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Upfront consolidation treatment with 131I-mIBG followed by myeloablative chemotherapy and hematopoietic stem cell transplantation in high-risk neuroblastoma

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Pediatric Investigation 2020年第3期4卷 168-177页

作者： Jianhua Feng Frankie WT Cheng Alex WK Leung Vincent Lee Eva WM Yeung Hoi Ching Lam Jeanny Cheung Grace KS Lam Terry TW Chow carol ls yan Chi Kong Li Department of Paediatrics The Chinese University of Hong KongHong KongChina Department of Paediatrics The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Department of Paediatrics and Adolescent Medicine Hong Kong Children’s HospitalHong KongChina Department of Clinical Oncology Prince of Wales HospitalThe Chinese University of Hong KongHong KongChina

Importance:131I-metaiodobenzylguanidine(131I-mIBG)has a significant targeted antitumor effect for neuroblastoma.However,currently there is a paucity of data for the use of 131I-mIBG as a"front-line"therapeutic agent in those patients with newly diagnosed high-risk neuroblastoma as part of the conditioning regimen for myeloablative chemotherapy(MAC).Objective:To evaluate the feasibility of upfront consolidation treatment with 131I-mIBG plus MAC and hematopoietic stem cell transplantation(HSCT)in high-risk neuroblastoma patients.Methods:A retrospective,single-center study was conducted from 2003-2019 on newly diagnosed high-risk neuroblastoma patients without progressive disease(PD)after the completion of induction therapy.They received 131I-mIBG infusion and MAC followed by HSCT.Results:A total of 24 high-risk neuroblastoma patients were enrolled with a median age of 3.0 years at diagnosis.After receiving this sequential consolidation treatment,3 of 13 patients who were in partial response(PR)before 131I-mIBG treatment achieved either complete response(CR)(n=1)or very good partial response(VGPR)(n=2)after HSCT.With a median follow-up duration of 13.0 months after 131I-mIBG therapy,the 5-year event-free survival and overall survival rates estimated were 29%and 38%for the entire cohort,and 53%and 67%for the patients who were in CR/VGPR at the time of 131I-mIBG treatment.Interpretation:Upfront consolidation treatment with 131I-mIBG plus MAC and HSCT is feasible and tolerable in high-risk neuroblastoma patients,however the survival benefit of this 131I-mIBG regimen is only observed in the patients who were in CR/VGPR at the time of 131I-mIBG treatment.

关键词： Neuroblastoma 131I-mIBG Transplantation

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MicroR-9c-5p and novel-mir50 co-target Akt to regulate Lasioderma serricorne reproduction

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Insect Science 2024年第1期31卷 106-118页

作者： Yi yan Dong-Dong Qin Hong yang Kang-Kang Xu Can Li Wen-Jia yang Provincial Key Laboratory for Agricultural Pest Management of Mountainous Region Institute of EntomologyGuizhou UniversityGuiyangChina Guizhou Provincial Key Laboratory for Rare Animal and Economic Insect of the Mountainous Region College of Biology and Environmental EngineeringGuiyang UniversityGuiyangChina

High fecundity is a common characteristic of insect pests which increases the difficulty of population control.Serine/threonine kinase Akt is an indispensable component of the insulin signaling pathway.Silencing of lsAkt severely hinders reproduction in Lasioderma serricorne,a stored product insect pest.However,the post-transcriptional pathway of lsAkt in L.serricorne remains unknown.This study identified 2 binding sites of miR-9c-5p and novel-mir50 in the coding sequences of lsAkt.The expression profiles of 2 microRNAs(miRNAs)and lsAkt displayed an opposite pattern during the adult stages.Luciferase reporter assay showed that novel-mir50 and miR-9c-5p could downregulate the expression of lsAkt.Overexpression of miR-9c-5p and novel-mir50 by injection of mimics inhibited the expression of lsAkt and reduced oviposition,decreased egg hatchability,and blocked ovarian development.It also decreased the expression of genes involved in ovarian development(lsVg and lsVgR)and the nutritional signaling pathway(lsTOR,lsS6K,and ls4EBP),and reduced the phosphorylation of Akt.Conversely,injection of miR-9c-5p and novel-mir50 inhibitors induced the expressions of lsAkt,lsVg,lsVgR,lsTOR,lsS6K,and ls4EBP,enhanced Akt phosphorylation level,and accelerated ovarian development.Injection of bovine insulin downregulated the expression of miR-9c-5p and novel-mir50 and upregulated the lsAkt expression.It also rescued the reproductive development defects associated with miR-9c-5p/novel-mir50 overexpression,forming a positive regulatory loop of insulin signaling.These results indicate that miR-9c-5p/novel-mir50 regulates the female reproduction of L.serricorne by targeting Akt in response to insulin signaling.The data also demonstrate the effects of the insulin/miRNA/Akt regulatory axis in insect reproduction.

