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Effects of Zinc Oxide Particles with Different Sizes on Root Development in Oryza sativa

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Rice science 2023年第5期30卷 449-458,I0021页

作者： Monica RUFFINI CASTIGLIONE Stefania BOTTEGA Carlo SORCE carmelina SPANÒ Department of Biology University of PisaVia Luca GhiniPisa 1356126Italy Centre for Climate Change Impact University of PisaVia del BorghettoPisa 8056124Italy

Given the consistent release of zinc oxide(ZnO)nanoparticles into the environment,it is urgent to study their impact on plants in *** this study,grains of rice were treated with two different concentrations of ZnO nanoparticles(NP-ZnO,10 and 100 mg/L),and their bulk counterpart(B-ZnO)were used to evaluate whether ZnO action could depend on particle *** test this hypothesis,root growth and development assessment,oxidative stress parameters,indole-3-acetic acid(IAA)content and molecules/enzymes involved in IAA metabolism were *** situ localization of Zn in control and treated roots was also *** Zn was visible inside root cells only following nanoparticle treatment,both materials(NP-ZnO and B-ZnO)were able to affect seedling growth and root morphology,with alteration in the concentration/pattern of localization of oxidative stress markers and with a different action depending on particle *** addition,only ZnO supplied as bulk material induced a significant increase in both IAA concentration and lateral root density,supporting our hypothesis that bulk particles might enhance lateral root development through the rise of IAA ***,IAA concentration was influenced more by the activity of the catabolic peroxidases than by the protective action of phenols.

关键词： zinc oxide indole-3-acetic acid lateral root rice bulk particle nanoparticle

Helicobacter pylori and extragastric diseases: A review

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World Journal of Gastroenterology 2018年第29期24卷 3204-3221页

作者： Antonietta Gerarda Gravina Rocco Maurizio Zagari Cristiana De Musis Lorenzo Romano carmelina Loguercio Marco Romano Dipartimento di "Medicina di Precisione" UOC Epatogastroenterologia Università della Campania "Luigi Vanvitelli" Dipertimento Di Scienze Mediche e Chirurgiche Università di Bologna

Helicobacter pylori(H. pylori) infection is very common and affects approximately half of the world population. It causes gastric diseases, but some authors have reported an association of H. pylori infection with other systemic manifestations beginning in 1994. The list of potential effects of H. pylori outside the stomach includes a number of extragastric manifestations and we focused on neurological, dermatological, hematologic, ocular, cardiovascular, metabolic, allergic, and hepatobiliary diseases. This review discusses these important reported manifestations that are not related to the gastrointestinal tract.

关键词： Helicobacter pylori Extragastric disease Neurological diseases Dermatological diseases Hematologic diseases Ocular diseases Cardiovascular diseases Metabolic diseases Allergic diseases Hepatobiliary diseases

Potential therapeutic applications of mesenchymal stem cells for the treatment of eye diseases

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World Journal of Stem Cells 2021年第6期13卷 632-644页

作者： Giuliana Mannino Cristina Russo Anna Longo carmelina Daniela Anfuso Gabriella Lupo Debora Lo Furno Rosario Giuffrida Giovanni Giurdanella Department of Biomedical and Biotechnological Sciences School of MedicineUniversity of CataniaCatania 95123Italy

Stem cell-based treatments have been extensively explored in the last few decades to develop therapeutic strategies aimed at providing effective alternatives for those human pathologies in which surgical or pharmacological therapies produce limited *** stem cells of different sources,mesenchymal stem cells(MSCs)offer several advantages,such as the absence of ethical concerns,easy harvesting,low immunogenicity and reduced tumorigenesis *** than a multipotent differentiation ability,MSCs can release extracellular vesicles conveying proteins,mRNA and *** to these properties,new therapeutic approaches have been designed for the treatment of various pathologies,including ocular *** this review,the use of different MSCs and different administration strategies are described for the treatment of diabetic retinopathy,glaucoma,and retinitis *** a large number of investigations,positive results have been obtained by in vitro experiments and by MSC administration in animal *** authors agree that beneficial effects are likely related to MSC paracrine *** on these considerations,many clinical trials have already been carried ***,although some adverse effects have been described,promising outcomes are *** can be assumed that in the near future,safer and more effective protocols will be developed for more numerous clinical applications to improve the quality of life of patients affected by eye diseases.

