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The potential of natural products for targeting PPARα

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Acta Pharmaceutica Sinica B 2017年第4期7卷 427-438页

作者： Daniela Rigano carmina Sirignano Orazio Taglialatela-Scafati Department of Pharmacy University of Naples Federico IINaples I-80131Italy

Peroxisome proliferator activated receptors(PPARs) α,-γ and-β/δ are ligand-activated transcription factors and members of the superfamily of nuclear hormone receptor. These receptors play key roles in maintaining glucose and lipid homeostasis by modulating gene expression. PPARs constitute a recognized druggable target and indeed several classes of drugs used in the treatment of metabolic disease symptoms, such as dyslipidemia(fibrates, e.g. fenofibrate and gemfibrozil) and diabetes(thiazolidinediones, e.g. rosiglitazone and pioglitazone) are ligands for the various PPAR isoforms. More precisely, antidiabetic thiazolidinediones act on PPARγ, while PPARα is the main molecular target of antidyslipidemic fibrates. Over the past few years, our understanding of the mechanism underlying the PPAR modulation of gene expression has greatly increased. This review presents a survey on terrestrial and marine natural products modulating the PPARα system with the objective of highlighting how the incredible chemodiversity of natural products can provide innovative leads for this "hot" target.

关键词： PPAR 自然产品行动的机制 Dyslipidemia 新陈代谢的症候群

Development of a chromatographic lateral flow immunoassay for detection of African swine fever virus antigen in blood

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Animal Diseases 2022年第3期2卷 139-153页

作者： Daniel W.Madden Sun-Young Sunwoo Natasha N.Gaudreault Jessie D.Trujillo Igor Morozov carmina Gallardo Juergen A.Richt Department of Diagnostic Medicine/Pathobiology College of Veterinary MedicineKansas State UniversityManhattanKSUSA Centro de Investigación en Sanidad Animal(CISA-INIA/CSIC) MadridSpain

African swine fever(ASF)is a highly lethal disease of domestic and wild swine caused by African swine fever virus(ASFV).The disease currently circulates in Africa,Europe,Asia and on the island of *** ongoing epizootics in Europe and Asia have produced millions of animal deaths and severe economic *** effective vaccine is available for ASF,making rapid and accurate detection of ASFV essential for disease mitigation *** available diagnostics for ASFV possess significant limitations related to assay performance,deployability,and/or turn-around time;therefore there is an unmet need for pen-side diagnostic tests with sufficient sensitivity and specificity.A chromatographic lateral flow immunoassay(LFIA)was developed for the detection of ASFV antigen in EDTA-treated whole blood using monoclonal antibodies targeting the viral p30 *** assay requires only water to perform and provides results in 25 min,making it well-suited for field *** LFIA was capable of detecting genotype I and genotype II strains of ASFV in EDTA blood from experimentally infected pigs at varying time-points after infection,though it was unable to detect a genotype X ASFV *** sensitivity correlated with clinical disease severity,body temperature,and viral DNA levels,and was over 90%in animals showing moderate to severe ASF-related symptoms after challenge with virulent genotype II *** LFIA also showed a robust diagnostic specificity of over 98%,which is essential to field testing for a high consequence to foregin animal *** LFIA targeting the viral p30 protein can reliably detect ASFV in whole blood from animals showing moderate to severe clinical signs of infection with virulent genotype I and II isolates,making it a promising candidate for use as a field-deployable antigen detection *** evaluation using field samples and different virus strains is required to further assess the utility of this rapid diagnostic test.

关键词： African swine fever Lateral flow immunoassay Point of care diagnostics

Neuroinflammation and neurological alterations in chronic liver diseases

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Neuroimmunology and Neuroinflammation 2015年第1期2卷 138-144页

作者： carmina Montoliu Marta Llansola Vicente Felipo Research Foundation of the Clinic Hospital of Valencia Health Research Institute-INCLIVA46010 ValenciaSpain Laboratory of Neurobiology Prince Felipe Research Center46012 ValenciaSpain

Several million people with chronic liver diseases(cirrhosis,hepatitis)show neurological alterations,named hepatic encephalopathy(HE)with cognitive and motor alterations that impair quality of life and reduces life *** acts synergistically with hyperammonemia to induce cognitive and motor alterations in patients with chronic liver disease and minimal hepatic encephalopathy(MHE).Previous studies in animal models have suggested that neuroinflammation is a major player in *** would also be the case in patients with liver cirrhosis or hepatitis C with *** with MHE show microglial activation and neuroinflammation that is associated with cognitive impairment and *** anti-inflammatory drug ibuprofen reduces microglial activation and neuroinflammation and restores cognitive and motor functions in rats with *** hyperammonemia per se induces *** peripheral inflammation and hyperammonemia would contribute to neuroinflammation in chronic liver ***,neuroinflammation may be a key therapeutic target to improve the cognitive and motor alterations in MHE and overt *** new targets to reduce neuroinflammation in MHE without inducing secondary effects would serve to develop new therapeutic tools to reverse the cognitive and motor alterations in patients with HE associated with chronic liver diseases.

