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实体肿瘤血管任意方向生成的二维数值模拟

医用生物力学 2007年第1期22卷 50-54页

作者：吴洁许世雄龙泉 Collins MW carola koenig 赵改平蒋雨平 Padhani AR 复旦大学力学与工程科学系上海200433 Brunel Institute for Bioengineering School of Engineering and Design Brunel UniversityUxbridgeUK: 复旦大学附属华山医院神经内科上海200040 Paul Strickland Scanner Centre Mount Vernon Hospital Middlesex HA6 2RNUK

目的二维数值生成实体肿瘤任意方向生长的血管网,为研究实体肿瘤内血液动力学、药物输运以及抗血管生成提供更趋真实的微血管网络结构。方法将新生血管芽尖的内皮细胞迁移方向由先前模型的上、下、左、右四个方向扩展为任意方向,建立相... 详细信息

目的二维数值生成实体肿瘤任意方向生长的血管网,为研究实体肿瘤内血液动力学、药物输运以及抗血管生成提供更趋真实的微血管网络结构。方法将新生血管芽尖的内皮细胞迁移方向由先前模型的上、下、左、右四个方向扩展为任意方向,建立相应的二维离散模型,数值模拟实体肿瘤微脉管系统的生成过程,比较模拟结果与相关实验数据的符合程度。结果对盲肠肿瘤微血管网进行数值模拟,与改进前的模型和其他模型比较,本模型生成的肿瘤微血管网结构特征,如血管的走向、扭曲、分叉与融合等,更接近生理实际,与实验观测图像的相似度更高。结论该模型可模拟实体肿瘤的微血管网生成,为肿瘤内血液微循环、药物传递以及抗血管生成的理论研究提供较为接近实际的微血管网络结构。

关键词：肿瘤血管生成任意方向数值模拟

注射方式对二维实体肿瘤中药物输运影响的数值研究

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医用生物力学 2006年第4期21卷 309-316页

作者：浏丹许世雄吴洁卫晶晶 Long Quan Collins MW carola koenig 蒋雨平 Padhani AR 复旦大学力学与工程科学系上海200433 Brunel Institute for Bioengineering School of Engineering and Design Brunel University UxBridge Middlesex UK 复旦大学附属华山医院上海200040 Paul Strickland Scanner Centre Mount Vernon Hospital Middlesex HA6 2RN UK

目的研究药物注射方式对二维实体肿瘤中药物输运的影响,确定较适当的注射方式。方法根据数值生成的肿瘤二维血管网,研究药物的输运。采用肿瘤中各部位药物浓度维持在最小药物浓度MEC水平以上的时间曲面下体积VUS来衡量药物的效果。对不... 详细信息

目的研究药物注射方式对二维实体肿瘤中药物输运的影响,确定较适当的注射方式。方法根据数值生成的肿瘤二维血管网,研究药物的输运。采用肿瘤中各部位药物浓度维持在最小药物浓度MEC水平以上的时间曲面下体积VUS来衡量药物的效果。对不同的施药注射方式进行了探讨。结果MEC较小时各种注射方式效果接近;MEC较大时,比较适合采用短时间集中注射方式。结论对肿瘤进行药物注射策略选取时,应根据肿瘤具体特性,以及药物施加方式对肿瘤细胞产生的不同作用来组合设计相应的优化施药方案。

关键词：二维实体肿瘤药物输运注射方式数值研究

Female reproductive success in a species with an age-inversed hierarchy

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Integrative Zoology 2016年第6期11卷 433-446页

作者： Dorien DE VRIES Andreas koenig carola BORRIES Interdepartmental Doctoral Program in Anthropological Sciences Stony Brook UniversitySUNYNYUSA Department of Anthropology Stony Brook UniversitySUNYNYUSA

