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Superoxide dismutase prevents development of adenocarcinoma in a rat model of Barrett's esophagus

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World Journal of Gastroenterology 2005年第47期11卷 7436-7443页

作者： Elena Piazuelo carmelo Cebrián Alfredo Escartín Pilar Jiménez Fernando Soteras Javier Ortego Angel Lanas Instituto Aragonés de Ciencias de la Salud Unidad Mixta de InvestigaciónC/Domingo Miral s/n 50009 ZaragozaSpain Service of Pathology Hospital Clínico Universitario "Lozano Blesa"Avenida San Juan Bosco15 50009 ZaragozaSpain Unidad Mixta de Investigatión University of ZaragozaDomingo Miral s/n 50009 ZaragozaSpain Unidad Mixta de Investigación University of ZaragozaDomingo Miral s/n 50009 ZaragozaSpain Service of Gastroenterology Hospital Clínico Universitario "Lozano Blesa"Avenida San Juan Bosco15 50009 ZaragozaSpain

AIM: To test whether antioxidant treatment could prevent the progression of Barrett's esophagus to ***: In a rat model of gastroduodenoesophageal reflux by esophagojejunal anastomosis with gastric preservation, groups of 6-10 rats were randomized to receive treatment with superoxide dismutase (SOD) or vehicle and followed up for 4 mo. Rat's esophagus was assessed by histological analysis, superoxide anion and peroxinitrite generation, SOD levels and DNA oxidative ***: All rats undergoing esophagojejunostomy developed extensive esophageal mucosal ulceration and inflammation by mo 4. The process was associated with a progressive presence of intestinal metaplasia beyondthe anastomotic area (9% 1st mo and 50% 4th mo) (94% at the anastomotic level) and adenocarcinoma(11% 1st mo and 60% 4th mo). These changes were associated with superoxide anion and peroxinitrite mucosal generation, an early and significant increase of DNA oxidative damage and a significant decrease in SOD levels (P＜0.05). Exogenous administration of SOD decreased mucosal superoxide levels, increased mucosal SOD levels and reduced the risk of developing intestinal metaplasia beyond the anastomotic area (odds ratio = 0.326; 95%CI: 0.108-0.981; P = 0.046),and esophageal adenocarcinoma (odds ratio = 0.243;95%CI: 0.073-0.804; P = 0.021).CONCLUSION: Superoxide dismutase prevents the progression of esophagitis to Barrett's esophagus and adenocarcinoma in this rat model of gastrointestinal reflux, supporting a role of antioxidants in the chemoprevention of esophageal adenocarcinoma.

关键词：过氧化物岐化酶食管疾病病理机制治疗

Endoscopic ultrasound-guided treatments: Are we getting evidence based- a systematic review

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World Journal of Gastroenterology 2014年第26期20卷 8424-8448页

作者： Carlo Fabbri carmelo Luigiano Andrea Lisotti Vincenzo Cennamo Clara Virgilio Giancarlo Caletti Pietro Fusaroli Unit of Gastroenterology and Digestive Endoscopy AUSL Bologna Bellaria-Maggiore Hospital Unit of Gastroenterology and Digestive Endoscopy Department of Medical and Surgical Sciences - DIMEC University of BolognaHospital S Maria della Scaletta

The continued need to develop less invasive alternatives to surgical and radiologic interventions has driven the development of endoscopic ultrasound(EUS)-guided *** include EUS-guided drainage of pancreatic fluid collections,EUS-guided necrosectomy,EUS-guided cholangiography and biliary drainage,EUSguided pancreatography and pancreatic duct drainage,EUS-guided gallbladder drainage,EUS-guided drainage of abdominal and pelvic fluid collections,EUS-guided celiac plexus block and celiac plexus neurolysis,EUSguided pancreatic cyst ablation,EUS-guided vascular interventions,EUS-guided delivery of antitumoral agents and EUS-guided fiducial placement and *** these procedures are technically challenging and require expertise in both EUS and interventional endoscopy,such as endoscopic retrograde cholangiopancreatography and gastrointestinal *** undertook a systematic review to record the entire body of literature accumulated over the past 2decades on EUS-guided interventions with the objective of performing a critical appraisal of published articles,based on the classification of studies according to levels of evidence,in order to assess the scientific progress made in this field.