关键词： Mesenchymal stem cells Eye diseases Diabetic retinopathy Glaucoma Retinitis pigmentosa Regenerative medicine

OxLDL induced p53-dependent apoptosis by activating p38MAPK and PKCδ signaling pathways in J774A.1 macrophage cells

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分子细胞生物学报:英文版 2011年第5期3卷 316-318页

作者： Giovannini, Claudio Varì, Rosaria Scazzocchio, Beatrice Sanchez, Massimo Santangelo, Carmela Filesi, carmelina D'Archivio, Massimo Masella, Roberta Veterinary Public Health and Food Safety Italian National Institute of Health Viale Regina Elena 299 Rome 00161 Italy Cell Biology and Neuroscience Departments Italian National Institute of Health Viale Regina Elena 299 Rome 00161 Italy

Dear Editor,The sub-endothelial retention of lipoproteins is one of the key events that trigger the atherosclerosis ***-density lipoprotein(LDL)particles trapped within the arterial wall are prone to progressive oxidation by monocytes/*** LDL(oxLDL)is present in atherosclerotic lesions,and has been suggested to play a significant role in atherogenesis(Nishi et al.,2002).

关键词： p38MAPK arterial p53

Wireless capsule endoscopy and proximal small bowel lesions in Crohn’s disease

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World Journal of Gastroenterology 2010年第26期16卷 3299-3304页

作者： carmelina Petruzziello Sara Onali Emma Calabrese Francesca Zorzi Marta Ascolani Giovanna Condino Elisabetta Lolli Paola Naccarato Francesco Pallone Livia Biancone GI Unit Department of Internal Medicine University "Tor Vergata" Rome 00133 Italy

AIM: To investigate the prevalence of proximal small bowel (SB) lesions detected by wireless capsule endoscopy (WCE) in Crohn's disease (CD). METHODS: WCE was performed in 64 patients: 32 with CD of the distal ileum, and 32 controls with iron-deficiency anemia (IDA) or diarrhea. WCE was performed using the Given SB-WCE, followed by small intestine contrast ultrasonography (SICUS). Findings compatible with CD by using WCE included erosions, aphthoid or deep ulcers, and strictures/stenosis. RESULTS: WCE detected proximal SB lesions in 16/32 (50%) patients (14 aphthoid ulcers, 2 deep ulcers, one stricture), which appeared not to be related to clinical parameters [epigastric pain, age, smoking, non-steroidalanti-inflammatory drugs (NSAIDs), IDA]. Among patients with proximal SB lesions, 6 (37%) were smokers, 3 (19%) NSAID users, 3 (19%) had epigastric pain and 4 (25%) had IDA. SICUS detected proximal SB lesions in 3/32 patients (19%) also showing lesions with WCE. No correlations were observed between proximal SB lesions assessed by WCE or by SICUS (χ2 = 1.5, P = 0.2). CONCLUSION: The use of WCE allows the detection of previously unknown upper SB lesions in a high proportion of patients with a previous diagnosis of CD involving the distal ileum.

关键词： Wireless capsule endoscopy Crohn’s disease Small bowel

Ileal lesions in patients with ulcerative colitis after ileo-rectal anastomosis:Relationship with colonic metaplasia

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World Journal of Gastroenterology 2008年第34期14卷 5290-5300页

作者： Livia Biancone Emma Calabrese Giampiero Palmieri carmelina Petruzziello Sara Onali Giuseppe Sigismondo Sica Marta Cossignani Giovanna Condino Kiron Moy Das Francesco Pallone Cattedra di Gastroenterologia Dipartimento di Medicina InternaUniversità di "Tor Vergata" Cattedra di Anatomia ed Istologia Patologica Università di "Tor Vergata" Cattedra di Gastroenterologia Dipartimento di Medicina InternaUniversità di "Tor Vergata" Cattedra di Chirurgia Generale Università di "Tor Vergata" Cattedra di Gastroenterologia Dipartimento di Medicina Interna Università di "Tor Vergata" GI Unit Department of Gastroenterology & Hepatology University of Medicine & Dentistry of New Brunswick

