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Small Cell Neuroendocrine Carcinoma of the Vulva: Case Report and Literature Review

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Open Journal of Obstetrics and Gynecology 2024年第2期14卷 295-300页

作者： Gabriela Françóes Rostirolla Alessandra guerra Maria carolina Rey Alt Luiza Tesser Dalla Libera Maria Eduarda Appel Binda Márcia Appel Fernando De Marco dos Santos Department of Obstetrics and Gynecology Caxias do Sul University Caxias do Sul Brazil Department of Pathology UNIVATES Lajeado RS Medical Student Caxias do Sul University Caxias do Sul Brazil Department of Obstetric and Gynecology Federal University of Rio Grande do Sul Porto Alegre Brazil Department of Oncology Surgeon Caxias do Sul University Caxias do Sul Brazil

Background: Neuroendocrine neoplasms are those that develop from a neuroendocrine cell. They most commonly affect the lungs, gastrointestinal tract, and pancreas, being rare conditions in the female genital tract. When present, these neoplasms often manifest with nonspecific signs and symptoms such as pain, itching, swelling, single-focus lesions, bleeding, and enlargement of inguinal lymph nodes, in addition to the presence of progressively enlarging vulvar nodules. Consequently, the diagnostic investigation involves histopathological examination and confirmation through immunohistochemistry. Objective: To present a comprehensive understanding of this rarely studied pathology. The primary objective is to provide valuable insights that could aid in the future development of universally applicable treatment guidelines. Case Presentation: A 57-year-old female, with no prior comorbidities, menopause at 36, who presented with a left vulvar nodule accompanied by intense pain and swelling, later diagnosed with small cell neuroendocrine carcinoma in the vulva. Conclusion: This case report highlights the importance of enhancing our knowledge regarding small cell neuroendocrine carcinoma in the vulva, given its scarcity in medical literature. The information presented here underscores the need for standardized diagnostic and treatment approaches, paving the way for future consensus on managing this uncommon but challenging neoplasm.

关键词： Vulvar Neoplasms Carcinoma Small Cell Carcinoma Neuroendocrine Genital Neoplasms Female Vulvar Diseases

Meta-analysis of CO_(2) conversion,energy efficiency,and other performance data of plasma-catalysis reactors with the open access PIONEER database

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Journal of Energy Chemistry 2023年第11期86卷 318-342,I0007页

作者： Antoine Salden Maik Budde carolina A.Garcia-Soto Omar Biondo Jairo Barauna Marzia Faedda Beatrice Musig ChloéFromentin Minh Nguyen-Quang Harry Philpott Golshid Hasrack Domenico Aceto Yuxiang Cai Federico Azzolina Jury Annemie Bogaerts Patrick Da Costa Richard Engeln María Elena Gálvez Timo Gans Tomas Garcia Vasco guerra Carlos Henriques Monika Motak Maria Victoria Navarro Vasile I.Parvulescu Gerard Van Rooij Bogdan Samojeden Ana Sobota Paolo Tosi Xin Tu Olivier Guaitella Department of Physics University of Trento38100 PovoItaly Department of Applied Physics and Science Education Eindhoven University of Technology5600 MB EindhovenThe Netherlands Instituto de Plasmas e Fusão Nuclear Instituto Superior TécnicoUniversidade de Lisboa1049-001 LisboaPortugal LPP CNRSÉcole PolytechniqueSorbonne UniversitéUniversitéParis-SaclayIP-Paris 91128 PalaiseauFrance Department of Organic Chemistry Biochemistry and CatalysisUniversity of BucharestBucharestRomania Research Group PLASMANT Department of ChemistryUniversity of AntwerpUniversiteitsplein 1Wilrijk B-2610Belgium DIFFER 5612AJ EindhovenThe Netherlands Instituto de Carboquímica ICB-CSIC Zaragoza 50018Spain Faculty of Energy and Fuels AGH University of KrakowKrakowPoland Institut Jean le Rond d’Alembert CNRS UMR 7190-Sorbonne UniversitéSaint-Cyr l’Ecole 78210France Laboratoire Catalyse et Spectrochimie(LCS) CNRS-ENSICAEN-Universitéde Caen6 boulevard du Maréchal-Juin14000 CaenFrance CQE Centro de Química EstruturalInstituto Superior TécnicoUniversidade de LisboaAv.Rovisco Pais1049-001 LisboaPortugal School of Physical Sciences and National Centre for Plasma Science and Technology Faculty of Science and HealthDublin City UniversityDublinIreland ASML De Run 65015504 DR VeldhovenThe Netherlands Faculty of Science and Engineering Maastricht University6229 GS MaastrichtThe Netherlands CNR Istituto per la Scienza e Tecnologia dei Plasmi(ISTP)Italy Department of Electrical Engineering and Electronics University of LiverpoolLiverpool L693GJUK

