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车世界 2005年第10期 64-67页

作者： Brian carolin

micra C+C的秀丽在于它典雅的玻璃顶盖。micra

关键词： micra C+C 驾驶体验前挡风玻璃巴黎车展自动开启车将副总裁动力系统扰流桑德兰

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社会认知:机动性策略的考察

心理科学进展 1986年第1期 1-10页

作者： carolin Showers Nancy Cantor 孙晔

本文主要介绍了八十年代以来社会认知和动机接面上的最新研究结果,分析了与个人动机有关的较为复杂的社会认知问题,动机转变为认知活动策略问题。作者着重研究了目的、心情、专长这些动机因素对行为的作用,它们指导着个人对情境的解释... 详细信息

本文主要介绍了八十年代以来社会认知和动机接面上的最新研究结果,分析了与个人动机有关的较为复杂的社会认知问题,动机转变为认知活动策略问题。作者着重研究了目的、心情、专长这些动机因素对行为的作用,它们指导着个人对情境的解释和行动的计划。

关键词：策略心情情境动机性社会认知

化产业如何为中小企业的环境、安全和健康保护做出积极贡献:来自BASF的样板

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生态毒理学报 2004年第4期26卷 24-25页

作者： carolin Kranz Ingo Sagasser BASF Aktiengesellschaft ZOA/N-C100 Sustainability Center 67056 Ludwigshafen Germany BASF Aktiengesellschaft GRC/KN-BENCK Global Purchasing Benckiserplatz 1 67056 Ludwigshafen Germany

　　作为一家化工企业,BASF对自己的产品负有专门的责任.……

关键词：产业中小企业环境安全健康保护化工企业责任产品

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无机泥芯制造工艺稳定性的控制

国外机车车辆工艺 2012年第2期 25-27+45页

作者： carolin Wallenhorst 齐斐斐不详

在推广新型无机粘结剂系统的过程中,建立标准化操作流程对于铸造企业来说具有里程碑的意义。为了保证工艺稳定性,必须酌情调整工艺参数和造型材料粘结剂的成分。有目的地控制泥芯制造参数,调整、融合、开发各种砂处理方法,可以显著提高... 详细信息

在推广新型无机粘结剂系统的过程中,建立标准化操作流程对于铸造企业来说具有里程碑的意义。为了保证工艺稳定性,必须酌情调整工艺参数和造型材料粘结剂的成分。有目的地控制泥芯制造参数,调整、融合、开发各种砂处理方法,可以显著提高泥芯的储存性能和抗潮湿性能。

关键词：无机粘结剂泥芯铸造工艺

Discussion:Food security and sustainable food systems:The role of soil

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International Soil and Water Conservation Research 2015年第2期3卷 154-159页

作者： matheus Alves Zanella maryam Rahmanian Leisa Nicola Perch carolin Callenius JoséLuis Rubio Faustin Vuningoma Stephan Rist Paul mapfumo Institute for Advanced Sustainability Studies(IASS) PotsdamGermany 14467 Centre for Development and Environment(CDE) University of BernSwitzerland CH-3012 Centre for Sustainable Development(CENESTA) No 108Azarbaijan StreetTehranIran World Centre for Sustainable Development(RIO+Centre) Rio de JaneiroBrazil 20031-145 Bread for the World-Protestant Development Service BerlinGermany10115 Centro de Investigaciones sobre Desertificación/Consejo Superior de Investigaciones Científicas(CIDE-CSIC) ValenciaSpain 46113 Participatory Ecological Land Use management(PELUm Association) 902Premium HouseIndependence AvenueLusakaZambia Soil Fertility Consortium for Southern Africa(SOFECSA) University of ZimbabweMt PleasantZimbabwe

Editorial notes This discussion is edited from a dialogue session of‘3rd Global Soil Week 2015'(***).The‘Global Soil Week'(GSW)is a multi-stakeholder platform of high-level policy-makers,scientists,NGOs,CSOs,farmers,artists,international organizations,and the private *** of the main purposes of the GSW is to raise public awareness of the issues of soil and ***‘Global Soil Week'advocates soil management in the context of sustainable development and promote equitable access to ***‘3rd Global Soil Week 2015'was held from 19 to 23 April 2014 in *** session,on April 202015,2015,discussed the topic of‘Food Security and Sustainable Food System:the Role of Soil'.

