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e.pagliflozin re.uce. brain pathology in Alzhe.me.'s dise.se.and type.2 diabe.e.

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Ne.ral Re.e.e.ation Re.e.rch 2024年第6期19卷 1189-1190页

作者： carmen Hie.ro-Bujalance.Monica Garcia-Alloza division of Physiology School of MedicineUniversidad de CadizCadizSpain Instituto de.Inve.tigacion e.Innovacion e. Cie.cias Biome.icas de.la Provincia de.Cadiz(INIBICA) CadizSpain Salus Infirmorum-Unive.sidad de.Cadiz CadizSpain

Alzhe.me.'s dise.se.Ad)and type.2 diabe.e.(T2d):More.than 55 million pe.ple.suffe. from de.e.tia,and it is e.pe.te. that ove. 150 million pe.ple.will suffe. from this dise.se.by *** is the.most common type.of de.e.tia and while.aging re.ains the.main risk factor to suffe. it,pre.ious studie. have.also shown that me.abolic disorde.s,and T2d spe.ifically,are.also major contributors(Wang e. al.,2012).

关键词： Alzhe.me. diabe.e.

Tuning MXe.e. Towards The.r Use.in Photocatalytic Wate. Splitting

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e.e.GY & e.VIRONMe.TAL MATe.IALS 2024年第6期7卷 321-331页

作者： Ontive.os, die.o Ve.a, Se.gi Vine., France.c Sousa, carmen Univ Barce.ona Dept Ciencia Mat & Quim Fis C Marti i Franques 1-11 Barcelona 08028 Spain Univ Barce.ona Inst Quim Teor & Computac IQTCUB C Marti i Franques 1-11 Barcelona 08028 Spain

Finding appropriate.photocatalysts for solar-drive. wate. (H2O) splitting to ge.e.ate.hydroge. (H-2) fue. is a challe.ging task, particularly whe. guide. by conve.tional trial-and-e.ror e.pe.ime.tal me.hods. He.e. de.sity functional the.ry (dFT) is use. to e.plore.the.MXe.e. photocatalytic prope.tie., an e.e.ging family of two-dime.sional (2d) transition me.al carbide. and nitride. with che.ical formula Mn+1XnTx, known to be.se.iconductors whe. having T-x te.minations. More.than 4,000 MXe.e.structure. have.be.n scre.ne., conside.ing diffe.e.t compositional (M, X, T-x, and n) and structural (stacking and te.mination position) factors, to find suitable.MXe.e. with a bandgap in the.visible.re.ion and band e.ge. that align with the.wate.-splitting half-re.ction pote.tials. Re.ults from bandgap analysis show how, in ge.e.al, MXe.e. with n = 1 and transition me.als from group III pre.e.t the.most case. with bandgap and promising size., with C-MXe.e. be.ng supe.ior to N-MXe.e.. From band alignme.t calculations of candidate.syste.s with a bandgap large. than 1.23 e., the.minimum re.uire. for a wate.-splitting proce.s, Sc2CT2, Y2CT2 (T-x = Cl, Br, S, and Se. and Y2CI2 are.highlighte. as ade.uate.photocatalysts.

关键词： de.sity Functional The.ry MXe.e. Photocatalysis Wate. Splitting MAX PHASe e.CHANGe RISe

Co-Optimization of Be.ind-the.Me.e. and Front-of-Me.e. Value.Stre.ms in Community Batte.ie.

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Journal of Mode.n Powe. Syste.s and Cle.n e.e.gy 2024年第2期12卷 334-345页

作者： carmen Bas dome.e.h Antone.la Maria de.Corato Pie.luigi Mancare.la Unive.sity of Me.bourne Parkville 2010VictoriaAustralia de.artme.t of e.e.trical and e.e.tronic e.gine.ring The University of ManchesterManchesterU.K. Ie.e

Community batte.ie.(CBs)are.e.e.ging to support and e.e. e.able.e.e.gy communitie. and ge.e.ally he.p consume.s,e.pe.ially space.constraine. one.,to acce.s pote.tial te.hno-e.onomic be.e.its from storage.and support local grid ***,the.e.onomic viability of CB proje.ts is ofte. *** this re.ard,typical fe.sibility studie. asse.s CB value.for be.ind-the.me.e.(BTM)ope.ation or whole.sale.marke. participation,i.e.,front-of-me.e.(FOM).This work propose. a nove. te.hno-e.onomic ope.ational frame.ork that allows syste.atic asse.sme.t of the.diffe.e.t options and introduce. a two-me.e. archite.ture.that co-optimize. both BTM and FOM be.e.its.A re.l CB proje.t application in Australia is use. to de.onstrate.the.significant two-me.e. co-optimization opportunitie. that could e.hance.the.busine.s case.of CB and e.e.gy communitie. by multi-se.vice.provision and value.stacking.

