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现代装饰（家居） 2015年第1期 34-42页

作者： Adelaide Testa Andrea Marcante carola Ripamonti 范嘉苑 UdA architects

极富浪漫色彩的“大旅游”（Grand Tour）是从前英国贵族子女遍游欧洲大陆的一项教育旅行,这趟旅程的精髓之处在于旅者需要通过了解和学习每个不同地区的传统与文化,由此去发现和思索每个地区的独特属性。而这个旨在“发现”的旅行理念... 详细信息

极富浪漫色彩的“大旅游”（Grand Tour）是从前英国贵族子女遍游欧洲大陆的一项教育旅行,这趟旅程的精髓之处在于旅者需要通过了解和学习每个不同地区的传统与文化,由此去发现和思索每个地区的独特属性。而这个旨在“发现”的旅行理念正是本案设计师在设计这座住宅初始的愿景：

关键词：欧洲大陆设计师旅行

等电子-等自旋与非等旋反应的G2(MP2)和G2研究

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物理化学学报 1995年第4期11卷 292-296页

作者：苏克和 carola.Deakyne T.J.Tegeler 西北工业大学化工系西安710072 DepartmentofChemistry EasternIllinoisUniv

Enthalpy changes of the reactions involved in our previous papers have been re-examined at the G2(MP2) and G2 levels. The G2(MP2) and G2 energies of Ar, Ar+,ArAr+, ArCl+, ArF+, ArH+, ArHe+, ArNe+, ArO+, ArS+, H2+, He, HeCl+, HeF+, HeO+,HeS+, Ne, NeCl+, NeF+, NeO+ and NeS+ have been calculated. The G2(MP2) and G2 results for all of the interested reactions have also been compared with those of the previous MP2/6-31G** and MP4/6-311G (2df, 2pd) calculations. All of the G2(MP2) and G2 reaction enthalpies are improved from the MP2 and MP4 level of calculations when compared with the experimental data for the four categories of reactions as (1) iso-electronic, isogyric; (2) valence isoelectronic, isogyric; (3) isogyric and (4)non-isogyric reactions with the average absolute deviations of 5.10, 4.60, 7.70 and 9.20 for G2(MP2) and 4.18, 5.19, 6.78 and 6.49kJ·mol-1 for G2, respectively. The individural deviation for almost all of the reactions involved in this work is not more than±13kJ·mol-1 for G2(MP2) and ±8.4kJ·mol-1 for G2. In this paper, an additional number of reactions examined at the G2(MP2) and G2 levels as well as at the MP2/6-31G** and MP4/6-311G (2df, 2pd) levels of calculations have also been reported. The MP2, MP4, G2(MP2) and G2 total energies for the interested chemical species have been calculated if these energies have not been reported in literatures. All of the reaction energies at different levels have been compared with the experimental data in a nummber of reactions devided into the above four categories. The average absolute deviations are 25.9, 36.0, 29.2 and 40.1 for MP2; 8.41, 18.3, 17.2 and 18.3 for MP4; 9.41, 5.98, 4.85 and 6.90 for G2(MP2) and 6.69, 4.06, 3.85 and 4.60 kJ·mol-1 for G2, respectively. It is clear that the MP2 calculation did quite poor for all of the foux categories of reactions and the MP4 did well only for the isoelectronic and isogyric reactions. The G2(MP2) and G2 reproduce the eaperimental reaction enthalpy changes very wel

关键词： G2理论等电子等自旋非等旋焓变

Chemosensitivity Testing of Circulating Epithelial Tumor Cells (CETC) in <i>Vitro</i>: Correlation to in <i>Vivo</i>Sensitivity and Clinical Outcome

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Journal of Cancer Therapy 2013年第2期4卷 597-605页

作者： Nadine Rudiger Ernst-Ludwig Stein Erika Schill Gabriele Spitz carola Rabenstein Martina Stauch Matthias Rengsberger Ingo B. Runnebaum Ulrich Pachmann Katharina Pachmann Clinic for Internal Medicine II University Hospital Friedrich Schiller University Jena Germany Onkologische Schwerpunktpraxis Kronach Germany Transfusionsmedizinisches Zentrum Bayreuth Germany Women’s Hospital University Hospital Friedrich Schiller University Jena Germany

Background: Chemotherapy is a mainstay of tumor therapy, however, it is predominantly applied according to empirically developed recommendations derived from statistical relapse rates occurring years after the treatment in the adjuvant situation and from progression-free interval data in the metastatic situation, without any possibility of individually determining the efficacy in the adjuvant situation and with loss of time and quality of life in the metastatic situation if the drugs chosen are not effective. Here, we present a method to determine the efficiency of chemotherapeutic drugs using tumor cells circulating in blood as the part of the tumor actually available in the patient’s body for chemosensitivity testing. Methodology/Principal Findings: After only red blood cell lysis, omitting any enrichment (analogous to other blood cell enumeration methods, including rare CD34 cells), the white cells comprising the circulating epithelial tumor cells (CETC) are exposed to the drugs in question in different concentrations and for different periods of time. Staining with a fluorescence-labeled anti-epithelial antibody detects both vital and dying tumor cells, distinguishing vital from dying cells through membrane permeability and nuclear staining with propidium iodide. Increasing percentages of dying tumor cells are observed dependent on time and concentration. The sensitivity can vary during therapy and was correlated with decrease or increase in CETC and clinical outcome. Conclusions/Significance: Thus, we are able to show that chemosensitivity testing of circulating tumor cells provides real-time information about the sensitivity of the tumor present in the patient, even at different times during therapy, and correlates with treatment success.

