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Cancer Communications 2022年第7期42卷 673-676页

作者： Johannes Diers Laura Acar Johanna C.Wagner Philip Baum Mohammed Hankir Sven Flemming carolin kastner Christoph-Thomas Germer Helmut L’hoest Ursula Marschall Johan Friso Lock Armin Wiegering Department of General VisceralTransplantationVascular and Pediatric SurgeryUniversity HospitalUniversity of WuerzburgWuerzburg 97080Germany Department Medizin und Versorgungsforschung Institut fuer GesundheitssystemforschungBarmerWuppertal 42275Germany Department of Biochemistry and Molecular Biology University ofWuerzburgWuerzburg 97074Germany Comprehensive Cancer Centre Mainfranken University of Wuerzburg Medical CentreWuerzburg 97080Germany

Dear Editor,The coronavirus disease of 2019(COVID-19)pandemic has necessitated that semi-urgent and elective medical cases,including cancer screenings,are postponed in hospitals worldwide to accommodate the increasing number of patients with severe COVID-19 symptoms[1-4].Consequently,several reports from the first COVID-19 wave in spring 2020 showed a significant decrease in new cancer diagnoses as well as cancer therapy and screenings[5,6].

关键词： diagnosis cancer Cancer

Proton pump inhibitors and all-cause mortality risk among cancer patients

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World Journal of Clinical Oncology 2025年第1期16卷 34-42页

作者： Arunkumar Krishnan carolin Victoria Schneider Declan Walsh Department of Supportive Oncology Atrium Health Levine CancerCharlotteNC 28204United States Department of Medicine Section of Hematology and OncologyWake Forest University School of MedicineWinston-SalemNC 27101United States Department of Medicine Ⅲ GastroenterologyMetabolic Diseasesand Intensive CareUniversity Hospital RWTH AachenAachen 52074Germany

BACKGROUND Proton pump inhibitors(PPIs)are widely used,including among cancer patients,to manage gastroesophageal reflux and other gastric acid-related *** evidence suggests associations between long-term PPI use and higher risks for various adverse health outcomes,including greater *** To investigate the association between PPI use and all-cause mortality among cancer patients by a comprehensive analysis after adjustment for various confounders and a robust methodological approach to minimize *** This retrospective cohort study used data from the TriNetX research network,with electronic health records from multiple healthcare *** study employed a new-user,active comparator design,which compared newly treated PPI users with non-users and newly treated histamine2 receptor antagonists(H2RA)users among adult cancer *** prescribed PPIs(esomeprazole,lansoprazole,omeprazole,pantoprazole,or rabeprazole)users were compared to non-users or newly prescribed H2RAs(cimetidine,famotidine,nizatidine,or ranitidine)*** primary outcome was all-cause *** patient in the main group was matched to a patient in the control group using 1:1 propensity score matching to reduce confounding *** Cox regression models were used to estimate hazard ratios(HRs)and 95% confidence interval(CI).RESULTS During the follow-up period(median 5.4±1.8 years for PPI users and 6.5±1.0 years for non-users),PPI users demonstrated a higher all-cause mortality rate than non-users after 1 year,2 years,and at the end of follow up(HRs:2.34-2.72).Compared with H2RA users,PPI users demonstrated a higher rate of all-cause mortality HR:1.51(95%CI:1.41-1.69).Similar results were observed across sensitivity analyses by excluding deaths from the first 9 months and 1-year post-exposure,confirming the robustness of these *** a sensitivity analysis,we analyzed all-cause mortality outcomes between former PPI users and individual

关键词： All-cause mortality Cancer Histamine-2 receptor antagonists Mortality Malignancy Proton pump inhibitors Carcinoma Outcome

In vitro Response of Human Mesenchymal Stromal Cells to Titanium Coated Peek Films and Their Suitability for Magnetic Resonance Imaging

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Journal of Materials Science & Technology 2015年第5期31卷 427-436页

作者： Cindy Elschner carolin Noack carolin PreilBler Andreas Krause Ulrich Scheler Ute Hempel Leibniz-Institut fr Polymerforschung Dresden e.V. Hohe Str.601069 DresdenGermany CRTD/DFG-Center for Regenerative Therapies Dresden Fetscherstr.10501307 DresdenGermany Institut fr Physiologische Chemie Technische Universitt DresdenFiedlerstr.4201307 DresdenGermany NaMlab gGmbH Nthnitzer Str.6401187 DresdenGermany