关键词： Endoscopic ultrasound Pseudocyst drainage Necrosec

Analyzing predictors of graft survival in patients undergoing liver transplantation with donors aged 70 years and over

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World Journal of Gastroenterology 2018年第47期24卷 5391-5402页

作者： Oscar Caso-Maestro Carlos Jiménez-Romero Iago Justo-Alonso Jorge Calvo-Pulido David Lora-Pablos Alberto Marcacuzco-Quinto Félix Cambra-Molero Alvaro García-Sesma Marina Pérez-Flecha Carlos Munoz- Arce carmelo Loinaz-Segurola Alejandro Manrique-Municio Unit of HBP Surgery and Abdominal Organs Transplantation Department of General Surgery“12 de octubre” University HospitalMadrid 28041Spain Clinical Research Department Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP)“12 de octubre” University HospitalMadrid 28041Spain

AIM To increase the number of available *** This is a single-center comparative analysis performed between April 1986 and May 2016. Two hundred and twelve liver transplantation(LT) were performed with donors ≥ 70 years old(study group). Then, we selected the first cases that were performed with donors < 70 years old immediately after the ones that were performed with donors ≥ 70 years old(control group).RESULTS Graft and patient survivals were similar between both groups without increasing the risk of complications, especially primary non-function, vascular complications and biliary complications. We identified 5 risk factors as independent predictors of graft survival: recipient hepatitis C virus(HCV)-positivity [hazard ratio(HR) = 2.35; 95% confidence interval(CI): 1.55-3.56; P = 0.00]; recipient age(HR = 1.04; 95%CI: 1.02-1.06; P = 0.00); donor age X model for end-stage liver disease(D-MELD)(HR = 1.00; 95%CI: 1.00-1.00; P = 0.00); donor value of serum glutamic-pyruvic transaminase(HR = 1.00; 95%CI: 1.00-1.00; P = 0.00); and donor value of serum sodium(HR = 0.96; 95%CI: 0.94-0.99; P = 0.00). After combining D-MELD and recipient age we obtained a new scoring system that we called DR-MELD(donor age X recipient age X MELD). Graft survival significantly decreased in patients with a DR-MELD score ≥ 75000, especially in HCV patients(77% vs 63% at 5 years in HCV-negative patients, P = 0.00; and 61% vs 25% at 5 years in HCV-positive patients; P = 0.00). CONCLUSION A DR-MELD ≥ 75000 must be avoided in order to obtain the best results in LT with donors ≥ 70 years old.

关键词： Liver transplantation Aged donors Old donors Marginal donors Donor age

Development of Nano-Structured AA1050 by ECAE and Thermal Treatments

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Soft Nanoscience Letters 2011年第4期1卷 120-129页

作者： carmelo J. Luis Javier León Rodrigo Luri Ignacio Puertas Ivan Pérez Daniel Salcedo 不详

In this present work, a study regarding the change in the mechanical properties and in the microstructure of the aluminium alloy AA1050 is made after being processed by severe plastic deformation (SPD) with Equal Channel Angular Extrusion (ECAE). Optical and scanning electron microscopy techniques will be employed in order to determine the evolution of the microstructure after different thermal treatments, subsequent to the severe plastic deformation process. This present work involves a profound study on the change in the mechanical properties for an alloy which has a very low value of strain hardening at room temperature. With this, it is demonstrated that it is possible to improve its mechanical properties significantly with an adequate combination of ECAE processing and thermal treatments.

关键词： ECAE SPD Aluminium UFG.

