检索结果-南通市图书馆

Stratified Cox Regression Analysis of Survival under CIMAvax^(■)EGF Vaccine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2013年第8期4卷 8-14页

作者： carmen viada gonzalez Jean-Francois Dupuy Martha Fors López Patricia Lorenzo Luaces Camilo Rodríguez Rodríguez Gisela González Marinello Elia Neninger Vinagera Beatriz García Verdecia Bárbara Wilkinson Brito Liana Martínez Pérez Mayelin Troche de la Concepción Tania Crombet-Ramos Center of Molecular Immunology HavanaCuba Institut National des Sciences Appliquées de Rennes RennesFrance National Coordinator Center of Clinical Trial HavanaCuba Hermanos Ameijeiras Hospital HavanaCuba

Background: The Center of Molecular Immunology (CIM) is a center in Cuba devoted to the research, development and manufacturing of biotechnological products. CIMAvax?EGF is a vaccine for the treatment of non-small cell lung cancer patients (NSCL). Purpose: The aim of this work is to evaluate the effects of some potential prognostic factors on the overall survival of patients treated with CIMAvax?EGF vaccine, based on data collected in a phase II and a phase III clinical trials. Methods: The stratified Cox regression model is used to evaluate the effects of these prognostic factors, based on separate analysis for each trial, and on the combined data from both trials. Results: Patients with Performance status 0 or 1, with IV stage of tumor and male under 60 years obtain more benefit in terms of overall survival if they receive CIMAvax?EGF. Conclusions: Vaccinated group has a better performance if patients have a performance status 0 or 1, stage IV and age under 60 years. These prognostic factors influence overall survival in a positive way for those patients that received CIMAvax?EGF.

关键词： Stratified Cox Regression Model Risk Factor Non-Small Lung Cancer Censored Data

Dynamic assessment of variations in pupil diameter using swept‑source anterior segment optical coherence tomography after phakic collamer lens implantation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Eye and Vision 2021年第6期8卷 396-403页

作者： Felix gonzalez‑Lopez carmen Bouza‑Miguens Victor Tejerina Vasyl Druchkiv Blas Mompean Julio Ortega‑Usobiaga Rafael Bilbao‑Calabuig Department of Refractive Surgery Clinica BavieraMelchor Fernández Almagro928029 MadridSpain Department of Research and Development Clinica BavieraValenciaSpain

Purpose:To dynamically assess variations in pupil diameter induced by changes in brightness in myopic eyes implanted with an implantable collamer lens(ICL,STAAR Surgical)with a central ***:This prospective,observational single-center case series study comprised 65 eyes from 65 consecutive patients undergoing ICL implant.A modified commercially available swept-source Fourier-domain anterior segment optical coherence tomography(AS-OCT)device was used for imaging and performing dynamic pupillometry under changing light conditions before and after a mean follow-up interval of four months after ***:Preoperative mean pupil size under photopic conditions was 3.38±0.64 mm;after surgery,this increased to 3.48±0.61 *** pupil size under scotopic light conditions was 5.72±0.79 mm before surgery and 5.84±0.77 mm *** differences between preoperative and postoperative pupil diameter in miosis and mydriasis were 0.10±0.44 mm(P=0.078)and 0.12±0.58 mm(P=0.098),*** scotopic pupil exceeded the optic zone of the implanted lens in 39 eyes(60%).The mean central vault value was 412±177μm under maximum miosis and 506±190μm under maximum *** found a positive correlation between vault and differences in pupil diameter under all light conditions(P<0.05).Conclusion:Dynamic AS-OCT enables a very precise determination of the pupillary diameter in the iris *** changes in the pupil diameter under different light conditions after the implantation of an ICL are related to the postoperative vault.

关键词： Phakic collamer lens ICL Pupil OCT Central hole Central port Posterior chamber phakic lens

维普期刊数据库

Functional physiotherapy method results for the treatment of idiopathic clubfoot

在线全文

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2019年第6期10卷 235-246页

作者： Noriela carmen Garcia-gonzalez Jorge Hodgson-Ravina Armando Aguirre-Jaime Servicio de Rehabilitacion Servicio de Ortopedia y TraumatologiaUnidad de Investigacion Clinica y ExperimentalHospital Universitario Nuestra Senora de CandelariaSanta Cruz de Tenerife 38010Spain Colegio de Enfermeria Laureate International UniversitiesSanta Cruz de Tenerife 38001Spain

