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World journal of Gastroenterology 2007年第37期13卷 4938-4946页

作者： Michael j Duryee Lynell W Klassen Geoffrey M thiele University of Nebraska Medical Center Department of Internal Medicine 986350 Nebraska Medical Center Omaha NE 68198-6350 Veterans Administration Alcohol Research Center Omaha Veterans Administration Medical Center 4101 Woolworth Avenue Omaha NE 68105 United States Veterans Administration Alcohol Research Center Omaha Veterans Administration Medical Center 4101 Woolworth Avenue Omaha NE 68105 United States University of Nebraska Medical Center Department of Pathology and Microbiology 986495 Nebraska Medical Center Omaha NE 68198-6495 United States

The development of alcoholic liver disease (ALD) can be attributed to many factors that cause damage to the liver and alter its functions. Data collected over the last 30 years strongly suggests that an immune component may be involved in the onset of this disease. This is best evidenced by the detection of circulating autoantibodies, infiltration of immune cells in the liver, and the detection of hepatic aldehyde modified proteins in patients with ALD. Experimentally, there are numerous immune responses that occur when proteins are modified with the metabolites of ethanol. These products are formed in response to the high oxidative state of the liver during ethanol metabolism, causing the release of many inflammatory processes and potential of necrosis or apoptosis of liver cells. Should cellular proteins become modified with these reactive alcohol metabolites and be recognized by the immune system, then immune responses may be initiated. Therefore, it was the purpose of this article to shed some insight into how the immune system is involved in the development and/or progression of ALD.

关键词： Alcoholic liver disease Liver endothelial cells Aldehyde adducts Oxidative stress Immune system Cytokines Metabolism

Effect of ethanol on pro-apoptotic mechanisms in polarizedhepatic cells

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World journal of Gastroenterology 2007年第37期13卷 4960-4966页

作者： Benita L McVicker Dean j Tuma carol A Casey Liver Study Unit Department of Veterans Affairs Medical Center and Departments of Internal Medicine and Biochemistry & Molecular Biology University of Nebraska Medical Center Omaha NE 68105 United States

Chronic ethanol consumption is associated with serious and potentially fatal alcohol-related liver injuries such as hepatomegaly, alcoholic hepatitis and cirrhosis. Moreover, it has been documented that the clinical progression of alcohol-induced liver damage may be associated with an increase in hepatocellular death that involves apoptotic mechanisms. Although much information has been learned about the clinical manifestations associated with alcohol-related diseases, the search continues for a better understanding of the molecular and/or cellular mechanisms by which ethanol exerts its deleterious effects such as the induction of pro-apoptotic mechanisms and related cell damaging events. As part of the effort to enhance our understanding of those particular cellular pathways and mechanisms associated with ethanol toxicity, researchers over the years have utilized a variety of model systems. Recently, work has come forth demonstrating the utility of a hybrid cell line (WIF-B) as a cell culture model system for the study of alcohol-associated alterations in hepatocellular mechanisms. Success with such emerging model systems could aid in the development of potential therapeutic treatments for the prevention of alcohol- induced apoptotic cell death that may ultimately serve as a significant target in delaying the onset and/or progression of clinical symptoms of alcohol-mediated liver disease. This review article summarizes the current understanding of ethanol-mediated modifications in cell survival and thus the promotion of pro-apoptotic events with emphasis on analyses made in various experimental model systems, particularly the more recently characterized WIF-B cell system.

关键词： Hepatoma hybrid cells Ethanol Apoptosis Fas receptor Caspase

慢性髓增生性疾病时骨髓的凋落与增生过程——生物学及预后意义

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德国医学 2000年第4期17卷 243-245页

作者： H.M.Kvasnicha j.thiele 武忠弼 Zentrum fr Pathologie der Universitt au Kln Joseph-Stelzmann-Straβe 9D-50924 KlnGermany 同济医科大学

凋落为造血过程功能调控的组成部分,对于保持其稳定性具有重要意义。在这方面,所谓微环境,即由骨髓间质与产生细胞因子的细胞所组成的功能网,有着重要的作用,后者,即产生细胞因子的细胞,能为造血干细胞的分化和增生提供正信号。如缺乏... 详细信息

