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SmartMat 2023年第4期4卷 145-177页

作者： Jiawei Liu carmen lee Yue Hu Zhishan Liang Rong Ji Xiang Yun Debbie Soo Qiang Zhu Qingyu Yan School of Materials Science and Engineering Nanyang Technological UniversitySingaporeSingapore Institute of Materials Research and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore

Developing sustainable and clean energy-conversion techniques is one of the strategies to simultaneously meet the global energy demand,save fossil fuels and protect the environment,in which nanocatalysts with high activity,selectivity and durability are of great *** nanocrystals,featuring their ordered atomic arrangements and predictable electronic structures,have been recognized as a type of active and durable catalysts in energy-related *** this minireview,the very recent progress in the syntheses and electrocatalytic applications of noble metal-based intermetallic nanocrystals is *** synthetic strategies,including the conventional thermal annealing approach and its diverse modifications,as well as the wet-chemical synthesis,for the construction of binary,ternary and high-entropy intermetallic nanocrystals have been discussed with representative examples,highlighting their strengths and ***,their electrocatalytic applications toward oxygen reduction reaction,small molecule oxidation reactions,hydrogen evolution reaction,CO_(2)/CO reduction reactions,and nitrogen reduction reaction are discussed,with the emphasis on how the ordered intermetallic structures contribute to the enhanced *** conclude the minireview by addressing the current challenges and opportunities of intermetallic nanocrystals in terms of syntheses and electrocatalytic applications.

关键词： binary intermetallic electrocatalysis high-entropy intermetallic intermetallic nanocrystals ternary intermetallic

High-entropy alloys and compounds for electrocatalytic energy conversion applications

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SusMat 2021年第4期1卷 482-505页

作者： Hang Liu Lenus Syama Like Zhang carmen lee Chuntai Liu Zhengfei Dai Qingyu Yan State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’anChina Xi’an Jiaotong University Suzhou Institute SuzhouChina École Nationale Superieure des Ingenieurs en Arts Chimiques et Technologiques ToulouseFrance School of Materials Science and Engineering Nanyang Technological UniversitySingapore Key Laboratory of Materials Processing and Mold Ministry of EducationZhengzhou UniversityZhengzhouChina

High-entropy materials,composed of five or more elements in near-equiatomic percentage,have been attracting tremendous interests due to their advantageous properties in a variety of ***,electrocatalysis on high-entropy alloys(HEAs)and high-entropy compounds(HECs)has emerged as a new and promising material owing to the tailored composition and the disordered con-figuration of HEAs and *** extensive efforts have been devoted to investigating the catalytic nature of HEAs and HECs,the details related to the active sites and intrinsic activity of such catalysts still remain uncertain due to the complexity of the multicomponent *** this review,the recent progress of HEAs and HECs is systematically reviewed in terms of their synthetic strate-gies and electrocatalytic ***,the computationally assisted methods(e.g.,density functional theory[DFT])are also presented to discover and design the optimumHEA-andHEC-based ***,the appli-cations of HEAs and HECs in electrocatalytic energy conversion reactions will be discussed,including hydrogen evolution reaction,oxygen evolution reaction,oxygen reduction reaction,carbon dioxide reduction reaction,nitrogen reduction reaction,methanol oxidation reaction,and ethanol oxidation reaction(EOR).Moreover,the prospects and future opportunities for this research field are cau-tiously discussed.A series of upcoming challenges and questions are thoroughly proposed from the experimental and theoretical aspects as well as other future applications in electrocatalysis.

关键词： alloys entropy compounds

MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergistic effects on cell motility

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Frontiers of Medicine 2015年第3期9卷 331-343页

作者： Felice Ho-Ching Tsang Sandy Leung-Kuen Au Lai Wei Dorothy Ngo-Yin Fan Joyce Man-Fong lee carmen Chak-Lui Wong Irene Oi-Lin Ng Chun-Ming Wong State Key Laboratory for Liver Research and Department of Pathology Li Ka Shing Faculty of Medicine The University of Hong Kong HongKong SAR China

MicroRNAs （miRNAs）, an important class of small non-coding RNAs, regulate gene expression at the post-transcriptional level, miRNAs are involved in a wide range of biological processes and implicated in different diseases, including cancers. In this study, miRNA profiling and qRT-PCR validation revealed that miR-142-3p and miR-142-5p were significantly downregulated in hepatocellular carcinoma （HCC） and their expression levels decreased as the disease progressed. The ectopic expression of miR-142 significantly reduced HCC cell migration and invasion. Overexpression of either miR-142-3p or miR-142-5p suppressed HCC cell migration, and overexpression of both synergistically inhibited cell migration, which indicated that miR-142-3p and miR-142-5p may cooperatively regulate cell movement, miR-142-3p and miR-142-5p, which are mature miRNAs derived from the 3＇- and 5＇-strands of the precursor miR-142, target distinct pools of genes because of their different seed sequences. Pathway enrichment analysis showed a strong association of the putative gene targets of miR-142-3p and miR-142-5p with several cell motility-associated pathways, including those regulating actin cytoskeleton, adherens junctions, and focal adhesion. Importantly, a number of the putative gene targets were also significantly upregulated in human HCC cells. Moreover, overexpression of miR-142 significantly abrogated stress fiber formation in HCC cells and led to cell shrinkage. This study shows that mature miR-142 pairs collaboratively regulate different components of distinct signaling cascades and therefore affects the motility of HCC cells.

