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Diversity, Chemical Compositions and Beneficial Effects of Some Spices and Aromatic Leaves Consumed in Benin and in the World: Critical Review

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American Journal of Plant Sciences 2023年第5期14卷 569-598页

作者： carole vikou Josiane Semassa Zoriţa Diaconeasa Gautier Roko Majoie Tohoyessou Durand Dah-Nouvlessounon Haziz Sina Andreea Stanilă Lamine Baba-Moussa Laboratory of Biology and Molecular Typing in Microbiology Faculty of Science and Technology University of Abomey-Calavi Abomey-Calavi Benin Republic Faculty of Food Science and Technology University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca Cluj-Napoca Romania

Spices and aromatic plants are products of plant origin used in food. They are used for the preparation of remedies, for seasoning dishes or for preserving food. This review takes stock of the diversity of spices and aromatic herbs, the chemical composition, the different properties and forms of use of six spices and aromatic herbs commonly used in Benin and around the world. These are Zingiber officinalis (ginger), Curcuma longa (curcuma), Syzygium aromaticum (clove) and three aromatic herbs Petroselinum crispum (parsley), Rosmarinus officinalis (rosemary), and Laurus nobilis (laurel). The methodology used is that of documentary research oriented towards the consultation of previous scientific documents that have highlighted the different pharmacological activities of the different species of spices and aromatic plants targeted. It is important to note that more than twenty plant species are used as spices and aromatic plants in Benin and around the world. Chemically, these different spices and aromatic herbs contain certain secondary metabolites such as flavonoids, tannins, coumarins, alkaloids, steroids, terpenes, saponins, and polyphenols. This diversity of secondary metabolites alone or in a possible synergy may be responsible for many beneficial properties attributed to spices and aromatic herbs.

关键词： Spices Aromatic Leaves Pharmacological Effects Humans

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PARAMETERS IDENTIFICATION IN A SALTWATER INTRUSION PROBLEM

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Acta Mathematica Scientia 2020年第5期40卷 1563-1584页

作者： Ji LI carole ROSIER College of Mathematics and Statistics Chongqing Technology and Business UniversityChongqing Key Laboratory of Social Economy and Applied StatistiesChongqing 400067China LMPA Laboratoire de Mathematiques Pures et Appliquees Joseph LiouvilleF-62100 CalaisFranceCNRS FR 2037France

This article is devoted to the identification, from observations or field measurements, of the hydraulic conductivity K for the saltwater intrusion problem in confined aquifers. The involved PDE model is a coupled system of nonlinear parabolic-elliptic equations completed by boundary and initial conditions. The main unknowns are the saltwater/freshwater interface depth and the freshwater hydraulic head. The inverse problem is formulated as an optimization problem where the cost function is a least square functional measuring the discrepancy between experimental data and those provided by the *** the exact problem as a constraint for the optimization problem and introducing the Lagrangian associated with the cost function, we prove that the optimality system has at least one solution. Moreover, the first order necessary optimality conditions are established for this optimization problem.

关键词： parameters identification optimization problem strongly coupled system nonlinear parabolic equations seawater intrusion

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Invitation to psychology carole Wade, Carol Tavris.

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2002年

作者： carole Wade Carol Tavris.

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Invitation to psychology carole Wade, Carol Tavris.

Invitation to psychology Carole Wade, Carol Tavris.

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2004年

作者： carole Wade Carol Tavris.

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Bridging the gap with multispecific immune cell engagers in cancer and infectious diseases

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Cellular & Molecular Immunology 2024年第7期21卷 643-661页

作者： Camille Rolin Jacques Zimmer carole Seguin-Devaux Department of Infection and Immunity Luxembourg Institute of Health29 Rue Henri KochL-4354 Esch-Sur-AlzetteLuxembourg.2University of Luxembourg Place de I'Universiteé L-4365 Esch-sur-AlzetteLuxembour

By binding to multiple antigens simultaneously,multispecific antibodies are expected to substantially improve both the activity and long-term efficacy of antibody-based *** cell engagers,a subclass of antibody-based constructs,consist of engineered structures designed to bridge immune effector cells to their target,thereby redirecting the immune response toward the tumor cells or infected *** increasing number of recent clinical trials evaluating immune cell engagers reflects the important role of these molecules in new therapeutic approaches for cancer and *** this review,we discuss how different immune cell types(T and natural killer lymphocytes,as well as myeloid cells)can be bound by immune cell engagers in immunotherapy for cancer and infectious ***,we explore the preclinical and clinical advancements of these constructs,and we discuss the challenges in translating the current knowledge from cancer to the virology ***,we speculate on the promising future directions that immune cell engagers may take in cancer treatment and antiviral therapy.