关键词： Akt insulin Lasioderma serricorne microRNA reproduction

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Tuning microstructures of TC4 ELI to improve explosion resistance

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Defence Technology（防务技术） 2024年第3期33卷 78-99页

作者： Changle Zhang yangwei Wang Lin Wang Zixuan Ning Guoju Li Dongping Chen Zhi-Wei yan Yuchen Song Xucai Wang School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China National Key Laboratory of Science and Technology on Materials under Shock and Impact Beijing 100081China State Key Laboratory of Explosive Science and Technology Beijing Institute of TechnologyBeijing 100081China Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China School of Aeronautical Engineering Zhengzhou University of AeronauticsHenan ProvinceZhengzhou 450046China Shanxi Jiangyang Chemical Co. Ltd.Shanxi ProvinceTaiyuan 030041China Shandong Institute of Non-metallic Materials Shandong ProvinceJinan 250031China

A reasonable heat treatment process for TC4 ELI titanium alloy is crucial to tune microstructures to improve its explosion resistance.However,there is limited investigation on tuning microstructures of TC4 ELI to improve explosion resistance.Moreover,the current challenge is quantifying microstructural changes'effects on explosion resistance and incorporating microstructural changes into finite element models.This work aims to tune microstructures to improve explosion resistance and elucidate their anti-explosion mechanism,and find a suitable method to incorporate microstructural changes into finite element models.In this work,we systematically study the deformation and failure characteristics of TC4 ELI plates with varying microstructures using an air explosion test and ls-DYNA finite element modeling.The Johnson-Cook(JC)constitutive parameters are used to quantify the effects of microstructural changes on explosion resistance and incorporate microstructural changes into finite element models.Because of the heat treatment,one plate has equiaxed microstructure and the other has bimodal microstructure.The convex of the plate after the explosion has a quadratic relationship with the charge mass,and the simulation results demonstrate high reliability,with the error less than 17.5%.Therefore,it is feasible to obtain corresponding JC constitutive parameters based on the differences in microstructures and mechanical properties and characterize the effects of microstructural changes on explosion resistance.The bimodal target exhibits excellent deformation resistance.The response of bimodal microstructure to the shock wave may be more intense under explosive loading.The well-coordinated structure of the bimodal target enhances its resistance to deformation.

关键词： Microstructure Finite element modelling Parameter optimization Failure characteristics Explosion resistance

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Analysis and Characterization of the GABA Transaminase and Succinate Semialdehyde Dehydrogenase Genes in the Microalga Isochrysis zhanjiangensis in Response to Abiotic Stresses

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Journal of Ocean University of China 2024年第3期23卷 775-785页

作者： TIAN Jiaojiao ZHANG Lin LU Xinyue YE Lingzhi WU Yuanyuan CHEN Deshui CAO Jiayi JIANG Jiaxin XU Jilin yan Xiaojun Key Laboratory of Marine Biotechnology of Zhejiang Province School of Marine SciencesNingbo UniversityNingbo 315211China Key Laboratory of Aquacultural Biotechnology Ministry of Education Ningbo UniversityNingbo 315211China Laizhou Bay Marine Technology Co. Ltd.Yantai 261400China Fujian Dalai Seed Science and Technology Co. Ltd.Ningde 352101China