关键词： Circulating Epithelial Tumor Cells Chemosensitivity Testing Breast Cancer Ovarian Cancer

FOLFIRI3-aflibercept in previously treated patients with metastatic colorectal cancer

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World Journal of Clinical Oncology 2018年第5期9卷 110-118页

作者： CANDice carola Fran?ois Ghiringhelli Stefano Kim Thierry ANDré Juliette Barlet Le?la Bengrine-Lefevre Hélène Marijon Marie-Line Garcia-Larnicol Christophe Borg Linda Dainese Nils Steuer Hubert Richa Magdalena Benetkiewicz Annette K Larsen Aimery de Gramont Benoist Chibaudel Department of Medical Oncology Franco-British Institute Department of Medical Oncology Centre George Fran?ois Leclerc Department of Medical Oncology CHU Besan?on Department of Medical Oncology Saint-Antoine Hospital and Sorbonne Universités UMPC Department of Anatomy-Pathology Paris Pathology Institute Department of Gastrointestinal Surgery Franco-British Institute Fondation ARCAD Cancer Biology and Therapeutics Centre de Recherche Saint-Antoine INSERM U938 Faculté de Médecine Sorbonne Université

AIM To evaluate the efficacy and safety of the modified FOLFIRI3-aflibercept as second-line therapy in patients with metastatic colorectal *** This is a retrospective multicenter cohort, evaluating the efficacy and safety of the association of aflibercept with FOLFIRI3(day 1: aflibercept 4 mg/kg, folinic acid 400 mg/m^2, irinotecan 90 mg/m^2, 5-fluorouracil infusion 2400 mg/m^2 per 46 h; day 3: irinotecan 90 mg/m^2) in patients with previously treated metastatic colorectal cancer. The primary endpoint was overall response rate(ORR). Secondary endpoints were disease control rate(DCR), progression-free survival(PFS), overall survival(OS), and *** Among 74 patients treated in four French centers, nine were excluded due to prior use of aflibercept(n = 3), more than one prior treatment line in irinotecanna?ve patients(n = 3), and inadequate liver function(n = 3). In the "irinotecan-na?ve" patients(n = 30), ORR was 43.3% and DCR was 76.7%. Median PFS and OS were 11.3 mo(95%CI: 6.1-29.0) and 17.0 mo(95%CI: 13.0-17.3), respectively. The most common(> 5%) grade 3-4 adverse events were diarrhea(37.9%), neutropenia(14.3%), stomatitis and anemia(10.4%), and hypertension(6.7%). In the "pre-exposed irinotecan" patients(n = 35), 20(57.1%) received ≥ 2 prior lines of treatment. ORR was 34.3% and DCR was 60.0%. Median PFS and OS were 5.7 mo(95%CI: 3.9-10.4) and 14.3 mo(95%CI: 12.8-19.5), *** Minimally modified FOLFIRI has improvement dramatically the FOLFIRI3-aflibercept efficacy, whatever prior use of irinotecan. A prospective randomized trial is warranted to compare FOLFIRI-aflibercept to FOLFIRI3-aflibercept.

关键词： Chemotherapy Irinotecan Aflibercept Second-line Colorectal cancer

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母猪的阶段饲喂

国外畜牧学（猪与禽） 2005年第1期25卷 23-24页

作者：袁欣敏 carola van der Peet-Schwering Mart Smolders

对母猪实行阶段饲喂可大大降低蛋白质和磷的排放量而不影响母猪的繁殖性。荷兰的研究表明 ,问题只是母猪第一胎和第二胎之间的返情数量。

关键词：母猪饲喂繁殖低蛋白数量阶段降低白质第二胎影响

栗木单宁对兔胴体特性、肉质、脂质氧化及脂肪酸组成的影响

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栗木单宁对兔胴体特性、肉质、脂质氧化及脂肪酸组成的影响

Unusual treatment of postoperative bleeding after cardiac surgery

第七届（2017）中国兔业发展大会

作者： Hua Wei Liu Francesco Gai Laura Gasco Alberto Brugiapaglia carola Lussiana Kai Jun Guo Jian Ming Tong Ivo Zoccarato 中国农业科学院动物科学研究所动物营养学国家重点实验室 Dipartimento di Scienze Zootecniche Turin University 北京农业大学动物科学系

