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International Journal of Ophthalmology(English edition) 2014年第4期7卷 697-703页

作者： Lukas Reznicek carmen stumpf Florian Seidensticker Anselm Kampik Aljoscha S Neubauer Marcus Kernt Department of Ophthalmology Ludwig Maximilians University Muenchen

·AIM:Toevaluatethe diagnostic properties of wide-field fundus autofluorescence(FAF) scanning laser ophthalmoscope(SLO) imaging for differentiating choroidal pigmented lesions.·METHODS: A consecutive series of 139 patients were included, 101 had established choroidal melanoma with13 untreated lesions and 98 treated with ***-eight had choroidal nevi. All patients underwent a full ophthalmological examination, undilated wide-field imaging, FAF and standardized US examination. FAF images and imaging characteristics from SLO were correlated with the structural findings in the two patient groups.·RESULTS: Mean FAF intensity of melanomas was significantly lower than the FAF of choroidal nevi. Only 1out of 38 included eyes with nevi touched the optic disc compared to 31 out of 101 eyes with melanomas. In 18 out of 101 melanomas subretinal fluid was seen at the pigmented lesion compared to none seen in eyes with confirmed choroidal nevi. In 'green laser separation', a trend towards more mixed FAF appearance of melanomas compared to nevi was observed. The mean maximal and minimal transverse and longitudinal diameters of melanomas were significantly higher than those of nevi.·CONCLUSION: Wide-field SLO and FAF imaging may be an appropriate non-invasive diagnostic screening tool to differentiate benign from malign pigmented choroidal lesions.

关键词： imaging autofluorescence scanning laser ophthalmoscopy choroidal lesion melanoma

Reactive oxygen species and antioxidant properties from mushrooms

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Synthetic and Systems Biotechnology 2017年第1期2卷 13-22页

作者： carmen Sanchez Laboratory of Biotechnology Research Centre for Biological SciencesUniversidad Autonoma de TlaxcalaIxtacuixtlaTlaxcalaCP.90062Mexico

Preventive medicine and food industry have shown an increased interest in the development of natural antioxidants,since those most commonly used synthetic antioxidants may have restricted use in *** could explain why there is currently much research on the antioxidant properties from natural products such as *** mushrooms have been reported to possess antioxidant properties,which enable them to neutralize free *** oxygen molecule is a free radical,which lead to the generation of the reactive oxygen species and can damage the *** damage caused by free radicals appears to be a major contributor to aging and degenerative *** antioxidant components are found in fruit bodies,mycelium and culture both,which include polysaccharides,tocopherols,phenolics,carotenoids,ergosterol and ascorbic acid among *** bodies or mycelium can be manipulated to produce active compounds in a relatively short period of time,which represent a significant advantage in antioxidant compounds extraction from *** compounds may be extracted to be used as functional additives or mushrooms can be incorporated into our food regime,representing an alternative source of food to prevent damage caused by oxidation in the human body.

关键词： Antioxidant Fruit body Mushroom Mycelium Reactive oxygen species

Selectivity in feeding preferences and ranging patterns in spider monkeys Ateles geoffroyi yucatanensis of northeastern Yucatan peninsula, Mexico

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Current Zoology 2013年第1期59卷 125-134页

作者： carmen SCHERBAUM Alejandro ESTRADA Department of Animal Ecology and Tropical Biology Biozentrum University of Wiirzburg Germany Estacion de Biologia Tropical Los Tuxtlas Instituto de Biologfa Universidad Nacional Aut6noma de M6xico Apartado Postal94 San Andres Tuxtla Veracruz M6xico C. P. 95700

The spider monkey, a fruit specialist and important seed dispersal agent in the Neotropics, is an endangered primate due to habitat loss, hunting and the pet trade. Spider monkeys have been the subject of a few studies in Central and South Ame- rica, but little is known about the diet and ranging for this primate in southern Mexico. Here we report the results of a six-month long study （October 2010 to March 2011） of the feeding preferences and ranging patterns of the Yucatan spider monkey Ateles geoffroyi yucatanensis living in the ＂Ya＇ax＇che＂ reserve by the Caribbean coast in northeast Yucatan peninsula. Focal animal and scan sampling as well as GPS tracking were used to document spider monkey feeding behavior, location of food trees and ranging in the reserve. The spider monkeys used 36 species of plants （94% trees; n = 432） and six non tree morphospecies as a source of food. Six tree species accounted for 〉~80% of total feeding time and for 74% of all trees used. Fruits accounted for 59% of total feeding time, followed by leaves （35%）, palm piths （5%） and other plant parts （1%）. Total range used by the monkeys was esti- mated at 43% of semievergreen rainforest habitat available （ca 40ha）. Range use was not random with segments showing light, moderate and heavy use; the use of different areas of their range varied monthly and was closely linked to the spatial dispersion of the trees used for food [Current Zoology 59 （1）： 125-134, 2013].

