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Regulatory circuits involving bud dormancy factor PpeDAM6

Horticulture Research 2021年第1期8卷 3488-3505页

作者： Alba Lloret Carles Quesada-Traver Ana Conejero Vicent Arbona Concepcion Gomez-Mena Cesar Petri Jesus A.Sanchez-Navarro Elena Zuriaga carmen Leida maria Luisa Badenes Gabino Rios Instituto Valenciano de Investigaciones Agrarias 46113 MoncadaValenciaSpain Departament de Ciencies Agraries i del Medi Natural Universitat Jaume ICastello de la PlanaSpain Instituto de Biologia Molecular y Celular de Plantas Universitat Politecnica de Valencia-Consejo Superior de Investigaciones Cientificas46022 ValenciaSpain Departamento de Fruticultura Subtropical y Mediterranea IHSM-UMA-CSICAvenida Dr.Wienbergs/n 29750 Algarrobo-CostaMalagaSpain

DORMANCY-ASSOCIATED MADS-BOX(DAM)genes have recently emerged as key potential regulators of the dormancy cycle and climate adaptation in perennial ***,PpeDAM6 has been proposed to act as a major repressor of bud dormancy release and bud break in peach(Prunus persica).PpeDAM6 expression is downregulated concomitantly with the perception of a given genotype-dependent accumulation of winter chilling time,and the coincident enrichment in H3K27me3 chromatin modification at a specific genomic *** have identified three peach BASIC PENTACYSTEINE PROTEINs(PpeBPCs)interacting with two GA-repeat motifs present in this H3K27me3-enriched ***,PpeBPC1 represses PpeDAM6 promoter activity by transient expression *** the other hand,the heterologous overexpression of PpeDAM6 in European plum(Prunus domestica)alters plant vegetative growth,resulting in dwarf plants tending toward shoot meristem *** alterations in vegetative growth of transgenic lines associate with impaired hormone homeostasis due to the modulation of genes involved in jasmonic acid,cytokinin,abscisic acid,and gibberellin pathways,and the downregulation of shoot meristem factors,specifically in transgenic leaf and apical *** expression of many of these genes is also modified in flower buds of peach concomitantly with PpeDAM6 downregulation,which suggests a role of hormone homeostasis mechanisms in PpeDAM6-dependent maintenance of floral bud dormancy and growth repression.

关键词： homeostasis impaired winter

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Motor Effects of 1,3-Disubstituted 8-Styrylxanthines as A_(1) and A_(2) Adenosine-Receptor Antagonists in Rats

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Pharmacology & Pharmacy 2013年第3期4卷 303-311页

作者： Ilhuicamina Daniel Limon-Perez de Leon maria del carmen Parra-Cid Alejandro Munoz-Zurita Saul Alejandro Merino-Contreras Sara Montiel-Smith Socorro Meza-Reyes Gerardo Ramirez-Meja Jesus Sandoval-Ramirez Facultad de Ciencias Quimicas Benemerita Universidad Autonoma de PueblaPueblaMexico Instituto Nacional de Rehabili-tacion Unidad de Ingenieria de TejidosTerapia Celular y Medicina RegenerativaMexico DFMexico.

A series of 1,3-substituted 8-styrylxanthines (11a-d) was synthesized, under chemo- and regioselective conditions, in a good overall yield. The compounds showed affinity towards both A1 and A2A-adenosine receptors by radioligand binding by means of in vitro assays. The (E)-3-ethyl-1-propyl-8-styrylxanthine (11a) showed the greatest affinity towards the A2A receptor, whereas (E)-3-pentyl-1-propyl-8-styrylxanthine (11d) showed the greatest affinity for the A1 receptor. When the 8-styrylxanthines 11a (A15Et) and 11c (A15Bu) were administrated in rats, which were previously injured with 6-hydroxydopamine at the substantia nigra pars compacta (SNc), the turning behavior decreased 50%. Based on these results we propose to A15Et as a potential compound to treat some symptoms of Parkinson’s disease.