关键词： hepatocellular carcinoma microRNA metastasis cytoskeletal reorganization

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垂直巷屋水舍南外滩精品酒店

城市环境设计 2023年第2期 27-37+26页

作者：蔡春燕 Markus Stoecklein carmen lee 汪艳鲁永新赵云 Zhili Liu 郭锡真刘薇 Derryck Menere Pedro Pegenaute Dirk Weiblen

当人们走近这座建于20世纪30年代的建筑时,便会发觉,历史的沧桑遍布其表,清晰可见。这个项目的真正挑战是在修复过程中保持理性,克制修复每一个“缺陷”的冲动。如恩在增添新的元素或保留固有设计上谨慎决策。虽然一些空间已经历过整修...

当人们走近这座建于20世纪30年代的建筑时,便会发觉,历史的沧桑遍布其表,清晰可见。这个项目的真正挑战是在修复过程中保持理性,克制修复每一个“缺陷”的冲动。如恩在增添新的元素或保留固有设计上谨慎决策。虽然一些空间已经历过整修,但部分墙壁仍然保持着原始粗粝的状态,破碎的砖块和易碎的板条暴露于老化的灰泥墙后。在玻璃屏罩之下,这些原始的墙壁截面如同在博物馆中陈列的物品,被忽视的平凡在刹那间变得弥足珍贵。如解剖般剥开层层表面,隐藏在每一个瑕疵中的生命和故事逐渐展开,记忆深处最亲密的栖居回忆亦呈现在世人眼前。

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来源：博看期刊

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美诺之家品牌体验馆

现代装饰 2011年第3期 110-115页

作者： Andrea Destefanis Filippo Gabbiani carmen lee 叶燕锋 Kokaistudios

本项目是德国美诺Miele品牌在中国境内的首个特别旗舰店，地处上海延安路和南京路之间，毗邻四季酒店和未来的“大中里”项目基地，位于上海市中心重要的开发区域。该建筑是1930年建造的三层老式别墅，这栋建筑最初由中国近代著名建筑... 详细信息

本项目是德国美诺Miele品牌在中国境内的首个特别旗舰店，地处上海延安路和南京路之间，毗邻四季酒店和未来的“大中里”项目基地，位于上海市中心重要的开发区域。该建筑是1930年建造的三层老式别墅，这栋建筑最初由中国近代著名建筑师范文照先生（Robert Fan）设计，

关键词：品牌中国境内旗舰店南京路开发区市中心建筑上海

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Transfusion-transmitted hepatitis E:What we know so far?

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World Journal of Gastroenterology 2022年第1期28卷 47-75页

作者： carmen Ka Man Cheung Sunny Hei Wong Alvin Wing Hin Law Man Fai Law Medicine and Therapeutics Prince of Wales HospitalHong Kong 852China Institute of Digestive Disease and Department of Medicine and Therapeutics the Chinese University of Hong KongHong Kong 852China lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 639798Singapore West Island School Hong Kong 852China

Hepatitis E virus(HEV)is a major cause of viral hepatitis *** is growing concern about transfusion-transmitted HEV(TT-HEV)as an emerging global health *** can potentially result in chronic infection in immunocompromised patients,leading to a higher risk of liver cirrhosis and even *** 0.0013%and 0.281%of asymptomatic blood donors around the world have HEV viremia,and 0.27%to 60.5%have anti-HEV immunoglobulin *** is infectious even at very low blood concentrations of the *** patients who develop persistent hepatitis E infection should have their immunosuppressant regimen reduced;ribavirin may be considered as *** interferon can be considered in those who are refractory or intolerant to ***,a nucleotide analog,showed modest antiviral activity in some clinical studies but sustained viral response was not ***,rescue treatment remains an unmet *** need for HEV screening of all blood donations remains *** screening has been adopted in some countries after consideration of risk and resource *** pathogen reduction methods have also been proposed to reduce the risk of *** studies are needed to define the incidence of transmission through transfusion,their clinical features,outcomes and prognosis.

