showed content above the established limit for medicinal plants stipulated by other countries. The root of the plant has low K, Mg, P, Na and Zn content. When the contents in roots of the plant are below the oral dose of reference, consumption of this plant can be considered safe and without risk to human health. On the other hand, concentration of elements such as Cu, Fe, Ni, Al, Cr and Se exceeding the allowable limit may cause serious health problems due to prolonged ingestion and large amounts consumed daily. The Brazilian legislation does not establish a permissible limit of macro- and micro-elements in medicinal plants;thus, the results presented in this study will contribute to the Brazilian public health policy on medicinal plants.

关键词： Macroelements Microelements Bredemeyera floribunda Wild Pau-De-Ovo ICP OES

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Septic shock 3.0 criteria application in severe COVID-19 patients:An unattended sepsis population with high mortality risk

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World Journal of Critical Care Medicine 2022年第4期11卷 246-254页

作者： JoséPedro Cidade LM Coelho Vasco Costa Rui Morais Patrícia Moniz Luís Morais Pedro Fidalgo António Tralhão carolina Paulino David Nora Bernardino Valério Vítor Mendes Camila Tapadinhas Pedro Povoa Polyvalent Intensive Care Unit Hospital São Francisco XavierCentro Hospitalar Lisboa OcidentalLisboa 1449-005Portugal Polyvalent Intensive Care Unit Hospital Sao Francisco XavierCentro Hospitalar Lisboa OcidentalLisbon 1449-005Portugal Polyvalent Intensive Care Unit Hospital São Francisco XavierCentro Hospitalar Lisboa OcidentalLisbon 1449-005Portugal Polyvalent Intesive Care Unit Hospital São Francisco XavierCentro Hospitalar Lisboa OcidentalLisbon 1449-005Portugal Polyvalent Intens Care Unit NOVA Medical SchoolHospital Sao Francisco XavierCentro Hospitalar Lisboa OcidentalLisbon 1449-005Portugal

BACKGROUND Coronavirus disease 2019(COVID-19)can be associated with life-threatening organ dysfunction due to septic shock,frequently requiring intensive care unit(ICU)admission,respi-ratory and vasopressor ***-fore,clear clinical criteria are pivotal for early recognition of patients more likely to need prompt organ *** most patients with severe COVID-19 meet the Sepsis-3.0 criteria for septic shock,it has been increasingly recognized that hyperlactatemia is frequently absent,possibly leading to an underestimation of illness severity and mortality *** To identify the proportion of severe COVID-19 patients with vasopressor support requirements,with and without hyperlactatemia,and describe their clinical outcomes and mortality METHODS We performed a single-center prospective cohort *** adult patients admitted to the ICU with COVID-19 were included in the analysis and were further divided into three groups:Sepsis group,without both criteria;Vasoplegic Shock group,with persistent hypotension and vasopressor support without hyperlactatemia;and Septic Shock 3.0 group,with both ***-19 was diagnosed using clinical and radiologic criteria with a severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)positive RT-PCR *** 118 patients(mean age 63 years,87%males)were included in the analysis(n=51 Sepsis group,n=26 Vasoplegic Shock group,and n=41 Septic Shock 3.0 group).SOFA score at ICU admission and ICU length of stay were different between the groups(P<0.001).Mortality was significantly higher in the Vasoplegic Shock and Septic Shock 3.0 groups when compared with the Sepsis group(P<0.001)without a significant difference between the former two groups(P=0.713).The log rank tests of Kaplan-Meier survival curves were also different(P=0.007).Ventilator-free days and vasopressor-free days were different between the Sepsis vs Vasoplegic Shock and Septic Shock 3.0 groups(both P<0.001),and similar in the last two groups(P=0.128

关键词： COVID-19 Critical care SARS-CoV-2 Septic shock Lactate Sepsis 3.0 criteria

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机械血栓切除术综合性卒中中心的要求和卒中血管内治疗医疗体系：血管和介入神经病学学会（SVIN）卒中血管内治疗标准委员会的推荐意见

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国际脑血管病杂志 2017年第6期25卷 498-505页