关键词： Cognitive impairment hepatic encephalopathy hyperammonemia inflammation motor function neuroinflammation

Gamma Irradiation Effect on Nylon 6-12 Modification under Argon Atmosphere

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材料科学与工程（中英文B版） 2012年第4期2卷 247-254页

作者： carmina menchaca Griselda Demesa Anabel Santiaguillo Gonzalo Martinez-Barrera Hetor Lopez-Valdivia Hetor Carrasco Jorge Uruchurtu Centro de Investigacion en Ingenieria y Ciencias Aplicadas （CIICAp） Universidad Aut6noma del Estado de Morelos Cuernavaca Morelos Mexico Laboratorio de Investigacion y Desarrollo de Materiales Avanzados （LIDMA） Facultad de Quimica Universidad Aut6noma del Estado de Mexico Edo. de Mexico Mexico Sintesis y Caracterizacion de Materiales Instituto Nacional de lnvestigaciones Nucleares Edo. de Mexico Mexico

Nylon is an important industrial material, and gamma irradiation is used for material modification. In this work, different gamma radiation dose were applied to crystalline fibres of nylon 6-12 at room temperature under argon atmosphere. Post-radiation effect was also studied, to know the effects of time. Some physical properties were measured obtaining the degree of modification with respect to the applied dose. X-ray values showed increment on the crystallinity and crystal size with dose increase up to 300 kGy. Brill Transition can be appreciated as a result of the in-situ X-ray with temperature study. Thermal analyses and AFM roughness measurements corroborate the modifying mechanisms in terms of the applied dose. For 15 and 50 kGy re-polymerization and crosslinking are the main mechanisms. Increment in the melting point at 15 kGy occurs, returning at 50 kGy to the original value. For 100 to 300 kGy the chain scission is the dominant mechanism because the melting point is lower than the original one. Both mechanisms take place in the amorphous zone.

关键词：改性尼龙辐射效应氩气保护伽玛辐射剂量原子力显微镜 γ射线辐照粗糙度测量

Augmented Reality:an Emerging Field in Pediatric Psycho-oncology Requiring Research

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Advances in Modern Oncology Research 2018年第6期4卷 1-4页

作者： carmina Castellano-Tejedor Andrés Cencerrado Psynaptic Psicología y Servicios Científicos y Tecnológicos S.L.P.Avenida Egara 3008192Sant Quirze del Vallès(Barcelona)Spain GIES Research Group Basic Psychology DepartmentUniversitat Autònoma de Barcelona08192Bellaterra(Barcelona)Spain RE-FiT BCN Research Group Parc Sanitari Pere Virgili&Vall d'Hebron Institute of Research08023Barcelona(Barcelona)Spain Computer Architecture and Operating Systems Department Universitat Autònoma de Barcelona08193Bellaterra(Barcelona)Spain

Augmented reality(onwards,AR)technologies are now much more complex and feature a higher number of details thanks to advancements in information and communication technologies(ICTs).Today’s systems can be easily adapted and packaged into smartphone apps which enable a wide range of applications in real and clinical *** impact on behavioral health treatments,rehabilitation and healthcare system in general is just beginning to become evident[1]but still,more research providing evidence-based practices is required.

关键词： details enable smart

Polymer Surface Roughness Determination throughout the Hurst Analysis from Optical Signal Measurements

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材料科学与工程（中英文版） 2010年第11期4卷 26-31页

作者： Antonio Marban Oscar Sarmiento-Martinez Darwin Mayorga-Cruz carmina menchaca Jorge Uruchurtu Centro de Investigaciones en Ingenieria y Ciencias Aplieadas-CIICAp Av Universidad 1001 Chamilpa Cuernavaca MorelosMexico Universidad Autonoma Metropolitana- UAM Azcapotzalco Avenida del Rosario Azcapotzalco Mexico D.F.

Otoacoustic Emissions and Evoked Potentials in Infants after Breast-Feeding Jaundice——Hearing Dysfunction in Breast-Feeding Jaundice

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Neuroscience & Medicine 2012年第3期3卷 270-274页

作者： Adrián Poblano Norma Ballesteros carmina Arteaga Blanca Flores Teodoro Flores Laboratory of Clinical Neu-rophysiology National Institute of Rehabilitation Mexico City Mexico Laboratory of Cognitive Neurophysiology National Institute of Rehabilitation Mexico City Mexico

We study hearing in a group of infants with Breast-feeding jaundice (BFJ) by means of Transient-evoked otoacoustic emissions (T-EOE) and Brainstem auditory evoked potentials (BAEP) searching for relationship between bilirubin serum levels and auditory dysfunction. Eleven infants born at-term with BFJ were selected for the study. We studied also 11 control age- and gender matched healthy at-term infants without signs of jaundice. T-EOAE studies were performed between 5-7 days after birth, and 3 months later. BAEP studies were performed once. BFJ group infants exhibited lower amplitudes in T-EOE than infants in the control group. These differences disappear at the 3-month evaluation. In BAEP, we observed a significant latency delay of waves I and V in Breast-feeding jaundice group infants. All infants in both groups demonstrated reproducible wave V response at 30 decibels. No significant correlation values were observed between bilirubin serum levels and T-EOE and BAEP variables. Our data suggest that BFJ can result in transient peripheral and central auditory dysfunction. Dysfunction is reversible after treatment of infants with BFJ.

关键词： Breast-Feed Jaundice Hyperbilirubinemia Hearing Neonates Transient-Evoked Otoacoustic Emissions Brainstem Auditory Evoked Potentials

Gamma-Irradiated Nylon Roughness as Function of Dose and Time by the Hurst and Fractal Dimension Analysis

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材料科学与工程（中英文版） 2010年第9期4卷 50-58页

作者： carmina menchaca Juan Carlos Nava Sofia Valdez Oscar Sarmiento-Martinez Jorge Uruchurtu Centro de Investigacion en lngenieria y Ciencias Aplicadas （CllCAp） Universidad Autonoma del Estado de Morelos Cuernavaea Morelos 62209 Mexico

FUNDAMENTAL STUDY ON A SECURE PRINTING PROCESS USING NANOWORK STENCILS FOR 01005 COMPONENTS

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FUNDAMENTAL STUDY ON A SECURE PRINTING PROCESS USING NANOWOR...