关键词： Hepatitis E virus Acute and chronic hepatitis Immunosuppression Blood transfusion Transplantation

Efficacy of Vaccine Protection Against COVID-19 Virus Infection in Patients with Chronic Liver Diseases

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Journal of Clinical and Translational Hepatology 2023年第3期11卷 718-735页

作者： carmen Ka Man Cheung Kimmy Wan Tung Law Alvin Wing Hin Law Man Fai Law Rita Ho Sunny Hei Wong Department of Medicine and Therapeutics Prince of Wales HospitalHong KongChina West Island School Hong KongChina Department of Medicine North District HospitalHong KongChina Institute of Digestive Disease and Department of Medicine and Therapeutics State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong KongChinaLee Kong Chian School of MedicineNanyang Technological UniversitySingapore

The outbreak of coronavirus disease 2019 (COVID-19) has resulted in significant morbidity and mortality worldwide. Vaccination against coronavirus disease 2019 is a use-ful weapon to combat the virus. Patients with chronic liver diseases (CLDs), including compensated or decompensated liver cirrhosis and noncirrhotic diseases, have a decreased immunologic response to coronavirus disease 2019 vaccines. At the same time, they have increased mortality if infected. Current data show a reduction in mortality when patients with chronic liver diseases are vaccinated. A suboptimal vac-cine response has been observed in liver transplant recipi-ents, especially those receiving immunosuppressive therapy, so an early booster dose is recommended to achieve a better protective effect. Currently, there are no clinical data com-paring the protective efficacy of different vaccines in patients with chronic liver diseases. Patient preference, availability of the vaccine in the country or area, and adverse effect profiles are factors to consider when choosing a vaccine. There have been reports of immune-mediated hepatitis after coronavi-rus disease 2019 vaccination, and clinicians should be aware of that potential side effect. Most patients who developed hepatitis after vaccination responded well to treatment with prednisolone, but an alternative type of vaccine should be considered for subsequent booster doses. Further prospec-tive studies are required to investigate the duration of immu-nity and protection against different viral variants in patients with chronic liver diseases or liver transplant recipients, as well as the effect of heterologous vaccination.

关键词： COVID-19 SARS-CoV-2 Chronic liver disease Liver transplanta-tion Vaccine mRNA.

The combined role of MRI prostate and prostate health index in improving detection of significant prostate cancer in a screening population of Chinese men

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Asian Journal of Andrology 2023年第6期25卷 674-679页

作者： Peter KF Chiu Thomas YT Lam Chi-Fai Ng Jeremy YC Teoh carmen CM Cho Hiu-Yee Hung Cindy Hong Monique J Roobol Winnie CW Chu Samuel YS Wong Joseph JY Sung SH Ho Urology Centre Department of SurgeryThe Chinese University of Hong KongHong Kong SARChina The Jockey Club School of Public Health and Primary Care The Chinese University of Hong KongHong Kong SARChina Department of Imaging and Interventional Radiology The Chinese University of Hong KongHong Kong SARChina Erasmus MC Cancer Institute Erasmus Medical UniversityRotterdam 3015The Netherlands lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore

Using prostate-specific antigen(PSA)for prostate cancer(PCa)screening led to overinvestigation and overdiagnosis of indolent *** aimed to investigate the value of prostate health index(PHI)and magnetic resonance imaging(MRI)prostate in an Asian PCa screening *** aged 50–75 years were prospectively recruited from a community-based PSA screening *** with PSA 4.0–10.0 ng ml^(−1) had PHI result *** prostate was offered to men with PSA 4.0–50.0 ng ml−1.A systematic prostate biopsy was offered to men with PSA 4.0–9.9 ng ml^(−1) and PHI≥35,or PSA 10.0–50.0 ng ml^(−1).Additional targeted prostate biopsy was offered if they had PI-RADS score≥*** significant PCa(csPCa)was defined as the International Society of Urological Pathology(ISUP)grade group(GG)≥2 or ISUP GG 1 with involvement of≥30%of total systematic *** total,12.8%(196/1536)men had PSA≥4.0 ng ml^(−1).Among 194 men with PSA 4.0–50.0 ng ml^(−1),187(96.4%)received MRI *** them,28.3%(53/187)had PI-RADS≥3 ***,7.0%(107/1536)men were indicated for biopsy and 94.4%(101/107)men received *** the men received biopsy,PCa,ISUP GG≥2 PCa,and csPCa was diagnosed in 42(41.6%),24(23.8%),and 34(33.7%)men,*** with PSA/PHI pathway in men with PSA 4.0–50.0 ng ml^(−1),additional MRI increased diagnoses of PCa,ISUP GG≥2 PCa,and csPCa by 21.2%(from 33 to 40),22.2%(from 18 to 22),and 18.5%(from 27 to 32),*** benefit of additional MRI was only observed in PSA 4.0–10.0 ng ml^(−1),and the number of MRI needed to diagnose one additional ISUP GG≥2 PCa was 20 in PHI≥35 and 94 in PHI<*** them,45.4%(89/196)men with PSA≥4.0 ng ml^(−1) avoided unnecessary biopsy with the use of PHI and MRI.A screening algorithm with PSA,PHI,and MRI could effectively diagnose csPCa while reducing unnecessary *** benefit of MRI prostate was mainly observed in PSA 4.0–9.9 ng ml^(−1) and PHI≥35 *** was an important risk stratification step for PCa

