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Sex-dependent resilience to extreme drought events: implications for climate change adaptation of a South American endangered tree species

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ecological Processes 2024年第02期13卷 48-60页

作者： Sergio Piraino Martín Ariel hadad Yanina Antonia Ribas-Fernández Fidel Alejandro Roig Laboratorio de Dendrocronología e Historia Ambiental (IANIGLA CONICeT ) Facultad de Ciencias Agrarias Universidad Nacional de Cuyo Laboratorio de Dendrocronología de Zonas áridas (CIGeOBIO CONICeT ) Gabinete de Geología Ambiental (INGEO UNSJ) Hémera Centro de Observación de la Tierra Facultad de Ciencias Universidad Mayor

Background Recent changes in climatic trends are resulting in an increased frequency and intensity of extreme events, with unknown effect on ecosystem dynamics in the near future. extreme drought episodes are recognized as disturbance factors capable of modifying forest dynamics and tree growth. Within this context, dioecious tree species may be impacted by climatic extremes, affecting male/female proportions and, consequently, reproductive processes and species persistence. Therefore, there is an urgent need for species-specific assessments of growth tolerance to extreme dry spells in dioecious tree species, to establish effective conservation strategies for these particular natural resources. Araucaria araucana(araucaria), an endangered dioecious Patagonian tree species, has recently undergone decay and mortality episodes in response to increasing dry climatic conditions. While sex-dependent tolerance to extreme drought episodes has been assessed in the species' humid distribution range, there is still a lack of information on the gender-based resilience of trees growing in the drier environments of the species' *** We reconstructed, through dendrochronological methods, the sex-dependent response of 105 araucaria individuals(55 female and 50 male trees) to five regional extreme dry spells employing a set of different indices. Resistance, recovery period, and average growth reduction of standardized tree-ring growth were examined, analysing the effect of biotic(sex, pre-drought stem tree growth) and abiotic(local climatic conditions before, during, and after extreme climatic episodes) factors on tree *** Sex influences only the species resistance to climatic disturbance, with male individuals showing lower tolerance to extreme drought events. Pre-drought radial growth rates and local meteorological conditions preceding, during, and following extreme dry spells strongly modulated araucaria radial growth resilience regardless of tree s

关键词： Araucaria Climate change Dendrochronology extreme drought event Resilience

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Influence of anodization conditions on deposition of Hydroxyapatite on α/β Ti alloys for Osseointegration: Atomic Force Microscopy Analysis

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Transactions of Nonferrous Metals Society of China 2024年

作者： Rania e.Hammam engie M.Safwat Soha A.Abdel-Gawad Madiha Shoeib Shimaa el-hadad Faculty of engineering， Modern University for Technology and Information (MTI) Restorative and Dental Materials Department， National Research Centre Giza Chemistry Department， Faculty of Science， Cairo University Central Metallurgical Research and Development Institute P.O.87

Integrating titanium-based implants with the surrounding bone tissue remains challenging. This study aims to explore the impact of different anodization voltages （20-80V） on the surface topography of two-phase （α/β） Ti alloys and to produce TiO2films with enhanced bone formation abilities. Scanning electron microscopy coupled with energy dispersive spectroscopy （SeM-eDS） and atomic force microscopy （AFM） were applied to investigate the morphological， chemical， and surface topography of the prepared alloys and to confirm the growth of hydroxyapatite （HA） on their surfaces. Results disclosed that the surface roughness of TiO2films formed on Ti-6Al-7Nb alloys was superior to that of Ti–6Al–4V alloys. Ti-6Al-7Nb alloy anodized at 80 V had the highest yields of HA after immersion in SBF with enhanced HA surface coverage. The developed HA layer had a mean thickness of 128.38 ± 18.13 μm， suggesting its potential use as an orthopedic implantable material due to its promising bone integration and， hence， remarkable stability inside the human body.

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Influence of chemical modification by Y2O3 on eutectic Si characteristics and tensile properties of A356 alloy

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Transactions of Nonferrous Metals Society of China 2019年第7期29卷 1365-1374页

作者： M. e. MOUSSA S. eL-hadad W. KHALIFA Department of Casting Technology Central Metallurgical Research and Development Institute (CMRDI) P. O. 87 Helwan Egypt Department of Mining Petroleum and Metallurgical Engineering Faculty of Engineering Cairo University P. O. 12613 Giza Egypt

The modification of A356 aluminum-silicon alloy using yttrium oxide (Y2O3) was studied. Addition levels of up to 2.5 wt.% Y2O3 were investigated. A premixed powder of Al-30wt.%Y2O3 was added to the melt at about 750℃ using vortex method. Samples were then poured in sand mold. The results showed that evident modification was obtained using the Y2O3 addition. The optimum level was 1.5 wt.%, and was corresponding to a eutectic temperature depression from 568 to 557℃. The eutectic Si particles were refined in length from 44.8 to 8.3 μm, and modified in aspect ratio from 6.8 to 0.98. Higher additions of Y2O3 caused de-modification of the eutectic Si particles. The ductility of the modified specimens was enhanced by more than 20% compared to the unmodified ones. This was associated with a gradual transfer from cleavage to a more ductile mode of fracture.