This paper brings the comparison of performances of CO_(2)conversion by plasma and plasma-assisted catalysis based on the data collected from literature in this field,organised in an open access online database.This tool is open to all users to carry out their own analyses,but also to contributors who wish to add their data to the database in order to improve the relevance of the comparisons made,and ultimately to improve the efficiency of CO_(2)conversion by plasma-catalysis.The creation of this database and database user interface is motivated by the fact that plasma-catalysis is a fast-growing field for all CO_(2)conversion processes,be it methanation,dry reforming of methane,methanolisation,or others.As a result of this rapid increase,there is a need for a set of standard procedures to rigorously compare performances of different systems.However,this is currently not possible because the fundamental mechanisms of plasma-catalysis are still too poorly understood to define these standard procedures.Fortunately however,the accumulated data within the CO_(2)plasma-catalysis community has become large enough to warrant so-called“big data”studies more familiar in the fields of medicine and the social sciences.To enable comparisons between multiple data sets and make future research more effective,this work proposes the first database on CO_(2)conversion performances by plasma-catalysis open to the whole community.This database has been initiated in the framework of a H_(2)0_(2)0 European project and is called the“PIONEER Data Base”.The database gathers a large amount of CO_(2)conversion performance data such as conversion rate,energy efficiency,and selectivity for numerous plasma sources coupled with or without a catalyst.Each data set is associated with metadata describing the gas mixture,the plasma source,the nature of the catalyst,and the form of coupling with the plasma.Beyond the database itself,a data extraction tool with direct visualisation features or advanced filtering functionalities has been developed a

关键词： Open-access database on plasma-catalysis experiment CO_(2) conversion Plasma-catalysis Carbon capture and utilisation(CCU) Energy efficiency Specific energy input Dielectric barrier discharge Packed bed reactor Methanation Dry reforming of methane

Tumor infiltrating lymphocytes in triple negative breast cancer receiving neoadjuvant chemotherapy

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World Journal of Clinical Oncology 2016年第5期7卷 387-394页

作者： Carlos A Castaneda Elizabeth Mittendorf Sandro Casavilca Yun Wu Miluska Castillo Patricia Arboleda Teresa Nunez Henry guerra Carlos Barrionuevo Ketty Dolores-Cerna carolina Belmar-Lopez Julio Abugattas Gabriela Calderon Miguel De La Cruz Manuel Cotrina Jorge Dunstan Henry L Gomez Tatiana Vidaurre Department of Research Instituto Nacional de Enfermedades Neoplasicas Department of Medical Oncology Instituto Nacional de Enfermedades Neoplasicas Department of Surgical Oncology the University of Texas MD Anderson Cancer Center Department of Pathology Instituto Nacional de Enfermedades Neoplasicas Department of Pathology Division of Pathology the University of Texas MD Anderson Cancer Center Department of Breast Cancer Surgery Instituto Nacional de Enfermedades Neoplasicas