Gamma-aminobutyric acid(GABA),widely existing in different organisms,is rapidly accumulated in plants in response to environmental stresses.The main biosynthesis and degradation pathways of GABA constitute the GABA shunt,which is tied to the tricarboxylic acid(TCA)cycle.GABA transaminase(GABA-T)and succinate semialdehyde dehydrogenase(SSADH)are two essential enzymes for the GABA degradation pathway.While there are abundant studies on GABA shunt in higher plants at the physiological and genetic levels,research on its role in microalgae remains limited.This study aimed at exploring the function of GABA-T and SSADH genes in Isochrysis zhanjiangensis,an important diet microalga,under different stresses.We cloned two GABA-T genes,IzGABA-T1 and IzGABA-T2,and one SSADH gene IzSSADH from Isochrysis zhanjiangensis and conducted heterologous expression experiments.The results showed that the overexpression of IzGABA-T1 or IzGABA-T2 enhanced the survival rates of yeast transformants under heat or NaCl stress,while the overexpression of IzSSADH improved yeast tolerance to NaCl stress but had no obvious effect on heat stress.Additionally,the results of quantitative real-time polymerase chain reaction(qPCR)showed that IzGABA-T1 transcription increased in the HT(salinity 25,35℃)and ls(salinity 15,25℃)groups.At 24 h,the IzGABA-T2 transcriptions increased in the HT,ls,and HS(salinity 35,25℃)groups,but their transcription levels decreased in all groups at 48 h.IzSSADH transcription increased in the ls group.These results suggest that IzGABA-T1,IzGABA-T2,and IzSSADH are associated with temperature and salinity stresses and possess a certain preference for different stresses.

关键词： abiotic stress GABA heterologous expression Isochrysis zhanjiangensis transcription

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Cooperative structure of Li/Ni mixing and stacking faults for achieving high-capacity Co-free Li-rich oxides

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Journal of Energy Chemistry 2024年第8期95卷 315-324页

作者： Zhen Wu Yu-Han Zhang Hao Wang Zewen Liu Xudong Zhang Xin Dai Kunyang Zou Xiaoming Lou Xuechen Hu Lijing Ma yan Liu Yongning Liu State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University Qingdao Industrial Energy Storage Research Institute Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences Hefei Advanced Computing Center Operation Management Corp Ltd Center for High Performance Computing Network Information Center Xi'an Jiaotong University Wuhan Dongfeng Motor Corporation Ltd School of Materials Science and Intelligent Engineering Nanjing University Key Laboratory of MEMS of the Ministry of Education Southeast University International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong University

Co-free Li-rich layered oxides（LLOs） are emerging as promising cathode materials for Li-ion batteries due to their low cost and high capacity.However,they commonly face severe structural instability and poor electrochemical activity,leading to diminished capacity and voltage performance.Herein,we introduce a Co-free LLO,Li1.167Ni0.222Mn0.611O2（Cf-L1）,which features a cooperative structure of Li/Ni mixing and stacking faults.This structure regulates the crystal and electronic structures,resulting in a higher discharge capacity of 300.6 mA h g-1and enhanced rate capability compared to the typical Co-free LLO,Li1.2Ni0.2Mn0.6O2（Cf-ls）.Density functional theory（DFT） indicates that Li/Ni mixing in LLOs leads to increased Li-O-Li configurations and higher anionic redox activities,while stacking faults further optimize the electronic interactions of transition metal（TM） 3d and non-bonding O 2p orbitals.Moreover,stacking faults accommodate lattice strain,improving electrochemical reversibility during charge/discharge cycles,as demonstrated by the in situ XRD of Cf-L1 showing less lattice evolution than Cf-ls.This study offers a structured approach to developing Co-free LLOs with enhanced capacity,voltage,rate capability,and cyclability,significantly impacting the advancement of the next-generation Li-ion batteries.

关键词： Co-free Li-rich oxides Electronic structure Li/Ni mixing Stacking faults

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海上风电打桩系统动力学建模与冲击动力特性分析

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太阳能学报 2024年第4期45卷 151-158页

作者：潘怡冯小星曹春潼梅卫东严岩孙蓓蓓东南大学机械工程学院南京211189 江苏龙源振华海洋工程有限公司南通226000

基于ls-DYNA建立3500 kJ海上风电打桩系统拒桩工况下的有限元模型,基于应力波原理分析打桩系统内部能量的传递和各部件的动力学响应。同时基于牛顿碰撞理论建立打桩系统的集中参数模型,该模型综合考虑各部件的质量和刚度,和有限元模型... 详细信息

基于ls-DYNA建立3500 kJ海上风电打桩系统拒桩工况下的有限元模型,基于应力波原理分析打桩系统内部能量的传递和各部件的动力学响应。同时基于牛顿碰撞理论建立打桩系统的集中参数模型,该模型综合考虑各部件的质量和刚度,和有限元模型的分析结果较吻合。从而在该集中参数模型的基础上,分别分析替打刚度、替打和锤质量比、替打环刚度对打桩系统冲击力的影响规律,表明冲击力的主要影响参数为替打刚度。

关键词：海上风电打桩动力学响应集中参数模型替打

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Direct cellular reprogramming and transdifferentiation of fibroblasts on wound healing-Fantasy or reality?