关键词： hypoeutectic Al-Si alloys modification yttrium oxide (Y2O3) ductility fracture mode

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Copper-uptake mediated by an ecofriendly zwitterionic ionic liquid: A new challenge for a cleaner bioeconomy

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Journal of environmental Sciences 2023年第8期130卷 92-101页

作者： Marie e.Vuillemin Christophe Waterlot Anthony Verdin Sylvain Laclef Christine Cézard David Lesur Catherine Sarazin Dominique Courcot caroli.e hadad eric Husson Albert Nguyen Van Nhien enzyme and Cell engineering UMR 7025 CNRSUniversity of Picardie Jules Verne-Faculty of Sciences33 rue Saint Leu80039 Amiens CedexFrance University of Lille Mines-Télécom InstituteUniversity of ArtoisJUNIAULR 4515-LGCgELaboratory of Civil Engineering and Geo-EnvironmentF-59000 LilleFrance environmental Chemistry and Life Interactions Unit UCEIV UR4492FR CNRS 3417University of Littoral Cote d’Opale(ULCO)DunkerqueFrance Laboratory of Glycochemistry Antimicrobials and AgroresourcesUMR CNRS 7378University of Picardie Jules Verne-Faculty of Sciences33 rue Saint Leu80039 Amiens CedexFrance Institute of Chemistry of Picardie FR CNRS 3085 80039 AmiensFrance

This study aims to investigate the ability of an imidazolium biobased Zwitterionic Ionic Liquids(ZILs)in enhancing the phytoavailability of copper from garden(G)and vineyard(V)soils using the model plant *** and artificially contaminated CuSO_(4) soils,unamended and ZIL-amended soil modalities were *** copper/ZIL molar ratio(1/4)introduced was rationally established based on molecular modeling and on the maximal copper concentration in artificially contaminated *** accumulation of copper in the shoots was detected for the uncontaminated and copper contaminated ZIL amended V soils(18.9 and 23.3 mg/kg,respectively)contrary to G soils together with a ZIL concentration of around 3%(W/W)detected by LC-MS *** data evidenced a Cu-accumulation improvement of 38%and 66%compared to non-amended V soils(13.6 and 13.9 mg/kg respectively).ZIL would be mainly present under Cu(II)-ZIL_(4) complexes in the *** impact on the chemical composition of shoot was also *** results show that depending on the soils modalitity,the presence of free copper and/or ZIL led to different chemical compositions in lignin and monomeric sugar *** the biorefinery context,performances of enzymatic hydrolysis of shoots were also related to the presence of both ZIL and copper under free or complex *** assessment of the vineyard soil samples indicated that the quantity of copper and ZIL remaining in the soils had no significant *** amendment in a copper-contaminated soil was demonstrated as being a promising way to promote the valorization of phytoremediation plants.

关键词： Cu-accumulation Biobased Zwitterionic Ionic Liquid (ZIL) enzymatic hydrolysis ecotoxicity

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Graphene quantum dots: From efficient preparation to safe renal excretion

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Nano Research 2021年第3期14卷 674-683页

作者： caroli.e hadad JoséMiguel González-Domínguez Silvia Armelloni Deborah Mattinzoli Masami Ikehata Akcan Istif Adrian Ostric Francesco Cellesi Carlo Maria Alfieri Piergiorgio Messa Belén Ballesteros Tatiana Da Ros Centre of excellence for Nanostructured Materials(CeNMAT) INSTMDepartment of Chemical and Pharmaceutical SciencesUniversity of TriesteVia L.Giorgieri 134127TriesteItaly Laboratoire LG2A-CNRS UMR 7378 Universitéde Picardie Jules Verne33 rue Saint Leu-UFR des Sciences80039AmiensFrance Instituto de Carboquímica(CSIC) C/Miguel Luesma Castán 4E-50018ZaragozaSpain Renal Research Laboratory-Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico via Pace 920122MilanItaly Dipartimento di Chimica Materiali ed Ingegneria Chimica“G.Natta”Politecnico di MilanoVia Mancinelli 720131MilanItaly Unit of Nephrology Dialysis and Renal Transplant Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinicovia della commenda 420122MilanItaly Department of Clinical Sciences and Community Health University of Milan20122MilanItaly Catalan Institute of Nanoscience and Nanotechnology(ICN2) CSIC and the Barcelona Institute of Science and TechnologyCampus UABBellaterra08193BarcelonaSpain