In most group-living mammals,reproductive success declines with increasing age and increases with increasing *** effects have mainly been studied in matrilineal and in“age positive”hierarchies,which are stable and in which high ranking females often outperform low ranking *** relationships are less well-understood in age-inversed dominance hierarchies,in which a female’s rank changes over *** analyzed demographic data of 2 wild,unprovisioned groups of gray langurs(Semnopithecus schistaceus)near Ramnagar,Nepal covering periods of 5 years *** rank was unstable and *** measured reproductive success via birth rates(57 births),infant survival(proportion of infants surviving to 2 years)and number of offspring surviving to 2 years of age(successful births)for 3 age and 3 rank *** found that old females performed significantly worse than expected(birth rate P=0.04;successful births P=0.03).The same was true for low ranking females(P=0.04,and P<0.01,respectively).Infant survival was highest for young and middle-aged as well as for high and middle ranking ***,the results for these unstable hierarchies were rather similar to those for stable hierarchies of other mammals,particularly several nonhuman ***pared to a provisioned population of a closely related species,the wild and unprovisioned population examined(i)showed stronger age effects,while(ii)female reproductive success was equally affected by *** comparative studies are needed to examine whether captive or provisioned populations deviate predictably from wild populations.

关键词： birth rate gray langurs offspring survival provisioning Semnopithecus schistaceus

Southeast Asian primate communities:the effects of ecology and Pleistocene refuges on species richness

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Integrative Zoology 2013年第4期8卷 417-426页

作者： Heather HASSEL-FINNEGAN carola BORRIES Qing ZHAO Phaivanh PHIAPALATH Andreas koenig Department of Anthropology Stony Brook UniversityStony BrookNYUSA Biology Department Swarthmore CollegeSwarthmorePAUSA College of Life Science Peking UniversityBeijingChina International Union for Conservation of Nature VientianeLao PDR

We examined historical and ecological factors affecting current primate biodiversity in Southeast *** Africa,Madagascar and South America,but not Southeast Asia,primate species richness is positively associated with average rainfall and distance from the equator(latitude).We predicted that Southeast Asia’s non-conformance may be due to the effect of dispersed Pleistocene refuges(locations of constricted tropical forests during glacial maxima which today are at least 305 m in altitude).Based on 45 forested sites(13 on large islands;32 on the mainland)of at least 100 km^(2) to minimize recent human impact,we determined correlations between extant primate species richness and rainfall,latitude and supplementary ecological variables,while controlling for refuges and *** found that refuge sites had significantly higher primate species richness than non-refuges(t=-2.76,P<0.05),and distance from the nearest Pleistocene refuge was negatively correlated with species richness for non-refuge sites(r=-0.51,P<0.05).There was no difference in species richness between sites on large islands and the mainland(t=-1.4,P=0.16).The expected positive relationship between rainfall and species richness was not found(r=0.17,P=0.28).As predicted,primate species richness was negatively correlated with latitude(r=-0.39,P<0.05)and positively correlated with mean temperature(r=0.45,P<0.05).General linear models indicated that a site’s latitude(F_(1,38)=6.18,P<0.05)and Pleistocene refuge classification(F_(1,42)=5.96,P<0.05)were the best predictors of species *** ecological and historical factors contribute to present day primate species richness in Southeast Asia,making its biodiversity less of an outlier than previously believed.

关键词： allopatric speciation island latitude mainland rainfall temperature

Mass asymmetry and tricyclic wobble motion assessment using automated launch video analysis

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Defence Technology（防务技术） 2016年第2期12卷 113-116页

作者： Ryan DECKER Joseph DONINI William GARDNER Jobin JOHN Walter koenig Armaments Research Design and Engineering CenterPicatinny Arsenal

This paper describes an approach to identify epicyclic and tricyclic motion during projectile flight caused by mass asymmetries in spinstabilized projectiles. Flight video was captured following projectile launch of several M110A2E1 155 mm artillery projectiles. These videos were then analyzed using the automated flight video analysis method to attain their initial position and orientation *** of the pitch and yaw histories clearly indicates that in addition to epicyclic motion's nutation and precession oscillations, an even faster wobble amplitude is present during each spin revolution, even though some of the amplitudes of the oscillation are smaller than 0.02 *** results are compared to a sequence of shots where little appreciable mass asymmetries were present, and only nutation and precession frequencies are predominantly apparent in the motion history results. Magnitudes of the wobble motion are estimated and compared to product of inertia measurements of the asymmetric projectiles.