关键词： Xantines Adenosine Receptors Antagonists Turning Behavior Anti-Parkinsonian Drugs

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Plasma Levels of Angiotensin-Converting Enzymes 1 and 2 and <i>AGTR</i>2 (T1247G and A5235G) Gene Polymorphisms Are Associated to Breast Cancer Progression

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Journal of Cancer Therapy 2013年第9期4卷 1403-1410页

作者： maria Del carmen Garcia Molina Wolgien Ismael Dale Cotrim Guerreiro da Silva Afonso Celso Pinto Nazário Clovis Riyuchi Nakaie Silvana Aparecida Alves Corrêa de Noronha Samuel Marcos Ribeiro de Noronha Gil Facina Biophisics Department Escola Paulista de Medicina da Universidade Federal de Sao Paulo (EPM-UNIFESP) Sao Paulo Brazil Gynecology Department Escola Paulista de Medicina/Universidade Federal de Sao Paulo (EPM-UNIFESP) Sao Paulo Brazil Surgery Department Escola Paulista de Medicina/Universidade Federal de Sao Paulo (EPM-UNIFESP) Sao Paulo Brazil

Background: Breast cancer is the most common type of cancer among women. Diagnosed and treated timely, patients may have good prognostics. In Brazil, in 2012, the estimate of new cases was 52,680 and the number of registered deaths in 2012 was 12,852. The Renin-Angiotensin System (RAS) is known for its role in arterial hypertension and in other cardiovascular diseases. Angiotensin-Converting Enzyme 2 (ACE2) is the key to Ang-(1-7) formation, and counterbalances the ACE1/AngII/AGTR1 axis actions. RAS components have complex interactions with different tissues and their actions are not restricted to the cardiovascular system. Recently, the RAS has been associated with different types of cancers and in particular with gynecological cancers. Objectives: Our aim is to investigate possible associations between allelic distribution of two genetic polymorphisms in the AGTR2 receptor with ACEs 1 and 2 plasma levels among women with breast cancer. Patients and Methods: Patients with breast cancer were genotyped for two polymorphisms of the AGTR2 (T1247G and A5235G). Genotyping assays (TaqMan) were performed with genomic DNA extracted from blood cells. ACEs plasma level measurements were conducted in women from the breast-cancer group (N = 53). ACEs were measured in the plasma of these patients using ELISA kits. Results: SNPs genotype distribution is correlated with ACEs plasma levels. ACEs plasma levels are also correlated with clinical variables and ACE2 high levels are associated with better prognostics. Conclusions: Changes in circulating levels of ECA1/AngII ECA2/ Ang-(1-7) determine the magnitude of the inflammatory response that an individual can trigger and the variation in ACE 1 and 2 plasma level measurements in the blood of breast cancer patients suggests an association with the process of mammary carcinogenesis. Thus, the RAS may be associated with the process of mammary carcinogenesis by both genotypic variations of RAS components and by circulating levels of ACEs

关键词： Angiotensin-Converting Enzyme 1 Angiotensin-Converting Enzyme 2 Angiotensin II Type 2 Receptor Breast Neoplasm ACEs Plasma Level Genetic Polymorphisms

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Satisfaction of the Service Provider with the Organization of the Timely Cervical Cancer Detection Program

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Health 2017年第2期9卷 289-298页

作者： Gutierrez-Enriquez Sandra Olimpia Teran-Figueroa Yolanda Gaytan-Hernandez Dario Diaz-Oviedo Aracely Zuniga-Martinez Ma.de Lourdes Hernandez-Nava Nereyda Cruz Ortiz Maribel Perez Rodriguez maria del carmen Ramirez-Ramirez Rocio Faculty of Nursing and Nutrition Autonomous University of San Luis PotosiSan Luis PotosiMexico Academic Coordination Altiplano Region Autonomous University of San Luis PotosiSan Luis PotosiMexico

Cervical cancer is a priority health problem in Mexico. The objective of this work was to know the degree of satisfaction of the service provider with the organization of the program of Timely Detection of Cervical Cancer, specifically in taking of the cervical cytology. The study design was observational, transversal and prospective conducted from January to May 2015 in Jurisdiction 1 of the Health Services of San Luis Potosí, Mexico, in 20 health centers. Participants were 87 service providers whose function is to take cervical cytology (Pap smears). A 32-question questionnaire was applied, with Likert scale with 5 levels of response: 1 (dissatisfied), 2 (little satisfied), 3 (indifferent), 4 (satisfied) and 5 (very satisfied). The score range was 32 points (minimum job satisfaction) up to 160 points (Maximum job satisfaction). We analyzed 2 dimensions: 1) intrinsic factors that have to do with motivation and professional recognition, and 2) extrinsic factors related to infrastructure, materials, remuneration and labor policies. Each factor consisted of four categories. Descriptive statistics and linear correlation of Pearson were applied for the analysis of data. Participants signed an informed consent letter. Of 4 categories, in the intrinsic dimension, the one with the highest percentage of satisfaction was “delegation of activities” with 28.8%. In the extrinsic dimension, the category with the highest percentage of satisfaction was “infrastructure and materials” with 49.4%;while satisfaction increase in intrinsic dimensions also does in extrinsic dimensions, such correlations are significant (p < 0.05), except between delegation of activities and remuneration (r = 0.074 and p = 0.497). The higher hierarchical level, the men, the bachelor academic level and older people showed the highest level of satisfaction.

