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Biological therapy in inflammatory bowel diseases:Access in Central and Eastern Europe

World Journal of Gastroenterology 2015年第6期21卷 1728-1737页

作者： Fanni Rencz Márta Péntek Martin Bortlik Edyta Zagorowicz Tibor Hlavaty Andrzej Sliwczyński Mihai M Diculescu limas Kupcinskas Krisztina B Gecse lászló Gulácsi Peter l lakatos Department of Health Economics Corvinus University of Budapest Semmelweis University Doctoral School of Clinical Medicine IBD Clinical and Research Centre ISCARE a.s.1~(st) Faculty of Medicine Charles University Department of Gastroenterology The Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology and Medical Center for Postgraduate Education Gastroenterology Unit Department of Internal Medicine V University Hospital Bratislava Public Health Department Health Sciences Faculty Medical University in ?ód? and National Health Fund Department of Gastroenterology and Hepatology Carol Davila University Department of Gastroenterology Medical Academy Lithuanian University of Health Sciences 1~(st) Department of Medicine Semmelweis University

Biological drugs opened up new horizons in the management of inflammatory bowel diseases(IBD).This study focuses on access to biological therapy in IBD patients across 9 selected Central and Eastern European(CEE)countries,namely Bulgaria,the Czech Republic,Estonia,Hungary,latvia,lithuania,Poland,Romania and *** data on the epidemiology and disease burden of IBD in CEE countries was systematically ***,we provide an estimation on prevalence of IBD as well as biological treatment *** all countries with the exception of Romania,lower biological treatment rates were observed in ulcerative colitis(UC)compared to Crohn’s disease despite the higher prevalence of *** heterogeneity(up to 96-fold)was found in access to biologicals across the CEE ***,Bulgaria,Romania and the Baltic States are lagging behind Hungary,Slovakia and the Czech Republic in their access to *** of reimbursement policy may be one of the factors explaining the differences to a certain extent in Bulgaria,latvia,lithuania,and Poland,but association with other possible determinants(differences in prevalence and incidence,price of biologicals,total expenditure on health,geographical access,and cost-effectiveness results)was not *** assume,nevertheless,that healthdeterioration linked to IBD might be valued differently against other systemic inflammatory conditions in distinct countries and which may contribute to the immense diversity in the utilization of biological drugs for *** conclusion,access to biologicals varies widely among CEE countries and this difference cannot be explained by epidemiological factors,drug prices or total health *** in reimbursement policy could contribute to better access to biologicals in some countries.

关键词： Inflammatory bowel diseases Ulcerative colitis Bio

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在加利福尼亚州用化学农药拌种防治大麦条纹病

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麦类作物学报 1986年第2期 46-47页

作者： T. R. Gordon ,R. K. webster ,刘平生

大麦条纹病是由病原真菌(Drechslera graminea (Rab) Shoem)引致的一种种传病害,其有性世代为大麦条纹病菌(Pyrenophora graminea Ito & Kurib).大麦(Hordeum vulgare l.)出苗前,颖壳和种皮内的菌丝体生长荫发侵染大麦幼苗.病害的症状... 详细信息

大麦条纹病是由病原真菌(Drechslera graminea (Rab) Shoem)引致的一种种传病害,其有性世代为大麦条纹病菌(Pyrenophora graminea Ito & Kurib).大麦(Hordeum vulgare l.)出苗前,颖壳和种皮内的菌丝体生长荫发侵染大麦幼苗.病害的症状为叶片呈条纹状坏死或纵裂,感病植株很少或根

关键词：大麦条纹病伊玛药剂大麦条斑病大麦品种加利福尼亚州

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Perforations of Gastro-Duodenal Ulcers in the Surgery Department “A” at the University Hospital Point G Bamako

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Surgical Science 2019年第8期10卷 265-270页

作者： O. Sacko S. Diallo l. Soumaré M. Camara S. Koumaré M. Sissoko S. Keita carol D. Dakouo M. Coulibaly M. Traoré G. Soumaré A. F. Traoré H. Dicko Y. Dianessi B. Traoré A. Koita Sanogo Zimogo Department of Surgery “A” University Hospital of Point G Bamako Mali Department of Surgery “B” University Hospital of Point G Bamako Mali Department of Gynecology-Obstetrics University Hospital of Point G Bamako Mali Department of Internal Medicine University Hospital of Point G Bamako Mali Department of Intensive Care University Hospital of Point G Bamako Mali

