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Journal of Geriatric Cardiology 2018年第1期15卷 66-75页

作者： Manolis Vavuranakis Konstantinos Kalogeras Angelos Michail Kolokathis Dimitrios Vrachatis Nikolaos Magkoutis Gerasimos Siasos Euaggelos Oikonomou Maria Kariori Theodoros Papaioannou Maria Lavda carmen moldovan Ourania Katsarou Dimitrios Tousoulis The First Department of Cardiology Hippokration Hospital Medical School National & Kapodistrian University of Athens Ilioupoli Greece

Transcatheter aortic valve implantation （TAVI） carries a significant thromboembolic and concomitant bleeding risk, not only during the procedure but also during the periprocedural period. Many issues concerning optimal antithrombotic therapy after TAVI are still under debate. In the present review, we aimed to identify all relevant studies evaluating antithrombotic therapeutic strategies in relation to clinical outcomes after the procedure. Four randomized control trials （RCT） were identified analyzing the post-TAVI antithrombotic strategy with all of them utilizing aspirin lifelong plus clopidogrel for 3-6 months. Seventeen registries have been identified, with a wide variance among them regarding baseline characteristics, while concerning antiplatelet therapy, clopidogrel duration was ranging from 3-12 months. Four non-randomized trials were identified, comparing single vs. dual antiplatelet therapy after TAVI, in respect of investigating thromboembolic outcome events over bleeding complications. Finally, limited data from a single RCT and a retrospective study exist with regards to anticoagulant treatment during the procedure and the optimal antithrombotic therapy when concomitant atrial fibrillation. In conclusion, due to the high risk and frailty of the treated population, antithrombotic therapy after TAVI should be carefully evaluated. Diminishing ischaemic and bleeding complications remains the main challenge in these patients with further studies to be needed in this field.

关键词： Antiplatelets Antithrombotic Bleeding Stroke Transcatheter aortic valve implantation

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Severe liver trauma with complex portal and common bile duct avulsion:A case report and review of the literature

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World Journal of Clinical Cases 2023年第16期11卷 3837-3846页

作者： Bianca Mitricof Alin Kraft Florentina Anton Alexandru Barcu Darina Barzan carmen Haiducu Vladislav Brasoveanu Irinel Popescu Cosmin Alec moldovan Florin Botea Medicine Doctoral School Titu Maiorescu University of BucharestBucharest 040441Romania Department of General Surgery Regina Maria Military Emergency HospitalBrasov 500007Romania Faculty of Medicine Carol Davila University of Medicine and PharmacyBucharest 050474Romania Dan Setlacec Center for General Surgery and Liver Transplant Fundeni Clinical InstituteBucharest 022328Romania Department of Medical-Surgical and Prophylactic Disciplines Faculty of MedicineTitu Maiorescu University of BucharestBucharest 031593Romania Department of General Surgery Witting Clinical HospitalBucharest 010243Romania

BACKGROUND Given its size and location,the liver is the third most injured organ by abdominal *** to recent advances,it is unanimously accepted that the nonoperative management is the current mainstay of treatment for hemodynamically stable ***,those patients with hemodynamic instability that generally present with severe liver trauma associated with major vascular lesions will require surgical ***,an associated injury of the main bile ducts makes surgery compulsory even in the case of hemodynamic stability,thereby imposing therapeutic challenges in the tertiary referral hepato-biliopancreatic centers’*** SUMMARY We present the case of a 38-year-old male patient with The American Association for the Surgery of Trauma grade V liver injury and an associated right branch of portal vein and common bile duct avulsion,due to a crush *** patient was referred to the nearest emergency hospital and because of the hemorrhagic shock,damage control surgery was performed by means of ligation of the right portal vein branch and right hepatic artery,and hemostatic ***,the patient was referred immediately to our tertiary hepato-bilio-pancreatic *** performed depacking,a right hepatectomy and Roux-en-Y *** the 9th postoperative day,the patient developed a high output anastomotic bile leak that required a redo of the *** postoperative period was marked by a surgical incision site of incomplete evisceration that was managed non-operatively by negative wound *** follow-up was optimal,with no complications at 55 *** In conclusion,the current case clearly supports that a favorable outcome in severe liver trauma with associated vascular and biliary injuries is achieved thru proper therapeutic management,conducted in a tertiary referral hepato-bilio-pancreatic center,where a stepwise and complex surgical approach is mandatory.