关键词：弹丸质量视频分析摆动运动不对称性自动启动三环评估行星运动

Spirituality,religiousness,and mental health:A review of the current scientific evidence

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World Journal of Clinical Cases 2021年第26期9卷 7620-7631页

作者： Giancarlo Lucchetti Harold G koenig Alessandra Lamas Granero Lucchetti School of Medicine Federal University of Juiz de ForaJuiz de Fora 36030-776Brazil Medical Center Duke UniversityDurhamNC 27710United States

Research in the field of“Spirituality and Health”has been growing,with spirituality/religiousness(S/R)being consistently related to both physical and mental *** objective of this article is to provide an updated review of the current scientific evidence on the relationship between S/R and mental health,highlighting the most important *** a secondary objective,the mechanisms that explain this relationship and the interventions that utilize this information in treating mental disorders will be *** findings reveal a large body of evidence across numerous psychiatric *** solid evidence is now available for depression,suicidality,and substance use,other diagnosis,such as post-traumatic stress disorder,psychosis,and anxiety,have also shown promising *** effects of S/R on mental health are likely bidirectional,and the manner in which religious beliefs are used to cope with distress(*** and positive),may affect mental health *** these findings,the mechanisms that explain these associations and the role of S/R interventions need further *** clinical practice,mental health providers should ask patients about S/R that are important in their lives to provide holistic and patient-centered care.

关键词： Spirituality Religion Depression Mental health Psychiatry

Liver sinusoidal endothelial and biliary cell repopulation following irradiation and partial hepatectomy

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World Journal of Gastroenterology 2010年第31期16卷 3928-3935页

作者： Petra Krause Margret Rave-Frank Hendrik Andreas Wolff Heinz Becker Hans Christiansen Sarah koenig Department of General Surgery University Medical Centre Goettingen Department of Radiotherapy University Medical Cen-tre Goettingen

AIM: To investigate whether irradiation (IR) and partial hepatectomy (PH) may prepare the host liver for nonparenchymal cell (NPC) ***: Livers of dipeptidyl peptidase(DPP)-deficient rats were pre-conditioned with external beam IR (25 Gy) delivered to two-thirds of the right liver lobules followed by a one-third PH of the untreated lob-ule. DPP-positive liver cells (NPC preparations enriched for liver sinusoidal endothelial cells (LSECs) and hepatocytes) were transplanted via the spleen into the recipient livers. The extent and quality of donor cell engraftment and growth was studied over a long-term interval of 16 wk after ***: Host liver staining demonstrated 3 different repopulation types. Well def ined clusters of donor-derived hepatocytes with canalicular expression of DPP were detectable either adjacent to or in between large areas of donor cells (covering up to 90% of the section plane) co-expressing the endothelial marker platelet endothelial cell adhesion molecule. The third type consisted of formations of DPP-positive duct-like structures which co-localized with biliary epithelial ***: Liver IR and PH as a preconditioning stimulus enables multiple cell liver repopulation by donor hepatocytes, LSECs, and bile duct cells.

关键词： Cell transplants Dipeptidyl peptidase protein Endothelial cells Liver cell transplantation Liver irradiation Liver repopulation

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Charles & Ray Eames

Charles & Ray Eames

Acknowledgement to reviewers

作者： Gloria koenig Peter Gossel editor.

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Matter and Radiation at Extremes 2021年第2期6卷 87-88页

作者： Michel koenig Weiyan Zhang Ho-Kwang Mao Laboratoire LULI CNRSCEAEcole PolytechniqueUPMCUniv.Paris 06 Sorbonne UniversitesInstitut Polytechnique de ParisF-91128 Palaiseau CedexFrance Center for Applied Physics and Technology Peking UniversityBeijing 100871China China Academy of Engineering Physics MianyangChina Center for High Pressure Science and Technology Advanced Research ShanghaiChina

In 2020,Matter and Radiation at Extremes(MRE)reached a particularly important milestone when it received its first official impact factor of 2.931,which indicates the high quality of the papers published to *** outstanding success can be attributed to the strong commitment and valuable contributions from all the *** Editors of MRE wish to express their deepest gratitude to the following individuals who generously provided advice on manuscripts as reviewers for MRE in the year of 2020.

关键词： knowledge Extreme individual