检索结果-南通市图书馆

Maternal low protein diet induces persistent expression changes in metabolic genes in male rats

World Journal of Diabetes 2020年第5期11卷 182-192页

作者： Allan de Oliveira Lira JoséLuiz de Brito Alves Mariana Pinheiro Fernandes Diogo Vasconcelos David Filipe Santana João Henrique da Costa-Silva Béatrice Morio carol góis leandro Luciano Pirola Department of Nutrition Federal University of PernambucoVitoria de Santo AntãoPernambuco 55608680Brazil Department of Nutrition Federal University of ParaíbaJoao Pessoa 74556060Brazil Henrique da Costa-Silva Luciano PirolaDepartment of Physical Education and Sport SciencesFederal University of PernambucoVitoria de Santo AntãoPernambuco 55608680Brazil Carmen(Cardiology Metabolism and Nutrition)LaboratoryINSERM U1060Lyon-1 UniversitySouth Lyon Medical FacultyPierre Benite 69310France

BACKgROUND Perinatal exposure to a poor nutritional environment predisposes the progeny to the development of metabolic disease at the adult age,both in experimental models and *** adaptive responses to maternal protein restriction have been reported in metabolic ***,the expression of glucose/fatty acid metabolism-related genes in adipose tissue and liver needs to be *** To evaluate the metabolic impact of perinatal malnutrition,we determined malnutrition-associated gene expression alterations in liver and adipose *** In the present study,we evaluated the alterations in gene expression of glycolytic/Krebs cycle genes(Pyruvate dehydrogenase kinase 4 and citrate synthase),adipogenic and lipolytic genes and leptin in the adipose tissue of offspring rats at 30 d and 90 d of age exposed to maternal isocaloric low protein(LP)diet throughout gestation and *** also evaluated,in the livers of the same animals,the same set of genes as well as the gene expression of the transcription factors peroxisome proliferator-activated receptor gamma coactivator 1,forkhead box protein O1 and hepatocyte nuclear factor 4 and of gluconeogenic *** In the adipose tissue,we observed a transitory(i.e.,at 30 d)downregulation of pyruvate dehydrogenase kinase 4,citrate synthase and carnitine palmitoyl transferase 1b gene *** transcriptional changes did not persist in adult LP rats(90 d),but we observed a tendency towards a decreased gene expression of leptin(P=0.052).The liver featured some gene expression alterations comparable to the adipose tissue,such as pyruvate dehydrogenase kinase 4 downregulation at 30 d and displayed other tissue-specific changes,including citrate synthase and fatty acid synthase upregulation,but pyruvate kinase downregulation at 30 d in the LP group and carnitine palmitoyl transferase 1b downregulation at 90 *** gene alterations,together with previously described changes in gene expression in

关键词： Metabolic adaptation Phenotype plasticity Liver Adipose tissue Metabolism Maternal protein undernutrition Rats

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bridging the gap:Unveiling the crisis of physical inactivity in inflammatory bowel diseases

引用

World Journal of gastroenterology 2024年第10期30卷 1261-1265页

作者： Remus Stafie Ana-Maria Singeap Adrian Rotaru carol Stanciu Anca Trifan Department of gastroenterology Faculty of Medicine“Grigore T.Popa”University of Medicine and PharmacyIasi 700115Romania Institute of gastroenterology and Hepatology “St.Spiridon”University HospitalIasi 700111Romania

In this editorial we comment on the article titled“Inflammatory bowel diseases patients suffer from significant low levels and barriers to physical activity:The BE-FIT-IBD study”published in a recent issue of the World Journal of gastroen-terology 2023;29(41):*** bowel diseases(IBD)are emerging as a significant global health concern as their incidence continues to rise on a global scale,with detrimental impacts on quality of *** many advances have been made regarding the management of the disease,physical inactivity in these patients represents an underexplored issue that may hold the key for further and better understanding the ramifications of *** pain,fatigue,and fear of exacerbating symptoms promotes physical inactivity among IBD patients,while the lack of clear guidelines on safe exercise regimens contributes to a norm of physical *** activity(PA)is accepted to have a positive effect on disease outcomes and quality of life,while inactivity exacerbates comorbidities like cardiovascular disease and mental health ***“BE-FIT-IBD”study,focusing on PA levels and barriers in IBD patients of Southern Italy,revealed that a significant proportion(42.9%)were physically *** lack of PA is attributed to barriers such as fear of flare-ups and misconceptions about exercise exacerbating the *** study also highlighted the need for better communication between healthcare providers and patients regarding the benefits of PA and safe incorporation into ***,physical inactivity may also contribute to disability in IBD patients,having a great impact on employment *** note is the fact that IBD also comes with an important psychological burden with relevant evidence suggesting that regular PA can improve mood,reduce anxiety,and enhance mental ***“BE-FIT-IBD”study advocated for the integration of PA into IBD management,emphasizing the bidirectional link between PA and *** exe