关键词： Severe Liver Trauma Avulsion Right portal vein Common bile duct Case report

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Reactive oxygen species and antioxidant properties from mushrooms

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Synthetic and Systems Biotechnology 2017年第1期2卷 13-22页

作者： carmen Sanchez Laboratory of Biotechnology Research Centre for Biological SciencesUniversidad Autonoma de TlaxcalaIxtacuixtlaTlaxcalaCP.90062Mexico

Preventive medicine and food industry have shown an increased interest in the development of natural antioxidants,since those most commonly used synthetic antioxidants may have restricted use in *** could explain why there is currently much research on the antioxidant properties from natural products such as *** mushrooms have been reported to possess antioxidant properties,which enable them to neutralize free *** oxygen molecule is a free radical,which lead to the generation of the reactive oxygen species and can damage the *** damage caused by free radicals appears to be a major contributor to aging and degenerative *** antioxidant components are found in fruit bodies,mycelium and culture both,which include polysaccharides,tocopherols,phenolics,carotenoids,ergosterol and ascorbic acid among *** bodies or mycelium can be manipulated to produce active compounds in a relatively short period of time,which represent a significant advantage in antioxidant compounds extraction from *** compounds may be extracted to be used as functional additives or mushrooms can be incorporated into our food regime,representing an alternative source of food to prevent damage caused by oxidation in the human body.

关键词： Antioxidant Fruit body Mushroom Mycelium Reactive oxygen species

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Selectivity in feeding preferences and ranging patterns in spider monkeys Ateles geoffroyi yucatanensis of northeastern Yucatan peninsula, Mexico

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Current Zoology 2013年第1期59卷 125-134页

作者： carmen SCHERBAUM Alejandro ESTRADA Department of Animal Ecology and Tropical Biology Biozentrum University of Wiirzburg Germany Estacion de Biologia Tropical Los Tuxtlas Instituto de Biologfa Universidad Nacional Aut6noma de M6xico Apartado Postal94 San Andres Tuxtla Veracruz M6xico C. P. 95700

The spider monkey, a fruit specialist and important seed dispersal agent in the Neotropics, is an endangered primate due to habitat loss, hunting and the pet trade. Spider monkeys have been the subject of a few studies in Central and South Ame- rica, but little is known about the diet and ranging for this primate in southern Mexico. Here we report the results of a six-month long study （October 2010 to March 2011） of the feeding preferences and ranging patterns of the Yucatan spider monkey Ateles geoffroyi yucatanensis living in the ＂Ya＇ax＇che＂ reserve by the Caribbean coast in northeast Yucatan peninsula. Focal animal and scan sampling as well as GPS tracking were used to document spider monkey feeding behavior, location of food trees and ranging in the reserve. The spider monkeys used 36 species of plants （94% trees; n = 432） and six non tree morphospecies as a source of food. Six tree species accounted for 〉~80% of total feeding time and for 74% of all trees used. Fruits accounted for 59% of total feeding time, followed by leaves （35%）, palm piths （5%） and other plant parts （1%）. Total range used by the monkeys was esti- mated at 43% of semievergreen rainforest habitat available （ca 40ha）. Range use was not random with segments showing light, moderate and heavy use; the use of different areas of their range varied monthly and was closely linked to the spatial dispersion of the trees used for food [Current Zoology 59 （1）： 125-134, 2013].