凋落为造血过程功能调控的组成部分,对于保持其稳定性具有重要意义。在这方面,所谓微环境,即由骨髓间质与产生细胞因子的细胞所组成的功能网,有着重要的作用,后者,即产生细胞因子的细胞,能为造血干细胞的分化和增生提供正信号。如缺乏相应介体的刺激,通常将导致程序性细胞死亡,而细胞因子水平的上升,则将促进造血细胞各系列的分化和成熟。与此相关联,造血过程的反应增生性或肿瘤性变异则包括细胞对正常刺激的应答障碍,或细胞增生与细胞死亡之间平衡关系的失衡。特别是在再生障碍性贫血以及髓发育不良综合征(MDS)时可以发现。

关键词：慢性髓增生性疾病骨髓细胞凋亡细胞增生

反应性淋巴小结抑或恶性淋巴瘤非霍奇金淋巴瘤骨髓浸润的鉴别诊断

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德国医学 2000年第4期17卷 240-242页

作者： j.thiele H.M.Kvasnicka 武忠弼 Zentrum fr Pathologie Universitt zu KlnJoseph-Stelzmannstraβc 9D-50924 KlnGermany 同济医科大学

欲对复杂的骨髓中淋巴样细胞浸润加以定性,首要的是必须选定合适的方法学,使之能直接与淋巴结的组织学表现作比较。因此,活检标本的固定和包埋必须能保证一系列的酶组化和免疫组化方法,首先是单克隆抗体的方法得以应用。根据我们日常诊... 详细信息

欲对复杂的骨髓中淋巴样细胞浸润加以定性,首要的是必须选定合适的方法学,使之能直接与淋巴结的组织学表现作比较。因此,活检标本的固定和包埋必须能保证一系列的酶组化和免疫组化方法,首先是单克隆抗体的方法得以应用。根据我们日常诊断工作的经验,首先仅使用较少量的这类抗体,即能标记B和T淋巴细胞抗福尔马林表位的抗体(表1)。

关键词：反应性淋巴结淋巴瘤骨髓浸润 NHL 鉴别诊断

Economics and Performance of 10 Gb/s Metro Transport Over Mixed Fiber Plant of G.655 NZDF and G.652.C Zero Water-Peak Fibers

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光学学报 2003年第S1期23卷 717-718页

作者： Hans-jrg thiele Santanu Das Raymond Boncek Lynn E. Nelson OFS 791 Holmdel-Keyport Road Holmdel NJ 07733OFS 19 Schoolhouse Road Somerset NJOFS 2000 Northeast Expressway Norcross GAOFS 791 Holmdel-Keyport Road Holmdel NJ 07733

Using lower-cost lasers, 30% savings are possible for 10-Gb/s uncompensated metro transmission over NZDF, compared to G.652 fiber. We present WDM transmission results for a mixed plant of NZDF rings interconnected to ... 详细信息

关键词： of or on as Economics and Performance of 10 Gb/s Metro Transport Over Mixed Fiber Plant of G.655 NZDF and G.652.C Zero Water-Peak Fibers dBm DML EML WDM

Feasibility study of phase-sensitive imaging based on multiple reference optical coherence tomography

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Chinese Optics Letters 2017年第9期15卷 25-30页

作者： Roshan Dsouza Hrebesh Subhash Kai Neuhaus Paul M.McNamara josh Hogan carol Wilson Martin j.Leahy Tissue Optics and Microcirculation Imaging Group School of PhysicsNational University of IrelandGalway H91 CF50Ireland Compact Imaging Ireland Ltd. Galway H91 CF50Ireland Colgate-Palmolive Global Technology Centre Piscataway NJ 08855USA Compact Imaging Inc.Mountain View 94043USA Royal College of Surgeons(RCSI) DublinIreland

Multiple reference optical coherence tomography（MR-OCT） is a recently developed, low-cost and compact time-domain OCT solution for primary care and consumer level applications. A combination of a voice coil actuator and a partial mirror（PM） extends the scan range for imaging depths of approximately 1 mm in biological samples. Our previous research on MR-OCT is based only on intensity information obtained from the depth-resolved interference signal. In this Letter, we extract the phase information from the MR-OCT signal and, hence, provide an additional contrast modality. The phase sensitivity of the system is measured to be approximately 0.2 and 1.5 rad for the first and twelfth orders of reflection when using a mirror as the *** Letter describes first results of phase-sensitive data measured on a phantom obtained with MR-OCT. Data from a chick embryo chorioallantoic membrane（CAM） is used to demonstrate the feasibility of MR-OCT for in vivo phase-sensitive imaging.

