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Efficacy and limits of sildenafil citrate in patients with arterial erectile dysfunction： role of peripheral arterial disease and cardiovascular comorbidities

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Asian Journal of Andrology 2008年第6期10卷 847-853页

作者： Enzo Vicari Mariano Malaguarnera Sandro La Vignera Fabio Calzavara carmelo battiato Aldo E. Calogero Section of Endocrinology Andrology and Internal Medicine and Master in Andrological and Human Reproduction Sciences Department of Biomedical Sciences University of Catania Catania 95123 Italy Department of Senescence Urological and Neurological Sciences University of Catania Catania 95021 Italy

Aim： To evaluate whether the response to sildenafil administration in patients with arterial erectile dysfunction （ED） was related to their peak systolic velocity （PSV）, peripheral atherosclerosis, cardiovascular risk factors （RF） and/or comorbidities at low cardiovascular risk. Methods： We enrolled 97 patients with 1-2 RF and comorbidities, combined with arterial ED alone （group A, n = 27）, ED plus atherosclerotic carotid artery （group B, n = 23）, ED plus lower limb artery abnormalities （group C, n = 25）, and ED plus carotid and lower limb artery abnormalities （group D, n = 22）. Sildenafil efficacy （100 mg twice a week for 12 weeks） was also examined in patients with ≥ 3 RF, peripheral a（herosclerosis and no cardiovascular comorbidities （group E, n = 20）. Results： Median PSV was 24.1, 21.0, 19.3, 14.5 and 17.5 cm/s in groups A, B, C, D and E, respectively. Sildenafil response was higher in group A patients （77.8%）, intermediate in groups B and C （65.2% and 56%） and lowest in groups D （45.4%） and E （50%）, and the response in latter two groups was significantly lower than in the other three groups. In addition, sildenafil response was nega- tively influenced by：〉 3 RF, peripheral atherosclerosis and no systemic comorbidity, or presence of 1-2 RF associated with extended atherosclerosis and comorbidities. The number of comorbidifies was positively related to atherosclerosis localization or extension （25, 35, 38 and 47 in groups A, B, C and D, respectively）. Conclusion： Low sildenafil efficacy in patients with arterial ED was associated with extended atherosclerosis. These patients should undergo extensive ultrasonography and a full cardiovascular examination.

关键词： arterial erectile dysfunction cardiovascular comorbidities peripheral atherosclerosis sildenafil efficacy

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Statistical analysis of physico-mechanical parameters of sandstones occurring in orogenic settings

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Journal of Mountain Science 2024年第4期21卷 1388-1402页

作者： PAPPALARDO Giovanna CARBONE Serafina MONACO carmelo ZOCCO Giordana MINEO Simone Dipartimento Di Scienze Biologiche Geologiche E AmbientaliUniversitàDegli Studi Di CataniaCorso Italia 5795129 CataniaItaly

In northeastern Sicily(Italy),sandstone rock masses widely crop out as cover deposits over crystalline terrains belonging to the orogenic *** being part of the same geological formation,these sandstones are characterized by highly different features in terms of texture and physico-mechanical *** poses a scientific question on the possibility of tracing these rocks to a single statistical model,which could be representative of their main engineering geological ***,it is worth investigating on the possible reasons of such differences,that should be searched either in the current geographical sandstone distribution or in the rock *** this study,sandstone samples were collected from different sites and were analyzed at both the hand and thin section *** sandstone types were recognized,characterized by a different ***,the laboratory characterization allowed estimating their main physico-mechanical and ultrasonic properties,such as porosity,density,mechanical strength,deformability,and ultrasonic *** rock mechanical strength proved linked to the rock compactness and to the presence of lithic fragments,while pores and a pseudo-matrix between grains represent weakening *** data were also statistically analyzed by grouping the specimens according to a geographical criterion,with respect to their sampling area,but no link was found between location and rock ***,with the aim of achieving mathematical laws that could be used to predict some rock properties from others,useful for practical purposes when dealing with such a high property variability,single and multiple regression analyses were carried *** show that the Uniaxial Compressive Strength,porosity,and P-wave velocity are the best predictors for a quick,indirect estimation of the main physico-mechanical *** methodological approach developed for this research can be taken as reference to study other world

关键词： Sandstone Laboratory test Uniaxial Compressive Strength Porosity Rocks

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Pollen analysis reveals the effects of uncovered interactions,pollen-carrying structures,and pollinator sex on the structure of wild bee-plant networks

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Insect Science 2024年第3期31卷 971-988页

作者： Clément Tourbez carmelo Gómez-Martínez MiguelÁngel Gonzalez-Estévez Amparo Lazaro Mediterranean Institute for Advanced Studies(UIB-CSIC) Global Change Research GroupEsporlesBalearic IslandsSpain Department of Biology Ecology AreaUniversity of the Balearic/slandsPalmaSpain