BACKGROUND Idiopathic clubfoot is a congenital deformity of multifactorial *** initial treatment is eminently conservative;one of the methods applied is the Functional physiotherapy method(FPM),which includes different approaches:Robert Debré(RD)and Saint-Vincent-de-Paul(SVP)among *** method is based on manipulations of the foot,bandages,splints and exercises adapted to the motor development of the child aimed to achieve a plantigrade and functional *** hypothesis was that the SVP method could be more efficient than the RD method in correcting deformities,and would decrease the rate of *** To compare the RD and SVP methods,specifically regarding the improvement accomplished and the frequency of surgery needed to achieve a plantigrade *** Retrospective study of 71 idiopathic clubfeet of 46 children born between February 2004 and January 2012,who were evaluated and classified in our hospital according to severity by the Dimeglio-Bensahel *** included moderate,severe and very severe ***-four feet were treated with the RD method and 37 feet with the SVP *** outcomes at a minimum of two years were considered as very good(by physiotherapy),good(by percutaneous heel-cord tenotomy),fair(by limited surgery),and poor(by complete surgery).RESULTS Complete release was not required in any case;limited posterior release was done in 23 cases(74%)with the RD method and 9(25%)with the SVP method(P<0.001).The percutaneous heel-cord tenotomy was done in 2 feet treated with the RD method(7%)and 6 feet(17%)treated with the SVP method(P<0.001).Six feet in the RD group(19%)and twenty-one feet(58%)in the SVP group did not require any surgery(P<0.001).CONCLUSION Our study provides evidence of the superiority of the SVP method over the RD method,as a variation of the FPM,for the treatment of idiopathic clubfoot.

关键词： Congenital clubfoot Clubfeet Talipes equinovarus Conservative treatment Physical therapy Physiotherapy techniques Conservative methods

El poder de la cooperacion y la comunicacion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

今日中国（西文版） 2022年第7期 47-48页

作者： carmen gonzalez 不详

SCORCHING THE ICE Donovan Carrillo,the figure skating ace representing Mexico at the 2022 Olympics

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Beijing Review 2022年第3期65卷 18-19页

作者： carmen gonzalez 不详

Just getting close to the rink is enough to send icy shivers down many a *** it doesn’t seem to bother the skaters in the least;what’s more,they enjoy *** move through the white space with agility and mastery,spinni... 详细信息

关键词： enough representing spinning

《北美自由贸易协定》是中国的良好范例吗?——来自墨西哥和美国的经验

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

江西社会科学 2009年第5期29卷 244-252页

作者： carmen G.gonzalez 郭蕾西雅图大学法学院武汉大学法学院

因为金融与粮食双重危机,中国面临着诸多挑战。中国为战胜这些挑战而做出的努力主要体现在其国际贸易谈判中,而这一谈判基于农业(农产品)贸易自由化有益于南方国家农民的理念。作为全球或地区性贸易协定范式,《北美自由贸易协定》深受... 详细信息

因为金融与粮食双重危机,中国面临着诸多挑战。中国为战胜这些挑战而做出的努力主要体现在其国际贸易谈判中,而这一谈判基于农业(农产品)贸易自由化有益于南方国家农民的理念。作为全球或地区性贸易协定范式,《北美自由贸易协定》深受美国贸易官员青睐,其在美国与墨西哥贸易中的实际影响,或许对中国未来参与双边或多边贸易,协调环境、社会、经济发展关系,正确发挥国家干预力量等能提供借鉴意义。

关键词：《北美自由贸易协定》粮食危机贸易谈判

Pharmacokinetics Evaluation of Nimotuzumab in Combination with Doxorubicin and Cyclophosphamide in Patients with Advanced Breast Cancer

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Life Sciences 2013年第11期7卷 1123-1133页

作者： Leyanis Rodriguez-Vera Eduardo Fernandez-Sanchez Jorge L. Soriano Noide Batista Maite Lima Joaquin gonzalez Robin Garcia carmen viada Concepcion Peraire Helena Colom Mayra Ramos-Suzarte Laboratory of Pharmacokinetic Department of Pharmacology & Toxicology Institute of Pharmacy & Foods 222 St. and 23 Avenue La Coronela La Lisa University of Havana Havana CP 13600 Cuba Center for Research and Biological Evaluation Institute of Pharmacy & Foods 222 St. and 23 Avenue La Coronela La LisaUniversity of Havana Havana CP 13600 Cuba Hermanos Ameijeiras Hospital San L6zaro Avenue and Street Belascoain Havana Center Havana Cuba Center of Molecular Immunology Street 216 and 15 Atabey Playa Havana Cuba Pharmacy and Pharmaceutical Technology Department School of Pharmacy University of Barcelona Barcelona Spain

