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neonatal Intestinal Obstruction in Acute Renal Failure in Premature Infant: A Case Report

2007年

作者： carol Porth

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PD-L1 in the palm of your hand:palmitoylation as a target for immuno-oncology

Open Journal of Pediatrics（儿科学期刊） 2024年第2期 338页

作者： Ondima Lucienne Irène Patricia Okiemy Niendet Cardinale Princilia Gandzali-ngabe Pierre Eric Caryne Mboutol-Mandavo Bosseba Missengui Rhodia Hélène Akobande Nuptia Erica

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Signal Transduction and Targeted Therapy 2019年第1期4卷 528-529页

作者： Andreas von Knethen Bernhard Brüne Institute of Biochemistry I-Pathobiochemistry Faculty of MedicineGoethe-University FrankfurtTheodor-Stern-Kai 760590 Frankfurt am MainGermany

A recent study by Yao et *** in Nature Biomedical Engineering showed the importance of palmitoylation in regulat-ing PD-L1 protein stability and trafficking.1 These researchers developed a competitive inhibitor that blocks PD-L1 palmitoyla-tion,which may provide a new strategy for targeting PD-L1 or other palmitoylated membrane proteins(Fig.1).

关键词： al. competitive traffic

Hypomagnesemia with Secondary Hypocalcemia Linked to a Novel TRPM6 Gene Mutation

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Open Journal of Pediatrics 2016年第4期6卷 290-294页

作者： amel Tej Bernd Dworniczak Asma Marzouk Najla Soyah Samia Tilouche Moez Gribaa Jihène Bouguila Lamia Boughamoura Pediatric Department Farhat Hached Sousse Tunisia Department of Human Genetics Westfaelishe Wilhelms Universitat Münster Germany Department of Human Genetics Farhat Hached Sousse Tunisia Medical faculty Ibn Jazzar University of Sousse Sousse Tunisia

Hypomagnesemia with secondary hypocalcemia (HSH) is a rare inherited disorder, characterized by extremely low levels of serum magesium associated with symptomatic hypocalcemia. HSH manifests in the new born period with neurological symptoms, including generalized seizures, which are refractory to anticonvulsant treatment. In this disorder, the basic abnormality is the defective intestinal absorption of magnesium. Mutations in TRPM6, the gene encoding the transient receptor potential cation channel subfamily member 6 have been found to be responsible for this disease. We report on a four-month-old Tunisian girl who presented with convulsions. Laboratory evaluation yielded extremely low serum magnesium levels, low calcium levels, and abnormal PTH levels. The diagnosis of HSH was confirmed by mutation analysis which identified the novel mutation c.1307A >G in exon 11 of TRPM6 (Lys436Arg). Our patient was homozygous for this mutation. Prenatal diagnosis was done during second pregnancy. DNA from trophoblast biopsy showed the same mutation as the proband.

关键词： Magnesium Hypomagnesemia Hypocalcemia Convulsion TRPM6

Clinically relevant factors associated with quantitative optical coherence tomography angiography metrics in deep capillary plexus in patients with diabetes

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Eye and Vision 2020年第1期7卷 64-74页

作者： Fang Yao Tang Erica O.Chan Zihan Sun Raymond Wong Jerry Lok Simon Szeto Jason C.Chan Alexander Lam Clement C.Tham Danny S.ng carol Y.Cheung Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong Kong Special Administrative RegionKowloonChina Hong Kong Eye Hospital Hong Kong Special Administrative RegionKowloonChina CUHK Eye Centre Hong Kong Eye Hospital147K Argyle StreetKlnKowloonHong KongChina

Background:To test clinically relevant factors associated with quantitative artifact-free deep capillary plexus(DCP)metrics in patients with diabetes mellitus(DM).Methods:563 eligible eyes(221 with no diabetic retinopathy[DR],135 with mild DR,130 with moderate DR,and 77 with severe DR)from 334 subjects underwent optical coherence tomography-angiography(OCT-A)with a swept-source OCT(Triton DRI-OCT,Topcon,Inc.,Tokyo,Japan).Strict criteria were applied to exclude from analysis those DCP images with artifacts and of poor quality,including projection artifacts,motion artifacts,blurriness,signal loss,B-scan segmentation error,or low-quality score.A customized MATLAB program was then used to quantify DCP morphology from the artifact-free DCP images by calculating three metrics:foveal avascular zone(FAZ),vessel density(VD),and fractal dimension(FD).Results:166(29.5%)eyes were excluded after quality control,leaving in the analysis 397 eyes(170 with no DR,101 with mild DR,90 with moderate DR,36 with severe DR)from 250 *** the multiple regression models,larger FAZ area was associated with more severe DR(β=0.687;p=0.037),shorter axial length(AL)(β=−0.171;p=0.003),thinner subfoveal choroid thickness(β=−0.122;p=0.031),and lower body mass index(BMI)(β=−0.090;p=0.047).Lower VD was associated with more severe DR(β=−0.842;p=0.001),shorter AL(β=0.107;p=0.039),and poorer visual acuity(VA)(β=−0.133;p=0.021).Lower FD was associated with more severe DR(β=−0.891;pness,age,and BMI in diabetic *** effects of ocular and systemic factors should be considered for meaningful interpretations of DCP changes in DM patients.