Carbon nanomaterials offer excellent prospects as therapeutic agents,and among them,graphene quantum dots(GQDs)have gained considerable interest thanks to their aqueous solubility and intrinsic fluorescence,which enable their possible use in theranostic approaches,if their biocompatibility and favorable pharmacokinetic are *** prepared ultra-small GQDs using an alternative,reproducible,top-down synthesis starting from graphene oxide with a nearly 100%*** materials were tested to assess their safety,demonstrating good biocompatibility and ability in passing the ultrafiltration barrier using an in vitro *** leads to renal excretion without affecting the ***,we studied the GQDs in vivo biodistribution confirming their efficient renal clearance,and we demonstrated that the internalization mechanism into podocytes is ***,considering the reported characteristics,it appears possible to vehiculate compounds to kidneys by means of GQDs,overcoming problems related to lysosomal degradation.

关键词： graphene quantum dots podocytes biodistribution uptake pathway renal clearance nanocarrier

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Severity of Coronary Artery Disease by Coronary CT Angiography in Relation to Left Ventricular Diastolic Function

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World Journal of Cardiovascular Diseases 2020年第4期10卷 235-245页

作者： Wassam eldin hadad elshafey Walaa Fareed Abdelaziz Mohamed Seleem Mohamed Osama Mohamed Abdallah Omar Cardiology Department Menoufia University Al Minufya Egypt National Heart Institute Embaba Cairo Egypt

Objectives:?The aim of this study is to evaluate the relationship between severity of CAD by coronary mutlislice computed tomography scan and the degree of diastolic function Methods:?The study consisted of 80 patients who underwent both coronary CTA and TTe within 1 year with no identifiable intervening cardiovascular event in National?Heart?Institute and Menoufia?University?Hospitals. All patients were subjected to detailed medical history, physical examination, full electrocardiography study including tissue Doppler imaging on mitral annulus, MSCT coronary angiography and different laboratory investigation as CBC, creatinine, lipid profile. Results:?From 80 patients who have done both echocardiography examination and MSCT coronary angiography, the CT scan results were 38 patients with non-obstructive coronary artery disease and 42 patients with obstructive CAD, higher number of patients with diastolic dysfunction with higher values of e/e’, medial e’, lateral e’, LAVI (left atrial volume index) and TRV (tricuspid regurge velocity) were found in the group with obstructive coronary artery disease.?Conclusion:?Our study showed that diastolic dysfunction is more prevalent in patients with obstructive coronary artery disease with higher grade of diastolic dysfunction.

关键词： Coronary Artery Disease Diastolic Dysfunction MSCT Coronary Angiography

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树轮记录的自公元1200年以来强火山喷发事件与高亚洲南部河流源区气候水文变化的关联

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第四纪研究 2021年第2期41卷 323-333页

作者：陈友平陈峰张合理胡茂王世杰 hadad Martín ARIeL Roig Junent Fidel ALeJANDRO 云南大学国际河流与生态安全研究院国际河流与跨境生态安全重点实验室云南昆明650504 中国气象局乌鲁木齐沙漠气象研究所树木年轮理化研究重点开放实验室/新疆树木年轮生态实验室新疆乌鲁木齐830002 Laboratorio de Dendrocronología e Historia Ambiental IANIGLACCT CONICETMendozaP.O.Box330MendozaArgentina

强火山喷发作为气候变化重要的外强迫因素,其所造成的气候环境效应一直是气候变化研究热点,而其对于流域水循环影响较少受关注。本文利用采自高亚洲南部河流源区麦吊云杉(Picea brachytyla)树轮样本,研制出一个长达885 a的树木年轮标准... 详细信息

强火山喷发作为气候变化重要的外强迫因素,其所造成的气候环境效应一直是气候变化研究热点,而其对于流域水循环影响较少受关注。本文利用采自高亚洲南部河流源区麦吊云杉(Picea brachytyla)树轮样本,研制出一个长达885 a的树木年轮标准宽度年表。基于树轮气候响应分析结果,利用线性回归模型重建研究区自公元1200年上年11月至当年2月平均最低气温变化,重建方程方差解释量47.1%。该气温重建序列显示,研究区自公元1200年经历了8个冷期和9个暖期,包含有10个极冷年和23个极暖年。同时,该气温重建序列验证了自公元1200年来27次强火山喷发(VeI≥5)对于青藏高原东南部河流源区气候的影响,包括1257年Samalas和1815年Tambora等强火山喷发事件。该气温重建序列与相关河流径流数据对比结果表明强火山喷发在引起高亚洲南部河流源区气温出现明显下降的同时,也可能会进一步导致水循环减缓,使得高亚洲南部河流径流量出现减少。