Medical imaging is an important tool for the post-operative checkup of an accurate position of an implant as well as for monitoring the integration in the adjacent tissue that may influence the success of a medical ***,the possibility to use imaging methods is associated with the implant material and all the established metallic materials for surgery do not show a proper 'imaging compatibility'.The present study is a combined investigation of the in vitro response to human mesenchymal stromal cells（hMSC） and magnetic resonance imaging（MRI） compatibility of the potential material combination polyetheretherketone/titanium（PEEK/Ti） for medical *** of the advantageous imaging properties and the mechanical and chemical stability,PEEK becomes more and more an alternative to common metallic implant materials like titanium or ***,PEEK is a bioinert material having a limited ability for direct bone *** to its excellent biocompatibility,Ti was chosen as coating material to enhance the cellular *** result is a combination with advantageous properties:the magnetic susceptibility and elastic modulus close to bone,corrosion resistance and mechanical flexibility of PEEK and the excellent biocompatibility of *** appearance of metal-related artifact was discussed in electrical resistivity and magnetic ***,two titanium coatings have been investigated:a complete coating and a structured surface avoiding surface *** determine the in vitro biocompatibility,the cell responses were assessed in terms of the overall morphology of the hMSC and their cell area distribution,proliferation,osteogenic differentiation and mineral *** cellular stress was evaluated by the prostaglandin *** bonded materials both produced no disturbing artifacts in magnetic resonance *** to the pure PEEK material,the titanium coated specimens showed an enhanced biocompatibilit

关键词： Polyetheretherketone Titanium coating Biocompatibi

Estimating wood quality attributes from dense airborne LiDAR point clouds

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Forest Ecosystems 2024年第2期11卷 226-235页

作者： Nicolas Cattaneo Stefano Puliti carolin Fischer Rasmus Astrup Norwegian Institute of Bioeconomy Research(NIBIO) Division of Forest and Forest ResourcesHøgskoleveien 81433ÅsNorway

Mapping individual tree quality parameters from high-density LiDAR point clouds is an important step towards improved forest *** present a novel machine learning-based workflow that uses individual tree point clouds from drone laser scanning to predict wood quality indicators in standing *** object reconstruction methods,our approach is based on simple metrics computed on vertical slices that summarize information on point distances,angles,and geometric attributes of the space between and around the *** models use these slice metrics as predictors and achieve high accuracy for predicting the diameter of the largest branch per log (DLBs) and stem diameter at different heights (DS) from survey-grade drone laser *** show that our models are also robust and accurate when tested on suboptimal versions of the data generated by reductions in the number of points or emulations of suboptimal single-tree segmentation *** approach provides a simple,clear,and scalable solution that can be adapted to different situations both for research and more operational mapping.

关键词： UAV laser scanning Wood quality Machine learning Point cloud metrics

Updating digital elevation models via change detection and fusion of human and remote sensor data in urban environments

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International Journal of Digital Earth 2015年第2期8卷 153-171页

作者： carolin Klonner Christopher Barron Pascal Neis Bernhard Hofle Department of Geography University of HeidelbergHeidelbergGermany

OpenStreetMap(OSM)currently represents the most popular project of Volunteered Geographic Information(VGI):geodata are collected by common people and made available for public *** Laser Scanning(ALS)enables the acquisition of high-resolution digital elevation models that are used for many *** study combines the advantages of both ALS and OSM,offering a promising new approach that enhances data quality and allows change detection:the mainly up-to-date 2D data of OSM can be combined with the high-resolution–but rarely updated–elevation information provided by *** case study investigates building objects of OSM and ALS data of the city of Bregenz,*** quality of OSM is discerned by the comparison of building footprints using different true positive definitions(*** area).High quality of OSM data is revealed,yet also limitations of each method with respect to heterogeneous regions and building outlines are *** the first time,an up-to-date Digital Surface Model(DSM)combining 2D OSM and ALS data is achieved.A multitude of applications such as flood simulations and solar potential assessments can directly benefit from this data combination,since their value and reliability strongly depend on an up-to-date DSM.

关键词： OpenStreetMap airborne laser scanning change detection 3D modelling up-to-date digital surface models

Fluidization behavior of graphitized glassy particles in a fluidized carbon bed cooling process for investment casting

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Particuology 2022年第6期20卷 32-38页

作者： Paul Git Matthias Hofmeister Robert F.Singer carolin Körner Chair of Materials Science and Engineering for Metals(WTM) Friedrich-Alexander UniversitätErlangen-Nürnberg(FAU)Martensstr.591058 ErlangenGermany

Fluidized Carbon Bed Cooling(FCBC)is an innovative investment casting process for directional solidification of superalloy *** takes advantage of a fluidized bed with a base of small glassy carbon beads for cooling and other low-density particles that form an insulating layer by floating to the bed *** so-called“Dynamic Baffle”protects the fluidized bed from the direct heat input from the high-temperature heating zone and provides the basis for an improved bed *** prerequisites for a stable casting process are stable fluidization conditions where neither collapse of the bed nor particle blow out at excessive bubble formation *** work aimed to investigate the fluidization behavior of spherical carbon bed material in argon and air at temperatures between 20 to 350℃.Systematic studies at reduced pressures using the FCBC prototype device were performed to understand the stable fluidization conditions at all stages of the investment casting *** particle shape factor and size distribution characterization and the measurement of the powder’s minimum fluidization velocity and bed voidage show that this material can be fully utilized as a cooling and buoyancy medium during the FCBC process.