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慢性疾病与转化医学:英文版 2023年第3期9卷 191-199页

作者： Juan Du Xuelai Liu carol Wing yan Wong Kenneth Kak Yuen Wong Zhixin Yuan Diabetic Foot Diagnosis and Treatment Centre Jilin Province People HospitalChangchunJilinChina Department of Surgery Capital Institute of Pediatrics Affiliated Children HospitalBeijingChina Department of Surgery Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina Department of Emergency Surgery Jilin Province People HospitalChangchunJilinChina

Induced pluripotent stem cell(iPSC)technology is one of the de novo approaches in regeneration medicine and has led to new research applications for wound healing in recent years.Fibroblasts have attracted wide attention as the first cell line used for differentiation into iPSCs.Researchers have found that fibroblasts can be induced into different types of cells in variable mediums or microenvironments.This indicates the potential“stem”characteristics of fibroblasts in terms of direct cellular reprogramming compared with the iPSC detour.In this review,we described the morphology and biological function of fibroblasts.The stem cell characteristics and activities of fibroblasts,including transdifferentiation into myofibroblasts,osteogenic cells,chondrogenic cells,neurons,and vascular tissue,are discussed.The biological values of fibroblasts are then briefly reviewed.Finally,we discussed the potential applications of fibroblasts in clinical practice.

关键词： direct cellular reprogramming fibroblast wound healing

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五年规划视角下中国共产党文化建设的范式考察

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贵州师范大学学报（社会科学版） 2024年第1期 13-23页

作者：孙绍勇刘艳西北工业大学马克思主义学院陕西西安710129

五年规划是由中国共产党领导编制实施的涉及国家经济、政治、文化、社会、生态等领域的中长期战略发展规划。从“一五”计划到“十四五”规划,社会主义文化建设是一以贯之的重要内容。新中国成立70多年以来,十四个五年规划推进文化建设... 详细信息

五年规划是由中国共产党领导编制实施的涉及国家经济、政治、文化、社会、生态等领域的中长期战略发展规划。从“一五”计划到“十四五”规划,社会主义文化建设是一以贯之的重要内容。新中国成立70多年以来,十四个五年规划推进文化建设经历了社会主义革命和建设时期、改革开放和社会主义现代化建设新时期以及中国特色社会主义新时代三个历史阶段,呈现出不同的时代主题和实践内容。以五年规划视角来解码中国共产党文化建设,彰显了中国共产党领导的政治优势、马克思主义指导的魂脉优势、中华优秀传统文化的根基优势、以人民为中心的主体优势以及科学系统的思维优势。与此同时,以五年规划推进文化建设在增进人民政治认同、理论认同、价值认同、情感认同上发挥着至关重要的作用。

关键词：五年规划文化建设独特优势范式考察

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干旱胁迫下外源褪黑素对王族海棠光合作用、ASA-GSH循环以及激素变化的影响

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河南农业科学 2024年第6期53卷 100-110页

作者：杨艳肖斌常州大学美术与设计学院江苏常州213159 西北农林科技大学园艺学院陕西杨凌712100

为探究干旱胁迫下外源褪黑素(MT)对王族海棠(Malus‘Royalty’)生长状况、光合作用、激素代谢以及抗坏血酸-谷胱甘肽(ASA-GSH)循环生理的影响,盆栽条件下设置正常水分(CK)、干旱胁迫(DS)以及干旱胁迫下叶片喷施6个质量分数(50、100、150... 详细信息

