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Using Geographic Information Systems (GIS) for Targeted National Recruitment of Community-Dwelling Caregivers Managing Dementia-Related Behavioral and Psychological Symptoms: A Recruitment Approach for a Randomized Clinical Trial

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Journal of Geographic Information System 2021年第3期13卷 302-317页

作者： Danny l. Scerpella Nicole G. Bouranis Melinda J. webster Maria Dellapina Sokha Koeuth lauren J. Parker Helen C. Kales laura N. Gitlin School of Public Health Johns Hopkins University Baltimore USA College of Nursing and Health Professions Drexel University Philadelphia USA Department of Psychiatry University of California-Davis Sacramento USA

Over 16 million caregivers of people living with dementia require support in a range of issues, including self-care, disease education, and guidance for how to manage behavioral and psychological symptoms of dementia (BPSD). Non-pharmacological interventions are needed to address these areas, and online applications have been shown to be safe and effective. To ensure the efficacy of such interventions, racially, ethnically, geographically, and socioeconomically diverse participants must be recruited to increase the generalizability of study outcomes. This protocol paper describes a recruitment plan using Geographic Information Systems (GIS) to reach a representative sample of caregivers across the United States for a national Phase III clinical study. Using publicly available census data from the American Community Survey (ACS), combined with location data for local aging resources such as Area Agencies on Aging (AAA), recruitment will be derived from data analysis conducted in ESRI ArcGIS v10.7.1. Datasets including age, gender, income, and education will be assessed nationally at the county and census tract spatial scale in a nine-step process to develop recruitment priority areas containing high concentrations of eligible participants living in the community. Overall, the current protocol will demonstrate the value of GIS in tailoring targeted outreach strategies to recruit community-dwelling populations through local resource institutions. This novel approach may have far-reaching implications in future recruitment initiatives and help to secure racially/ethnically diverse samples.

关键词： Geographic Information Systems Recruitment Clinical Trial GIS Dementia or Caregiving

Cancer and age related colonic crypt deficiencies in cytochrome c oxidase Ⅰ

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World Journal of Gastrointestinal Oncology 2010年第12期2卷 429-442页

作者： carol Bernstein Alexander Facista Huy Nguyen Beryl Zaitlin Nadia Hassounah Cristy loustaunau Claire Margaret Payne Bhaskar Banerjee Steve Goldschmid V liana Tsikitis Robert Krouse Harris Bernstein Department of Cell Biology and Anatomy College of MedicineUniversity of ArizonaTucsonAZ 85724United State Schulich School of Civil Engineering University of CalgaryCalgary Alberta T2L 1M3Canada Department of Cell Biology and Anatomy College of MedicineUniversity of ArizonaTucsonAZ 85724United States Biomedical Diagnostics and Research Inc TucsonAZ 85719United States Department of Medicine College of MedicineUniversity of ArizonaTucsonAZ 85724United States Department of Surgery College of MedicineUniversity of ArizonaTucsonAZ 85724United States Southern Arizona Veterans Affairs Health Care System TucsonAZ 85723United States

AIM: To investigate whether defi ciency of expressionof cytochrome c oxidase I (CcOI) in colonic crypts is associated with colon ***: The pattern and level of expression of CcOI in non-neoplastic colonic crypts,and in dysplastic tissues,was assessed using standard immunohis-tochemical *** were obtained from individuals undergoing colonoscopies for screening purposes or for a medically indicated *** samples were also obtained from surgical colonic *** from resections were taken from colonic mucosa 1 and 10 cm from tumors and from the tumors *** were evaluated for frequency of crypts with reduced or absent expression of *** most crypts the loss was apparent throughout the entire crypt,while in a small minority the loss was *** strong immunoreactivity using this monoclonal antibody makes the scoring *** percent of crypts with reduced or absent expression of CcOI or (infrequent) segmented loss of expression was then *** analyses were performed using SPSS statistical package ***: The average frequency of CcOI deficient crypts (CcOI-DC) is low in individuals between 20 and 39 years of age,with 0.48% ± 0.40% CcOI-DC for women and 1.80% ± 0.35% for ***-DC increases after age 40 years,so that between the ages of 40 and 44 years the average frequency of CcOI- DC goes up to 5.89% ± 0.84% in women and 2.15% ± 1.27% in *** 80-84 years of age,the average frequency of CcOI-DC goes up in women to 15.77% ± 0.97% and in men to 22.6% ± 0.65%.The increases in CcOI-DC from ages 40-44 years compared to 80-84 years in women and men are significantly different with P lon cancer,being 4.03% ± 0.27% in individuals free of neoplasia in the age range 55-64 yearsand 14.13% ± 0.