关键词： Inflammatory bowel disease Physical activity Disability Psychological burden Body composition Quality of life

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Repeatability,interocular correlation and agreement of optic nerve head vessel density in healthy eyes:a sweptsource optical coherence tomographic angiography study

引用

International Journal of Ophthalmology(English edition) 2024年第5期17卷 896-903页

作者： Dan-Qi Fang Da-Wei Yang Xiao-Ting Mai carol Y Cheung Hao-Yu Chen Joint Shantou International Eye Center Shantou University&the Chinese University of Hong KongShantou 515041Guangdong ProvinceChina Department of Ophthalmology and Visual Sciences Chinese University of Hong KongHong Kong 999077China

AIM:To assess the repeatability,interocular correlation,and agreement of quantitative swept-source optical coherence tomography angiography(OCTA)optic nerve head(ONH)parameters in healthy ***:Thir ty-three healthy subjects were *** ONH of both eyes were imaged four times by a swept-source-OCTA using a 3 mm×3 mm scanning *** of the radial peripapillary capillary were analyzed by a customized Matlab program,and the vessel density,fractal dimension,and vessel diameter index were *** repeatability of the four scans was determined by the intraclass correlation coefficient(ICC).The most well-centered optic disc from the four repeated scans was then selected for the interocular correlation and agreement analysis using the Pearson correlation coefficient,ICC and Bland-Altman ***:All swept-source-OCTA ONH parameters exhibited certain repeatability,with ICC>0.760 and coefficient of variation(CoV)≤7.301%.The obvious interocular correlation was observed for papillary vessel density(ICC=0.857),vessel diameter index(ICC=0.857)and fractal dimension(ICC=0.906),while circumpapillary vessel density exhibited moderate interocular correlation(ICC=0.687).Bland-Altman plots revealed an agreement range of-5.26%to 6.21%for circumpapillary vessel ***:OCTA ONH parameters demonstrate good repeatability in healthy *** interocular correlations of papillary vessel density,fractal dimension and vessel diameter index are high,but the correlation for circumpapillary vessel density is moderate.

关键词： interocular correlation repeatability optic nerve head optical coherence tomography angiography vessel density

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

AI-Based Advanced Approaches and Dry Eye Disease Detection Based on Multi-Source Evidence:Cases,Applications,Issues,and Future Directions

引用

Big Data Mining and Analytics 2024年第2期7卷 445-484页

作者： Mini Han Wang Lumin Xing Yi Pan Feng gu Junbin Fang Xiangrong Yu Chi Pui Pang Kelvin Kam-Lung Chong carol Yim-Lui Cheung Xulin Liao Xiaoxiao Fang Jie Yang Ruoyu Zhou Xiaoshu Zhou Fengling Wang Wenjian Liu Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University/The First Affiliated Hospital of Faculty of Medicine Macao University of Science and Technology) Zhuhai 519000China Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong Kong 999077China Faculty of Data Science City University of MacaoMacao 999078China Zhuhai Institute of Advanced Technology Chinese Academy of Sciences Zhuhai 519000China Perspective Technology group Zhuhai 519000China First Affiliated Hospital of Shandong First Medical University Shandong Provincial Qianfoshan Hospital Jinan 250000China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518000China College of Staten Island The City University of New YorkNY 10314USA Department of Optoelectronic Engineering Jinan UniversityGuangzhou 510000China Zhuhai Aier Eye Hospital Zhuhai 519000China College of Artificial Intelligence Chongqing Industry and Trade PolytechnicChongqing 400000China Centre for Science and Technology Exchange and Cooperation between China and Portuguese-Speaking Countries Zhuhai 519000China School of Artificial Intelligence Hezhou UniversityHezhou 542899China

This study explores the potential of Artificial Intelligence(AI)in early screening and prognosis of Dry Eye Disease(DED),aiming to enhance the accuracy of therapeutic approaches for eye-care *** the promising opportunities,challenges such as diverse diagnostic evidence,complex etiology,and interdisciplinary knowledge integration impede the interpretability,reliability,and applicability of AI-based DED detection *** research conducts a comprehensive review of datasets,diagnostic evidence,and standards,as well as advanced algorithms in AI-based DED detection over the past five *** DED diagnostic methods are categorized into three groups based on their relationship with AI techniques:(1)those with ground truth and/or comparable standards,(2)potential AI-based methods with significant advantages,and(3)supplementary methods for AI-based DED *** study proposes suggested DED detection standards,the combination of multiple diagnostic evidence,and future research directions to guide further ***,the research contributes to the advancement of ophthalmic disease detection by providing insights into knowledge foundations,advanced methods,challenges,and potential future perspectives,emphasizing the significant role of AI in both academic and practical aspects of ophthalmology.