关键词： Feasibility study of phase-sensitive imaging based on multiple reference optical coherence tomography VCM Figure CAM

Feeding the world: impacts of elevated [CO_(2)] on nutrient content of greenhouse grown fruit crops and options for future yield gains

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Horticulture Research 2023年第4期10卷 83-100页

作者： Nicholas H.Doddrell Tracy Lawson Christine A.Raines carol Wagstaff Andrew j.Simkin NIAB New RoadEast MallingKentME196BJ UK Department of Food and Nutritional Sciences University of ReadingWhiteknightsReadingBerkshire RG66DZUK School of Life Sciences University of EssexColchester CO44SQUK School of Biosciences University of KentCanterburyUnited Kingdom CT27NJUK

Several long-term studies have provided strong support demonstrating that growing crops under elevated[CO_(2)]can increase photosynthesis and result in an increase in yield,flavour and nutritional content(including but not limited to Vitamins C,E and pro-vitamin A).In the case of tomato,increases in yield by as much as 80%are observed when plants are cultivated at 1000 ppm[CO_(2)],which is consistent with current commercial greenhouse productionmethods in the tomato fruit *** results provide a clear demonstration of the potential for elevating[CO_(2)]for improving yield and quality in greenhouse *** major focus of this review is to bring together 50 years of observations evaluating the impact of elevated[CO_(2)]on fruit yield and fruit nutritional *** the final section,we consider the need to engineer improvements to photosynthesis and nitrogen assimilation to allow plants to take greater advantage of elevated CO_(2) growth conditions.

关键词： crops greenhouse content

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人体造血干细胞的功能与形态学

德国医学 1995年第4期12卷 247-250页

作者： C.Wickenhauser j.thiele T.Kümmel R.Fischer 阮幼冰 Institut für Pathologie der Universitat zu Koln Josef-Stelzmann Str.9D-50924 KolnGermany 同济医科大学

人的血细胞生成是由一小群在胚胎发育的一个短时内形成的多能干细胞加以维持,随后通过自身更新功能而保证终身的造血。其调节机制至今尚不清楚,但可以肯定,多能干细胞通过细胞分裂而自我更新,并有助于干细胞群的保持。其向一定造血细胞... 详细信息

人的血细胞生成是由一小群在胚胎发育的一个短时内形成的多能干细胞加以维持,随后通过自身更新功能而保证终身的造血。其调节机制至今尚不清楚,但可以肯定,多能干细胞通过细胞分裂而自我更新,并有助于干细胞群的保持。其向一定造血细胞系方向的分化包括一种不可逆的过程。为了解血细胞更新调节机制而进行了一系列模型实验,其中本世纪初,提示的二元论、多元论及一元论,相互对抗,

关键词：血细胞形态学造血细胞干细胞

Recent Advances of Multi-Channel Transmission in Metro Access Networks

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光学学报 2003年第S1期23卷 731-732页

作者： H.j. thiele L.E. Nelson B. Eichenbaum S.K. Das OFS 791 Holmdel-Keyport Road Holmdel NJ 07733OFS 791 Holmdel-Keyport Road Holmdel NJ 07733OFS 19 Schoolhouse Road Somerset NJ 08873OFS 19 Schoolhouse Road Somerset NJ 08873

We discuss the concept of coarse wavelength-division multiplexing (CWDM) for metro networks. After reviewing the requirements on components such as lasers and fiber, we propose different architectures for a flexible u... 详细信息

关键词： CWDM on as of Recent Advances of Multi-Channel Transmission in Metro Access Networks DWDM in