用72只雄兔(Bianca Ⅰtaliana)研究在饲料中添加(0%、0.5%和1.0%)栗木天然提取物(Silvafeed ENC)对兔肉生产性状、胴体特征、肉质、脂肪氧化和脂肪酸组成的影响。结果表明ENC对活体重、生产性状、热胴体重、屠宰率、皮重、pH值、蒸煮损... 详细信息

用72只雄兔(Bianca Ⅰtaliana)研究在饲料中添加(0%、0.5%和1.0%)栗木天然提取物(Silvafeed ENC)对兔肉生产性状、胴体特征、肉质、脂肪氧化和脂肪酸组成的影响。结果表明ENC对活体重、生产性状、热胴体重、屠宰率、皮重、pH值、蒸煮损失、剪切力和颜色均无显著影响;投喂含ENC 1.0%饲料的兔子背最长肌和腰肌(LTL)肌肉中铁含量高于对照组;0.5%ENC组TBARS平均值显著低于(P<0.05)对照组和1.0%ENC组;投喂1.0%ENC日粮的兔LTL肌中肉豆蔻酸(C14:0;P<0.01)、棕榈油酸(C16:1 cis-9;P<0.05)和十五烷酸(C15:0;P<0.01)的含量较低,然而该组兔的棕榈油酸(C16:0)的含量较高(P<0.05)。此外,与投喂对照组饲料的兔子相比,投喂含0.5%ENC日粮的兔子反式亚油酸(C18:1 trans-11)水平较低(P<0.01);各组饱和(SFA)、单不饱和(MUFA)、多不饱和(PUFA)脂肪酸及PUFA/SFA和n-6/n–3比无显著差异。

关键词：板栗单宁脂肪氧化脂肪酸肉质兔子

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World Journal of Cardiovascular Diseases 2013年第5期3卷 377-379页

作者： José Rubio-Alvarez Juan Sierra-Quiroga Belén Adrio-Nazar Laura Reija López ángela Granda Bauza carola Rubio Taboada Jose Manuel Martinez-Cereijo Department of Cardiac Surgery Universitary Hospital Santiago de Compostela Santiago Spain Department of Vascular Surgery Universitary Hospital of Elche Alicante Spain

A young patient was presented to the emergency department with chest pain and palpitations. A transthoracic echocardiogram showed a right atrial mass. Coronary angiography showed a right coronary artery with collateral circulation to a large mass. The tumor could only be partially resected and the patient experienced persistent postoperative bleeding. We performed a new right coronary artery angiography which showed an important free extravasation of contrast into the pericardium through the collateral circulation. Using covered stents, the bleeding was controlled. The pathological examination performed later revealed a primary cardiac angiosarcoma. After asymptom-free survival of 14 months the patient presented bone metastases.

关键词： Angiosarcoma Coronary Stenting Postoperative Bleeding

单一Repaglinide治疗使用糖皮质激素的糖尿病

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世界医学杂志 2003年第19期7卷 18-21页

作者： SusanS．Braithwaitc carola．Kaufman JocelynR．Wittrock 王守俊不详 UmvcrsityofNorthCarol-ina UNCDiabetesCareCenter5316HighgateDriveSuite221 Durham NC27713

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瑞典北部山区亚北极区湖泊的汞污染趋势

AMBIO－人类环境杂志 2007年第5期36卷 383-387页

作者： carola Lindeberg Richard Bindler Christian Bigler Peter Rosén Ingemar Renberg 赵海珍瑞典于默奥大学生态与环境科学系环境变化影响研究组瑞典于默奥大学阿比斯库气候影响研究中心(CIRC)

尽管有关汞污染的研究已有多年,然而涉及欧洲高纬度区域的数据非常有限,尤其是长期时间趋势的研究。高纬度汞负荷是遵循欧洲近期下降的汞排放趋势,还是因持续的全球排放负荷仍然很高,尚不清楚。本研究利用位于瑞典山区北极圈以北12个湖... 详细信息

尽管有关汞污染的研究已有多年,然而涉及欧洲高纬度区域的数据非常有限,尤其是长期时间趋势的研究。高纬度汞负荷是遵循欧洲近期下降的汞排放趋势,还是因持续的全球排放负荷仍然很高,尚不清楚。本研究利用位于瑞典山区北极圈以北12个湖泊的沉积物,评价过去和近来尤其是近200年来的汞污染状况。在19世纪后期或20世纪初期沉积的沉积物中明显增大的汞负荷在1960～1990年间达到峰值。此峰值代表超过背景浓度1.4～4.2倍的富集状态。此富集状态与低纬度和北极其它区域沉积物的富集状态相当。自20世纪90年代以来,12个湖泊中的8个湖泊的汞浓度已下降,与欧洲的排放趋势相似。

关键词：北部山区汞污染北极区湖泊污染趋势瑞典排放负荷沉积物