Pollination networks are increasingly used to model the complexity of interactions between pollinators and flowering plants in *** methods exist to sample these interactions,with direct observations of plant-pollinator contacts in the field being by far the most *** the identification of pollen carried by pollinators allows uncovering interactions and increasing sample sizes,the methods used to build pollen-transport networks are variable and their effect on network structure remains *** understand how interaction sampling influences the structure of networks,we analyzed the pollen found on wild bees from eight communities across Mallorca Island and investigated the differences in pollen loads between bee body parts(scopa ***)and *** then assessed how these differences,as well as the uncovered interactions not detected in the field,influenced the structure of wild bee-plant *** identified a higher quantity and diversity of pollen in the scopa than in the rest of the female body,but these differences did not lead to differences in structure between plant-pollination(excluding scopa pollen)and bee-feeding interaction(including scopa pollen)***,networks built with pollen data were richer in plant species and interactions and showed lower modularity and specialization(H2'),and higher nestedness than visitation networks based on field *** interactions with plants were stronger compared to those of males,although not ***,females were more generalist(low d')and tended to be more central in interaction networks,indicating their more key role structuring pollination networks in comparison to *** study highlights the importance of palynological data to increase the resolution of networks,as well as to understand important ecological questions such as the differences between plant-pollination and bee-feeding interaction networks,and the role of sexes in pollination.

关键词： palynology pollen-transport networks pollination role of bee sexes sampling methodology visitation networks

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Testosterone replacement therapy and vascular thromboembolic events: a systematic review and meta-analysis

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Asian Journal of Andrology 2024年第2期26卷 144-154页

作者： Rossella Cannarella carmelo Gusmano Claudia Leanza Vincenzo Garofalo Andrea Crafa Federica Barbagallo Rosita A Condorelli Sandro La Vignera Aldo E Calogero Department of Clinical and Experimental Medicine University of CataniaCatania 95123Italy Glickman Urological&Kidney Institute Cleveland Clinic FoundationClevelandOH44195USA

To evaluate the relationship between testosterone replacement therapy(TRT)and arterial and/or venous thrombosis in patients with pre-treatment total testosterone(TT)<12 nmol I^(-1),we performed a meta-analysis following the Population Intervention Comparison Outcome ***:men with TT<12 nmol I^(-1) or clear mention of hypogonadism in the inclusion criteria of patients;intervention:TRT;comparison:placebo or no therapy;outcomes:arterial thrombotic events(stroke,myocardial infarction[MI],upper limbs,and lower limbs),VTE(deep vein thrombosis[DVT],portal vein thrombosis,splenic thrombosis,and pulmonary embolism),and mortality.A total of 2423 abstracts were assessed for ***-four studies,including 14 randomized controlled trials(RCTs),were finally included,with a total of 4027 and 310288 hypotestosteronemic male patients,from RCTs and from observational studies,*** on RCT-derived data,TRT did not influence the risk of arterial thrombosis(odds ratio[OR]=1.27,95%confidence interval[CI]:0.47-3.43,P=0.64),stroke(OR=1.34,95%CI:0.09-18.97,P=0.83),MI(OR=0.51,95%CI:0.11-2.31,P=0.39),VTE(OR=1.42,95%CI:0.22-9.03,P=0.71),pulmonary embolism(OR=1.38,95%CI:0.27-7.04,P=0.70),and mortality(OR=0.70,95%CI:0.20-2.38,P=0.56).Meanwhile,when only observational studies are considered,a significant reduction in the risk of developing arterial thrombotic events,Ml,venous thromboembolism,and mortality was *** risk for DVT remains uncertain,due to the paucity of RCT-based *** in men with TT<12 nmol I^(-1) is safe from the risk of adverse cardiovascular *** studies specifically assessing the risk of DVT in men on TRT are needed.

关键词： hypogonadism testosterone testosterone replacement therapy thromboembolism thrombosis TRT

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The outcomes and safety of patients undergoing endoscopic retrograde cholangiopancreatography combining a single-use cholangioscope and a single-use duodenoscope:A multicenter retrospective international study