EGFr （Epidermal growth factor receptor） overexpression has been detected in many tumors of epithelial origin, specifically in breast cancer and it is often associated with tumor growth advantages and poor prognosis. The nimotuzumab is a genetically engineered humanized MAb （monoclonal antibody） that recognizes an epitope located in the extracellular domain of human EGFr. The aim of this study was to assess the pharmacokinetics of nimotuzumab in patients with locally advanced breast cancer who are receiving neoadyuvant therapy combined with the AC chemotherapy regimen （i.e., 60 mg/m2 of Doxorubicin and 600 mg/m2 of Cyclophosphamide in 4 cycles every 21 days）. A single center, non-controlled, open Phase I clinical trial, with histopathological diagnosis of locally advanced stage III breast cancer, was conducted in 12 female patients. Three patients were enrolled at each of the following fixed dose levels： 50, 100, 200 and 400 mg/week. Multiple intermittent short-term intravenous infusions of nimotuzumab were administered weekly, except on weeks 1 and 10, when blood samples were drawn for pharmacokinetic assessments. Nimotuzumab showed dose-dependent kinetics. No anti-idiotypic response against nimotuzumab was detected in blood samples of participants. There was not interaction between the administration of nimotuzumab and chemotherapy at the dose levels studied. The optimal biological doses ranging were estimated to be 200 mg/weekly to 400 mg/weekly.

关键词： Breast cancer epidermal growth factor receptor monoclonal antibody nimotuzumab pharmacokinetics

Lymph node non-Hodgkin's lymphoma incidentally discovered during a nephrectomy for renal cell carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2013年第3期1卷 121-123页

作者： Sergio Fernandez-Pello Luis Rodriguez Villamil Ivan gonzalez Rodriguez Victoria Venta Javier Cuervo carmen Luz Menéndez Urology Department Cabuenes Hospital33203 GijónSpain Pathology Department Cabuenes Hospital33203 GijónSpain

We report the case of a left laparoscopic nephroureterectomy with the incidental discovery of a non-Hodgkin's lymphoma in one of the lymph nodes of the renal hilum. A laparoscopic nephroureterectomy was decided on for a 64-year-old man. Renal cell carcinoma in the kidney and one lymph node of the renal hilum with non-Hodgkin's lymphoma was found. Chemotherapy was not started for the lymphoma discovery. There are no signs of relapse after two years of follow up. Coexistence in the same patient is an extremely rare condition. We review the literature about this issue to clarify this association.

关键词： Renal cell carcinoma Lymphoma Nephrectomy

Comparison of clinical outcomes between unrelated single umbilical cord blood and"ex-vivo"T-cell depleted haploidentical transplantation in children with hematological malignancies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2021年第6期17卷 609-618页

作者： carmen Gomez-Santos Marta gonzalez-Vicent Blanca Molina Natalia Deltoro Blanca Herrero Julia Ruiz Antonio Perez-Martinez Miguel A Diaz Department of Pediatrics Hematopoietic Stem Cell Transplantation UnitHospital Infantil Universitario"Nino Jesus"Menedez Pelayo 6528009 MadridSpain Hospital Infantil Universitario"La Pa"Madrid MadridSpain

Background Over the last two decades,umbilical cord blood(UCB)and haploidentical transplantation(HaploHSCT)have emerged as alternative sources of hematopoietic stem cell for allogeneic *** are few retrospective studies and no prospective studies comparing both types of alternative transplantation in pediatric *** We analyzed the data of 134 children with hematological malignancies who received a hematopoietic stem cell transplantation from a single umbilical cord blood(UCB)(n=42)or an"tex-vivo"T-cell depleted transplant from a haploi-dentical-related donor(HaploHSCT)(n=92)between 1996 and *** recovery was faster after HaploHSCT than the UCB transplant group(median times to neutrophil and platelet recovery:13 vs.16 days,10 vs.57 days,respectively)(P<0.001).The HaploHSCT group had a significantly early immune reconstitution based on NK and CD8+T cells compared with the UCB ***,after the first year *** had a lower number of CD4+ T and B lymphocytes compared with the UCB transplant *** cumulative incidence of TRM was 29±8%in the HaploHSCT group versus 40±5%in the UCB *** incidence was 21±7%in the HaploHSCT group and 19±8%in the UCB *** of DFS was 58±8%in the HaploHSCT group versus 40±9%in the UCB group(P=0.051).Conclusions TCD haploidentical transplant is associated with advantages in terms of engraftment and early immune reconstitution *** haploidentical transplant was associated with lower incidence of infectious and non-infectious complications,especially in the early phases of the transplant compared with UCB transplant ***,there are no advantages in transplant outcomes compared with UCB transplant.

关键词： Children Cord blood transplant Hematologic malignancies Immune reconstitution TCD haploidentical transplant