关键词： Job Satisfaction Cervical Cancer Health Providers

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Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer

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Engineering 2021年第10期7卷 1393-1412页

作者： Ana Montero-Calle Itziar Aranguren-Abeigon María Garranzo-Asensio carmen Poves María Jesús Fernández-Aceñero Javier Martínez-Useros Rodrigo Sanz Jana Dziaková Javier Rodriguez-Cobos Guillermo Solís-Fernández Eloy Povedano maria Gamella Rebeca Magnolia Torrente-Rodríguez Miren Alonso-Navarro Vivian de los Ríos J.Ignacio Casal Gemma Domínguez Ana Guzman-Aranguez Alberto Peláez-García JoséManuel Pingarrón Susana Campuzano Rodrigo Barderas Chronic Disease Program(UFIEC) Carlos III Health InstituteMadrid E-28220Spain Department of Biochemistry and Molecular Biology Faculty of Optics and OptometryComplutense University of MadridMadrid E-28040Spain Gastroenterology Unit San Carlos Clinical HospitalMadrid E-28040Spain Surgical Pathology Department San Carlos Clinical HospitalMadrid E-28040Spain Translational Oncology Division OncoHealth InstituteJimenez Diaz Foundation University HospitalMadrid E-28040Spain Department of Biochemistry Faculty of MedicineAlberto Sols Institute of Biomedical ResearchCSIC-UAMMadrid E-28029Spain Department of Analytical Chemistry Faculty of Chemical SciencesComplutense University of MadridMadrid E-28040Spain Center for Biological Research Spanish National Research Council(CSIC)MadridE-28040Spain Molecular Pathology and Therapeutic Targets Group La Paz University Hospital(IdiPAZ)Madrid E-28046Spain

Colorectal cancer(CRC)is the second leading cause of cancer-related death *** five-year survival rate of CRC patients depends on the stage at diagnosis,being higher than 80%when CRC is diagnosed in the early stages but lower than 10%when CRC is diagnosed in advanced *** against specific CRC autoantigens(tumor-associated antigens(TAAs))in the sera of patients have been widely demonstrated to aid in early ***,we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid *** that end,we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis.A total of 103 proteins were identified as potential autoantigens specific to *** bioinformatics and meta-analysis,we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot(WB)and immunohistochemistry(IHC).We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients,along with an association of nine of these proteins with CRC *** validation,all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals,either by luminescence Halotag-based beads,or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC *** together,our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases;they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here

关键词： Autoantibodies Diagnosis Colorectal cancer Exosomes Tumor microenviroment Humoral immune response Point of care Biosensors

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Visible Losses to the Mechanical Harvesting of Ratoon Sugarcane Using the Harvester John Deere 3520

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American Journal of Analytical Chemistry 2018年第11期9卷 580-590页

作者： carmen maria Coimbra Manhaes Francisco Mauricio Alves Francelino Rafael Alves de Araujo Danilo Gomes de Oliveira Helenilson de Oliveira Francelino Mirian Peixoto Soares da Silva Aline da Silva Santos Mauricio Donato de Moura Junior Federal Institute of Education Science and Technology of Tocantins—FTOPalmasBrazil State University of North Fluminense Rio de JaneiroBrazil

