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Novel approaches in search for biomarkers of cholangiocarcinoma

World Journal of Gastroenterology 2022年第15期28卷 1508-1525页

作者： Lavinia-Patricia Mocan Maria Ilieș carmen stanca melincovici Mihaela Spârchez RareșCrăciun Iuliana Nenu Adelina Horhat Cristian Tefas Zeno Spârchez Cristina Adela Iuga Tudor Mocan carmen Mihaela Mihu Department of Histology Faculty of Medicine"Iuliu Hațieganu"University of Medicine and PharmacyCluj-Napoca 400012Romania Department of Proteomics and Metabolomics MedFUTURE Research Center for Advanced Medicine"Iuliu Hațieganu"University of Medicine and PharmacyCluj-Napoca 400349Romania ^(nd)Pediatrics Department Faculty of Medicine"Iuliu Hațieganu"University of Medicine and PharmacyCluj-Napoca 400012Romania ^(rd)Medical Department Faculty of Medicine"Iuliu Hațieganu"University of Medicine and PharmacyCluj-Napoca 400012Romania Department of Gastroenterology "Prof.dr.Octavian Fodor"Institute for Gastroenterology and HepatologyCluj-Napoca 400162Romania Department of Pharmaceutical Analysis Faculty of Pharmacy"Iuliu Hațieganu"University of Medicine and PharmacyCluj-Napoca 400012Romania

Cholangiocarcinoma(CCA)arises from the ductular epithelium of the biliary tree,either within the liver(intrahepatic CCA)or more commonly from the extrahepatic bile ducts(extrahepatic CCA).This disease has a poor prognosis and a growing worldwide *** poor outcomes of CCA are partially explained by the fact that a final diagnosis is challenging,especially the differential diagnosis between hepatocellular carcinoma and intrahepatic CCA,or distal CCA and pancreatic head *** patients present with an advanced disease,unresectable disease,and there is a lack in non-surgical therapeutic *** least,there is an acute lack of prognostic biomarkers which further complicates disease ***,there is a dire need to find alternative diagnostic and follow-up pathways that can lead to an accurate result,either singlehandedly or combined with other *** the"-omics"era,this goal can be attained by various means,as it has been successfully demonstrated in other primary *** variants can reach a biomarker status ranging from circulating nucleic acids to proteins,metabolites,extracellular vesicles,and ultimately circulating tumor ***,given the relatively heterogeneous data,extracting clinical meaning from the inconsequential noise might become a tall *** current review aims to navigate the nascent waters of the non-invasive approach to CCA and provide an evidence-based input to aid clinical decisions and provide grounds for future research.

关键词： Cholangiocarcinoma Biomarker Proteomics Metabolomics Extracellular vesicles Circulating nucleic acids

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Hepatocellular transport proteins and their role in liver disease

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World Journal of Gastroenterology 2001年第2期7卷 157-169页

作者： carmen stanca Diana Jung Peter J.Meier Gerd A.Kullak-Ublick Division of Gastroenterology and Hepatology and Division of Clinical Pharmacology and Toxicology Department of Internal MedicineUniversity HospitalCH-8091 Zurich/Switzerland

MOLECULAR PHYSIOLLGY OF HEPATOCELLULAR TRANSPORT PROTEINS Basolaferal transport systems Na+-dependent bile salt uptake Uptake of bile salts into the liver was first isolated perfused rat liver[1],isolated hepatocyte... 详细信息

关键词： ATP-Binding Cassette Transporters Animals Carrier Proteins Hepatocytes Humans Liver Liver Diseases Organic Anion Transporters Organic Cation Transport Proteins Research Support, Non-U.S. Gov't

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