关键词： Primates Frugivory Neotropics Conservation Seed dispersal

Effect of dephytinization on bioavailability of iron,calcium and zinc from infant cereals assessed in the Caco-2 cell model

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World Journal of Gastroenterology 2009年第16期15卷 1977-1984页

作者： carmen Frontela Maria Laura Scarino Simonetta Ferruzza Gaspar Ros carmen Martínez Department of Food Science and Nutrition Faculty of Veterinary Science and Food Science and TechnologyMurcia University INRAN National Research Institute for Food and Nutrition

AIM： To test the effect of the dephytinization of three different commercial infant cereals on iron, calcium, and zinc bioavailability by estimating the uptake, retention, and transport by Caco-2 cells. METHODS： Both dephytinized （by adding an exogenous phytase） and non-dephytinized infant cereals were digested using an in vitro digestion protocol adapted to the gastrointestinal conditions of infants younger than 6 too. Mineral cell retention, transport, and uptake from infant cereals were measured using the soluble fraction of the simulated digestion and the Caco-2 cells. RESULTS： Dephytinization of infant cereals significantly increased （P 〈 0.05） the cell uptake efficiency （from 0.66%-6.05% to 3.93%-13%）, retention （from 6.04%-16.68% to 14.75%-20.14%） and transport efficiency （from 0.14%-2.21% to 1.47%-6.02%）, of iron, and the uptake efficiency （from 5.0%-35.4% to 7.3%-41.6%） and retention （from 4.05%-20.53% to 14.45%-61.3%） of zinc, whereas calcium only cell uptake showed a significant increase （P 〈 0.05） after removing phytate from most of the samples analyzed. A positive relationship （P 〈 0.05） between mineral solubility and the cell uptake and transport efficiencies was observed. CONCLUSION： Removing phytate from infant cereals had a beneficial effect on iron and zinc bioavailability when infant cereals were reconstituted with water. Since in developing countries cereal-based complementary foods for infants are usually consumed mixed with water, exogenous phytase additions could improve the nutritional value of this weaning food.

关键词： Infant cereals Phytate Iron Calcium Zinc Caco-2 cells BioavaUability

GRID-INDEPENDENT CONSTRUCTION OF MULTISTEP METHODS

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Journal of Computational Mathematics 2017年第5期35卷 672-692页

作者： carmen Arevalo Gustaf Soderlind Numerical Analysis Centre for Mathematical Sciences Box 118 SE-22100 Lund Sweden.

A new polynomial formulation of variable step size linear multistep methods is pre- sented, where each k-step method is characterized by a fixed set of k - 1 or k parameters. This construction includes all methods of maximal order （p = k for stiff, and p = k ＋ 1 for nonstiff problems）. Supporting time step adaptivity by construction, the new formulation is not based on extending classical fixed step size methods; instead classical methods are obtained as fixed step size restrictions within a unified framework. The methods are imple- mented in MATLAB, with local error estimation and a wide range of step size controllers. This provides a platform for investigating and comparing different multistep method in realistic operational conditions. Computational experiments show that the new multi- step method construction and implementation compares favorably to existing software, although variable order has not yet been included.

关键词： Linear multistep methods Variable step size Adaptive step size Step sizecontrol Explicit methods Implicit methods Nonstiff methods Stiff methods Initial valueproblems Ordinary differential equations Differential-algebraic equations Implementa-tion.

Empagliflozin reduces brain pathology in Alzheimer's disease and type 2 diabetes

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Neural Regeneration Research 2024年第6期19卷 1189-1190页

作者： carmen Hierro-Bujalance Monica Garcia-Alloza Division of Physiology School of MedicineUniversidad de CadizCadizSpain Instituto de Investigacion e Innovacion en Ciencias Biomedicas de la Provincia de Cadiz(INIBICA) CadizSpain Salus Infirmorum-Universidad de Cadiz CadizSpain

Alzheimer's disease(AD)and type 2 diabetes(T2D):More than 55 million people suffer from dementia,and it is expected that over 150 million people will suffer from this disease by *** is the most common type of dementia and while aging remains the main risk factor to suffer it,previous studies have also shown that metabolic disorders,and T2D specifically,are also major contributors(Wang et al.,2012).

关键词： Alzheimer diabetes

Adjuvant treatment in biliary tract cancer: To treat or not to treat?

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World Journal of Gastroenterology 2012年第21期18卷 2591-2596页

作者： Stefano Cereda carmen Belli Michele Reni Department of Oncology San Raffaele Scientific Institute20132 Milan Italy

Biliary tract cancer is a rare malignant tumor. There is limited knowledge about biology and natural history of this disease and considerable uncertainty remains regarding its optimal diagnostic and therapeutic man- agement. The role of adjuvant therapy is object of debate and controversy. Although resection is identified as the most effective and the only potentially curative treatment, there is no consensus on the impact of ad- juvant chemotherapy and/or radiotherapy on the high incidence of disease recurrence and on survival. This is mainly due to the rarity of this disease and the consequent difficulty in performing randomized trials. The only two prospectively controlled trials concluded that adjuvant chemotherapy did not improve survival. Most of the retrospective trials, which had limited sample size and included heterogeneous patients population and non-standardized therapies, suggested a marginal benefit of chemoradiotherapy in reducing locoregional recurrence and an uncertain impact on survival. Welldesigned multi-institutional randomized trials are necessary to clarify the role of adjuvant therapy. Two ongoing phase Ⅲ trials may provide relevant information.