AIM To determine influence of neoadjuvant-chemotherapy(NAC) over tumor-infiltrating-lymphocytes(TIL) intriple-negative-breast-cancer(TNBC).METHODS TILs were evaluated in 98 TNBC cases who came to Instituto Nacional de Enfermedades Neoplasicas from 2005 to 2010. Immunohistochemistry staining for CD3, CD4, CD8 and FOXP3 was performed in tissue microarrays(TMA) sections. Evaluation of H/E in full-face and immunohistochemistry in TMA sections was performed in pre and post-NAC samples. STATA software was used and P value < 0.05 was considered statistically significant. RESULTS Higher TIL evaluated in full-face sections from pre-NAC tumors was associated to pathologic-complete-response(pCR)(P = 0.0251) and outcome(P = 0.0334). TIL evaluated in TMA sections showed low level of agreement with full-face sections(ICC = 0.017-0.20) and was not associated to pCR or outcome. TIL in post-NAC samples were not associated to response or outcome. PostNAC lesions with pC R had similar TIL levels than those without pCR(P = 0.6331). NAC produced a TIL decrease in full-face sections(P < 0.0001). Percentage of TIL subpopulations was correlated with their absolute counts. Higher counts of CD3, CD4, CD8 and FOXP3 in pre-NAC samples had longer disease-free-survival(DFS). Higher counts of CD3 in pre-NAC samples had longer overallsurvival. Higher ratio of CD8/CD4 counts in pre-NAC was associated with pCR. Higher ratio of CD4/FOXP3 counts in pre-NAC was associated with longer DFS. Higher counts of CD4 in post-NAC samples were associated with pCR.CONCLUSION TIL in pre-NAC full-face sections in TNBC are correlated to longer survival. TIL in full-face differ from TMA sections, absolute count and percentage analysis of TIL subpopulation closely related.

关键词： Triple-negative breast cancer Survival Tumor-infiltrating lymphocytes Neoadjuvant therapy

The apple REFPOP—a reference population for genomics-assisted breeding in apple

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Horticulture Research 2020年第1期7卷 364-379页

作者： Michaela Jung Morgane Roth Maria JoséAranzana Annemarie Auwerkerken Marco Bink Caroline Denancé Christian Dujak Charles-Eric Durel carolina Font i Forcada Celia M.Cantin Walter guerra Nicholas P.Howard Beat Keller Mariusz Lewandowski Matthew Ordidge Marijn Rymenants Nadia Sanin Bruno Studer Edward Zurawicz François Laurens Andrea Patocchi Hélène Muranty Molecular Plant Breeding Institute of Agricultural SciencesETH Zurich8092 ZurichSwitzerland Breeding Research group Agroscope 8820 WädenswilSwitzerland IRTA(Institut de Recerca i Tecnologia Agroalimentàries) 08140 Caldes de MontbuiBarcelonaSpain Centre for Research in Agricultural Genomics(CRAG)CSIC-IRTA-UAB-UB Campus UAB08193 BellaterraBarcelonaSpain Better3fruit N.V. 3202 RillaarBelgium Biometris Wageningen University and Research6708 PB WageningenThe Netherlands Hendrix Genetics Research Technology and Services B.V.PO Box 1145830AC BoxmeerThe Netherlands IRHS Universitéd’AngersINRAEInstitut AgroSFR 4207 QuaSaV49071 BeaucouzéFrance ARAID(Fundación Aragonesa para la Investigación y el Desarrollo) 50018 ZaragozaSpain Research Centre Laimburg 39040 AuerItaly Department of Horticultural Science University of MinnesotaSt.PaulMN 55108USA Institute of Biology and Environmental Sciences University of Oldenburg26129 OldenburgGermany Research Institute of Horticulture 96-100 SkierniewicePoland School of Agriculture Policy and DevelopmentUniversity of ReadingWhiteknights RG66AR ReadingUK Laboratory for Plant Genetics and Crop Improvement KU Leuven B-3001 LeuvenBelgium GAFL INRAE84140 MontfavetFrance