关键词： Cytochrome c oxidase Aging Colon crypts Colorectal cancer Focal lesions

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闺密消亡史

快乐阅读 2020年第13期 40-41页

作者： carol 不详

很多时候,我和别人聊起她,都会说: “这是我从初中到现在最好的朋友.”尽管这几年我们见面的次数屈指可数,微信上的交流也越发稀少,总是隔很长的时间才有一段短暂的聊天. 暂且称呼她为l吧,我和她已经认识11年了. 2007年,初中.

关键词：微信聊天初中

白藜芦醇和芦丁对人单核及多核白细胞分泌Il-8和Il-6的抑制作用

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中国新药杂志 2009年第2期18卷 151-154页

作者：武晓捷 Damon A.lowes Helen F.Galley Nigel R.webster 上海复旦大学附属华山医院抗生素研究所上海200040 Academic Unit of Anaesthesia and Intensive Care School of MedicineUniversity of Aberdeen

目的:研究2种类黄酮化合物白藜芦醇和芦丁对人单核及多核白细胞分泌白介素8(Il-8)和白介素6(Il-6)的抑制作用,探讨其对于治疗脓毒血症患者是否具有临床意义。方法:采10例健康人静脉血,分离白细胞,加入20μmol.l-1白藜芦醇或50μmol.l-1... 详细信息

目的:研究2种类黄酮化合物白藜芦醇和芦丁对人单核及多核白细胞分泌白介素8(Il-8)和白介素6(Il-6)的抑制作用,探讨其对于治疗脓毒血症患者是否具有临床意义。方法:采10例健康人静脉血,分离白细胞,加入20μmol.l-1白藜芦醇或50μmol.l-1芦丁,在37℃和5%CO2条件孵育箱培养4 h,加入20 mg.l-1脂多糖(lPS)或20μmol.l-1肽聚糖(PGN),培育过夜后测定培养基中Il-8和Il-6浓度,分别与阳性对照(只在细胞中加入lPS或PGN)和DMSO阴性对照比较。结果:芦丁和白藜芦醇均显著降低lPS刺激后单核细胞的Il-8分泌量(n=10,Pl-6分泌量(n=10,Pl-8和Il-6的有抑制作用,这种抑制作用可能具有细胞特异性。

关键词：白藜芦醇芦丁白细胞 Il-8 Il-6

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不同发育期的曼氏血吸虫对吡喹酮敏感性差异的体内、体外试验观察

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中国寄生虫学与寄生虫病杂志 1983年第4期 27-28页

作者：肖树华,B.A.Catto,l.T.webster,Jr. 中国预防医学中心寄虫病研究所美国凯司西储大学医学院药理系美国凯司西储大学医学院药理系

在体外培养试验中,以虫的活动兴奋和肌肉收缩为指标时,虫龄为3小时、3天、7天、14天、28天、35天和42天的曼氏血吸虫对吡喹酮的敏感性无明显差异。若以体表的泡状物形成为指标,则有明显差异,其中以3日龄和7日龄虫的体表泡状物的形成较... 详细信息

在体外培养试验中,以虫的活动兴奋和肌肉收缩为指标时,虫龄为3小时、3天、7天、14天、28天、35天和42天的曼氏血吸虫对吡喹酮的敏感性无明显差异。若以体表的泡状物形成为指标,则有明显差异,其中以3日龄和7日龄虫的体表泡状物的形成较慢且少,

关键词：曼氏血吸虫敏感性差异小鼠小家鼠血药浓度

Anti-viral drug resistance in avian H5N1 viruses

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Anti-viral drug resistance in avian H5N1 viruses

2006年第二届新生病毒性疾病控制学术研讨会

作者： J．Rayner Cheung C．l． G．J．Smith R．G.webster J．S．M．Peiris 陈鸿霖 State Key laboratory of Emerging Infectious Diseases Department of MicrobiologyThe University of Hong KongFaculty of Medicine Building 21 Sassoon Road Pokfulam Hong Kong SARChina Joint Influenza Research Center (SUMC & HKU)Shantou University Medical CollegeShantouGuangdong 515031 China State Key laboratory of Emerging Infectious Diseases Department of MicrobiologyThe University of Hong Kong Faculty of Medicine Building 21 Sassoon RoadPokfulamHong Kong SARChina Joint Influenza Research Center (SUMC & HKU)Shantou University Medical CollegeShantouGuangdong 515031China State Key laboratory of Emerging Infectious Diseases Department of MicrobiologyThe University of Hong KongFaculty of Medicine Building21 Sassoon RoadPokfulamHong Kong SARChina Virology DivisionDepartment of Infectious DiseasesSt Jude Children’s Research HospitalMemphisTN 38105USA State Key laboratory of Emerging Infectious Diseases Department of MicrobiologyThe University of Hong KongFaculty of Medicine Building21 Sassoon RoadPokfulamHong Kong SARChina Joint Influenza Research Center (SUMC & HKU)Shantou University Medical CollegeShantouGuangdong 515031China

H5N1 avian influenza virus is expanding its geographical distribution and human infections are being repeatedly detected in affected countries. Stockpiling antiviral drugs has been considered as a component of preparedness for a potential H5N1 influenza pandemic. However, resistance to amantadine, an ion channel blocker, has been identified in the majority of isolates from some affected countries. While the stockpiling of the neuraminidase inhibitor oseltamivir has been started in many countries, viral resistance has been detected in some patients with H5N1 disease being treated with oseltamivir. Resistance to anti-influenza virus drugs is a matter of great concern and relevance for pandemic preparedness.