The purpose of this study was to investigate the clinical and therapeutic aspects of peritonitis by perforation of gastric and duodenal ulcer. This was a retrospective and descriptive study over 8 years (2010-2018) which allowed to collect 54 cases of peptic ulcer. Included in the study were all patients with confirmed gastroduodenal perforation on histology or laparotomy. We collected 54 cases of peptic ulcer perforated s. The age group of 30 - 49 years was the majority. The male sex was dominant with 90.7% of cases;the clinical picture was dominated by abdominal contracture associated with pain in 74.07% of cases. X-ray of the abdomen without preparation (AWP) revealed in 87.03% of cases of pneumoperitoneum. The perforation was in 68.52% of cases on the gastric antrum and in 31.48% on the duodenum. The surgical procedure used was the bank of excision, and a suture reinforcement epiploic in 68.52% of cases, a simple suture made in 31.48% of cases, the disease was marked by a fistula (1.90%) and mortality was 5.55% of cases. The gastroduodenal ulcer perforation is potentially serious and responsible peritonitis whose surgical treatment involves the peritoneal toilet and sutures the puncture.

关键词： Perforated Gastric or Duodenal Ulcer Peritonitis Surgery

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leptotrichia hongkongensis ***.,a novel leptotrichia species with the oral cavity as its natural reservoir

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第6期11卷 391-401页

作者： Patrick C. Y. WOO Samson S. Y. WONG Jade l. l. TENG Kit-Wah lEUNG Antonio H. Y. NGAN Dong-qing ZHAO Herman TSE Susanna K. P. lAU Kwok-Yung YUEN State Key laboratory of Emerging Infectious Diseases The University of Hong Kong Hong Kong China Research Centre of Infection and Immunology The University of Hong Kong Hong Kong China Department of Microbiology The University of Hong Kong Hong Kong China carol Yu Centre for Infection The University of Hong Kong Hong Kong China

A straight, non-sporulating, Gram-variable bacillus (HKU24T) was recovered from the blood culture of a patient with metastatic breast carcinoma. After repeated subculturing in BACTEC Plus Anaerobic/F blood culture broth, HKU24T grew on brucella agar as non-hemolytic, pinpoint colonies after 96 h of incubation at 37 °C in an anaerobic environment and aerobic environment with 5% CO2. Growth was enhanced with a streak of Staphylococcus aureus. HKU24T was non-motile and catalase-negative, but positive for alkaline phosphatase, β-glucosidase, and α-glucosidase. It hydrolyzed phenylphosphonate and reduced resazurin. 16S rRNA, groEl, gyrB, recA, and rpoB sequencing showed that HKU24T occupies a distinct phylogenetic position among the leptotrichia species, being most closely related to leptotrichia trevisanii. Using HKU24T groEl, gyrB, recA, and rpoB gene-specific primers, fragments of these genes were amplified from one of 20 oral specimens. Based on phenotypic and genotypic characteristics, we propose a new species, leptotrichia hongkongensis sp. nov., to describe this bacterium.

关键词： leptotrichia hongkongensis Bacterium Blood culture Anaerobic bacteria Novel species

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Tumor microenvironment-dependent epigenetic imprinting in the vasculature predicts colon cancer outcome

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Cancer Communications 2023年第11期43卷 1280-1285页

作者： Elisabeth Naschberger Maximilian Fuchs Nicholas Dickel Meik Kunz Bernt Popp Charles Gwellem Anchang Richard Demmler Yanmin lyu Steffen Uebe Arif Bülent Ekici carol Immanuel Geppert Arndt Hartmann Christian Flierl Katja Petter Tobias Gass Simon Völkl Michael Scharl Andreas Ramming Claudia Günther Susanne Merkel Vera Simone Schellerer Michael Stürzl Division of Molecular and Experimental Surgery Translational Research CenterUniversitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN) ErlangenBavariaGermany Chair of Medical Informatics Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Fraunhofer Institute of Toxicology and Experimental Medicine Lower saxonyHannoverGermany Institute of Human Genetics Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Department of Medicine 3 Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Institute of Pathology Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Department of Internal Medicine 5 – Hematology and Oncology Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Department of Gastroenterology and Hepatology University Hospital ZurichUniversity of ZurichCanton ZurichZurichSwitzerland Department of Medicine 1 Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Department of Surgery Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany

Dear Editor,Tumor microenvironment(TME)-dependent stromal cell plasticity governs tumor development and therapy *** endothelial cells(TECs)are a major cellular component in this context[1].In colorectal carcinoma(CRC),the stromal cell-dependent impact of the TME is illustrated by an improved survival depending on an interferon(IFN)-γ-dominated Th1-like TME associated with high T-cell density[2]and suppressed angiogenesis[3,4].Cellular transcriptional memory is reported in cell lines after repeated exposure to IFN-γin vitro[5],suggesting that a Th1-like TME may also exert stable imprinting effects in ***,we investigated whether TME-dependent transcriptional imprinting in TECs from CRC patients can be exploited to retrieve clinically relevant signatures predicting outcomes.

关键词： imprinting colon interferon

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一项关于“视锥细胞营养不良疾病中视杆细胞ERG超常反应”的表型研究

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世界核心医学期刊文摘（眼科学分册） 2005年第8期1卷 44-45页

作者： Michaelides M. Holder G.E. webster A.R. A.T. Moore 王海燕 Institute of Ophthalmology University College London 11-43 Bath Street London EC1V 9EL United Kingdom Prof.

Aims: To characterise the detailed phenotype of “cone dystrophy with supernor mal rod ERG”in a case series of 10 patients. Methods: 10 affected patients were examined clinically and underwent colour fundus photography, with nine undergoi ng detailed electrophysiological testing. Five patients were assessed further wi th fundus autofluorescence (AF)imaging, automated photopic and dark adapted peri metry, and dark adaptometry. Detailed colour vision assessment was performed in six subjects. Blood samples were taken from four patients for DNA extraction and mutation screening of NR2E3was undertaken. Results: The onset of symptoms was i n the first and second decades of life. Subjects presented with reduced central vision and marked photophobia. All individuals were myopic and colour vision tes ting revealed severely reduced colour discrimination predominantly along the red -green axes; tritan colour vision was relatively well preserved. Nyctalopia is a later feature of the disorder. Funduscopy and AF imaging revealed a range of m acular appearances. There was electrophysiological evidence of marked macular dy sfunction, reduced and delayed cone responses, and supernormal and delayed rod r esponses. Photopic and dark adapted perimetry revealed central scotomata with wi despread peripheral sensitivity loss. No disease causing sequence variants in NR 2E3 were identified. Conclusions: The largest case series to date has been descr ibed of the clinical, psychophysical and electrophysiological characteristics of this unusual cone dystrophy with supernormal rod responses. Electrophysiologica l data were consistent with a post-phototransduction, but pre-inner nuclear la yer, site of dysfunction. While the definitive diagnosis can only be made with e lectrophysiological testing, several characteristics that may increase suspicion of this diagnosis are presented.

关键词：视杆细胞 ERG 中心视力自发荧光色觉检查暗适应计黄斑部内核层眼底照相视野计

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加强股四头肌血流限制训练法治疗髌股关节疼痛

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中国康复 2017年第5期 440-440页

作者： Giles l.webster KE McClelland J 岳寿伟山东大学齐鲁医院

髌股关节疼痛(PFP)是青少年运动引发膝前痛的常见原因。该研究给予这些因疼痛致活动受限的PFP患者一次最大推荐负载阻力(1RM)的60～70%阻力进行训练。现已发现血流限制训练法作用于目标肌肉的强度可加强至最大推荐负载阻力的20～30%,这... 详细信息

髌股关节疼痛(PFP)是青少年运动引发膝前痛的常见原因。该研究给予这些因疼痛致活动受限的PFP患者一次最大推荐负载阻力(1RM)的60～70%阻力进行训练。现已发现血流限制训练法作用于目标肌肉的强度可加强至最大推荐负载阻力的20～30%,这项研究比较两种类型的强化训练对髌股关节疼痛的影响。受试者为年龄在18～40岁之间有非创伤性PFP的患者。被随机分为BFR(血流限制训练)组的受试者进行动脉评估,受试者保持站立位,在其大腿近端放置动脉阻塞压袖。然后,袖带压力增

关键词：髌股关节训练法

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经皮腔内射频闭塞术治疗冠状动脉瘘一例

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中华心血管病杂志 2004年第10期32卷 936-937页