Efficacy, risk factors and complications of endoscopic polypectomy: Ten year experience at a single center

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World Journal of Gastroenterology 2008年第15期14卷 2364-2369页

作者： Pierluigi Consolo carmelo Luigiano Giuseppe Strangio Maria Grazia Scaffidi Giuseppa Giacobbe Giovanna Di Giuseppe Agata Zirilli Luigi Familiari Department of Medicine and Pharmacology University Hospital "G. Martino" Via Consolare Valeria Messina 98100 Italy Department of Statistics University of Messina Messina 98100 Italy

AIM: To examine the efficacy and complications of colonoscopic resection of colorectal polypoid lesions. METHODS: We retrospectively reviewed 1354 polypectomies performed on 1038 patients over a ten- year period. One hundred and sixty of these were performed for large polyps, those measuring ≥ 20 mm. Size, shape, location, histology, the technique of polypectomy used, complications, drugs assumption and associated intestinal or extra intestinal diseases were analyzed. For statistical analysis, the Pearson χ2 test, NPC test and a Binary Logistic Regression were used. RESULTS: The mean patient age was 65.9 ± 12.4 years, with 671 men and 367 women. The mean size of polyps removed was 9.45 ± 9.56 mm while the size of large polyps was 31.5 ± 10.8 mm. There were 388 pedunculated and 966 sessile polyps and the most common location was the sigmoid colon (41.3%). The most frequent histology was tubular adenoma (55.9%) while for the large polyps was villous (92/160 -57.5%). Coexistent malignancy was observed in 28 polyps (2.1%) and of these, 20 were large polyps. There were 17 procedural bleeding (1.3%) and one perforation. The statistical analysis showed that cancer is correlated to polyp size (P < 0.0001); sessile shape (P < 0.0001) and bleeding are correlated to cardiac disease (P = 0.034), tubular adenoma (P = 0.016) and polyp ***: The endoscopic resection is a simple and safe procedure for removing colon rectal neoplastic lesions and should be considered the treatment of choice for large colorectal polyps. The polyp size is an important risk factor for malignancy and for bleeding.

关键词：结肠癌息肉切除术内窥镜风险因子

Endoscopic treatment of orbital tumors

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World Journal of Clinical Cases 2015年第3期3卷 270-274页

作者： Francesco Signorelli carmelo Anile Mario Rigante Gaetano Paludetti Angelo Pompucci Annunziato Mangiola Department of Neurosurgery Catholic University School of Medicine Department of Otolaryngology Catholic University School of Medicine

Different orbital and transcranial approaches are performed in order to manage orbital tumors, depending on the location and size of the lesion within the orbit. These approaches provide a satisfactory view of the superior and lateral aspects of the orbit and the optic canal but involve risks associated with their invasiveness because they require significant displacement of orbital structures. In addition, external approachesto intraconal lesions may also require deinsertion of extraocular muscles, with subsequent impact on extraocular mobility. Recently, minimally invasive techniques have been proposed as valid alternative to external approaches for selected orbital lesions. Among them, transnasal endoscopic approaches, "pure" or combined with external approaches, have been reported, especially for intraconal lesions located inferiorly and medially to the optic nerve. The avoidance of muscle detachment and the shortness of the surgical intraorbital trajectory makes endoscopic approach less invasive, thus minimizing tissue damage. Endoscopic surgery decreases the recovery time and improves the cosmetic outcome not requiring skin incisions. The purpose of this study is to review and discuss the current surgical techniques for orbital tumors removal, focusing on endoscopic approaches to the orbit and outlining the key anatomic principles to follow for safe tumor resection.

关键词： Orbit Orbital tumor Endoscopy Surgery Approach

Early Surgery in Femoral Neck Fractures in Elderly: Does Preoperative ASA Score Matter?