AIM:To assess whether in ulcerative colitis (UC) patients with ileo-rectal anastomosis (IRA), ileal lesions may develop in the neo-terminal-ileum and their possible relation with phenotypic changes towards colonic epithelium. METHODS: A total of 19 patients with IRA under regular follow up were enrolled, including 11 UC and 8 controls (6 Crohn’s disease, CD; 1 familial adenomatous polyposis, FAP; 1 colon cancer, colon K). Ileal lesions were identifi ed by ileoscopy with biopsies taken from the ileum (involved and uninvolved) and from the rectal stump. Staining included HE and immunohistochemistry using monoclonal antibodies against colonic epithelial protein CEP (Das-1) and human tropomyosin isoform 5, hTM5 (CG3). Possible relation between development of colonic metaplasia and ileal lesions was ***: Stenosing adenocarcinoma of the rectal stump was detected in 1 UC patient. The neo-terminal ileum was therefore investigated in 10/11 UC patients. Ileal ulcers were detected in 7/10 UC, associated with colonic metaplasia in 4/7 (57.1%) and Das-1 and CG3 reactivity in 3/4 UC. In controls, recurrence occurred in 4/6 CD, associated with colonic metaplasia in 3/4 and reactivity with Das-1 and CG3 in 2/3. CONCLUSION: Present fi ndings suggest that in UC, ileal lesions associated with changes towards colonic epithelium may develop also after IRA. Changes of the ileal content after colectomy may contribute to the development of colonic metaplasia, leading to ileal lesions both in the pouch and in the neo-terminal ileum after IRA.

关键词： Ulcerative colitis Ileo-rectal anastomosis Ileal lesions Colonic metaplasia

Gastrointestinal involvement in paediatric COVID-19 — from pathogenesis to clinical management: A comprehensive review

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World Journal of Gastroenterology 2021年第23期27卷 3303-3316页

作者： carmelina Calitri Ilaria Fumi Maria Giovanna Ignaccolo Elena Banino Stefania Benetti Maria MaddalenaLupica Francesca Fantone Mariella Pace Franco Garofalo Department of Paediatrics Infermi HospitalASLTO3Rivoli 10098Italy

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the causative agent of coronavirus disease 2019(COVID-19),is responsible for the first pandemic of the 21st *** found in adults,signs and symptoms related to the disease mainly involve the respiratory tract in the paediatric ***,a considerable number of children present with gastrointestinal symptoms such as vomiting,abdominal pain,and *** purpose of this review is an accurate description,from pathogenesis to clinical presentation,diagnosis and treatment,of COVID-19 effects on the gastrointestinal system at a paediatric ***-CoV-2 can be identified in stool specimens of affected children by real-time polymerase chain reaction *** can last for several weeks after the end of the symptomatic *** signs and symptoms are generally self-limited,can correlate with blood tests and imaging alterations,and may require supportive treatment such as ***,they can precede severe disease manifestations such as the COVID-19-related multisystem inflammatory *** belonging to risk categories such as those affected by celiac disease,inflammatory bowel disease,and hepatic disease seem to not have a more severe course than the others,even if they are undergoing immunosuppressant *** follow-ups of patients with chronic diseases need to be revised during the pandemic period in order to postpone unnecessary tests,mainly endoscopic ones.

关键词： SARS-CoV-2 COVID-19 Paediatric Gastrointestinal Diarrhea Hydration

Small intestine contrast ultrasonography vs computed tomography enteroclysis for assessing ileal Crohn's disease

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World Journal of Gastroenterology 2012年第42期18卷 6088-6095页

作者： Sara Onali Emma Calabrese carmelina Petruzziello Francesca Zorzi Giuseppe Sica Roberto Fiori Marta Ascolani Elisabetta Lolli Giovanna Condino Giampiero Palmieri Giovanni Simonetti Francesco Pallone Livia Biancone Department of Systems Medicine University "Tor Vergata"00133 RomeItaly Department of Surgery University "Tor Vergata"00133 RomeItaly Radiology Unit Department of ImagingUniversity "Tor Vergata"00133 RomeItaly Pathology Unit University "Tor Vergata"00133 RomeItaly