关键词： Artificial Intelligence(AI) ophthalmology Dry Eye Disease(DED)detection multi-source evidence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

女性商学院院长增多缩小性别差距

引用

商业周刊（中文版） 2024年第5期 14-15页

作者： carol Hymowitz 汪泽(译) 不详

在美国商学院中,担任领导职务的女性和男性之间的差距一直在缩小,特别是越来越多的女性被提拔到有望担任院长的后备职位上。据美国精英商学院协会(Association to Advance Collegiate Schools of Business,简筒称AACSB)的一项研究,2023-... 详细信息

在美国商学院中,担任领导职务的女性和男性之间的差距一直在缩小,特别是越来越多的女性被提拔到有望担任院长的后备职位上。据美国精英商学院协会(Association to Advance Collegiate Schools of Business,简筒称AACSB)的一项研究,2023-2024年,美国368所商学院的女院长占总数的30%。这比2007-08年的17%有所提高。

关键词：领导职务 AACSB 商学院性别差距

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Lonely Moon

引用

语数外学习(初中版) 2024年第6期 1-1页

作者： carol Coven grannick

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neocosmopolitan distributions of invertebrate aquatic invasive species due to euryhaline geographic history and human-mediated dispersal: Ponto-Caspian versus other geographic origins

引用

Ecological Processes 2023年第1期12卷 15-30页

作者： Aldona Dobrzycka-Krahel carol A.Stepien Zofia Nuc WSB University in gdańsk Faculty of Oceanography and geography Institute of Oceanography University of Gdansk Department of Vertebrate Zoology Smithsonian Institution National Museum of Natural History

Background: Aquatic invertebrate species that have broad salinity tolerances may be pre-adapted for invasion success and biogeographic distributional range expansions, facilitated by human-mediated dispersal(HMD), leading to a trend to become neocosmopolitan across many regions of the world. This pattern appears to characterize many Ponto-Caspian(P-C) aquatic invertebrates, which have a > 100-year history as aquatic invasive species(AIS), spreading throughout much of Eurasia and for some, in North America and beyond. Our study compiles comparative salinity conditions and distributional data for AIS invertebrate species globally versus those originating from the P-C region, to test whether they statistically ***: Our investigation discerns that a total of 1861 invertebrate AIS taxa have been recorded worldwide, with(A)70.5% exclusively living in the saline adaptive zone of brackish(0.5–30 ppt; A1) and/or marine waters(> 30 ppt; A2),(B) 20% in the freshwater adaptive zone alone(0–0.5 ppt),(C) 7.5% being euryhaline(across both A and B), and(D) 2%being semi-aquatic in either(D1) freshwater/terrestrial or(D2) saline/terrestrial environments. In contrast, our results indicate the following proportions for AIS invertebrates of P-C origins:(A) 27% exclusively inhabit the saline adaptive zone,(B) 25% are entirely freshwater,(C) 45% are euryhaline, and(D) 3% are semi-aquatic, significantly differing from the global pattern. Euryhaline AIS native to the P-C region thus markedly outnumber(45%) those originating from other regions(7.5%), likely pre-adapting them for widespread establishment in harbors, estuaries, and coastal ***, most P-C invertebrate AIS(70%) contain freshwater-tolerant populations(B + C), rendering them very successful invaders of inland water bodies. These broad salinity tolerances of P-C AIS underlie their tremendous invasion successes and growing neocosmopolitan distributions with ***: An evolutionary and recent history of

关键词： Aquatic invasive species Biogeography Distribution pattern Euryhalinity Freshwater adaptive zone Invasive species Neocosmopolitan Nonindigenous species Saline adaptive zone Zebra mussel

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Vulnerability analysis of the Chinese coupled aviation and high-speed railway network