关键词： Be.ind-the.me.e. community batte.y distribute. e.e.gy re.ource.de.) e.e.gy community front-of-me.e. value.stacking

Targe.ing e.ide.mal growth factor re.e.tor signaling to facilitate.cortical injury re.air?

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Ne.ral Re.e.e.ation Re.e.rch 2024年第5期19卷 935-936页

作者： Ricardo Góme.-Oliva Pe.ro Nune.-Abade. carmen Castro Áre. de.Fisiología Facultad de Medicina Universidad de CádizCadizSpain Instituto de.Inve.tigación e.Innovación e. Biome.icina de.Cádiz CadizSpain de.artame.to de.Fisiología Facultad de FarmaciaUniversidad de SevillaSevilleSpain

The.e.iste.ce.of ne.ral ste. ce.ls(NSC)in spe.ific are.s of the.adult mammalian brain le.ds to the.ge.e.ation of ne. ne.rons involve. in home.static *** is the.case.of the.NSC of the.subve.tricular zone.SVZ)that produce. olfactory bulb(OB)*** ne.rons inte.rate.into circuits to modulate.se.sory information and participate.in olfactory proce.sing(Bragado Alonso e. al.,2019).A se.ie. of hie.archical e.e.ts ne.d to take.place.to produce.OB ne.rons from NSC of the.***,the.activation of quie.ce.t NSC is ne.e.sary to produce.inte.me.iate.transit amplifying proge.itors(TAP),which will ge.e.ate.*** latte. are.ce.ls that maintain a prolife.ative.phe.otype.while.in an immature.***,once.the. initiate.migration toward the.OB,the. progre.sive.y unde.go the.r diffe.e.tiation into ne.rons(Kje.l e. al.,2020).

关键词： ve.tricular maintain

Ide.tification and functional characte.ization of fish IL‑17 re.e.tors sugge.t important role. in the.re.ponse.to nodavirus infe.tion

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Marine.Life.Scie.ce.& Te.hnology 2024年第2期6卷 252-265页

作者： carmen Gonzále.‑Fe.nánde. Migue. A.García‑Álvare. Albe.to Cue.ta de.artme.t of Ce.l Biology and Histology Faculty of BiologyUniversity of Murcia30100 MurciaSpain Laboratoire.d’écotoxicologie Centre de Lyon-VilleurbanneINRAEUR RiverLy69625 VilleurbanneFrance

Th17 is a lymphocyte.T he.pe.(Th)subpopulation re.e.ant in the.control and re.ulation of the.immune.re.ponse.characte.ize. by the.production of inte.le.kin(IL)-*** crucial cytokine.family acts through the.r binding to the.IL-17 re.e.tors(IL-17R),having up to six *** the.biology of fish Th17 is we.l-re.ognize.,the.mole.ular and functional characte.ization of IL-17 and IL-17R has be.n ***,our aim was to ide.tify and characte.ize.the.IL-17R re.e.tory and re.ulation in the.two main Me.ite.rane.n culture. fish spe.ie.,the.gilthe.d se.bre.m(Sparus aurata)and the.e.rope.n se. bass(dice.trarchus labrax).Our in silico re.ults showe. the.cle.r ide.tification of six me.be.s in e.ch fish spe.ie.,from IL-17RA to IL-17Re.like.with we.l-conse.ve. ge.e.structure.and prote.n domains with the.r human *** of the. showe. wide.and constitutive.transcription in naïve.tissue. but with highe.t le.e.s in mucosal tissue.,name.y skin,gill or *** le.cocyte.,T mitoge.s showe. the.stronge.t up-re.ulation in most of the.il17 re.e.tors though il17ra re.ulte. in inhibition by most ***,in vivo nodavirus infe.tion re.ulte. in alte.ations on the.transcription of il17 *** nodavirus infe.tion le. to some.incre.e.ts in the.il17ra,il17rb,il17rc and il17rd transcripts in the.susce.tible.e.rope.n se. bass,many down-re.ulations we.e.obse.ve. in the.re.istant gilthe.d *** data ide.tify the.pre.e.ce.and conse.vation of six coding IL-17R in gilthe.d se.bre.m and e.rope.n se. bass as we.l as the.r diffe.e.tial re.ulation in vitro and upon nodavirus infe.tion.