关键词： Primates Frugivory Neotropics Conservation Seed dispersal

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Effect of dephytinization on bioavailability of iron,calcium and zinc from infant cereals assessed in the Caco-2 cell model

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World Journal of Gastroenterology 2009年第16期15卷 1977-1984页

作者： carmen Frontela Maria Laura Scarino Simonetta Ferruzza Gaspar Ros carmen Martínez Department of Food Science and Nutrition Faculty of Veterinary Science and Food Science and TechnologyMurcia University INRAN National Research Institute for Food and Nutrition

AIM： To test the effect of the dephytinization of three different commercial infant cereals on iron, calcium, and zinc bioavailability by estimating the uptake, retention, and transport by Caco-2 cells. METHODS： Both dephytinized （by adding an exogenous phytase） and non-dephytinized infant cereals were digested using an in vitro digestion protocol adapted to the gastrointestinal conditions of infants younger than 6 too. Mineral cell retention, transport, and uptake from infant cereals were measured using the soluble fraction of the simulated digestion and the Caco-2 cells. RESULTS： Dephytinization of infant cereals significantly increased （P 〈 0.05） the cell uptake efficiency （from 0.66%-6.05% to 3.93%-13%）, retention （from 6.04%-16.68% to 14.75%-20.14%） and transport efficiency （from 0.14%-2.21% to 1.47%-6.02%）, of iron, and the uptake efficiency （from 5.0%-35.4% to 7.3%-41.6%） and retention （from 4.05%-20.53% to 14.45%-61.3%） of zinc, whereas calcium only cell uptake showed a significant increase （P 〈 0.05） after removing phytate from most of the samples analyzed. A positive relationship （P 〈 0.05） between mineral solubility and the cell uptake and transport efficiencies was observed. CONCLUSION： Removing phytate from infant cereals had a beneficial effect on iron and zinc bioavailability when infant cereals were reconstituted with water. Since in developing countries cereal-based complementary foods for infants are usually consumed mixed with water, exogenous phytase additions could improve the nutritional value of this weaning food.

关键词： Infant cereals Phytate Iron Calcium Zinc Caco-2 cells BioavaUability

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GRID-INDEPENDENT CONSTRUCTION OF MULTISTEP METHODS

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Journal of Computational Mathematics 2017年第5期35卷 672-692页

作者： carmen Arevalo Gustaf Soderlind Numerical Analysis Centre for Mathematical Sciences Box 118 SE-22100 Lund Sweden.

A new polynomial formulation of variable step size linear multistep methods is pre- sented, where each k-step method is characterized by a fixed set of k - 1 or k parameters. This construction includes all methods of maximal order （p = k for stiff, and p = k ＋ 1 for nonstiff problems）. Supporting time step adaptivity by construction, the new formulation is not based on extending classical fixed step size methods; instead classical methods are obtained as fixed step size restrictions within a unified framework. The methods are imple- mented in MATLAB, with local error estimation and a wide range of step size controllers. This provides a platform for investigating and comparing different multistep method in realistic operational conditions. Computational experiments show that the new multi- step method construction and implementation compares favorably to existing software, although variable order has not yet been included.

关键词： Linear multistep methods Variable step size Adaptive step size Step sizecontrol Explicit methods Implicit methods Nonstiff methods Stiff methods Initial valueproblems Ordinary differential equations Differential-algebraic equations Implementa-tion.

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Empagliflozin reduces brain pathology in Alzheimer's disease and type 2 diabetes

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Neural Regeneration Research 2024年第6期19卷 1189-1190页

作者： carmen Hierro-Bujalance Monica Garcia-Alloza Division of Physiology School of MedicineUniversidad de CadizCadizSpain Instituto de Investigacion e Innovacion en Ciencias Biomedicas de la Provincia de Cadiz(INIBICA) CadizSpain Salus Infirmorum-Universidad de Cadiz CadizSpain

Alzheimer's disease(AD)and type 2 diabetes(T2D):More than 55 million people suffer from dementia,and it is expected that over 150 million people will suffer from this disease by *** is the most common type of dementia and while aging remains the main risk factor to suffer it,previous studies have also shown that metabolic disorders,and T2D specifically,are also major contributors(Wang et al.,2012).

关键词： Alzheimer diabetes

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Adjuvant treatment in biliary tract cancer: To treat or not to treat?