Breeding of apple is a long-term and costly process due to the time and space requirements for screening selection candidates.Genomics-assisted breeding utilizes genomic and phenotypic information to increase the selection efficiency in breeding programs,and measurements of phenotypes in different environments can facilitate the application of the approach under various climatic conditions.Here we present an apple reference population:the apple REFPOP,a large collection formed of 534 genotypes planted in six European countries,as a unique tool to accelerate apple breeding.The population consisted of 269 accessions and 265 progeny from 27 parental combinations,representing the diversity in cultivated apple and current European breeding material,respectively.A high-density genome-wide dataset of 303,239 SNPs was produced as a combined output of two SNP arrays of different densities using marker imputation with an imputation accuracy of 0.95.Based on the genotypic data,linkage disequilibrium was low and population structure was weak.Two well-studied phenological traits of horticultural importance were measured.We found marker–trait associations in several previously identified genomic regions and maximum predictive abilities of 0.57 and 0.75 for floral emergence and harvest date,respectively.With decreasing SNP density,the detection of significant marker–trait associations varied depending on trait architecture.Regardless of the trait,10,000 SNPs sufficed to maximize genomic prediction ability.We confirm the suitability of the apple REFPOP design for genomics-assisted breeding,especially for breeding programs using related germplasm,and emphasize the advantages of a coordinated and multinational effort for customizing apple breeding methods in the genomics era.

关键词： breeding planted utilize

GOECP/SEOR radiotherapy guidelines for small-cell lung cancer

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World Journal of Clinical Oncology 2021年第3期12卷 115-143页

作者： Felipe Couñago carolina de la Pinta Susana Gonzalo Castalia Fernández Piedad Almendros Patricia Calvo Begoña Taboada Antonio Gómez-Caamaño JoséLuis López guerra Marisa Chust JoséAntonio GonzálezFerreira AnaÁlvarez González Francesc Casas Department of Radiation Oncology Hospital Universitario Quirónsalud MadridHospital La LuzUniversidad Europea de MadridMadrid 28223MadridSpain Department of Radiation Oncology Hospital Universitario Ramón y CajalMadrid 28034Spain Department of Radiation Oncology Hospital Universitario La PrincesaMadrid 28006Spain Department of Radiation Oncology GenesisCare MadridMadrid 28043Spain Department of Radiation Oncology Hospital General UniversitarioValencia 46014Spain Department of Radiation Oncology Hospital Clínico Universitario Santiago de CompostelaSantiago de Compostela 15706Spain Department of Radiation Oncology Hospital Universitario Virgen del RocíoSevilla 41013Spain Department of Radiation Oncology Fundación Instituto Valenciano de OncologíaValencia 46009Spain Department of Radiation Oncology GenesisCare-SpainSevilla 41092Spain Department of Radiation Oncology HGU Gregorio MarañónMadrid 28007Spain Department of Radiation Oncology Thoracic UnitHospital ClinicBarcelona 08036Spain

Small cell lung cancer(SCLC)accounts for approximately 20%of all lung cancers.The main treatment is chemotherapy(Ch).However,the addition of radiotherapy significantly improves overall survival(OS)in patients with non-metastatic SCLC and in those with metastatic SCLC who respond to Ch.Prophylactic cranial irradiation reduces the risk of brain metastases and improves OS in both metastatic and non-metastatic patients.The 5-year OS rate in patients with limited-stage disease(non-metastatic)is slightly higher than 30%,but less than 5%in patients with extensive-stage disease(metastatic).The present clinical guidelines were developed by Spanish radiation oncologists on behalf of the Oncologic Group for the Study of Lung Cancer/Spanish Society of Radiation Oncology to provide a current review of the diagnosis,planning,and treatment of SCLC.These guidelines emphasise treatment fields,radiation techniques,fractionation,concomitant treatment,and the optimal timing of Ch and radiotherapy.Finally,we discuss the main indications for reirradiation in local recurrence.