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 71-76页

作者： Alessandro Fugazza Matteo Colombo Michel Kahaleh V.Raman Muthusamy Bick Benjamin Wim Laleman carmelo Barbera Carlo Fabbri Jose Nieto Abed Al-Lehibi Mohan Ramchandani Amy Tyberg Haroon Shahid Avik Sarkar Dean Ehrlich Stuart Shermand Cecilia Binda Marco Spadaccini Andrea Iannone Kareem Khalaf Nageshwar Reddy Andrea Anderloni Alessandro Repici Division of Gastroenterology and Digestive Endoscopy Humanitas Research Hospital-IRCCSVia Manzoni 5620089RozzanoMilanoItaly Gastroenterology Rutgers Robert Wood JohnsonNew BrunswickNew JerseyUSA Vatche and Tamar Manoukian Division of Digestive Diseases University of CaliforniaLos Angeles School of Medicine at UCLALos AngelesCaliforniaUSA Division of Digestive and Liver Disorders Indiana University School of MedicineIndianapolisINUSA Department of Gastroenterology and Hepatology University Hospitals LeuvenKU Leuven3000 LeuvenBelgium U.O.C.di Gastroenterologia ed Endoscopia Digestiva Ospedale Giuseppe MazziniASL TeramoItaly Gastroenterology and Digestive Endoscopy Unit Forlì-Cesena HospitalsAUSL RomagnaForlì-CesenaItaly Borland Groover Clinic JacksonvilleFloridaUSA Department of Gastroenterology and Hepatology King Fahad Medical CityRiyadhSaudi Arabia Asian Institute of Gastroenterology HyderabadIndia Section of Gastroenterology Department of Emergency and Organ TransplantationUniversity of BariBari 70124Italy Department of Biomedical Sciences Humanitas UniversityVia Rita Levi Montalcini 420090Pieve EmanueleMilanItaly

Background: Duodenoscope-related multidrug-resistant organism(MDRO) infections raise concerns. Disposable duodenoscopes have been recently introduced in the market and approved by regulatory agencies with the aim to reduce the risk of endoscopic retrograde cholangiopancreatography(ERCP) associated infections. The aim of this study was to evaluate the outcome of procedures performed with single-use duodenoscopes in patients with clinical indications to single-operator cholangiopancreatoscopy. Methods: This is a multicenter international, retrospective study combining all patients who underwent complex biliopancreatic interventions using the combination of a single-use duodenoscope and a single-use cholangioscope. The primary outcome was technical success defined as ERCP completion for the intended clinical indication. Secondary outcomes were procedural duration, rate of cross-over to reusable duodenoscope, operator-reported satisfaction score(1 to 10) on performance rating of the single-use duodenoscope, and adverse event(AE) rate. Results: A total of 66 patients(26, 39.4% female) were included in the study. ERCP was categorized according to ASGE ERCP grading system as 47(71.2%) grade 3 and 19(28.8%) grade 4. The technical success rate was 98.5%(65/66). Procedural duration was 64(interquartile range 15-189) min, cross-over rate to reusable duodenoscope was 1/66(1.5%). The satisfaction score of the single-use duodenoscope classified by the operators was 8.6 ± 1.3 points. Four patients(6.1%) experienced AEs not directly related to the single-use duodenoscope, namely 2 post-ERCP pancreatitis(PEP), 1 cholangitis and 1 ***: Single-use duodenoscope is effective, reliable and safe even in technically challenging procedures with a non-inferiority to reusable duodenoscope, making these devices a viable alternative to standard reusable equipment.

关键词： Single-operator cholangioscopy Single-use duodenoscope Endoscopic retrograde cholangiopancreatography Indeterminate biliary stricture Difficult biliary stones

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On Some Numerical Semigroup Transforms

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Algebra Colloquium 2022年第3期29卷 509-526页

作者： carmelo Cisto Universita di Messina Dipartimento di Scienze Matematiche e Informatiche Scienze Fisiche e Scienze della TerraViale Ferdinando Stagno D'Alcontres 3198166 MessinaItaly

In this paper we introduce a particular semigroup transform A that fixes the invariants involved in Wilf's conjecture,except the embedding *** also allows one to arrange the set of non-ordinary and non-irreducible numerical semigroups in a family of rooted *** addition,we study another transform,having similar features,that has been introduced by Bras-Amorós,and we make a comparison of *** particular,we study the behavior of the embedding dimension under the action of such transforms,providing some consequences concerning Wilf's conjecture.

关键词： numerical semigroup embedding dimension genus left element Wilf's conjecture

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A new definition of soil to promote soil awareness,sustainability,security and governance

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International Soil and Water Conservation Research 2022年第1期10卷 99-108页

作者： carmelo Dazzi Giuseppe Lo Papa Department of Agricultural Food and Forest SciencesUniversity of PalermoItaly

In these last decades,the awareness that soil is a very important resource for humans has noticeably *** actions and initiatives to promote soil governance,aiming at sustainable soil manage-ment and soil security have been undertaken by several national and international institutions and in many *** of the changes of soil perception over the centuries allows highlighting a perfect harmony between the evolution of soil awareness and the level of knowledge and technology achieved by humans during their history and *** these many achievements,soils continue to be scarcely considered in politics and *** suggest some thoughts and reflections that could lead to an up-to-date and effective definition of soil that directly focuses the public attention on its economic *** our opinion,soil economic value could be the only aspect that truly attracts the attention of politicians and administrators,which could increase soil awareness and encourage soil sustainability,security and Sustainable Development Goals and finally promote soil governance.