关键词： Optical coherence tomography angiography Diabetic retinopathy Deep capillary plexus Visual acuity

Stabilizing periodic orbits of Chua’s system using adaptive fuzzy sliding mode controller

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International Journal of Intelligent Computing and Cybernetics 2019年第1期12卷 102-126页

作者： Hanène Medhaffar Moez Feki Nabil Derbel CEMLab ENISUniversity of SfaxSfaxTunisia ESSTHS University of SousseSousseTunisia

Purpose–The purpose of this paper is to investigate the stabilization of unstable periodic orbits of Chua’s system using adaptive fuzzy sliding mode controllers with moving ***/methodology/approach–For this aim,the sliding mode controller and fuzzy systems are combined to achieve the ***,the authors propose a moving sliding surface to improve robustness against uncertainties during the reaching phase,parameter variations and extraneous ***–Afterward,the authors design a sliding observer to estimate the unmeasurable states which are used in the previously designed ***/value–Numerical results are provided to show the effectiveness and robustness of the proposed method.

关键词： Sliding mode control Sliding mode observer Chaos control Fuzzy adaptive systems,Moving sliding surface

In vitro immunotoxicity of untreated and treated urbanwastewaters using various treatment processes to rainbow trout leucocytes

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Journal of Environmental Sciences 2013年第7期25卷 1400-1407页

作者： Franois Gagné Marlène Fortier Michel Fournier Shirley-Anne Smyth Emerging Methods Aquatic Contaminants Research Division Water Science and Technology Environment Canada105 McGill Street Montral Qubec Canada INRS-Institut Armand-Frappier 531 boul.des Prairies Laval Qubec Canada Effluents and Wastewaters Aquatic Contaminants Research Division Water Science and Technology Environment Canada867 Lakeshore Road BurlingtonOntario Canada

Municipal effluents are known to impede the immune system of aquatic organisms. The purpose of this studywas to examine the immunotoxicity of urbanwastewaters before and after 6 treatment processes from 12 cities toward trout leucocytes. Freshly prepared trout leucocyteswere exposed to increasing concentrations of solid phase （C18） extracts ofwastewaters for24 hr at 15°C. Immunocompetencewasdetermined by following changes in leucocyte viability and the proportion of cells able to ingest at least one （immunoactivity） and at least three （immunoefficiency） fluorescent beads. The influentswere treated by sixdifferent treatment strategies consisting of facultative aerated lagoons, activated sludge, biological aerated filter, biological nutrient removal, chemically-assisted physical treatment and trickling filter/solid contact. Water quality parameters of thewastewaters revealed that the plants effectively removed total suspended solids and reduced the chemical oxygendemand. The results revealed that the effluents＇ immunotoxic propertieswere generally more influenced by the properties of the untreatedwastewaters than by the treatment processes. About half of the incoming influentsdecreased leucocyte viabilitywhile4 treatment plantswere able to reduce toxicity. The influents readily increased phagocytosis activity for 8/12 influentswhile itwasdecreased in4/12 influents. This increasewas abolished for4/12 of the effluents using treatments involving biological and oxidative processes. In conclusion, municipal effluents have the potential to alter the immune system in fish and more researchwill be needed to improve the treatments ofwastewaters to better protect the quality of the aquatic environment.

关键词： municipal effluents fish leucocytes viability phagocytosis

BRICS nations and the opportunities for community physical activity interventions

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Journal of Sport and Health Science 2019年第6期8卷 509-511页

作者： carol Ewing Garber Department of Biobehavioral Sciences Teachers CollegeColumbia University

Decreases in physical activity(PA)in the populations of developing countries have occurred alongside the rapidly changing urban form,greater availability of automobiles,pollution,shifts in the nature of work,and other... 详细信息

关键词： pollution automobile nations

Traumatic Diaphragmatic Hernia in Children: A Case Report

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Digital ID framework for human-centric monitoring and control of smart buildings

Surgical Science（外科学） 2024年第3期 111页

作者： Lucienne Irène Patricia Ondima Rhodia Hélène Bosseba Missengue Nuptia Erica Akobande Cardinale Princilia Okiemy Niendet Jean-Claude Mieret Caryne Mboutol-Mandavo1

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Building Simulation 2022年第10期15卷 1709-1728页

作者： Min Deng Xi Wang Da Li carol C.Menassa Department of Civil and Environmental Engineering University of MichiganAnn ArborMI 48109USA Glenn Department of Civil Engineering Clemson UniversityClemsonSC 29634USA

Smart offices can help employers attract and retain talented people and can positively impact well-being and *** to emerging technologies and increased computational power,smart buildings with a specific focus on personal experience are gaining ***-time monitoring and estimation of the human states are key to achieving individual *** some studies have incorporated real-time data into the buildings to predict occupants’indoor experience(e.g.,thermal comfort and work engagement),a detailed framework to integrate personal prediction models with building systems has not been well ***,this paper proposes a framework to predict and track the real-time states of each individual and assist with decision-making(e.g.,room assignment and indoor environment control).The core idea of the framework is to distinguish individuals by a new concept of Digital ID(DID),which is then integrated with recognition,prediction,recommendation,visualization,and feedback *** establishment of the DID database is discussed and a systematic prediction methodology to determine occupants’indoor comfort is *** on the prediction results,the Comfort Score Index(CSI)is proposed to give recommendations regarding the best-fit rooms for each *** addition,a visualization platform is developed for real-time monitoring of the indoor *** demonstrate the framework,a case study is *** thermal sensation is considered the reference for the room allocation,and two groups of people are used to demonstrate the framework in different *** one group of people,it is assumed that they are existing occupants with personal DID *** in another group are considered the new occupants without any personal database,and the public database is used to give initial guesses about their thermal *** results show that the recommended rooms can provide better thermal environments for the occupan

关键词： smart office digital ID(DID) comfort prediction space recommendation human-centric monitoring real-time visualization