AIM:To compare computed tomography enteroclysis(CTE) vs small intestine contrast ultrasonography(SICUS) for assessing small bowel lesions in Crohn's disease(CD),when using surgical pathology as gold ***:From January 2007 to July 2008,15 eligible patients undergoing elective resection of the distal ileum and coecum(or right colon) were prospectively *** patients were under *** study population included 6 males and 9 females,with a median age of 44 years(range:18-80 years).Inclusion criteria:(1) certain diagnosis of small bowel requiring elective ileo-colonic resection;(2) age between 18-80 years;(3) elective surgery in our Surgical Unit;and(4) written informed *** and CTE were performed ≤ 3 mo before surgery,followed by surgical *** following small bowel lesions were blindly reported by one sonologist,radiologist,surgeon and histolopathologist:disease site,extent,strictures,abscesses,fistulae,small bowel *** between findings at SICUS,CTE,surgical specimens and histological examination was made by assessing the specificity,sensitivity and accuracy of each technique,when using surgical findings as gold ***:Among the 15 patients enrolled,CTE was not feasible in 2 patients,due to urgent surgery in one patients and to low compliance in the second patient,refusing to perform CTE due to the discomfort related to the naso-jejunal *** analysis for comparing CTE vs SICUS findings was therefore performed in 13 out of the 15 CD patients *** from CTE,SICUS was feasible in all the 15 patients *** complications were observed when using SICUS or *** pathology findings in the tested population included:small bowel stricture in 13 patients,small bowel dilation above ileal stricture in 10 patients,abdominal abscesses in 2 patients,enteric fistulae in 5 patients,lymphnodes enlargement(> 1 cm) in 7 patients and mesenteric enlargement in 9 *** order to compare fi

关键词： Crohn's disease Ileal lesions Computed tomography enteroclysis Small intestine contrast ultrasonography Surgical findings

Vertically acquired hepatitis C virus infection:Correlates oftransmission and disease progression

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World Journal of Gastroenterology 2016年第4期22卷 1382-1392页

作者： Pier-Angelo Tovo carmelina Calitri Carlo Scolfaro Clara Gabiano Silvia Garazzino Department of Pediatrics School of MedicineUniversity of TorinoOspedale Infantile Regina MargheritaCittàdella Salute e della Scienza10126 TorinoItaly

The worldwide prevalence of hepatitis C virus(HCV)infection in children is 0.05%-0.4% in developed countries and 2%-5% in resource-limited settings, where inadequately tested blood products or un-sterile medical injections still remain important routes of infection. After the screening of blood donors, motherto-child transmission(MTCT) of HCV has become the leading cause of pediatric infection, at a rate of 5%. Maternal HIV co-infection is a significant risk factor for MTCT and anti-HIV therapy during pregnancy seemingly can reduce the transmission rate of both viruses. Conversely, a high maternal viral load is an important, but not preventable risk factor, because at present no anti-HCV treatment can be administered to pregnant women to block viral replication. Caution is needed in adopting obstetric procedures, such as amniocentesis or internal fetal monitoring, that can favor fetal exposure to HCV contaminated maternal blood, though evidence is lacking on the real risk of single obstetric practices. Mode of delivery and type of feeding do not represent significant risk factors for MTCT. Therefore, there is no reason to offer elective caesarean section or discourage breast-feeding to HCV infected parturients. Information on the natural history of vertical HCV infection is limited. The primary infection is asymptomatic in infants. At least one quarter of infected children shows a spontaneous viral clearance(SVC) that usually occurs within 6 years of life. IL-28 B polymorphims and genotype 3 infection have been associated with greater chances of SVC. In general, HCV progression is mild or moderate in children with chronic infection who grow regularly, though cases with marked liver fibrosis or hepatic failure have been described. Non-organ specific autoantibodies and cryoglobulins are frequently found in children with chronic infection, but autoimmune diseases or HCV associated extrahepatic manifestations are rare.

关键词： Hepatitis C virus Vertical transmission Riskfactors Spontaneous viral clearance Disease progression Pediatrics