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International Journal of Clinical Medicine 2016年第12期7卷 829-836页

作者： Stefania De Sanctis Raffaella Alonzo Silvia Frontini Ilaria Nicolosi Fabio Belvederi Edoardo Monaco Attilio Speranza carmelo D’Arrigo Università di Roma La Sapienza Rome Italy

Introduction: Early surgical treatment (within 48 hours) has been recommended for femoral neck fractures in order to avoid complications and reduce mortality rate, regardless of presence and severity of comorbidity and preoperative status (ASA score). However some studies evidenced that early surgery doesn’t always have a beneficial effect on mortality and complications. Therefore further studies could be useful in order to better assess risk related factors of patients requiring surgical treatment for femoral neck fracture. The purpose of this study is to evaluate the effect of preoperative ASA score and timing of surgery on mortality, complications and clinical outcome. Methods: All 336 patients operated in our center from January 2013 to December 2014 were selected for this retrospective study. Patients were divided in three groups as follows: group 1 patients treated within 48 hours;group 2 patients treated between 48 to 96 hours;group 3 patients treated over 96 hours. The preoperative ASA score was recorded for each patient. Complication, clinical outcome and mortality at one-year follow-up were evaluated. At follow-up ambulation was graded as: confined to bed, assisted ambulation, and normal ambulation. Complications both local (infections, malunion, dislocation) and systemic (deep vein thrombosis, pulmonary embolism, lung infections, ischemic disorders of heart) were recorded as well as number of transfusions. Statistical analysis was performed with chi square test and P value Results: 308 patients’ data were fully available for this study. At one-year follow-up return to normal ambulation was higher for patients of group 1 as compared with group 2 and 3 and in group 2 as compared with group 3 (P = 0.04). There was no difference in mortality and return to ambulation between patients with ASA score 1 and 2 (P = 0.06);patients with ASA score ≥ 3 showed a statistically significant higher mortality (P = 0.004) and rate of complications (0.0008) regardless of timi

关键词： Femur Fractures ASA Score Early Surgery Elderly Hip Surgery

Gastric metastasis by lung small cell carcinoma

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World Journal of Gastroenterology 2006年第25期12卷 4096-4097页

作者： Giovanni Casella Camillo Di Bella Antonino Roberto Cambareri carmelo Antonio Buda Gianluigi Corti Filippo Magri Stefano Crippa Vittorio Baldini Department of Medicine Desio Hospital DesioMilanItaly Pathology Department Desio Hospital DesioMilanItaly Surgery Department Desio Hospital DesioMilanItaly Oncology Department Università di Messina MessinaItaly

胃肠道的转移瘤是稀罕的。我们由于主要的肺癌症描述胃的转移的一个案例，由上面的胃肠的内视镜检查法(UGIE ) 揭示了。到胃的造血的转移是一个稀罕事件。到我们的知识，仅仅 55 个案例在国际文学被描述了。在这些病人，预后是很差的。... 详细信息

胃肠道的转移瘤是稀罕的。我们由于主要的肺癌症描述胃的转移的一个案例，由上面的胃肠的内视镜检查法(UGIE ) 揭示了。到胃的造血的转移是一个稀罕事件。到我们的知识，仅仅 55 个案例在国际文学被描述了。在这些病人，预后是很差的。我们此处由肺报导胃的转移的一个案例小房间癌，与关于这个稀罕实体的文学的评论。

关键词：胃转移肝细胞癌治疗病理报告

细粒棘球绦虫——用包虫囊液抗原和头节抗原作间接血凝反应诊断人体包虫病

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新疆医科大学学报 1982年第S1期 23-24页

作者： carmelo Tassi 薛弘燮

引言即将被采用的囊液抗原组分,较目前所用的人体包虫病生物学诊断的反应物有较大的敏感性和特异性。目前常用绵羊包虫有头囊囊液,用50％硫酸铵处理获得球蛋白抗原,用它致敏羊红细

关键词：包虫病包虫囊液血凝反应敏感性抗原头节间接血凝