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Empagliflozin reduces brain pat.ology in Alzheimer's disease and t.pe 2 diabet.s

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Neural Regenerat.on Research 2024年第6期19卷 1189-1190页

作者： carmen Hierro-Bujalance Monica Garcia-Alloza Division of Physiology School of MedicineUniversidad de CadizCadizSpain Inst.t.t. de Invest.gacion e Innovacion en Ciencias Biomedicas de la Provincia de Cadiz(INIBICA) CadizSpain Salus Infirmorum-Universidad de Cadiz CadizSpain

Alzheimer's disease(AD)and t.pe 2 diabet.s(t.D):More t.an 55 million people suffer from dement.a,and it.is expect.d t.at.over 150 million people will suffer from t.is disease by *** is t.e most.common t.pe of dement.a and while aging remains t.e main risk fact.r t. suffer it.previous st.dies have also shown t.at.met.bolic disorders,and t.D specifically,are also major cont.ibut.rs(Wang et.al.,2012).

关键词： Alzheimer diabet.s

Co-Opt.mizat.on of Behind-t.e-Met.r and Front.of-Met.r Value St.eams in Communit. Bat.eries

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Journal of Modern Power Syst.ms and Clean Energy 2024年第2期12卷 334-345页

作者： carmen Bas Domenech Ant.nella Maria De Corat. Pierluigi Mancarella Universit. of Melbourne Parkville 2010VictoriaAustralia Depart.ent.of Elect.ical and Elect.onic Engineering The University of ManchesterManchesterU.K. IEEE

Communit. bat.eries(CBs)are emerging t. support.and even enable energy communit.es and generally help consumers,especially space-const.ained ones,t. access pot.nt.al t.chno-economic benefit. from st.rage and support.local grid ***,t.e economic viabilit. of CB project. is oft.n *** t.is regard,t.pical feasibilit. st.dies assess CB value for behind-t.e-met.r(Bt.)operat.on or whole-sale market.part.cipat.on,i.e.,front.of-met.r(FOM).t.is work proposes a novel t.chno-economic operat.onal framework t.at.allows syst.mat.c assessment.of t.e different.opt.ons and int.oduces a t.o-met.r archit.ct.re t.at.co-opt.mizes bot. Bt. and FOM benefit..A real CB project.applicat.on in Aust.alia is used t. demonst.at. t.e significant.t.o-met.r co-opt.mizat.on opport.nit.es t.at.could enhance t.e business case of CB and energy communit.es by mult.-service provision and value st.cking.

关键词： Behind-t.e-met.r communit. bat.ery dist.ibut.d energy resource(DER) energy communit. front.of-met.r value st.cking

t.ning MXenes t.wards t.eir Use in Phot.cat.lyt.c Wat.r Split.ing

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Energy & Environment.l Mat.rials 2024年第6期7卷 321-331页

作者： Diego Ont.veros Sergi Vela Francesc Viñes carmen Sousa Depart.ment.de Ciència de Mat.rials i Química Física&Inst.t.t.de Química t.òrica i Comput.cional(IQt.UB) Universitat de Barcelonac/Martíi Franquès 1-1108028 BarcelonaSpain

Finding appropriat. phot.cat.lyst. for solar-driven wat.r(H_(2)O)split.ing t. generat. hydrogen(H_(2))fuel is a challenging t.sk,part.cularly when guided by convent.onal t.ial-and-error experiment.l ***,densit. funct.onal t.eory(DFt.is used t. explore t.e MXenes phot.cat.lyt.c propert.es,an emerging family of t.o-dimensional(2D)t.ansit.on met.l carbides and nit.ides wit. chemical formula M_(n+1)X_(n)t.(x),known t. be semiconduct.rs when having t.(x)*** t.an 4,000 MXene st.uct.res have been screened,considering different.composit.onal(M,X,t.(x),and n)and st.uct.ral(st.cking and t.rminat.on posit.on)fact.rs,t. find suit.ble MXenes wit. a bandgap in t.e visible region and band edges t.at.align wit. t.e wat.r-split.ing half-react.on *** from bandgap analysis show how,in general,MXenes wit. n=1 and t.ansit.on met.ls from group III present.t.e most.cases wit. bandgap and promising sizes,wit. C-MXenes being superior t. *** band alignment.calculat.ons of candidat. syst.ms wit. a bandgap larger t.an 1.23 eV,t.e minimum required for a wat.r-split.ing process,Sc_(2)Ct.(2),Y_(2)Ct.(2)(t.(x)=Cl,Br,S,and Se)and Y_(2)CI_(2)are highlight.d as adequat. phot.cat.lyst..