关键词： magnetic resonance imaging prostate prostate cancer prostate health index prostate-specific antigen screening

Preparation of elastomeric nanocomposites using nanocellulose and recycled alum sludge for flexible dielectric materials

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Journal of Advanced Dielectrics 2023年第1期13卷 57-65页

作者： Dongyang Sun Bernard L.H.Saw Amaka J.Onyianta Bowen Wang Callum Wilson Dominic O’Rourke Chan H.See carmen-Mihaela Popescu Mark Dorris Islam Shyha Zhilun Lu School of Engineering and Built Environment Edinburgh Napier UniversityEdinburghUK lee Kong Chian Faculty of Engineering and Science Universiti Tunku Abdul Rahman KajangMalaysia Bristol Composites Institute School of CivilAerospace and Mechanical Engineering University of BristolUniversity WalkBristolBS81TRUK School of Engineering and Materials Science Queen Mary University of LondonLondonUK Petru Poni Institute of Macromolecular Chemistry of the Romanian Academy IasiRomania

Flexible dielectric materials with environmental-friendly,low-cost and high-energy density characteristics are in increasing demand as the world steps into the new Industrial 4.0 *** this work,an elastomeric nanocomposite was developed by incorporating two components:cellulose nanofibrils(CNFs)and recycled alum sludge,as the reinforcement phase and to improve the dielectric properties,in a bio-elastomer *** and alum sludge were produced by processing waste materials that would otherwise be disposed to landfills.A biodegradable elastomer polydimethylsiloxane was used as the matrix and the nanocomposites were processed by casting the materials in Petri *** extraction and heat treatment of alum sludge were conducted and characterized using various techniques including scanning electron microscopy(SEM),thermogravimetric analysis/derivative thermogravimetric(TGA/DTG)and X-ray diffraction(XRD)*** preparing the nanocomposite samples,various amount of alum sludge was added to examine their impact on the mechanical,thermal and electrical *** have shown that it could be a sustainable practice of reusing such wastes in preparing flexible,lightweight and miniature dielectric materials that can be used for energy storage applications.

关键词： Nanocellulose biodegradable sustainable alum sludge nanocomposite flexible dielectric

Peripheral vestibular system: Age-related vestibular loss and associated deficits

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Journal of Otology 2021年第4期16卷 258-265页

作者： Jennifer Coto carmen L.Alvarez Ivette Cejas Brett M.Colbert Bonnie E.Levin Joshua Huppert Tatjana Rundek Carey Balaban Susan H.Blanton David J.lee David Loewenstein Michael Hoffer Xue Zhong Liu University of Miami Miller School of Medicine Department of OtolaryngologyMiamiFLUSA San Juan Bautista Medical School CaguasPRUSA Medical Scientist Training Program University of Miami Miller School of MedicineMiamiFLUSA University of Miami Miller School of Medicine Department of Neurology and the Evelyn F.McKnight Brain InstituteMiamiFLUSA University of Pittsburgh Departments of OtolaryngologyNeurobiologyCommunication Sciences&Disordersand BioengineeringPittsburghPAUSA University of Miami Miller School of Medicine Dr.John T.Macdonald Department of Human GeneticsMiamiFLUSA University of Miami Miller School of Medicine Department of Public Health SciencesMiamiFLUSA University of Miami Miller School of Medicine Department of Psychiatry and Behavioral SciencesMiamiFLUSA

Given the interdependence of multiple factors in age-related vestibular loss (e.g., balance, vision,cognition), it is important to examine the individual contributions of these factors with ARVL. While therelationship between the vestibular and visual systems has been well studied (Bronstein et al., 2015),little is known about the association of the peripheral vestibular system with neurodegenerative disorders (Cronin et al., 2017). Further, emerging research developments implicate the vestibular system asan opportunity for examining brain function beyond balance, and into other areas, such as cognition andpsychological functioning. Additionally, the bidirectional impact of psychological functioning is understudied in ARVL. Recognition of ARVL as part of a multifaceted aging process will help guide thedevelopment of integrated interventions for patients who remain at risk for decline. In this review, wewill discuss a wide variety of characteristics of the peripheral vestibular system and ARVL, how it relatesto neurodegenerative diseases, and correlations between ARVL and balance, vision, cognitive, and psychological dysfunction. We also discuss clinical implications as well as future directions for research, withan emphasis on improving care for patients with ARVL.

关键词： Peripheral vestibular system Age-related vestibular loss Balance Vision Cognitive Psychological

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