关键词： policy soil sustainable

Focal neurological deficit in acute anemia: Case reports and review of the literature

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World Journal of Neuroscience 2013年第2期3卷 53-56页

作者： Salvatore Giuffrida Giuseppe Carpinteri Daniela modica manuela Pennisi Alfio Catalano Rita Bella Giovanni Pennisi carolin Cornelius Giuseppe Lanza Department “G. F. Ingrassia” Section of Neurosciences University of Catania Catania Italy Department of Chemistry School of Medicine University of Catania Catania Italy medicina e Chirurgia d’Accettazione d’Urgenza “Policlinico–Vittorio Emanuele” University Hospital Catania Italy

Introduction: Although anemia is not regarded as an usual vascular risk factor for stroke, it is one of the potential mechanism by which the brain does not receive adequate oxygenation. moreover, the relationship between drop of hemoglobin and acute focal neurological deficits is not clear. We report two patients with cerebral infarction due to acute anemia. Case Reports: Case 1 was a 73-year-old man who complained an episode of loss of consciousness followed by right hemiparesis and dysarthria after few hours. The day after admission he presented melena caused by a duodenal ulcer bleeding. The hemoglobin dropped from 11.3 g/dl to5.6 g/dl in 24 hours. Areas of acute infarctions were evident at diffusion-weighted imaging (DWI) of the brain. Case 2 was a 77-year-old man with a transient episode of aphasia, right lower limb paresis and mental confusion twelve hours after an intervention of PTA and stenting of the left internal carotid artery. Hemoglobin was11.8 g/dl before intervention and9 g/dl 48 hours later. DWI showed bilateral and widespread acute infarcts. Conclusion: Anemia has to be considered as a potential factor in determining or worsening cerebral infarction, especially in patients with carotid or intracranial stenosis, high cerebrovascular lesions load or insufficient collateral supply. Acute or severe anemia may negatively impact the cerebral blood flow and decrease oxygen-carrying capacity, promote rapid deterioration of ischemic penumbra. Brain DWI and treatment of the underlying etiology of acute anemia are crucial in early identification and recovery of cerebral infarctions.

关键词： Low Hemoglobin Level Focal Neurological Sign Brain Diffusion-Weighted Imaging Cerebral Hemodynamic Cerebral Infarction

Structure-based redesign of docking domain interactions modulates the product spectrum of a rhabdopeptide-synthesizing NRPS

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Structure-based redesign of docking domain interactions modu...

molecular Epidemiology of Nontuberculous mycobacteria in a German CF Center and Clinical Course of NTm Positive Patients

中国化学会第十二届全国天然有机化学学术会议

作者：蔡晓凤 carolin Hacker Carsten Kegler Lei Zhao Helge B.Bode Jens W?hnert molecular Biotechnology Department of BiosciencesGoethe University Frankfurt

Several peptides in clinical use are derived from non-ribosomal peptide synthetases(NRPS).In these systems,multiple NRPS subunits interact with each other in a specific linear order mediated by specific docking domains(DDs) whose structures are not known yet to synthesize well-defined peptide *** contrast to these classical NRPSs,the subunits of the rhabdopeptide/xenortide-like peptide(RXPs) producing NRPSs can act iteratively and in different order depending on the protein amount resulting in libraries of peptide products. In order to define the structural and thermodynamic basis for their unusual interaction patterns,we determined the structures of all N-terminal DDs(NDDs) as well as of an DD-DD complex and characterized all putative DD interactions thermodynamically for one such *** amino acid residues for DD interactions were identified that upon their exchange not only changed the DD affinity but also resulted in rationally predictable changes in peptide production.A simple set of ’recognition rules’ for DD interactions was identified that also operates in other megasynthase complexes.

关键词： RXP-NRPSs docking domain structures RXP biosynthesis

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Open Journal of medical microbiology 2013年第1期3卷 39-47页

作者： carolin Kroner Barbara Ganster matthias Kappler Ann-Christin Grimmelt Bernd H.Belohradsky michael Hogardt Gudrun Laniado michael meissner Soren Schubert matthias Griese Paediatric Pneumology Dr.von Hauner Children’s HospitalLudwig-Maximilians-UniversityMunichGermany Institute for Clinical Chemistry Molecular DiagnosticsMedical Microbiology and Hygiene DepartmentLudwigshafen General HospitalLudwigshafenGermany Institute for medical microbiology and Infection Control University HospitalJohann-Wolfgang-Goethe-UniversityFrankfurt/MainGermany max von Pettenkofer Institute of Hygiene and medical microbiology Ludwig-Maximilians-UniversityMunichGermany