为探究干旱胁迫下外源褪黑素(MT)对王族海棠(Malus‘Royalty’)生长状况、光合作用、激素代谢以及抗坏血酸-谷胱甘肽(ASA-GSH)循环生理的影响,盆栽条件下设置正常水分(CK)、干旱胁迫(DS)以及干旱胁迫下叶片喷施6个质量分数(50、100、150、200、250、300 mg/kg,分别记为MT1、MT2、MT3、MT4、MT5、MT6)的褪黑素,共8个处理,分析干旱胁迫下不同质量分数褪黑素处理对王族海棠生长量、叶绿素含量、光合参数、激素代谢以及ASA-GSH循环中相关酶活性和抗氧化物质含量的影响。结果表明,与DS处理相比,DS+MT3处理下的株高、基径、总干质量、根系总体积以及根系平均直径分别增加54.7%、20.0%、143.2%、33.5%、6.9%;叶绿素a、叶绿素b以及类胡萝卜素含量分别增加20.5%、115.7%和83.0%;光合参数中净光合速率(Pn)、蒸腾速率(Tr)、气孔导度(Gs)以及水分利用效率(WUE)分别增加51.8%、110.9%、55.5%和96.6%,且Pn恢复至CK水平,胞间CO_(2)浓度(Ci)和气孔限制值(ls)则分别下降43.3%和57.0%;PSⅡ最大光化学量子效率(Fv/Fm)、PSⅡ潜在活性(Fv/Fo)、PSⅡ实际光化学量子效率(ΦPSⅡ)以及PSⅡ有效光化学量子效率(Fv′/Fm′)分别增加5.4%、61.8%、171.6%和168.7%。王族海棠AsA-GSH循环中抗坏血酸过氧化物酶(APX)、脱氢抗坏血酸还原酶(DHAR)、单脱氢抗坏血酸还原酶(MDHAR)以及谷胱甘肽还原酶(GR)活性分别增加168.3%、90.4%、167.2%和126.0%;抗坏血酸(ASA)含量、谷胱甘肽(GSH)含量、抗坏血酸/脱氢抗坏血酸(ASA/DHA)、还原型/氧化型谷胱甘肽(GSH/GSSG)分别增加102.5%、67.5%、129.8%和342.1%;生长素(IAA)、赤霉素(GA)、玉米素核苷(ZR)含量分别增加26.2%、24.6%和89.3%,脱落酸(ABA)含量降低49.0%。干旱胁迫下,王族海棠的生长参数、光合作用以及ASA-GSH循环过程受到抑制,激素平衡遭到破坏。叶片喷施不同质量分数的褪黑素能够调节内源激素的代谢水平,提高光合作用,增强ASA-GSH循环中相关酶活性以及抗氧化物质含量,促进光合色素的合成和积累,改善叶绿素荧光参数,进而提高植物的生物量,增强王族海棠的抗旱能力,其中以叶片喷施150 mg/kg的褪黑素提高王族海棠的抗旱性效果最好。

关键词：王族海棠褪黑素干旱胁迫 ASA-GSH 光合叶绿素激素

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柱形装药形状对加筋板架动态响应的影响研究

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火工品 2024年第3期 77-83页

作者：王琰蒋海燕韩璐苏健军西安近代化学研究所陕西西安710065

为了研究近距爆炸时柱形装药形状对某典型缩比板架结构动态响应的影响,基于ls-DYNA软件建立了板架结构在近距爆炸载荷下的有限元模型,分析了柱形装药长径比对板架变形损伤与能量吸收的影响,并通过野外爆炸试验对仿真模型的正确性进行了... 详细信息

为了研究近距爆炸时柱形装药形状对某典型缩比板架结构动态响应的影响,基于ls-DYNA软件建立了板架结构在近距爆炸载荷下的有限元模型,分析了柱形装药长径比对板架变形损伤与能量吸收的影响,并通过野外爆炸试验对仿真模型的正确性进行了验证。结果表明:1.5kg药柱轴向布置时,随着长径比增大,靶板的塑性损伤逐渐降低,长径比分别为1/3,1/2,1,2和3时,靶板表面最大塑性应变依次为0.264,0.203,0.159,0.119和0.115。靶板残余位移与装药质量近似呈线性关系,当装药轴向布置时,长径比越小,曲线斜率越大,靶板最大残余位移随装药质量增加的速率越快;装药径向布置时的变化趋势与此相反。随着长径比增大,装药轴向布置时靶板的残余位移和吸能值均呈现非线性减小趋势,径向布置时二者均呈现非线性增大的趋势,这说明近距爆炸时装药形状对板架结构响应的影响不可忽略。

关键词：柱形装药装药形状板架结构动态响应

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