关键词： Biliary tract cancer Adjuvant therapy Chemotherapy Chemoradiation Surgery

Using fluorescence-based microplate assay to assess DOM-metal binding in reactive materials for treatment of acid mine drainage

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Journal of Environmental Sciences 2011年第6期23卷 891-896页

作者： carmen Mihaela Neculita Yves Dudal Gerald J Zagury Department of Civil and Environmental Engineering KAIST335 GwahangnoYuseong-guDaejeon 305-701Korea Institut National de la Recherche Agronomique UMR Eco&Sols-Ecologie Fonctionnelle et Biogéochimie des SolsMontpellier SupAgro-INRA-IRD2Place Pierre VialaBatiment 1234060 Montpellier Cedex 2France Department of Civil Geologicaland Mining EngineeringE'cole Polytechnique de Montre'alC.P.6079 Station Centre-villeMontrealQCH3C 3A7Canada

One potential drawback of compost-based passive bioreactors,which is a promising biotechnology for acid mine drainage（AMD） treatment,is the transport of dissolved organic matter（DOM）-metal complexes in surface *** address this problem,the objective of this study was to assess the maximum capacity of organic substrates to release soluble DOM-metal complexes in treated water. The reactivities of DOM in maple wood chips and sawdust,composted poultry manure,and leaf compost were quantified toward Cd2＋,Ni2＋,Fe2＋,and Cu2＋ using fluorescence *** DOM showed the highest reactivity toward Fe,but a limited number of available sites for sorption,whereas DOM-Cd complexes exhibited the lowest fluorescence ***,the DOM from a mixture of wastes formed higher concentrations of DOM-metal complexes relative to sole *** DOM-metal complexes, the concentrations of DOM-Ni complexes were the *** reaching steady-state,low concentrations of DOM-metal complexes were released in treated water,which is in agreement with theoretical predictions based on geochemical ***,in addition to physicochemical characterization,fluorescence quenching technique is recommended for the substrate selection of bioreactors.

关键词： passive bioreactors acid mine drainage DOM reactivity fluorescence quenching metal complexation

Investigation on directional effects of Vrancea subcrustal earthquakes

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Earthquake Engineering and Engineering Vibration 2015年第3期14卷 399-410页

作者： Florin Pavel Radu Vacareanu Mircea Radulian carmen Cioflan Seismic Risk Assessment Center Technical University of Civil Engineering Bucharest National Institute for Earth Physics (INFP)

This paper evaluates possible directional effects from strong ground motions recorded during the last four significant subcrustal earthquakes produced in the Vrancea seismic zone（Romania） in August 1986（Mw=7.1）,May 1990（Mw=6.9 and 6.4） and October 2004（Mw=6.0）.Several measures of the horizontal component of the ground motion given in the literature（Boore et al.,2006;Boore,2010） are computed and are related to the geometric mean of the as-recorded horizontal *** method is applied in order to quantify the influence of the earthquake magnitude and of the soil class on some strong ground motion parameters（*** intensity,PGV/PGA,or mean period TM）.The study of the directional effects is performed using the distribution of IJMAand of the rotation angle corresponding to a measure of the horizontal component of the ground motion（RotD 100） and the results reveal a visible directional pattern for IJMA,while in the case of RotD100 the directional patterns are less visible.

关键词： response spectra horizontal ground motion directio

Co-Optimization of Behind-the-Meter and Front-of-Meter Value Streams in Community Batteries

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 334-345页

作者： carmen Bas Domenech Antonella Maria De Corato Pierluigi Mancarella University of Melbourne Parkville 2010VictoriaAustralia Department of Electrical and Electronic Engineering The University of ManchesterManchesterU.K. IEEE

Community batteries(CBs)are emerging to support and even enable energy communities and generally help consumers,especially space-constrained ones,to access potential techno-economic benefits from storage and support local grid ***,the economic viability of CB projects is often *** this regard,typical feasibility studies assess CB value for behind-the-meter(BTM)operation or whole-sale market participation,i.e.,front-of-meter(FOM).This work proposes a novel techno-economic operational framework that allows systematic assessment of the different options and introduces a two-meter architecture that co-optimizes both BTM and FOM benefits.A real CB project application in Australia is used to demonstrate the significant two-meter co-optimization opportunities that could enhance the business case of CB and energy communities by multi-service provision and value stacking.

关键词： Behind-the-meter community battery distributed energy resource(DER) energy community front-of-meter value stacking