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Molecular basis of the potential of mesalazine to prevent colorectal cancer

World Journal of Gastroenterology 2008年第28期14卷 4434-4439页

作者： carmine stolfi Roberto Pellegrini Eleonora Franzè Francesco Pallone Giovanni Monteleone Department of Internal Medicine University Tor Vergata of RomeRome 00133Italy

Patients with ulcerative colitis (UC) and Crohn's disease (CD) are at increased risk for developing colorectal cancer (CRC), and this is believed to be a result of chronic inflammation. Although conclusive evidence is still missing, both epidemiological and experimental observations suggest that certain drugs used to treat inflammation, such as mesalazine, can reduce the incidence of colitis-associated CRC. Therefore, in recent years, several studies have been conducted to dissect the mechanisms by which mesalazine interferes with CRC cell growth and survival. This review summarizes the current information on the molecular mechanisms that underlie the antineoplastic action of mesalazine.

关键词： Chemoprevention Colorectal cancer Cyclooxygenase-2 Epidermal growth factor receptor Inflammatory bowel disease Mesalazine Wnt/β-catenin

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Detection methods and clinical significance of free peritoneal tumor cells found during colorectal cancer surgery

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World Journal of Gastrointestinal Surgery 2015年第9期7卷 178-184页

作者： Simone Sibio Cristina Fiorani carmine stolfi Andrea Divizia Roberto Pezzuto Fabrizio Montagnese Giulia Bagaglini Paolo Sammartino Giuseppe Sigismondo Sica Department of Surgery Pietro Valdoni Sapienza University of Rome Department of Surgical Science Tor Vergata University of Rome

Peritoneal washing is now part of the standard clinical practice in several abdominal and pelvic neoplasias. However, in colorectal cancer surgery, intra-peritoneal free cancer cells(IFCC) presence is not routinely investigated and their prognostic meaning is still unclear. When peritoneal washing results are positive for the presence of IFCC a worse outcome is usually expected in these colorectal cancer operated patients, but it what is not clear is whether it is associated with an increased risk of local recurrence. It is authors' belief that one of the main reasons why IFCC are not researched as integral part of the routine staging system for colon cancer is that there still isn't a diagnostic or detection method with enough sensibility and specificity. However, the potential clinical implications of a routine research for the presence IFCC in colon neoplasias are enormous: not only to obtain a more accurate clinical staging but also to offer different therapy protocols, based on the presence of IFCC. Based on this, adjuvant chemotherapy could be offered to those patients found to be positive for IFCC; also, protocols of proactive intraperitoneal chemotherapy could be applied. Although presence of IFCC appears to have a valid prognostic significance, further studies are needed to standardize detection and examination procedures, to determine if there are and which are the stages more likely to benefit from routine search for IFCC.

关键词： Colorectal cancer Cytology Free cancer cells Perit

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