关键词： Immune cell engagers Multispecific antibodies Cancer Virus Immunotherapy

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Effects of classical random external field on the dynamics of entanglement in a four-qubit system

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Chinese Physics B 2021年第11期30卷 240-252页

作者： Edwige carole Fosso Fridolin Tchangnwa Nya Lionel Tenemeza Kenfack Martin Tchoffo Research Unit of Condensed Matter Electronic and Signal ProcessingDepartment of PhysicsDschang School of Sciences and TechnologyUniversity of DschangPO Box:67 DschangCameroon Material Science Research Group Physics LaboratoryDepartment of PhysicsPost Graduate SchoolUniversity of MarouaPO Box:814 MarouaCameroon Centre d’Etudes et de Recherches en Agronomie et en Biodiversite Faculte d’Agronomie et des Sciences AgricolesUniversite de DschangCameroun

We investigate the dynamics of entanglement through negativity and witness operators in a system of four noninteracting qubits driven by a classical phase noisy laser characterized by a classical random external field(CREF).The qubits are initially prepared in the GHZ-type and W-type states and interact with the CREF in two different qubit-field configurations,namely,common environment and independent environments in which the cases of equal and different field phase probabilities are *** find that entanglement exhibits different decaying behavior,depending on the input states of the qubits,the qubit-field coupling configuration,and field phase *** the one hand,we demonstrate that the coupling of the qubits in a common environment is an alternative and more efficient strategy to completely shield the system from the detrimental impacts of the decoherence process induced by a CREF,independent of the input state and the field phase probabilities ***,we show that GHZ-type states have strong dynamics under CREF as compared to W-type *** the other hand,we demonstrate that in the model investigated the system robustness’s can be greatly improved by increasing the number of qubits constituting the system.

关键词： entanglement qubit and classical random external field

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FAIR Data Reuse-the Path through Data Citation

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Data Intelligence 2020年第1期2卷 78-86,305页

作者： Paul Groth Helena Cousijn Tim Clark carole Goble Informatics Institute University of AmsterdamAmsterdam 1090 GHThe Netherlands DataCite Welfengarten 1BHannover 30167Germany Data Science Institute University of VirginiaCharlottesvilleVA 22903-1738USA Department of Computer Science The University of ManchesterOxford RoadManchester M139PLUK

One of the key goals of the FAIR guiding principles is defined by its final principle-to optimize data sets for reuse by both humans and *** do so,data providers need to implement and support consistent machine readable metadata to describe their data *** can seem like a daunting task for data providers,whether it is determining what level of detail should be provided in the provenance metadata or figuring out what common shared vocabularies should be ***,for existing data sets it is often unclear what steps should be taken to enable maximal,appropriate *** citation already plays an important role in making data findable and accessible,providing persistent and unique identifiers plus metadata on over 16 million data *** this paper,we discuss how data citation and its underlying infrastructures,in particular associated metadata,provide an important pathway for enabling FAIR data reuse.

关键词： FAIR data Data citation Research objects Data provenance

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An Empirical Exploration of the Capabilities of People with Disabilities in Coping with Disasters

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International Journal of Disaster Risk Science 2020年第5期11卷 602-614页

作者： Khanh That Ton JC Gaillard carole Adamson Caglar Akgungor Ha Thanh Ho School of Environment The University of AucklandAuckland 1010New Zealand Unit for Environmental Sciences and Management North-West UniversityPotchefstroomSouth Africa School of Counselling.Human Services and Social Work The University of AucklandAuckland 1010New Zealand Resilience Advisors Network Dublin 4 D04 ED73Ireland Centre for Climate Change Study in Central Vietnam Hue University of Agriculture and ForestryHue CityVietnam

While the capability approach is increasingly being adopted for evaluating well-being and social justice in the field of human development,this approach in disaster research has remained *** research thus seeks to address the disaster risk that humans face through a lens of capabilities,with a focus on the lives of people with disabilities.A multi-case study approach was adopted and two rural communes in Vietnam were selected as study con *** were collected using focus group discussions and interviews that involved people with disabilities,parents/caregivers of people with intellectual/psychosocial disabilities,and representatives from related *** was found that people with disabilities are affected by disasters due to the lack of capabilities that they value in coping with disasters.A range of capabilities that people with disabilities value was revealed in the study sites,with many being valued not only in times of disasters but also in daily *** findings also highlight that,to actualize their valued capabilities,people with disabilities need access not only to resources but also to the factors that enable them to convert the resources to their valued *** most cases,the limitations to the achievement of capabilities are related to the external environment.