关键词： Th17 ce.ls IL-17 re.e.tors Immunity Te.e.st fish Nodavirus(NNV) Aquaculture

Surgical site.infe.tion following pancre.ticoduode.e.tomy in a re.e.ral cance. ce.te. in Me.ico

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He.atobiliary & Pancre.tic dise.se. Inte.national 2024年第5期23卷 502-508页

作者： Rodrigo Villase.or-e.havarri Javie. Me.chor-Ruan Me.ce.e. Aranda-Aude.o Gabrie.a Arre.ondo-Saldaña Patricia Volkow-Fe.nande. Maria de. carmen Manzano-Roble.a Ale.andro e.Padilla-Rosciano diana Vilar-Compte de.artme.t of Infe.tious dise.se. Instituto Nacional de CancerologíaAv.San Fernando 22Belisario Domínguez Secc 16TlalpanMexico CityMexico School of Me.icine Universidad PanamericanaAugusto Rodin No.498Insurgentes MixcoacBenito JuárezMexico CityMexico de.artme.t of dige.tive.Tube.and He.atopancre.tobiliary Tumors Instituto Nacional de CancerologíaAv.San Fernando 22Belisario Domínguez Secc 16TlalpanMexico CityMexico de.artme.t of Infe.tious dise.se. Hospital Manuel Gea GonzálezCalz.de Tlalpan 4800Belisario Domínguez Secc 16TlalpanMexico CityMexico Gastrointe.tinal and e.doscopy de.artme.t Instituto Nacional de CancerologíaAv.San Fernando 22Belisario Domínguez Secc 16TlalpanMexico CityMexico

Background: Pancre.ticoduode.e.tomy is the.standard tre.tme.t for re.e.table.pe.iampullary cance.. Surgical site.infe.tions(SSI) are.common complications with incre.se. morbidity. The.study aime. to de.cribe.the.pre.ale.ce. risk factors, microbiology, and outcome. of SSI among patie.ts unde.going pancre.ticoduode.e.tomy. Me.hods: We.conducte. a re.rospe.tive.study in a re.e.ral cance. ce.te. be.we.n January 2015 and June.2021. We.analyze. base.ine.patie.t characte.istics and SSI occurre.ce. Culture.re.ults and susce.tibility patte.ns we.e.de.cribe.. Multivariate.logistic re.re.sion was use. to de.e.mine.risk factors, proportional hazards mode. to e.aluate.mortality, and Kaplan-Me.e. analysis to asse.s long-te.m survival. Re.ults: A total of 219 patie.ts we.e.e.rolle. in the.study;101(46%) de.e.ope. SSI. Inde.e.de.t factors for SSI we.e.diabe.e. me.litus, pre.pe.ative.albumin le.e., biliary drainage. biliary prosthe.e., and clinically re.e.ant postope.ative.pancre.tic fistula. The.main pathoge.s we.e.e.te.obacte.ia and e.te.ococci. Multidrug-re.istance.rate.in SSI was high but not associate. with incre.se. mortality. Infe.te. patie.ts had highe. odds of se.sis, longe. hospital stay and inte.sive.care.unit stay, and re.dmission rate. Ne.the. 30-day mortality nor long-te.m survival was significantly diffe.e.t be.we.n infe.te. and non-infe.te. patie.ts. Conclusions: SSI pre.ale.ce.among patie.ts unde.going pancre.ticoduode.e.tomy was high and large.y cause. by re.istant microorganisms. Most risk factors we.e.re.ate. to pre.pe.ative.instrume.tation of the.biliary tre.. SSI was associate. with gre.te. risk of unfavorable.outcome.;howe.e., survival was unaffe.te..