The aim of this study was to evaluate the visible loss of sugar cane and the damage to the knuckles, using the John Deere 3520 harvester on three different travel speeds (3.0;4.0 and 5.0 km·h-1), in DIC with five repetitions in Campos dos Goytacazes, Rio de Janeiro/Brazil. Each treatment was composed by six lines of harvested cane stumps, with a length of 290 m each. In these six lines, the remains of sugar cane left in the field were collected by placing the sampling frame in two central lines every 50 m, and separating 40 m of edge. The sampling area was surrounded by 2 m wide and 10 m long, totaling 20 m2. To calculate the damage to stumps, a visual methodology by [1], was used, which classifies the damage grade, ranging from 1 to 4. Fifty stumps were assessed randomly for each speed, in a sampling area of 1800 m2. The data were submitted to ANOVA and Tukey test at 5%, in order to compare the effect of different speeds on the losses and damages. There was no significant difference regarding the loss or damage by comparing the different speeds. Therefore, it is more advantageous to use the speed of 5.0 km·h-1, harvesting more in less time and causing the same level of damage.

关键词： Damages Saccharum spp. Travel Speed John Deere 3520 Harvester

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First genetic linkage map of Lathyrus cicera based on RNA sequencing-derived markers: Key tool for genetic mapping of disease resistance

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Horticulture Research 2018年第1期5卷 345-358页

作者： carmen Santos Nuno Felipe Almeida Mara Lisa Alves Ralf Horres Nicolas Krezdorn Susana Trindade Leitão Thaïs Aznar-Fernández Björn Rotter Peter Winter Diego Rubiales maria Carlota Vaz Patto Instituto de Tecnologia Química e Biológica António Xavier Universidade Nova de LisboaAv.da RepúblicaOeiras2780-157Portugal GenXPro GmbH Frankfurt am MainD-60438Germany Institute for Sustainable Agriculture CSICCórdobaE-14004Spain

The Lathyrus cicera transcriptome was analysed in response to rust(Uromyces pisi)infection to develop novel molecular breeding tools with potential for genetic mapping of resistance in this robust orphan legume *** RNA-seq library each was generated from control and rust-inoculated leaves from two *** genotypes with contrasting quantitative resistance,de novo assembled into contigs and sequence polymorphisms were *** toto,19,224 SNPs differentiate the susceptible from the partially resistant genotype’s *** addition,we developed and tested 341 expressed E-SSR markers from the contigs,of which 60.7%varied between the two *** genotypes.A first *** linkage map was created using part of the developed markers in a RIL population from the cross of the two *** map contains 307 markers,covered 724.2 cM and is organised in 7 major and 2 minor linkage groups,with an average mapping interval of 2.4 *** genic markers also enabled us to compare their position in *** map with the physical position of the same markers mapped on Medicago truncatula genome,highlighting a high macrosyntenic conservation between both *** study provides a large new set of genic polymorphic molecular markers with potential for mapping rust *** represents the first step towards genomics-assisted precision breeding in ***.

关键词： breeding linkage resistance

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Solvent-Free Synthesis of Carboxylic Acids and Amide Analogs of CAPE(Caffeic Acid Phenethyl Ester)under Infrared Irradiation Conditions

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Green and Sustainable Chemistry 2015年第2期5卷 81-91页

作者： Pablo A.Martínez-Soriano Jose R.Macías-Perez Ana maria Velazquez Brigida del carmen Camacho-Enriquez Gustavo Pretelin-Castillo Monica B.Ruiz-Sanchez Victor H.Abrego-Reyes Saul Villa-Trevino Enrique Angeles Laboratorio de Quimica Medicinal y Teorica Departamento de Ciencias QuimicasFES CuautitlanUniversidad Nacional Autonoma de MexicoCuautitlan IzcalliMexico Departamento de Biologia celular Centro de Investigacion y Estudios AvanzadosInstituto Politecnico NacionalMexicoD.F.Mexico Qsar Analytics S.A.de C.V.Ciudad Satelite Naucalpan de JuarezMexico

A convenient and easy method is described for the formation of carboxamides from carboxylic acids and primary amines in solventless conditions using infrared (IR) light. Thus, under IR light, cinnamic acid derivatives... 详细信息

关键词： Amides Carboxylic Acids Amines Infrared Light Solventless CAPE CAPA Cinnamic Acid Analogs

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Cutaneous Melanoma:A Single Center Experience in Brazil

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Journal of Pharmacy and Pharmacology 2018年第11期6卷 970-977页