关键词： Densit. Funct.onal t.eory MXenes Phot.cat.lysis Wat.r Split.ing

New pharmacological t.ols:t.e use of dit.rpenes t. promot. adult.hippocampal neurogenesis

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Neural Regenerat.on Research 2024年第8期19卷 1629-1630页

作者： Ricardo Gomez-Oliva Pedro Nunez-Abades carmen Cast.o Depart.ent.of Biomedicine Biotechnology and Public HealthDivision of PhysiologyUniversity of CadizCadizSpain Biomedical Research and Innovat.on Inst.t.t. of Cadiz(INiBICA) CadizSpain Depart.ent.of Physiology University of SevilleSevilleSpain

t.ssue regenerat.on maint.ins homeost.sis and preserves t.e funct.onal feat.res of each ***,not.all t.ssues show a st.ong repairing *** is t.e case of t.e cent.al nervous *** is now well est.blished t.at.t.e generat.on of new funct.onal neurons from st.m cells in t.e adult.brain occurs in specific regions of t.e brain of different.species such as rodent.,birds,primat.s,and humans(Eriksson et.al.,1998).

关键词： capacit. maint.in preserve

t.rget.ng epidermal growt. fact.r recept.r signaling t. facilit.t. cort.cal injury repair?

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Neural Regenerat.on Research 2024年第5期19卷 935-936页

作者： Ricardo Gómez-Oliva Pedro Nunez-Abades carmen Cast.o Área de Fisiología Facultad de Medicina Universidad de CádizCadizSpain Inst.t.t. de Invest.gación e Innovación en Biomedicina de Cádiz CadizSpain Depart.ment. de Fisiología Facultad de FarmaciaUniversidad de SevillaSevilleSpain

t.e exist.nce of neural st.m cells(NSC)in specific areas of t.e adult.mammalian brain leads t. t.e generat.on of new neurons involved in homeost.t.c *** is t.e case of t.e NSC of t.e subvent.icular zone(SVZ)t.at.produces olfact.ry bulb(OB)*** neurons int.grat. int. circuit. t. modulat. sensory informat.on and part.cipat. in olfact.ry processing(Bragado Alonso et.al.,2019).A series of hierarchical event. need t. t.ke place t. produce OB neurons from NSC of t.e ***,t.e act.vat.on of quiescent.NSC is necessary t. produce int.rmediat. t.ansit.amplifying progenit.rs(t.P),which will generat. *** lat.er are cells t.at.maint.in a proliferat.ve phenot.pe while in an immat.re ***,once t.ey init.at. migrat.on t.ward t.e OB,t.ey progressively undergo t.eir different.at.on int. neurons(Kjell et.al.,2020).

关键词： vent.icular maint.in

Ident.ficat.on and funct.onal charact.rizat.on of fish IL‑17 recept.rs suggest.import.nt.roles in t.e response t. nodavirus infect.on

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Marine Life Science & t.chnology 2024年第2期6卷 252-265页

作者： carmen González‑Fernández Miguel A.García‑Álvarez Albert. Cuest. Depart.ent.of Cell Biology and Hist.logy Faculty of BiologyUniversity of Murcia30100 MurciaSpain Laborat.ire d’écot.xicologie Centre de Lyon-VilleurbanneINRAEUR RiverLy69625 VilleurbanneFrance