Goal of this study was to analyse the clinical course of cystic fibrosis (CF) patients with nontuberculous mycobacteria (NTm) in their respiratory secretions and to investigate the molecular epidemiology of the most prevalent NTm species by multilocus sequence analysis (mLSA). The respiratory specimen and the clinical parameters forced expiratory volume in one second (FEV1), body-mass-index (BmI), erythrocyte sedimentation rate (ESR) 1 h and immunoglobulin G (IgG) of 357 CF patients, 0 - 52.4 years, mean FEV1 2009 81.5% pred were analysed between 1998 and 2010. In 13 patients NTm were detected. 12 of 13 patients carried m. abscessus, for one patient the NTm species was not characterized. 4 patients carried a second NTm species (m. avium, m. chelonae (2x), m. intracellulare). 6 patients exhibited a significant decline in FEV1, however changes in BmI, IgG and ESR were discordant. molecular genotyping of m. abscessus isolates revealed a unique mLSA pattern in 6 patients. 2 patients harboured identical strains, and one patient a closely related strain. Whether the presence of identical strains is attributed to the acquisition of NTm clones from common environmental sources or to patient-to-patient transmission cannot be definitely clarified. Although cross-in- fection of the three patients with identical/closely related strains in the present cohort is highly unlikely, we recommend strict hygiene measures for all CF patients harbouring NTm.

关键词： mycobacteria Nontuberculous mycobacterium abscessus Cystic Fibrosis molecular Epidemiology multilocus Sequence Analysis(mLSA) Interferon Gamma

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何故为敌

finDr:A web server for in silico D-peptide ligand identification

作者： (德)卡罗琳·艾姆克(carolin Emcke)

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Synthetic and Systems Biotechnology 2021年第4期6卷 402-413页

作者： Helena Engel Felix Guischard Fabian Krause Janina Nandy Paulina Kaas Nico Hofflin maja Kohn Normann Kilb Karsten Voigt Steffen Wolf Tahira Aslan Fabian Baezner Salom´e Hahne carolin Ruckes Joshua Weygant Alisa Zinina Emir Bora Akmeriç Enoch B.Antwi Dennis Dombrovskij Philipp Franke Klara L.Lesch Niklas Vesper Daniel Weis Nicole Gensch Barbara Di Ventura mehmet Ali Oztürk Signalling Research Centres BIOSS and CIBSS University of FreiburgSchanzlestr.1879104FreiburgGermany Institute of Biology III Faculty of BiologyUniversity of FreiburgSchanzlestr.179104FreiburgGermany Institute of Biology II Faculty of BiologyUniversity of FreiburgSchanzlestr.179104FreiburgGermany AG Roth-Lab for microarrayCopying ZBSA-Centre for Biological Systems AnalysisUniversity of FreiburgHabsburgerstrasse 4979104FreiburgGermany Biomolecular Dynamics Institute of PhysicsUniversity of FreiburgHermann-Herder-Strasse 3a79104FreiburgGermany Core Facility Signalling Factory Centre for Biological Signaling Studies(BIOSS)University of FreiburgSchanzlestr.1879104FreiburgGermany Spemann Graduate School of Biology and medicine(SGBm) University of FreiburgAlbertstraße 19A79104FreiburgGermany Internal medicine IV Department of MedicineMedical CenterUniversity of FreiburgHugstetter Straße 5579106FreiburgGermany Institute for Biochemistry University of FreiburgAlbertstr.2179104FreiburgGermany

In the rapidly expanding field of peptide therapeutics,the short in vivo half-life of peptides represents a considerable limitation for drug action.D-peptides,consisting entirely of the dextrorotatory enantiomers of naturally occurring levorotatory amino acids(AAs),do not suffer from these shortcomings as they are intrinsically resistant to proteolytic degradation,resulting in a favourable pharmacokinetic *** experimentally identify D-peptide binders to interesting therapeutic targets,so-called mirror-image phage display is typically performed,whereby the target is synthesized in D-form and L-peptide binders are screened as in conventional phage *** technique is extremely powerful,but it requires the synthesis of the target in D-form,which is challenging for large *** we present finDr,a novel web server for the computational identification and optimization of D-peptide ligands to any protein structure(https://***/).finDr performs molecular docking to virtually screen a library of helical 12-mer peptides extracted from the RCSB Protein Data Bank(PDB)for their ability to bind to the *** a separate,heuristic approach to search the chemical space of 12-mer peptides,finDr executes a customizable evolutionary algorithm(EA)for the de novo identification or optimization of D-peptide *** a proof of principle,we demonstrate the validity of our approach to predict optimal binders to the pharmacologically relevant target phenol soluble modulin alpha 3(PSmα3),a toxin of methicillin-resistant Staphylococcus aureus(mRSA).We validate the predictions using in vitro binding assays,supporting the success of this *** to conventional methods,finDr provides a low cost and easy-to-use alternative for the identification of D-peptide ligands against protein targets of choice without size *** believe finDr will facilitate D-peptide discovery with implications in biotechnology and biomedicine.

关键词： D-peptide Web server Evolutionary algorithm Peptide design molecular docking mirror-image phage display