引用

Chinese Journal of Aeronautics 2022年第12期35卷 189-199页

作者： Yiqiao WANg Xianbin CAO Fangyun QIN Lu(carol)TONg School of Electronic and Information Engineering Beihang UniversityBeijing 100191China School of Information Engineering Capital Normal UniversityBeijing 100191China

The integrated aviation and High-Speed Railway(HSR)transportation system plays a vital role for today’s inter-city transportation ***,an increasing number of unexpected disruptions(such as operation failures,natural disasters,or intentional attacks)pose a considerable threat to the normal operation of the system,especially on ground transfer,leading to the extensive research on its *** approaches mainly focus on interruptions within a single transportation mode,neglecting the role of ground transfer which serves as a coupled connection between aviation and High-Speed *** paper proposes a network-based framework for evaluating the vulnerability of the Chinese Coupled Aviation and High-Speed Railway(CAHSR)network from the viewpoint of ground transfer *** the end-to-end travel time and passenger flow information into consideration as an evaluation measure and analyzing from the perspective of urban agglomerations,an adaptive method is developed to identify the critical cities and further investigate their failure impacts on the geographic distribution of *** addition,the proposed model explores variations of vulnerability under different failure time *** on the empirical study,some major conclusions are highlighted as follows:(A)Only a few cities show significant impacts on the network’s vulnerability when ground transfer interruptions occurred.(B)The distribution of vulnerability is not proportional to the distance between failure city and influenced city.(C)The vulnerability is more serious in the morning and evening when the ground transfer is *** findings may provide new insights for maintenance and optimization of the CAHSR network and other real-world transportation networks.

关键词： Air transportation Complex networks Railway network Transfer Vulnerability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

生物学、命运、摄影:戴安·阿勃丝的差异性

引用

世界美术 2024年第2期 53-65页

作者：卡罗尔·阿姆斯特朗洪枫(译) 耶鲁大学艺术史北京大学新闻与传播学院

序起初是罅隙。罅隙区分了光与暗、男与女、物种与物种、个体与个体、特殊性与特殊性。罅隙滋生更多的裂缝;差异繁衍更多的分歧。罅隙无休止地变异、激增,遍布整个世界,直至世界充满裂缝,成为一个无限的、无等级编号、无可精简的差异集... 详细信息

序起初是罅隙。罅隙区分了光与暗、男与女、物种与物种、个体与个体、特殊性与特殊性。罅隙滋生更多的裂缝;差异繁衍更多的分歧。罅隙无休止地变异、激增,遍布整个世界,直至世界充满裂缝,成为一个无限的、无等级编号、无可精简的差异集。而摄影生于这罅隙,它的命运是在白与灰中找到黑,复制差异,再现罅隙。

关键词：男与女摄影生物学罅隙差异性特殊性命运

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Digital ID framework for human-centric monitoring and control of smart buildings

引用

Building Simulation 2022年第10期15卷 1709-1728页

作者： Min Deng Xi Wang Da Li carol C.Menassa Department of Civil and Environmental Engineering University of MichiganAnn ArborMI 48109USA glenn Department of Civil Engineering Clemson UniversityClemsonSC 29634USA

Smart offices can help employers attract and retain talented people and can positively impact well-being and *** to emerging technologies and increased computational power,smart buildings with a specific focus on personal experience are gaining ***-time monitoring and estimation of the human states are key to achieving individual *** some studies have incorporated real-time data into the buildings to predict occupants’indoor experience(e.g.,thermal comfort and work engagement),a detailed framework to integrate personal prediction models with building systems has not been well ***,this paper proposes a framework to predict and track the real-time states of each individual and assist with decision-making(e.g.,room assignment and indoor environment control).The core idea of the framework is to distinguish individuals by a new concept of Digital ID(DID),which is then integrated with recognition,prediction,recommendation,visualization,and feedback *** establishment of the DID database is discussed and a systematic prediction methodology to determine occupants’indoor comfort is *** on the prediction results,the Comfort Score Index(CSI)is proposed to give recommendations regarding the best-fit rooms for each *** addition,a visualization platform is developed for real-time monitoring of the indoor *** demonstrate the framework,a case study is *** thermal sensation is considered the reference for the room allocation,and two groups of people are used to demonstrate the framework in different *** one group of people,it is assumed that they are existing occupants with personal DID *** in another group are considered the new occupants without any personal database,and the public database is used to give initial guesses about their thermal *** results show that the recommended rooms can provide better thermal environments for the occupan

关键词： smart office digital ID(DID) comfort prediction space recommendation human-centric monitoring real-time visualization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：