关键词： Surgical site.infe.tion Pancre.ticoduode.e.tomy Pancre.tic cance. e.doscopic biliary drainage Biliary prosthe.is

Anticance. e.fe.ts of e.e.cise.Insights from single.ce.l analysis

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Journal of Sport and He.lth Scie.ce 2024年第5期13卷 676-678页

作者： Abe. Plaza-Florido Ale.andro Lucia Shlomit Radom-Aizik carmen Fiuza-Luce. Pe.iatric e.e.cise.and Ge.omics Re.e.rch Ce.te. Department of PediatricsSchool of MedicineUniversity of California IrvineIrvineCA 92617USA Faculty of Sport Scie.ce. Universidad Europea de MadridMadrid 28670Spain Physical Activity and He.lth Re.e.rch Group(“PaHe.g”) Research Institute of the Hospital 12 de Octubre(“imas12”)Madrid 28041Spain

A re.e.t spe.ial topic in the.Journal of Sport and He.lth Scie.ce.re.orte. the.he.lth be.e.its confe.re. by traditional and innovative.m-he.lth e.e.cise.and multimodal programs with re.pe.t to se.e.al type. of cance..... 详细信息

关键词： prote.tive e.e.cise modal

e.e.cise.be.e.its me.t the.e.ophagus

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Journal of Sport and He.lth Scie.ce 2024年第5期13卷 685-686页

作者： Ale.andro Santos-Lozano Pe.ro L.Vale.zue.a carmen Fiuza-Luce. Ale.andro Lucia i+He.LTH European University Miguel de CervantesValladolid 47012Spain Re.e.rch Institute.of the.Hospital 12 de.Octubre.“imas12”) Madrid 28041Spain de.artme.t of Syste.s Biology University of AlcalaAlcala de Heranes 28801Spain Faculty of Sport Scie.ce. Universidad Europea de MadridVillaviciosa de Odon(Madrid)28670Spain

Gastroe.ophage.l re.lux dise.se.Ge.d)is de.ine. by re.urre.t and trouble.ome.he.rtburn and e.fortle.s re.urgitation or by the.spe.ific complications of this condition—that is,e.ophagitis,e.ophage.l pe.tic stricture.,and Barre.t e.ophagus.1Although Ge.d is cause. by gastric conte.ts're.ching the.e.ophagus,gastric juice. can also re.ch othe. anatomical locations(pharynx,mouth,larynx,and airways),le.ding to(or worse.ing)e.tra-e.ophage.l conditions(notably asthma)or symptoms(e.g.,whe.zing,cough).1 Toge.he. with obe.ity,Ge.d is the.main risk factor for gastroe.ophage.l malignancie..

关键词： e.ophagus e.ophage.l Barre.t

e.e.kine.re.ponse.to acute.e.e.cise.Still much to discove.

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Journal of Sport and He.lth Scie.ce 2024年第6期13卷 759-760页

作者： Pe.ro L.Vale.zue.a Be.triz Rivas-Bae.a carmen Fiuza-Luce. Ale.andro Lucia Physical Activity and He.lth Re.e.rch Group(“PaHe.g”) Research Institute of Hospital“12 de Octubre”(“imas12”)Madrid 28041Spain de.artme.t of Syste.s Biology University of AlcalaMadrid 28871Spain Ce.tro de.Salud Luis Vive. Alcala de HenaresMadrid 28803Spain Faculty of Sport Scie.ce. Universidad Europea de MadridMadrid 28670Spain

Strong e.ide.ce.supports the.be.e.its of re.ular physical activity/e.e.cise.for the.pre.e.tion and manage.e.t of nume.ous non-communicable.dise.se..^(1,2)Howe.e.,de.pite.important advance.(particularly the.imple.e.tation of comple.“omics”approache.),the.unde.lying mole.ular me.hanisms re.ain to be.cle.rly *** the.past de.ade.the.role.of e.e.kine.—a myriad of signaling moie.ie.(e.g.,mainly cytokine. but also othe. small pe.tide.,pe.tide.,nucle.c acids,lipids,or me.abolite.,among othe.s)re.e.se. by muscle.(myokine.)and othe. tissue. in re.ponse.to e.e.cise.that induce. e.docrine.at the.multisyste. le.e.),paracrine.or autocrine.e.fe.ts—has gaine. atte.tion.^(3,4)Inde.d it has be.n propose. that some.of the.salutary e.fe.ts of re.ular e.e.cise.i.e.,re.e.te. se.sions of acute.e.e.cise.might be.due.at le.st partly,to the.progre.sive.accumulation of fre.ue.t,acute.e.isode. of e.e.kine.re.e.se.^(5)

关键词： gaine. multisyste. pre.e.tion