关键词： Small cell lung cancer Chemotherapy Hyperfractionated radiation therapy Prophylactic brain irradiation Brain metastases Reirradiation

Nodal involvement and p16-staining in upper alveolar ridge and hard palate cancer

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Journal of Cancer Metastasis and Treatment 2018年第1期4卷 186-198页

作者： Edgar Salas Pedro Sanchez Juan Postigo Carlos A.Castaneda Miluska Castillo Valeria Villegas Luis Cano Sandro Casavilca Luis A.Bernabe carolina Belmar Maria R.Villa-Robles Raul Mantilla Henry guerra Head&Neck Surgery Department Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Research Department Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Faculty of Medicine Universidad Peruana San Juan BautistaLima 15067Peru Pathology Department Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru

Aim:Upper alveolar ridge and hard palate squamous cancer is an infrequent malignancy.We evaluated factors associated with neck involvement and with p16-staining.Methods:Head and neck squamous-cell carcinoma(SCC)patients who went to Head and Neck Department between 1997 and 2011 were screened,and 73 resected upper alveolar ridge and 5 hard palate SCC were selected.Tumors with available tissue were stained with p16 immunohistochemistry.Results:Median age was 64.4 years,55.1%were female,and 73.1%were in clinical stage IV.Neck dissections were performed in 24 and pathologically confirmed node metastases were found in 19(24.3%).Cervical recurrence was found in 18 patients(23.1%)and was associated with histological grade(P=0.037).Three(7.3%)of 41 lesions were positive for p16 and tended to be younger(P=0.067).Lymphovascular invasion was associated with shorter disease-free survival(DFS)(P=0.026)and overall survival(OS)(P=0.021).Larger cT(P=0.019),perineural invasion(P=0.039)and neck dissection(P=0.010)were associated with shorter OS.Neck node involvement tended to have shorter DFS(31%vs.48.7%,P=0.278)and OS(25.1%vs.48.5%,P=0.340),and neck recurrence tended to have shorter OS(9.3%vs.52.3%,P=0.064).Conclusion:Neck involvement and recurrence are frequent in this location.P16-positive cases were present in 7.3%and tended to be associated with younger age.

关键词： P16 head neck maxilla prognosis survival

Intravitreal Bevacizumab for the Treatment of Chronic or Recurrent Central Serous Chorioretinopathy

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Open Journal of Ophthalmology 2014年第3期4卷 57-64页

作者： Mitzy E. Torres Soriano Gerardo García Aguirre Maximiliano Gordon Angelozzi Veronica Kon Jara Jans Fromow guerra Michael D. Ober Hugo Quiroz Mercado Centro de la Visión Gordon Manavella Rosario Argentina Department of Ophthalmology University of North Carolina Chapel Hill USA Ophthalmology Service at Denver Health Medical Center Denver USA Retina Consultants of Michigan Southfield USA Retina Department Asociación para evitar la Ceguera Hos-pital Dr. Luis Sanchez Bulnes Mexico City Mexico Unidad Oftalmológica “Dr Torres López” Centro Médico Cagua Cagua Venezuela

Background: We report the use of intravitreal bevacizumab as an option for the treatment of chronic or recurrent central serous chorioretinopathy (CSC). Methods: Eight eyes with chronic or recurrent CSC received intravitreal bevacizumab (1.25 mg/0.05 cc) and underwent best corrected visual acuity (VA), optical coherent tomography (OCT), fluorescein angiography (FA) and indocyanine green angiography (ICG) before, and one, three and six months after treatment. Results: All patients showed improvement in visual acuity, fluorescein angiographic leakage, choroidal hyperpermeability and reduced or resolved neurosensory detachment following treatment. Two patients require a second dose of intravitreal bevacizumab. Conclusions: Intravitreal injection of bevacizumab was associated with visual improvement and reduced neurosensory detachment without adverse events in patients with chronic or recurrent CSC. Although these results are promising, further investigations would be helpful to understand this therapy for patients with CSC.

关键词： Central Serous Chorioretinopathy Intravitreal Bevacizumab Retinal Pigment Epithelium Detachment