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超滤——制药工业中有价值的工艺技术

中国生化药物杂志 1983年第3期 39-42页

作者： J l Short D.W.webster 李惠欣施汉章

一、前言早在七十年代初,超滤技术已正规地被应用于酶发酵工业的纯化和浓缩,为此,超滤技术对制药工业提出了巨大的挑战,也提供了潜力。目前,超滤还应用于白蛋白、血浆的纯化;疫苗、抗生素的加工,水中除去热原。随着工业生化技术受到遗... 详细信息

一、前言早在七十年代初,超滤技术已正规地被应用于酶发酵工业的纯化和浓缩,为此,超滤技术对制药工业提出了巨大的挑战,也提供了潜力。目前,超滤还应用于白蛋白、血浆的纯化;疫苗、抗生素的加工,水中除去热原。随着工业生化技术受到遗传工程的震撼,超滤将被应用于通过遗传变异的微生物所产生的有医学价值的化合物的生产和通过发酵制造化学制品工业的生产。

关键词：超滤技术溶剂入渗流型超滤法下渗流谱制药工业制药业生物膜中空纤维异形纤维低分子量大分子透滤 VCF

Physical Activity, Screen Time, and Prevalence of Overweight/Obesity among Adolescents in a Creative, Problem-Solving Program

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Food and Nutrition Sciences 2012年第4期3卷 568-578页

作者： Jill M. Maples Eugene C. Fitzhugh carol A. Costello Naima Moustaid-Moussa David R. Basset Marsha l. Spence Betty P. Greer Department of Animal Science The University of Tennessee Knoxville USA Department of Exercise and Sport Science East Carolina University Greenville USA Department of Exercise Sport and Leisure Studies The University of Tennessee Knoxville USA Department of Nutrition The University of Tennessee Knoxville USA Department of Retail Hospitality and Tourism Management The University of Tennessee Knoxville USA Institute of Agriculture AgResearch The University of Tennessee Knoxville USA.

Certain dietary, physical activity, and sedentary behaviors have been studied extensively and consistently have been found to be associated with childhood overweight and obesity Productive sedentary-to-light activity pursuits may enhance the relationship among positive health behaviors. The purpose of this study was to identify the prevalence of overweight and obesity in a population of adolescents participating in a creative, problem-solving afterschool program and to identify the physical activity, sedentary, and dietary behaviors related to overweight and obesity in this group. This study describes health behaviors thought to be related to weight status for 1679 adolescents in grades 6 12 participating in a competitive, creative, team-oriented, problem-solving afterschool program. Self-reported dietary, physical activity, and sedentary behavior data were collected in this convenience sample based on the 2007 Youth Risk Behavior Survey. Measured height and weight data were collected to calculate BMI percentile. Using multinomial regression, models were constructed to predict the likelihood of being classified as overweight/obese. The prevalence of overweight in the study population was 15.6%, obese was 11.4%. Fruit/vegetable intake, milk consumption, moderate-to-vigorous physical activity, television time, and total screen time were all independently associated with weight status. After controlling for all covariates, male gender, minority racial/ethnic status, and high screen time while not meeting the physical activity recommendation significantly increased the likelihood of overweight/obesity. The participants in the current study are leaner and engage in healthier behaviors compared to national data for adolescents. The interactive variable combining both sedentary and PA measures is a relatively new technique used to provide a better understanding of the relationship between sedentary and physical activity behaviors as they relate to weight status. Even among

关键词： Health Behaviors Physical Activity Adolescent Obesity

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l2休闲吧——用lED打造的高端休闲空间

照明设计 2009年第5期 100-103页

作者： carol C（编译）

l2休闲吧安静地藏匿于华盛顿乔治敦附近的个富有历史感的混合用作市政厅和仓库的建筑之中，其所处的位置是乔治敦的一个正日益发展成为设计中心的高档区域，鹅卵石铺就的道路两侧分布着砖墙建筑，拥有很多家具连锁店、古董店和时尚小店。

关键词：休闲空间 lED 混凝土地板设计中心市政厅历史感华盛顿鹅卵石