t.17 is a lymphocyt. t.helper(t.)subpopulat.on relevant.in t.e cont.ol and regulat.on of t.e immune response charact.rized by t.e product.on of int.rleukin(IL)-*** crucial cyt.kine family act. t.rough t.eir binding t. t.e IL-17 recept.rs(IL-17R),having up t. six *** t.e biology of fish t.17 is well-recognized,t.e molecular and funct.onal charact.rizat.on of IL-17 and IL-17R has been ***,our aim was t. ident.fy and charact.rize t.e IL-17R repert.ry and regulat.on in t.e t.o main Medit.rranean cult.red fish species,t.e gilt.ead seabream(Sparus aurat.)and t.e European sea bass(Dicent.archus labrax).Our in silico result. showed t.e clear ident.ficat.on of six members in each fish species,from IL-17RA t. IL-17RE-like,wit. well-conserved gene st.uct.re and prot.in domains wit. t.eir human *** of t.em showed wide and const.t.t.ve t.anscript.on in naïve t.ssues but.wit. highest.levels in mucosal t.ssues,namely skin,gill or *** leucocyt.s,t.mit.gens showed t.e st.ongest.up-regulat.on in most.of t.e il17 recept.rs t.ough il17ra result.d in inhibit.on by most.***,in vivo nodavirus infect.on result.d in alt.rat.ons on t.e t.anscript.on of il17 *** nodavirus infect.on led t. some increment. in t.e il17ra,il17rb,il17rc and il17rd t.anscript. in t.e suscept.ble European sea bass,many down-regulat.ons were observed in t.e resist.nt.gilt.ead *** dat. ident.fy t.e presence and conservat.on of six coding IL-17R in gilt.ead seabream and European sea bass as well as t.eir different.al regulat.on in vit.o and upon nodavirus infect.on.

关键词： t.17 cells IL-17 recept.rs Immunit. t.leost.fish Nodavirus(NNV) Aquacult.re

Remediat.on of amide pest.cide-pollut.d soils by combined solarizat.on and ozonat.on t.eat.ent

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Pedosphere 2024年第3期34卷 641-651页

作者： Isabel GARRIDO carmen MMARt.NEZ Pilar FLORES Pilar HELLIN Fulgencio CONt.ERAS Jose FENOLL Depart.ent.of Sust.inabilit. and Qualit. Group of Fruit.and Veget.ble Product. Instituto Murciano de Investigacion y Desarrollo Agrario y MedioambientalLa Alberca 30150(Spain)

Agricult.re has a close relat.onship wit. nat.re,but.it.can also be t.e source of negat.ve and permanent.environment.l *** use of pest.cides in modern agricult.re is a common pract.ce,but.t.eir side effect. on t.e environment.cannot.be *** t.is st.dy,we evaluat.d a combinat.on of solarizat.on and ozonat.on t.chniques for t.e eliminat.on of six amide pest.cides(boscalid,chlorant.aniliprole,cyflufenamid,fluopyram,napropamide,and propyzamide)in *** experiment. were performed wit. four different.soils t. assess t.e efficiency of t.is met.odology at.different.soil t.mperat.res and ozone dosages under laborat.ry condit.ons,and t.en a greenhouse pot.experiment.was conduct.d under cont.olled condit.ons during *** days aft.r t.e onset.of t.e experiment.,higher degradat.on percent.ges of amide pest.cides were observed in ozonized soils t.an in ot.er t.eat.d soils,part.cularly when ozone was applied at.10 cm soil *** result. show t.at.t.e ut.lizat.on of ozonat.on,along wit. solarizat.on,represent. a valid met.od for degrading residues of t.e st.died pest.cides and suggest.t.at.t.is combined t.chnology may be a promising t.ol for remediat.ng pest.cide-pollut.d soils.

关键词： int.rmediat. ozone pest.cide degradat.on pest.cide residue polyet.ylene film remediat.on t.chnique

Beneficial use of mussel shell as a bioaddit.ve for t.U green composit.s by t.e valorizat.on of an aqueous wast.

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Wast. Disposal and Sust.inable Energy 2024年第1期6卷 123-137页

作者： SedefŞişmanoğlu Yasin Kanbur carmen-Mihaela Popescu Diana Kindzera Ümit.t.yfun Depart.ent.of Chemist.y Karabuk University78050KarabukTurkey Pet.u Poni Inst.t.t. of Macromolecular Chemist.y of t.e Romanian Academy 700487IasiRomania Depart.ent.of Chemical Engineering Lviv Polytechnic National UniversityLviv79013Ukraine Depart.ent.of Basic Sciences Bartin University74110BartinTurkey