关键词： Capability approach Disasters People with disabilities Vietnam Vulnerability

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Experimental evidence for heritable reproductive time in 2 allochronic populations of pine processionary moth

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Insect Science 2017年第2期24卷 325-335页

作者： Manuela Branco Maria-Rosa Paiva Helena Maria Santos Christian Burban carole Kerdelhue Centro de Estudos Florestais (CEF) Instituto Superior de Agronomia (ISA) Universidade de Lisboa (ULisboa) 1349-017 Lisboa Portugal CENSE Faculty of Sciences and Technology (FCT) Universidade Nova de Lisboa (UNL) 2829-516 Caparica Portugal INRA Centre de Bordeaux UMR1202 BIOGECO Cestas cedex France INRA Centre de Montpellier UMR CBGP F-34988 Montferrier-sur-Lez cedex France

Phenology allows organisms to overcome seasonally variable conditions through life-cycle adjustment. Changes in phenology can drastically modify the evolutionary tra- jectory of a population, while a shift in the reproductive time may cause allochronic differentiation. The hypothesis of heritable reproductive time was experimentally tested, by studying a unique population of the pine processionary moth Thaumetopoeapityocampa （Den. ＆ Schiff.） which has a shifted phenology, and however co-occurs with the typical population following the classical life cycle. When populations of both types were reared under controlled conditions, the reproductive time was maintained asynchronous, as ob- served in the field. The shifted population was manipulated in the laboratory to reproduce later than usual, yet the offspring emerged in the next year at the expected dates thus ＂com- ing back＂ to the usual cycle. Hybrids from crosses performed between the 2 populations showed an intermediate phenology. From the emergence times of parents and offspring, a high heritability of the reproductive time （h = 0.76） was observed. The offspring ob- tained from each type of cross was genetically characterized using microsatellite markers. Bayesian clustering analysis confirmed that hybrids can he successfully identified and separated from the parental genetic classes by genotyping. Findings support the hypothesis that, for this particular population, incipient allochronic speciation is due to a heritable shift in the reproductive time that further causes assortative mating and might eventually cause ecological adaptation/maladaptation in response to environmental changes.

关键词： allochronic speciation experimental crossings heritability phenology reproductive isolation Thaumetopoeapityocampa

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Exploring the Current Practices,Costs and Benefits of FAIR Implementation in Pharmaceutical Research and Development:A Qualitative Interview Study

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Data Intelligence 2021年第4期3卷 507-527页

作者： Ebtisam Alharbi Rigina Skeva Nick Juty Caroline Jay carole Goble School of Computer Science University of ManchesterManchesterManchester M139PLUK College of Computer and Information Systems Umm Al-Qura UniversityMeccaMakkah 21421Saudi Arabia

The findable,accessible,interoperable,reusable(FAIR)principles for scientific data management and stewardship aim to facilitate data reuse at scale by both humans and *** and development(R&D)in the pharmaceutical industry is becoming increasingly data driven,but managing its data assets according to FAIR principles remains costly and *** date,little scientific evidence exists about how FAIR is currently implemented in practice,what its associated costs and benefits are,and how decisions are made about the retrospective FAIRification of data sets in pharmaceutical R&*** paper reports the results of semi-structured interviews with 14 pharmaceutical professionals who participate in various stages of drug R&D in seven pharmaceutical *** thematic analysis identified three primary themes of the benefits and costs of FAIRification,and the elements that influence the decision-making process for FAIRifying legacy data *** collectively acknowledged the potential contribution of FAIRification to data reusability in diverse research domains and the subsequent potential for *** costs,however,were still considered a barrier by participants,with the need for considerable expenditure in terms of resources,and cultural *** decisions were made about FAIRification was influenced by legal and ethical considerations,management commitment,and data *** findings have significant implications for those in the pharmaceutical R&D industry who are engaged in driving FAIR implementation,and for external parties who seek to better understand existing practices and challenges.

关键词： FAIR FAIRification Retrospective FAIRification Pharmaceutical R&D Cost-benefit Decision-making process

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