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<i>SEPT10</i>Expression in Chronic Lymphocytic Leukemia. Correlation with Clinical and Biological Prognostic Factors

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Open Journal of Blood Diseases 2013年第3期3卷 11-16页

作者： Ana Travella Julieta Panero carmen stanganelli Raimundo Bezares Irma Slavutsky División Patología Molecular Instituto de Investigaciones Hematológicas Academia Nacional de Medi- cina Buenos Aires Argentina Laboratorio de Genética de Neoplasias Linfoides Instituto de Medicina Experimental CONICET-Academia Nacional de Medicina Buenos Aires Argentina Servicio de Hematología Hospital General de Agudos “Dr Teodoro álvarez” Buenos Aires Ar- gentina.

Chronic lymphocytic leukemia (CLL) is characterized by a highly variable clinical course. Microarray studies allowed highlight genes differentially expressed in this pathology. In this study, we have evaluated the prognostic significance of SEPT10 expression in CLL patients. Results were correlated with immunoglobulin heavy-chain variable (IGHV) genes mutational status, genomic rearrangements and clinical parameters. SEPT10 mRNA levels were determined by quantitative real-time PCR in 70 newly diagnosed CLL patients consecutively referred to our Institution. A wide heterogeneity for SEPT10 expression was found. Gene upregulation was observed in 18.5% of cases. The univariate analysis showed a positive association between gen expression and platelet count (p 0.0001) and a negative correlation with hemoglobin levels (p = 0.0094). Although no significant differences were observed, mean treatment free survival was shorter in patients with high expression (31 months) with respect to those with low mRNA levels (72 months). Cases with abnormal karyotypes had increased expression compared to those with normal karyotypes and no association between gene expression and FISH (fluorescence in situ hybridization) risk groups and IGHV mutational status was found. Cases using IGHV3-23 gene rearrangement had low SEPT10 expression. Our results showed an association between SEPT10 expression and features of adverse outcome but without independent prognostic value. The study of SEPT10 expression may be important for a better understanding of disease heterogeneity, adding further information to those provided by established prognostic factors.

关键词： Chronic Lymphocytic Leukemia SEPT10 Expression FISH Cytogenetics IGHV Mutational Status

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