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World Journal of Gastroenterology 2012年第21期18卷 2591-2596页

作者： Stefano Cereda carmen Belli Michele Reni Department of Oncology San Raffaele Scientific Institute20132 Milan Italy

Biliary tract cancer is a rare malignant tumor. There is limited knowledge about biology and natural history of this disease and considerable uncertainty remains regarding its optimal diagnostic and therapeutic man- agement. The role of adjuvant therapy is object of debate and controversy. Although resection is identified as the most effective and the only potentially curative treatment, there is no consensus on the impact of ad- juvant chemotherapy and/or radiotherapy on the high incidence of disease recurrence and on survival. This is mainly due to the rarity of this disease and the consequent difficulty in performing randomized trials. The only two prospectively controlled trials concluded that adjuvant chemotherapy did not improve survival. Most of the retrospective trials, which had limited sample size and included heterogeneous patients population and non-standardized therapies, suggested a marginal benefit of chemoradiotherapy in reducing locoregional recurrence and an uncertain impact on survival. Welldesigned multi-institutional randomized trials are necessary to clarify the role of adjuvant therapy. Two ongoing phase Ⅲ trials may provide relevant information.

关键词： Biliary tract cancer Adjuvant therapy Chemotherapy Chemoradiation Surgery

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Using fluorescence-based microplate assay to assess DOM-metal binding in reactive materials for treatment of acid mine drainage

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Journal of Environmental Sciences 2011年第6期23卷 891-896页

作者： carmen Mihaela Neculita Yves Dudal Gerald J Zagury Department of Civil and Environmental Engineering KAIST335 GwahangnoYuseong-guDaejeon 305-701Korea Institut National de la Recherche Agronomique UMR Eco&Sols-Ecologie Fonctionnelle et Biogéochimie des SolsMontpellier SupAgro-INRA-IRD2Place Pierre VialaBatiment 1234060 Montpellier Cedex 2France Department of Civil Geologicaland Mining EngineeringE'cole Polytechnique de Montre'alC.P.6079 Station Centre-villeMontrealQCH3C 3A7Canada

One potential drawback of compost-based passive bioreactors,which is a promising biotechnology for acid mine drainage（AMD） treatment,is the transport of dissolved organic matter（DOM）-metal complexes in surface *** address this problem,the objective of this study was to assess the maximum capacity of organic substrates to release soluble DOM-metal complexes in treated water. The reactivities of DOM in maple wood chips and sawdust,composted poultry manure,and leaf compost were quantified toward Cd2＋,Ni2＋,Fe2＋,and Cu2＋ using fluorescence *** DOM showed the highest reactivity toward Fe,but a limited number of available sites for sorption,whereas DOM-Cd complexes exhibited the lowest fluorescence ***,the DOM from a mixture of wastes formed higher concentrations of DOM-metal complexes relative to sole *** DOM-metal complexes, the concentrations of DOM-Ni complexes were the *** reaching steady-state,low concentrations of DOM-metal complexes were released in treated water,which is in agreement with theoretical predictions based on geochemical ***,in addition to physicochemical characterization,fluorescence quenching technique is recommended for the substrate selection of bioreactors.

关键词： passive bioreactors acid mine drainage DOM reactivity fluorescence quenching metal complexation

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Investigation on directional effects of Vrancea subcrustal earthquakes

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Earthquake Engineering and Engineering Vibration 2015年第3期14卷 399-410页

作者： Florin Pavel Radu Vacareanu Mircea Radulian carmen Cioflan Seismic Risk Assessment Center Technical University of Civil Engineering Bucharest National Institute for Earth Physics (INFP)

This paper evaluates possible directional effects from strong ground motions recorded during the last four significant subcrustal earthquakes produced in the Vrancea seismic zone（Romania） in August 1986（Mw=7.1）,May 1990（Mw=6.9 and 6.4） and October 2004（Mw=6.0）.Several measures of the horizontal component of the ground motion given in the literature（Boore et al.,2006;Boore,2010） are computed and are related to the geometric mean of the as-recorded horizontal *** method is applied in order to quantify the influence of the earthquake magnitude and of the soil class on some strong ground motion parameters（*** intensity,PGV/PGA,or mean period TM）.The study of the directional effects is performed using the distribution of IJMAand of the rotation angle corresponding to a measure of the horizontal component of the ground motion（RotD 100） and the results reveal a visible directional pattern for IJMA,while in the case of RotD100 the directional patterns are less visible.

关键词： response spectra horizontal ground motion directio

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