关键词： Gas-solid fluidization Glassy carbon Reduced pressure Increased temperature Fluidized carbon bed

Natural variation in social conditions affects male mate choosiness in the amphipod Gammarus roeselii

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Current Zoology 2022年第4期68卷 459-467页

作者： Konrad Lipkowski Sophie Steigerwald Lisa M Schulte carolin Sommer-Trembo Jonas Jourdan Department of Wildlife/Zoo-Animal-Biology and Systematics Institute for EcologyEvolution and Diversity Goethe University FrankfurtMaxvon-Laue-Straße 13Frankfurt am MainD-60438Germany Department of Environmental Science Stockholm UniversitySvante Arrheniusväg 8StockholmSE-11418Sweden Zoological Institute University of BaselVesalgasse 1BaselCH-4051Switzerland Department of Aquatic Ecotoxicology Institute for EcologyEvolution and DiversityGoethe University Frankfurt am MainFrankfurt am MainGermany

The extent of male mate choosiness is driven by a trade-off between various environmental factors associated with the costs of mate acquisition,quality assessment and opportunity *** knowledge about natural variation in male mate choosiness across different populations of the same species,however,remains *** this study,we compared male mate choosiness across 10 natural populations of the freshwater amphipod Gammarus roeselii(Gervais 1835),a species with overall high male mating investments,and evaluated the relative influence of population density and sex ratio(both affecting mate availability)on male mate *** investigated amplexus establishment after separating mating pairs and presenting focal males with a novel,size-matched female from the same *** analysis revealed considerable effects of sex ratio and(to a lesser extent)population density on time until amplexus establishment(choosiness).Male amphipods are able to perceive variable social conditions(e.g.,sex ratio)and modify their mating strategy accordingly:We found choosiness to be reduced in increasingly male-biased populations,whereas selectivity increases when sex ratio becomes female *** this,our study expands our limited knowledge on natural variations in male mate choosiness and illustrates the importance of sex ratio(i.e.,level of competition)for male mating decisions in natural *** for variation in sex ratios,therefore,allows envisioning a distinctive variation of choosiness in natural populations and highlights the importance of considering social background information in future behavioral studies.

关键词： amplexus Crustacea local adaptation mate choice population density sex ratio

Participatory Mapping and Visualization of Local Knowledge:An Example from Eberbach, Germany

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International Journal of Disaster Risk Science 2021年第1期12卷 56-71页

作者： carolin Klonner Tomás J.Usón Nicole Aeschbach Bernhard Höfle Institute of Geography Heidelberg University69120 HeidelbergGermany Institute of European Ethnology and IRI THESys(Integrative Research Institute on Transformations of Human-Environment Systems) Humboldt University of Berlin10117 BerlinGermany

A rise in the number of flood-affected people and areas has increased the interest in new methods and concepts that account for this *** are integrated into disaster risk reduction processes through participatory approaches and can provide valuable up-to-date local *** a field study in Eberbach(Baden–Wuerttemberg,Germany)sketch maps and questionnaires were used to capture local knowledge about *** on a previous study on urban flooding in Santiago de Chile,the tools were adapted and applied to river flooding in the city of Eberbach,which is regularly flooded by the Neckar River,a major river in southwest *** empirical database of the study comprises 40 participants in the study area and 40 in a control *** of the participants in each group are residents and half are *** sampling was used,and the questionnaires aimed to gather demographic information and explore what factors,such as property,influence the risk perception of the study *** results show that residents identify a larger spatial area as at risk than pedestrians,and owning property leads to higher risk *** flood type influenced the choice of the base maps for the sketch *** river flooding,one map with an overview of the area was sufficient,while for urban flooding a second map with more details of the area also enables the marking of small *** information gathered can complement authoritative data such as from flood *** participatory approach also increases the communication and trust between local governments,researchers,and citizens.