关键词： Definition of soil Soil perception Soil governance Soil awareness Ecosystem services Soil security

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Designs andmethodologies to recreate in vitro human gutmicrobiota models

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Bio-Design and Manufacturing 2023年第3期6卷 298-318页

作者： Francesco Biagini Costanza Daddi Marco Calvigioni carmelo De Maria Yu Shrike Zhang Emilia Ghelardi Giovanni Vozzi Research Center(E.Piaggio) University of PisaPisaItaly Department of Information Engineering University of PisaPisaItaly Department of Translational Research and New Technologies in Medicine and Surgery University of PisaPisaItaly Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMAUSA

The human gut microbiota is widely considered to be a metabolic organ hidden within our bodies,playing a crucial role in the host’s *** factors affect its composition,so a wide variety of microbes residing in the gut are present in the world *** excessive imbalances in microbial composition are often associated with human disorders and pathologies,and new investigative strategies to gain insight into these pathologies and define pharmaceutical therapies for their treatment are *** vitro models of the human gut microbiota are commonly used to study microbial fermentation patterns,community composition,and host-microbe *** and microfluidic devices have been designed to culture microorganisms from the human gut microbiota in a dynamic environment in the presence or absence of eukaryotic cells to interact *** this review,we will describe the overall elements required to create a functioning,reproducible,and accurate in vitro culture of the human gut *** addition,we will analyze some of the devices currently used to study fermentation processes and relationships between the human gut microbiota and host eukaryotic cells.

关键词： Gut microbiota In vitro models Bioreactors Host-microbiome Fermentation

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Endoscopic management of intramural spontaneous duodenal hematoma:A case report

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World Journal of Gastroenterology 2022年第20期28卷 2243-2247页

作者： Giorgio Valerii Vittorio Maria Ormando Carlo Cellini Luca Sacco carmelo Barbera Gastroenterology and Endoscopy Unit Ospedale G.MazziniTeramo 64100Italy Gastroenterology and Endoscopy Unit AORN San Giuseppe MoscatiAvellino 83100Ital Surgery Unit Ospedale G.MazziniTeramo 64100Italy

BACKGROUND Intramural duodenal hematoma is a rare condition described for the first time in *** condition is usually associated with blunt abdominal trauma in *** non-traumatic risk factors for spontaneous duodenal haematoma include several pancreatic diseases,coagulation disorders,malignancy,collagenosis,peptic ulcers,vasculitis and upper endoscopy *** adults the most common risk factor reported is anticoagulation *** clinical presentation may vary from mild abdominal pain to acute abdomen and intestinal obstruction or gastrointestinal *** SUMMARY The aim of this case summary is to show a case of intramural spontaneous hematoma with symptoms of intestinal obstruction that was properly drained endoscopically by an innovative system lumen-apposing metal stent Hot AXIOS™stent(Boston Scientific Corp.,Marlborough,MA,United States).CONCLUSION Endoscopic lumen-apposing metal stent Hot AXIOS™stent is a safe and feasible treatment of duodenal intramural hematoma in our case.

关键词： Duodenal hematoma Several pancreatic diseases Endoscopy complication AXIOS™stent Case report

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Physical exercises for preventing injuries among adult male football players:A systematic review

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Journal of Sport and Health Science 2022年第1期11卷 115-122页

作者： Jorge Pérez-Gómez Josécarmelo Adsuar Pedro EAlcaraz Jorge Carlos-Vivas Health EconomyMotricity and Education(HEME)Research GroupFaculty of Sports SciencesUniversity of ExtremaduraCaceres 10003Spain UCAM Research Center for High Performance Sport Catholic University of MurciaMurcia 30107Spain Faculty of Sport Sciences Catholic University of MurciaMurcia 30107Spain

Background:Football is the most practised sport in the world and is associated with the risk of injuries in the *** studies have been published that identify injury prevention programs,but there is no review of the full body of evidence on injury prevention programs for use by football *** aim of this article was to carry out a systematic review of published studies on injury prevention programs for adult male footballers,identify points of common understanding and establish recommendations that should be considered in the design of injury prevention ***:PubMed and EMBASE databases were used to identify relevant published articles using the following keywords:"soccer"AND"injury"AND"prevention".Results:A total of 2512 studies were identified initially,but only 11 studies met the inclusion criteria,and their outcomes are *** revealed that injury prevention programs in football have focused on strength training,proprioceptive training,multicomponent programs(balance,core stability,and functional strength and mobility),and warm-up ***:Based on results from the studies analyzed,football players can lower the incidence of match and training injuries by participating in dynamic warm-up programs that include preventive exercises before games or during training sessions,and by adding strength,balance,and mobility training to the training sessions.

关键词： Balance Core stability Injury prevention programs Soccer Warm-up

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