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Gastrointestinal Kaposi's sarcoma: Case report and review of the literature

World Journal of Gastrointestinal Pharmacology and Therapeutics 2015年第3期6卷 89-95页

作者： Ann Joo Lee Lacie Brenner Bashar Mourad carmela monteiro Kenneth J Vega Juan Carlos Munoz Division of Gastroenterology Department of Medicine University of Florida College of Medicine Jacksonville Department of Medicine University of Florida College of Medicine Jacksonville Department of Pathology University of Florida College of Medicine Jacksonville Division of Digestive Diseases and Nutrition University of Oklahoma Health Sciences Center

Kaposi's sarcoma(KS) of the gastrointestinal tract is not an uncommon disease among individuals with acquired immunodeficiency syndrome(AIDS). The majority is asymptomatic, and for this reason, gastrointestinal KS(GI-KS) remains undiagnosed. With continued tumor growth, considerable variation in clinical presentation occurs including abdominal pain, nausea, vomiting, iron deficiency anemia(either chronic or frank gastrointestinal bleeding), and rarely mechanical obstruction alone or combined with bowel perforation. Endoscopy with biopsy allows for histological and immunohistochemical testing to confirm the diagnosis of GI-KS among those with clinical symptoms. In previous studies, dual treatment with highly active antiretroviral therapy and systemic chemotherapy have been associated with improved morbidity and mortality in individuals with visceral KS. Therefore, investigators have suggested performing screening endoscopies in select patients for early detection and treatment to improve outcome. In this review, we describe a 44 years old man with AIDS and cutaneous KS who presented for evaluation of postprandial abdominal pain, vomiting, and weight loss. On upper endoscopy, an extensive, infiltrative,circumferential, reddish mass involving the entire body and antrum of the stomach was seen. Histologic examination later revealed spindle cell proliferation, and confirmatory immunohistochemical testing revealed human herpes virus 8 latent nuclear antigen expression consistent with a diagnosis of gastric KS. Following this, we present a comprehensive review of literature on KS with emphasis on gastrointestinal tract involvement and management.

关键词： Kaposi sarcoma Acquired immunodeficiency syndrome Gastrointestinal endoscopy Epidemiology Gastrointestinal tumor symptoms

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Syndecans in Alzheimer's disease:pathogenetic mechanisms and potential therapeutic targets

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Neural Regeneration Research 2025年第9期20卷 2594-2595页

作者： carmela Rita Balistreri Roberto Monastero Cellular Molecular and Clinical Pathological LaboratoryDepartment of BiomedicineNeuroscience and Advanced Diagnostics(Bi.N.D.)University of PalermoPalermoItaly Memory and Parkinson’s disease Center Policlinico“Paolo Giaccone”PalermoDepartment of BiomedicineNeuroscience and Advanced Diagnostics(Bi.N.D.)University of PalermoVia La Loggia 1PalermoItaly

With increasing age,humans become more susceptible to the onset of neurodegenerative diseases(NDs),and among these,Alzheimer's disease(AD)is the most frequent(Nicoletti et al.,2023).NDs are primarily characterized by neuronal loss and atrophy,but also by lesions involving the cerebral and/or cardiovascular system(Balistreri,2021).Lesions such as macroinfa rcts,microinfarcts,hemorrhages,white matter lesions,atherosclerosis,and arteriolosclerosis have also been significantly described in the preclinical stages of cognitive impairment characterizing NDs(Mariani et al.,2007).

关键词： Alzheimer cardiovascular

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Squarefree Monomial Modules and Extremal Betti Numbers

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Algebra Colloquium 2016年第3期23卷 519-530页

作者： Marilena Crupi carmela Ferro University of Messina Department of Mathematics and Computer Science Viale Ferdinando Stagno d'Alcontres 31 Messina 98166 Italy

Let K be a field and let S = K[x1,...,xn] be a polynomial ring over K. Let F = ir=1 Sei be a finitely generated graded free S-module with basis {e1,..., er} in degrees f1,..., fr such that f1≤ f2 ~≤……≤ fr. We examine some classes of squarefree monomial submodules of F. Hence, we focalize our attention on the Betti table of such classes in order to analyze the behavior of their extremal Betti numbers.