关键词：树木年轮气温重建火山喷发水文效应青藏高原

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Molecular and epidemiologic characterization of Wilms tumor from Baghdad, Iraq

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World Journal of Pediatrics 2018年第6期14卷 585-593页

作者： Hannah M.Phelps Mazin F.Al-Jadiry Natasha M.Corbitt Janene M.Pierce Bingshan Li Qiang Wei Raina R.Flores Hernan Correa Stefania Uccini Haydar Frangoul Adel R.Alsaadawi Safaa A.F.Al-Badri Amir F.Al-Darraji Raghad M.Al-Saeed Salma A.Al-hadad Harold N.LovvornⅢ Vanderbilt University School of Medicine 2215 Garland AvenueNashvilleTN 37232-9780USA Oncology Unit Children’s Welfare Teaching HospitalBaghdad University Medical CityBaghdadIraq Department of P ediatric Surgery Vanderbilt University Medical CenterNashvilleUSA Department of Molecular Physiology and Bioph ysics Vanderbilt University School of MedicineNashvilleUSA Division of P ediatric Pathology Vanderbilt University Medical CenterNashvilleUSA Department of Clinical and Molecular Medicine Sapienza UniversityRomeItaly Division of P ediatric Hematology and Oncology Vanderbilt University Medical CenterNashvilleUSA Department of P athology Baghdad University Medical CityBaghdadIraq Oncology Unit Children’s Welfare Teaching HospitalWasit University College of MedicineWasitIraq

Background Wilms tumor (WT) is the most common childhood kidney cancer worldwide, yet its incidence and clinical behavior vary according to race and access to adequate healthcare resources. To guide and streamline therapy in the war-torn and resource-constrained city of Baghdad, Iraq, we conducted a first-ever molecular analysis of 20 WT specimens to characterize the biological features of this lethal disease within this challenged population. Methods Next-generation sequencing of ten target genes associated with WT development and treatment resistance (WT1, CTNNB1, WTX, IGF2, CITeD1, SIX2, p53, N-MYC, CRABP2, and TOP2A) was completed. Immunohistochemistry was performed for 6 marker proteins of WT (WT1, CTNNB1, NCAM, CITeD1, SIX2, and p53). Patient outcomes were compiled. Results Mutations were detected in previously described WT 'hot spots' (e.g., WT1 and CTNNB1) as well as novel loci that may be unique to the Iraqi population. Immunohistochemistry showed expression domains most typical of blastemal-predominant WT. Remarkably, despite the challenges facing families and care providers, only one child, with combined WT1 and CTNNB1 mutations, was confirmed dead from disease. Median clinical follow-up was 40.5 months (range 6–78 months). Conclusions These data suggest that WT biology within a population of Iraqi children manifests features both similar to and unique from disease variants in other regions of the world. These observations will help to risk stratify WT patients living in this difficult environment to more or less intensive therapies and to focus treatment on cell-specific targets.

关键词： Iraq Low- and middle-income countries Next-generation sequencing Pediatric cancer Wilms tumor

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基于白扦树轮蓝光强度的中国华北暖季温度重建

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Journal of Geographical Sciences 2023年第12期33卷 2511-2529页

作者：陈巧湄岳伟鹏陈峰马丁·哈达德菲德尔·罗伊格赵晓恩胡茂曹红华 Yunnan Key Laboratory of International Rivers and Transboundary eco-Security Institute of International Rivers and Eco-SecurityYunnan UniversityKunming650500China Key Laboratory of Tree-ring Physical and Chemical Research of the Chinese Meteorological Administration/Xinjiang Laboratory of Tree-ring ecology Institute of Desert MeteorologyChinese Meteorological AdministrationUrumqi830002China Laboratorio de Dendrocronología de ZonasÁridas CIGeOBIO(CONICeT-UNSJ) Gabinete de Geología Ambiental(INGEO-UNSJ)San JuanArgentina Laboratorio de Dendrocronología e Historia Ambiental IANIGLA-CCT CONICET-Universidad Nacional de CuyoMendozaArgentina Hémera Centro de Observación de la Tierra Escuela de Ingeniería ForestalFacultad de CienciasUniversidad MayorHuechurabaSantiagoChile