关键词： Disaster risk reduction Flooding Local knowledge Participatory approach Sketch maps Volunteered geographic information

Smarter in the city?Lizards from urban and semi-natural habitats do not differ in a cognitive task in two syntopic species

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Current Zoology 2024年第3期70卷 361-370页

作者： Isabel Damas-Moreira Birgit Szabo Georgios Drosopoulos carolin Stober Duje Lisičić Barbara A.Caspers Department of Behavioural Ecology Bielefeld University33615Germany Division of Behavioural Ecology University of Bern3032Switzerland Department of Biology University of Zagreb10000Croatia Joint Institute of Individualisation in a Changing Environment(JICE) University of Münster and Bielefeld University33615Germany

Urbanization occurs at a global scale,imposing dramatic and abrupt environmental changes that lead to biodiversity ***,some animal species can handle these changes,and thrive in such artifcial *** possible explanation is that urban individuals are equipped with better cognitive abilities,but most studies have focused on birds and mammals and yielded varied *** have received much less attention,despite some lizard species being common city *** Italian wall lizard,Podarcis siculus,and the common wall lizard,Podarcis muralis,are two successful lizards in anthropogenic habitats that thrive in urban *** test for differences in a cognitive skill between urban and semi-natural environments,we investigated inhibitory control through a detour task in syntopic populations of the two species,across 249 lizards that were tested in partially artifcial feld *** inhibitory control is considered essential for higher degrees of cognitive fexibility and other higher-level cognitive *** this task,we confronted lizards with a transparent barrier,separating them from a desired shelter area that they could only reach by controlling their impulse to go straight and instead detour the *** found no differences between lizards in urban and semi-natural environments,nor between species,but females overall performed better than ***,48%of the lizards in our study did not perform a correct trial in any of the 5 trials,hinting at the diffculty of the task for these *** study is among the frst to address lizard cognition,through their inhibitory control,as a potential explanation for success in cities and highlights one should be careful with assuming that urban animals generally have enhanced cognitive performance,as it might be taxa,task,or condition dependent.

关键词： Podarcis siculus Podarcis muralis Behavior Cognition Detour task Reptile.

Limb symmetry index in competitive alpine ski racers:Reference values and injury risk identification according to age-related performance levels

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Journal of Sport and Health Science 2018年第4期7卷 405-415页

作者： Lisa Steidl-Müller carolin Hildebrandt Erich Müiller Christian Fink Christian Raschner Department of Sport Science University oflnnsbruekInnsbruck 6020Austria Department of Sport Science and Kinesiology University of SalzburgSalzburg 5400Austria Research Unit for Orthopedic Sports Medicine and Injury Prevention Institute of Psychology（ISAG）The Health ＆ Life Sciences University（UMIT）Innsbruck 6020Austria Gelenkpunkt-Sports and Joint Surgery Innsbruck 6020Austria Corresponding author.E-mail address：lisa.steidl-mueller@uibk.ac.at

Purpose： The aims of this study were to assess differences of limb symmetry index （LSI） in strength- and coordination-related tasks between high-level, competitive, noninjured ski racers of different age-related performance levels and to prospectively assess limb differences as a possible risk factor for traumatic and overuse injury in youth ski racers. Methods： The study （Study 1） included 285 high-level competitive ski racers （125 females, 160 males） of 3 age-related performance levels and based on the school system： 95 youth （10-14 years, secondary modem school）, 107 adolescent （15-19 years, grammar school）, and 83 elite athletes （20-34 years）. To investigate the second aim （Study 2）, 67 of the 95 youth athletes were included and any traumatic or overuse injuries were prospectively recorded over 2 seasons. All athletes performed 4 unilateral tests （strength related： one-leg counter movement jump （OL-CMJ） and one-leg isometric/isokinetic press strength test （OL-ILS）; coordination related： one-leg stability test （OL-ST） and one-leg speedy jump test （OL-SJ））. The LSI was calculated by dividing the dominant leg by the nondominant leg and multiplying by 100. Kruskal-Wallis H tests and binary logistic regression analyses were conducted. Results： There were significant differences between the LSI of the 3 age-related performance-level groups only in the strength-related tests： the OL-CMJ （X^2（2, 285） = 9.09; p = 0.01） and the OL-ILS （X^2（2,285） = 14.79; p 〈 0.01）. The LSI for OL-ILS was found to be a significant risk factor for traumatic injury in youth ski racers （Wald = 7.08; p 〈 0.01）. No significant risk factors were found for overuse injuries. Conclusion： Younger athletes display slightly greater LSI values only in the strength-related tests. The cut-off value of limb differences of 〈 10% for return to sport decisions seems to be appropriate for elite athletes, but for youth and adolescent athletes it has to be critically discussed. It seems to be necessary to defi

关键词： Age-related performance levels Alpine ski racing Injury risk Limb differences Youth athletes