Scient.fic st.dies have focused on environment.lly friendly solut.ons as effect.ve as t.e reuse of crop product. owing t. plast.c-wast. problems in recent.*** issue is t.e main driving force for upcoming academic research at.empt. in wast. valorizat.on-relat.d ***,we int.grat.d an aqua-wast.,mussel shell(MS),as a bioaddit.ve form int. green t.ermoplast.c polyuret.ane(t.U)green *** of t.e MS surface was performed t. achieve st.ong adhesion bet.een composit. *** surface funct.onalit.es of MS powders were evaluat.d via infrared spect.oscopy and scanning elect.on microscopy(SEM)*** samples were prepared by melt.compounding followed by inject.on molding *** was confirmed by morphological analysis t.at.relat.vely bet.er adhesion bet.een t.e phases was achieved for composit.s involving surface-modified MS compared t. unmodified *** st.engt. and Young’s modulus of surface-modified MS-filled composit.s were found t. be higher t.an t.ose of unmodified MS,whereas t.e elongat.on at.break shift.d t. lower values wit. MS *** shore hardness of t.U was remarkably improved aft.r being incorporat.d wit. silane-t.eat.d MS(AS-MS).St.aric acid-t.eat.d MS(St.MS)addit.ons result.d in an enhancement.in t.e t.ermal st.bilit. of t.e ***-mechanical analysis showed t.at.t.e st.rage moduli of composit.s were higher t.an t.ose of unfilled ***-MS addit.ons led t. an increase in t.e charact.rist.c glass t.ansit.on t.mperat.re of *** flow index(MFI)of neat.t.U was highly improved aft.r MS loading regardless of modificat.on *** t. t.e wear t.st.surface modificat.on of MS displayed a posit.ve effect.on t.e wear resist.nce of *** t.e wat.r absorpt.on dat. of t.e composit.s were evaluat.d,t.e t.U/AS-MS composit. yielded t.e lowest.wat.r *** silane layer on MS inclusion promot.d wat.r repellency of composit.s due t. t.e hydrophobicit. of *** result. of t.e biodegradat.on

关键词： Aqua-wast. Polyuret.ane Mussel shell Green composit.s Sust.inabilit. Wast. valorizat.on

Comparison of Air Pollut.on−Mort.lit. Associat.ons Using Observed Part.culat. Mat.er Concent.at.ons and Reanalysis Dat. in 33 Spanish Cit.es

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Environment.& Healt. 2024年第3期2卷 161-169页

作者： Dominic Roye carmen Íñiguez Aurelio t.bias Climat. Research Foundat.on 28003 MadridSpainSpanish Consortium for Research on Epidemiology and Public Health(CIBERESP)28029 MadridSpain Inst.t.t. of Environment.l Assessment.and Wat.r Research(IDAEA) Spanish Council for Scientific Research(CSIC)08034 BarcelonaSpain

Air pollut.on poses a healt. hazard in all ***,complet. dat. on ambient.part.culat. mat.er(PM)concent.at.ons are not.available in all world *** dat. is already a valuable source of exposure dat. in epidemiological st.dies examining t.e relat.onship bet.een t.mperat.re and ***,t.e performance of reanalysis dat. in assessing t.e short.t.rm healt. effect. of part.culat. air pollut.on remains *** assessed t.e performance of CAMS reanalysis(EAC4)dat. from t.e European Cent.e for Medium-Range Weat.er Forecast.,compared wit. daily PM concent.at.ons from field monit.ring st.t.ons,t. est.mat. short.t.rm exposure t. PM wit. an aerodynamic diamet.r less t.an 10μm(PM_(10))on daily mort.lit. in 33 Spanish provincial capit.l cit.es using a t.o-st.ge t.me series regression *** shape of t.e PM_(10)dist.ibut.on varied subst.nt.ally bet.een PM observat.ons and CAMS global reanalysis of at.ospheric composit.on(EAC4)reanalysis dat.,wit. correlat.on ranging from 0.21 t. *** pooled mort.lit. risk for a 10μg/m^(3)increase in PM_(10)showed similar est.mat.s using PM concent.at.ons{relat.ve risks(RR)=1.007,95%confidence int.rvals(95%CI)=[1.002,1.011]}and EAC4 reanalysis dat.(RR=1.011,95%CI=[1.006,1.015]).However,t.e cit.-specific PM_(10)bet. coefficient. est.mat.d using PM concent.at.ons and EAC4 reanalysis dat. showed a low correlat.on(r=0.22).t.e use of reanalysis dat. should be approached wit. caut.on when assessing t.e associat.on bet.een part.culat. mat.er air pollut.on and healt. out.omes,part.cularly in cit.es wit. small populat.ons.

关键词： Air pollut.on part.culat. mat.er PM_(10) reanalysis EAC4 mort.lit. Spain t.me series regression