作者： Emilly Neves Souza maria carmen Ferreira Lopes Silva Santos Universidade Federal do Espírito Santo(UFES) VitóriaES29040-090Brazil Department of Pathology Universidade Federal do Espírito Santo(UFES)VitóriaES29040-090Brazil Anatomic Pathology Service Hospital Universitário Cassiano Antonio Moraes(HUCAM)Universidade Federal do Espírito Santo(UFES)VitóriaES29043-260Brazil

The aim is to evaluate the profile of cutaneous melanoma in rural and urban areas of the State of Espírito Santo and compare the results between *** information collected included gender and age at diagnosis,city of residence,tumor morphology,anatomic site,histological subtype,level of invasion,tumor thickness and staging.A retrospective observational study was conducted,using the Pathology Department’s database of Hospital Universitário Cassiano Antonio de Moraes(HUCAM).Statistical analysis was performed using SPSS Statistics.A total of 258 histopathological reports of Cutaneous Melanomas were identified between 2003 and *** skin cancer was more common among women,in the age group from 50 to 79 *** majority of lesions was localized in the malar region of the face,usually classified as in situ or with superficial invasion and presented Breslow’s thickness less than 1 *** the diagnosis,the male population was older and had more aggressive melanomas with higher rates of Clark’s levels IV and V and Breslow’s thickness when compared to the female *** was a great concentration of patients in the central mesoregion(173 cases—67.06%),probably because this is the most populous regional area of Espírito *** prevalence of melanoma between 2003-2016 was higher in the rural area(21.52 cases/100,000 habitants)when compared to the urban area(4.15 cases/100,000 habitants).

关键词： Cutaneous melanoma skin cancer sun exposure

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Angiotensin-(1-7)and Human Chorionic Gonadotropin(hCG)Modulate the Nuclear Transcription Factors or Nuclear Receptors Genes in the Tumorigenic Undifferentiated Breast Cancer Cell Line SKBR3

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Journal of Cancer Therapy 2013年第7期4卷 70-74页

作者： Isidoro Binda Neto Samuel Marcos Ribeiro de Noronha Silvana Aparecida Alves Correa de Noronha maria Del carmen Garcia Molina Wolgien Alexandre Jesus Barros Clovis Ryiuchi Nakaie Suma Imura Shimuta Gil Facina Ismael Dale Cotrim Guerreiro da Silva Laboratorio de Ginecologia Molecular Universidade Federal de Sao PauloSao PauloBrazil Universidade Federal do Estado do Rio de Janeiro Rio de JaneiroBrazil Laboratorio de Cirurgia Translacional Departamento de CirurgiaUNIFESP/EPMSao PauloBrazil Departamento de Biofísica Universidade Federal de Sao PauloSao PauloBrazil

Breast cancer is the most common cancer among women. Angiotensin-(1 - 7) [Ang-(1 - 7)] has been correlated with cancer antiproliferative and apoptotic effects, similar properties of the human Chorionic Gonadotrofin (hCG). The aims of this work are to evaluate the role of Ang-(1 - 7) and of hCG in modulating the expression of Nuclear Receptors and Coregulators related genes in the tumorigenic breast cell line SK-BR3. Three experimental groups were created: control, hCG and hCG + Ang-(1 - 7). Cells were treated for 11 days and then had their RNA extracted. Samples were loaded into PCR Array plates containing 84 genes relate to Nuclear Receptors and Coregulators pathways. Gene expression data were used to construct canonical pathways (MetacoreTM). hCG and hCG + Ang-(1 - 7) treatments markedly modulate the expression of Nuclear Receptors and Coregulators related genes. hCG differentially expressed 17% of the genes, being 29% upregulated and 71% downregulated. Meanwhile, hCG + Ang-(1 - 7) changed the expression of 30% of the genes on the plate, among these genes 56% were upregulated and 44% downregulated. Among these differentially expressed genes, we highlight Esr1, Nr2f2, and Nr2f1, Esr1, Hdac5, and Nr4A1 (>4 fold). Finally MetaCore analysis based on Gene Ontology (GO) generated six networks for hCG and ten networks for the combined treatment. All generated networks are related to regulation of apoptosis or to Programmed Cell Death processes. In summary, our results herein demonstrate that the modulation of sexual hormones and of other nuclear factor genes expression might underlie the tumorigenic protection effect and the induction of cell differentiation caused by the hormones hCG and Ang-(1 - 7), especially in Cancer Stem Cells.

关键词： Breast Stem Cancer Cells SK-BR3 hCG Angiotensin-(1-7)

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