作者：张陈匀蔡运昌杨天和范寿年易韦吴强蒋清安刘晓桥郑亚西李世英王华义周松文安智 Mark webster Richard C Padgett 贵州省心血管病研究所贵州省人民医院心内科贵阳550002 新西兰奥克兰Green lane医院美国俄勒冈心脏病医院

患者女,66岁,劳力性心绞痛2年,加重1个月,疑诊"冠心病"收治,无冠心病易患因素.体检:血压正常,心脏不大,l3～4闻Ⅱ/VI级舒张期血流杂音、静息心电图正常,运动心电图ST段V 4～6轻度缺血性下移.心脏超声、胸片正常.左室造影左前侧壁节段性... 详细信息

患者女,66岁,劳力性心绞痛2年,加重1个月,疑诊"冠心病"收治,无冠心病易患因素.体检:血压正常,心脏不大,l3～4闻Ⅱ/VI级舒张期血流杂音、静息心电图正常,运动心电图ST段V 4～6轻度缺血性下移.心脏超声、胸片正常.左室造影左前侧壁节段性舒张期膨隆,左室射血分数0.65.选择性冠状动脉造影(CAG)见左主干较短,前降支开口及近端分别可见两条异常分支血管,直径分别是2.0 mm、2.3 mm,向右前上方移行,蜿蜒迂曲,无规则分支,相互盘绕如环状,终末开口段不规则扩张,终端血流呈烟雾状涌入主肺动脉并弥散至左、右肺动脉.前降支中、远段血管分布及管壁正常,管腔较细小,血流充盈延迟(TIMIⅡ级,图1),余冠状动脉无异常.右心导管检查各房室、大血管压力正常,主肺动脉血氧轻度增高(PO2:41.5),肺动脉根部造影于左后下方似有一异常不规则血管影,以"血氧测定法"计算体循环血流量(Qs:2.87l/min)及肺循环血流量(Qp:3.41l/min),其左向右分流量为0.54 l/min。

关键词：治疗舒张期冠状动脉瘘腔内造影经皮心电图闭塞射频易患因素

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85岁老人的健康和疾病状况：英国纽卡斯尔港市85岁以上老人队列研究的基本发现（摘要）

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英国医学杂志中文版 2010年第2期13卷 109-110页

作者： Joanna Collerton Karen Davies carol Jagger Andrew Kingston John Bond Martin P Eccles Carmen Martin-Ruiz Thomas von Zglinicki Oliver F W James Thomas B l Kirkwood 王翠娣(译) Institute for Ageing and Health Newcastle University Gampus for Ageing and Vitality Newcastle upon Tyne NE4 5PL Department of Health Sciences University of Leicester Leicester Institute of Health and Society Newcastle University Newcastle upon Tyne 卫生部北京医院神经内科

目的英国纽卡斯尔港市85岁以上老人队列研究目的是：对非选择性的85岁老人的临床、生理、社会心理特性进行系统研究，追踪老人入选以后的健康状况；报道他们的基本健康状况。

关键词：健康状况队列研究老人疾病状况英国摘要非选择性心理特性

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First Report of Tsukamurella conjunctivitidis CAPD-related Peritonitis

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Infectious Microbes & Diseases 2020年第3期2卷 121-123页

作者： Jade l.l.Teng Kenny M.N.Fok Jordan Y.H.Fong Tak-lun Que Susanna K.P.lau Patrick C.Y.Woo Department of Microbiology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina State Key laboratory of Emerging Infectious Diseases The University of Hong KongHong KongChina carol Yu Centre for Infection The University of Hong KongHong KongChina Department of Pathology Tuen Mun HospitalHong KongChina Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The University of Hong KongHong KongChina

Introduction Using the information obtained from analysis of 16S rRNA gene sequences,Tsukamurella was first proposed as a genus in 1988,1 despite the fact that the first strain of this group of bacteria was described in 1941,2 and the first human isolate was reported in 1971.3 Similar to related genera of the order Corynebacteriales,such as Nocardia,Rhodococcus,and Gordonia,members of Tsukamurella are Gram-positive,aerobic,catalase-positive,and partially acid-fast as a result of the presence of mycolic acid in the cell *** to their similar phenotypic properties,differentiation of these genera and speciation within these genera is difficult in most clinical microbiology laboratories.

关键词： Tsukamurella conjunctivitidis peritonitis continuous ambulatory peritoneal dialysis(CAPD)

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