作者： Joey D. English Dileep R. Yavagal Rishi Gupta Vallabh Janardhan Osama O. Zaidat Andrew R. xavier Raul G. nogueira Jawad F. Kirmani Tudor G. Jovin 刘晓昀许岩孙文 From the Neurointerventional Surgery California Pacific Medical Center San Francisco Calif. Neurology and Neurosurgery University of Miami School of Medicine Miami Fla. Neurosurgery WellStar Medical Group Marietta Ga. Neurology Medical City Dallas Hospital Dallas Tex. Medical College of Wisconsin Milwaukee Wis. Neurology Detroit Medical Center Detroit Mich. Emory University School of Medicine Atlanta Ga. Stroke and Neurovascular Center JFK Medical Center Edison N.J. Neurology University of Pittsburgh Medical Center Pittsburgh Pa. 南京大学医学院附属金陵医院(南京军区南京总医院)神经内科 210002

最近，5项具有里程碑意义的多中心、前瞻性、随机、开放标签、盲法终点的临床试验证实，在伴有颅内大血管闭塞的急性缺血性卒中（acute ischemic stroke，AIS）患者中，应用机械血栓切除术进行血管内治疗具有显著的临床获益。血管和介... 详细信息

最近，5项具有里程碑意义的多中心、前瞻性、随机、开放标签、盲法终点的临床试验证实，在伴有颅内大血管闭塞的急性缺血性卒中（acute ischemic stroke，AIS）患者中，应用机械血栓切除术进行血管内治疗具有显著的临床获益。血管和介入神经病学学会（Society of Vascular and Interventional，SVIN）任命了一个专业写作委员会来总结这些新证据，并就如何应用这些数据指导AIS患者的急诊血管内治疗提出了推荐意见。

关键词：急性缺血性卒中大血管闭塞机械取栓术医疗体系

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Viticultural Performance of Merlot and Cabernet Sauvignon （Vitis vinifera L.） Cultivated in High Altitude Regions of Southern Brazil

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Journal of Life Sciences 2015年第9期9卷 399-410页

作者： Jaqueline nogueira Muniz Suzeli Simon Alberto Fontanella Brighenti Luciane Isabel Malinovski carolina Pretto Panceri Gabriella Vanderlinde Juliana Welter Debora Dal Zotto Aparecido Lima da Silva Santa Catarina Federal University Plant Genetic Resources Post Graduate Program Rod. Admar Gonzaga 1346 ItacorubiFlorian6polis 88034-001 SC Brazil Santa Catarina State Agricultural Research and Rural Extension Agency EPAGRI Rua Josd Arafijo Lima 102 CEP S~oJoaquim 88600-000 SC Brazil Santa Catarina Federal University Food Science Post Graduate Program Rod. Admar Gonzaga 1346 CEP FIorian6polis88034-001 SC Brazil Santa Catarina Federal University Agronomy College Rod. Admar Gonzaga 1346 Itaeorubi Florian6polis 88034-001 SC Brazil

Different studies show that the altitude regions of the State of Santa Catarina have great potential for the production of grapevine varieties. The aim of this study was to characterize the phenological development, determine the thermal requirements in degree-days (DD), the index heliothermic (IH) and climatic variables during the vegetative and productive development of varieties Merlot and Cabernet Sauvignon grown in Campo Belo do Sul (27°40′04″ S, 50°44′48″ W, altitude 950 m a. s. l.) and S?o Joaquim (28°15′13″ S, 49°57′02″ W, altitude 1,400 m a. s. l.) during 2012/2013 cycle. Phenological stages evaluated were bud break, full bloom, veraison and maturity. Higher temperatures, global radiation, PAR and lower volumes of rainfall were the main climatic parameters that differentiated Campo Belo do Sul from S?o Joaquim. Due to occurrence of higher temperatures, Campo Belo do Sul presented thermal summation around 40% higher than S?o Joaquim. The low temperatures of S?o Joaquim extended the period of grape ripening and were responsible for the highest levels of titratable acidity and the higher concentrations of anthocyanins and total polyphenols in both varieties. The results show that in the altitude ranges studied (900 and 1400 m), climatic behavior and viticultural performance of Cabernet Sauvignon and Merlot were suitable for producing quality wines.

关键词：高海拔地区葡萄品种赤霞珠栽培表现西南部梅生产潜力发育程度

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