In the past 30 years,observational climate datasets reveal a significant a drying and warming trend over in North *** of climatic variability over North China and its driving mechanism in a long-term perspective is,however,limited to a few sites only,especially the lack of temperature reconstructions based on latewood density and blue *** this study,we developed a 281-year latewood blue intensity chronology based on 45 cores of Picea meyeri in western North *** on the discovery that the warm season(May–August)mean maximum temperature is the main controlling factor affecting the change in blue light reflection intensity,we established a regression model that explained 37%of the variance during the calibration period(1950–2020),allowing to trace the mean maximum temperature up to 1760 *** the past 261 years,we identified seven persistent high temperature periods(1760–1773,1778–1796,1805–1814,1869–1880,1889–1934,1984–2000,2004–2020)and three persistent low temperature periods(1815–1868,1935–1963,1969–1983)in North *** of a nearby temperature reconstructions and climate gridded data indicate that our reconstruction record a wide range of temperature variations in North *** analysis of links between large-scale climatic variation and the temperature reconstruction showed that there is a relationship between extremes in the warm season temperature and anomalous SSTs in the equatorial eastern Pacific,and implied that the extremes in the warm season temperature in North China will be intensified under future global warming.

关键词： blue intensity Picea meyeri mean maximum temperature North China dendroclimatology

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左氧氟沙星、加替沙星及莫西沙星对肺结核患者的早期及延长早期杀菌活性

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国际结核病与肺部疾病杂志 2006年第2期1卷 52-58页

作者： J. L. Johnson D. J. hadad W. H. Boom C. L. Daley C. A. Peloquin K. D. eisenach D. D. Jankus S. M. Debanne e. D. Charlebois e. Maciel M. Palaci R. Dietzet 马玙（译）屠德华（校）张立兴（审） Department of Medicine. Division of Infectious Diseases Case Western Reserve University School of Medicine and University Hospitals of Cleveland Cleveland Ohio USA Núcleo de Doencas Infecciosas Centro Biomédico Universidade Federal do Espirito Santo Vitória Brazil Division of Mycobacterial and Respiratory Infections National Jewish Medical and Research Center Denver Infectious Disease Pharmacokinetics Laboratory National Jewish Medical and Research Center Denver Schools of Pharmacy and Medicine. University of Colorado Denver Colorado University of Arkansas for Medical Sciences Little Rock Arkansas Department of epidemiology and Biostatistics Case Western Reserve University School of Medicine Cleveland Ohio AIDS Research Institute University of California-San Francisco San Francisco. California USA 不详

目的:评估左氧氟沙星、加替沙星及莫西沙星等新氟喹诺酮类药物对肺结核患者的早期杀菌活性及延长早期杀菌活性。设计:随机开放临床试验。40例成年新诊断的涂阳肺结核患者(每组10例)分别每日单一接受异烟肼300mg,或左氧氟沙星1000mg,或... 详细信息

目的:评估左氧氟沙星、加替沙星及莫西沙星等新氟喹诺酮类药物对肺结核患者的早期杀菌活性及延长早期杀菌活性。设计:随机开放临床试验。40例成年新诊断的涂阳肺结核患者(每组10例)分别每日单一接受异烟肼300mg,或左氧氟沙星1000mg,或加替沙星400mg,或莫西沙星400mg的7天治疗。治疗前2天及单药治疗7天期间,每日收集痰液进行定量培养。计量单药治疗开始的头2天(0-2天)及治疗后5天(2-7天)的菌量下降情况,以评估各药的早期及延长早期杀菌活性。对实验室工作人员关于病人治疗分组信息采用单盲法。结果:异烟肼的早期杀菌活性为0.67log10cfu/毫升/天,高于莫西沙星(0.33log10cfu/毫升/天)及加替沙星(0.35log10cfu/毫升/天)。与每日1000mg左氧氟沙星的早期杀菌活性(0.45log10cfu/毫升/天)相比,无统计学差异(P=0.14)。3种氟喹诺酮类药物的早期杀菌活性(0-2天)与延长早期杀菌活性(2-7天)相似。总体说来,氟喹诺酮类药物的延长早期杀菌活性高于异烟肼。结论:莫西沙星、加替沙星及高剂量左氧氟沙星,虽然略低于异烟肼,但均有良好的早期杀菌活性,并具有较高的延长早期杀菌活性。有理由对这些药物敏感的结核病人进行进一步的治疗研究。

关键词：结核氟喹诺酮类药物莫西沙星左氧氟沙星加替沙星抗结核作用早期杀菌活性

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