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Six-minute walking test performance is associated with survival in cirrhotic patients

World Journal of Hepatology 2021年第11期13卷 1791-1801页

作者： carolina frade m g pimentel Ana Cristina de Castro Amaral Adriano miziara gonzalez michelle Lai Danielde Oliveira mota maria Lucia gomes Ferraz Wilson mathias Junior mario Kondo Department of medicine Federal University of Sao PauloSao Paulo 04026090Brazil Department of gastroenterology Federal University of Sao PauloSao Paulo 04023062Brazil Department of Surgery Liver Transplantation ServiceFederal University of Sao PauloSao Paulo 04026090Brazil Department of medicine Division of Gastroenterology and HepatologyBeth Israel Deaconess Medical CenterBostonMA 02215United States Department of Industrial Engineering University of Sao PauloSao Paulo 05508010Brazil Department of Cardiology Heart InstituteUniversity of Sao PauloSao Paulo 05403900Brazil

BACKgROUND Patients with cirrhosis are at risk of cirrhotic cardiomyopathy,with resulting cardiac dysfunction and exercise *** minute walking test(6mWT)assesses functional status and predicts morbidity and mortality in cardiopulmonary *** To determine if it associates with mortality by analyzing 6mWT performance in patients with liver *** A cohort of 106 cirrhotic patients was evaluated in the outpatient setting with echocardiogram and 6mWT and follow up for one year to document hepatic decompensation and *** distance in meters was recorded at the end of 6 min(6mWD).RESULTS This cohort had a mean age of 51 years and 56%male;patients were staged as Child A in 21.7%,B 66%and C 12.3%.Walk distance inversely correlated with Child scores,and was significantly reduced as Child stages *** who died(10.4%)showed shorter mean 6mWD(P=0.006).Low 6mWD was an independent predictor of mortality(P=0.01).CONCLUSION 6mWT is a noninvasive inexpensive test whose result is related to Child scores and *** is useful to identify patients with liver cirrhosis at high risk of mortality for closer monitoring and potential early intervention.

关键词： Six-minute walking test Liver cirrhosis Hospital admission and mortality Child score

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Reference genes for quantitative RT-PCR data in gastric tissues and cell lines

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World Journal of gastroenterology 2013年第41期19卷 7121-7128页

作者： Fernanda Wisnieski Danielle Queiroz Calcagno mariana Ferreira Leal Leonardo Caires dos Santos carolina de Oliveira gigek Elizabeth Suchi Chen Thaís Brilhante Pontes Paulo pimentel Assumpo mnica Barauna de Assumpo Smia Demachki Rommel Rodríguez Burbano marília de Arruda Cardoso Smith Disciplina de genética Departamento de Morfologia e GenéticaUniversidade Federal de So PauloSo Paulo 04023900Brazil Departamento de Ortopedia e Traumatologia Universidade Federal de So PauloSo Paulo 04038031Brazil Núcleo de Pesquisa em Oncologia Hospital Joo de Barros BarretoUniversidade Federal do ParáBelém 60673000Brazil Laboratório de Citogenética Humana Instituto de Ciências BiológicasUniversidade Federal do ParáBelém 66075110Brazil

AIm:To evaluate the suitability of reference genes in gastric tissue samples and cell ***:The suitability of genes ACTB,B2m,gAPDH,RPL29,and 18S rRNA was assessed in21 matched pairs of neoplastic and adjacent nonneoplastic gastric tissues from patients with gastric adenocarcinoma,27 normal gastric tissues from patients without cancer,and 4 cell lines using reverse transcription quantitative real-time polymerase chain reaction(RT-qPCR).The ranking of the best single and combination of reference genes was determined by NormFinder,geNorm,BestKeeper,and *** addition,genEx software was used to determine the optimal number of reference *** validate the results,the mRNA expression of a target gene,DNmT1,was quantified using the different reference gene combinations suggested by the various software packages for ***:ACTB was the best reference gene for all gastric tissues,cell lines and all gastric tissues plus cell ***+B2m or ACTB+B2m was the best combination of reference genes for all the gastric *** the other hand,ACTB+B2m was the best combination for all the cell lines tested and was also the best combination for analyses involving all the gastric tissues plus cell *** to the genEx software,2 or 3 genes were the optimal number of references genes for all the gastric *** relative quantification of DNmT1 showed similar patterns when normalized by each combination of reference *** level of expression of DNmT1 in neoplastic,adjacent non-neoplastic and normal gastric tissues did not differ when these samples were normalized using gAPDH+B2m(P=0.32),ACTB+B2m(P=0.61),or gAPDH+B2m+ACTB(P=0.44).CONCLUSION:gAPDH+B2m or ACTB+B2m is the best combination of reference gene for all the gastric tissues,and ACTB+B2m is the best combination for the cell lines tested.

关键词： gastric cancer Reference gene Normalization gene expression Quantitative real-time polymerase chain reaction

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Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer

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World Journal of gastroenterology 2016年第35期22卷 7951-7962页

作者： Kelly Cristina da Silva Oliveira Taíssa maíra Thomaz Araújo Camila Inagaki Albuquerque gabriela Alcantara Barata carolina Oliveira gigek mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues mello Junior André Salim Khayat Paulo pimentel de Assumpcao Rommel mário Rodriguez Burbano marília Cardoso Smith Danielle Queiroz Calcagno Núcleo de Pesquisas em Oncologia Universidade Federal do Pará Hospital Universitário Joao de Barros Barreto Disciplina de genética Departamento de Morfologia e Genética Universidade Federal de Sao Paulo Laboratório de Citogenética Humana Instituto de Ciências Biológicas Universidade Federal do Pará

Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity.

关键词： gastric cancer Epigenetic Diagnostic biomarkers miRNAs Prognostic biomarkers

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