关键词： graded modules squarefree monomial modules minimal graded resolutions

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Silybin and the liver: From basic research to clinical practice

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World Journal of Gastroenterology 2011年第18期17卷 2288-2301页

作者： carmela Loguercio Davide Festi Gastroenterology School-Interuniversity Research Centre on Foods Nutrition and Gastrointestinal Tract (CIRANAD) 2nd University of Naples Department of Clinical Medicine University of Bologna

Herbal products are increasingly used, mainly in chronic liver disease. Extracts of milk thistle, Silymarin and silybin, are the most prescribed natural compounds, with different indications, but with no definitive results in terms of clinical efficacy. This review analyzes the available studies on the effects of the purified product silybin, both as a free and a conjugated molecule, on liver cells or on experimentally induced liver damage, and in patients with liver disease. We searched PUBMED for articles pertaining to the in vitro and in vivo effects of silybin, its antifibrotic, anti-inflammatory, and antioxidant properties, as well as its metabolic effects, combined with the authors’ own knowledge of the literature. Results indicate that the bioavailability of silybin phytosome is higher than that of silymarin and is less influenced by liver damage; silybin does not show significant interactions with other drugs and at doses < 10 g/d has no significant side effects. Experimental studies have clearly demonstrated the antifibrotic, antioxidant and metabolic effects of silybin; previous human studies were insufficient for confirming the clinical efficacy in chronic liver disease, while ongoing clinical trials are promising. On the basis of literature data, silybin seems a promising drug for chronic liver disease.

关键词： Milk thistle Silymarin Liver disease Hepatic fibrosis Hepatic inflammation Radical species

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Fungal spores and pollen in particulate matter collected during agricultural activities in the Po Valley(Italy)

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Journal of Environmental Sciences 2016年第8期28卷 229-240页

作者： Chiara Telloli Milvia Chicca Marilena Leis carmela Vaccaro Italian National Agency for New Technologies Energy and Sustainable Economic Development (ENEA) Technical Unit for Environmental Assessment Models Methods and Technologies (UTVALAMB) Air Quality Laboratory (AIR) Department of Life Science and Biotechnologies Ferrara University Department of Physics and Earth Sciences Ferrara University

Airborne particulate matter（PM） containing fungal spores and pollen grains was sampled within a monitoring campaign of wheat threshing, plowing and sowing agricultural operations. Fungal spores and pollen grains were detected and identified on morphological basis. No studies were previously available about fungal spore and pollen content in agricultural PM in the Po Valley. Sampling was conducted in a Po Valley farmland in Mezzano（Ferrara, Italy）. The organic particles collected were examined by scanning electron microscopy with energy dispersive X-ray spectrometer. Fungal spores and pollen grains were identified when possible at the level of species. The most frequent components of the organic particles sampled were spores of Aspergillus sp., which could represent a risk of developing allergies and aspergillosis for crop farmers.

关键词： Wheat Aspergillosis Emilia-Romagna Morphology SEM–EDS

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Investigations of a nanostructured FeMnSi shape memory alloy produced via severe plastic deformation

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International Journal of Minerals,Metallurgy and Materials 2016年第11期23卷 1315-1322页

作者： Gheorghe Gurau carmela Gurau Vedamanickam Sampath Leandru Gheorghe Bujoreanu Faculty of Engineering "Dun?rea de Jos" University of Galati Department of Metallurgical and Materials Engineering Indian Institute of Technology Madras Faculty of Materials Science and Engineering "Gheorghe Asachi" Technical University of Ia?i

Low-cost iron-based shape memory alloys（SMAs） show great potential for engineering applications. The developments of new processing techniques have recently enabled the production of nanocrystalline materials with improved properties. These developments have opened avenues for newer applications for SMAs. The influence of severe plastic deformation induced by the high-speed high-pressure torsion（HSHPT） process on the microstructural evolution of an Fe–Mn–Si–Cr alloy was investigated. Transmission electron microscopic analysis of the alloy revealed the existence of nanoscale grains with an abundance of stacking faults. The high density of dislocations characteristic of severe plastic deformation was not observed in this alloy. X-ray diffraction studies revealed the presence of ε-martensite with an HCP crystal structure and γ-phase with an FCC structure.

关键词： iorn manganese silicon alloys shape memory effect nanostructured materials martensite plastic deformation

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Groups with Supersoluble Non-normal Subgroups

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Algebra Colloquium 2016年第2期23卷 213-218页

作者： Maria De Falco Maria Martusciello carmela Musella Dipartimento di Matematica e Applicazioni Universita di Napoli Federico II Complesso Universitario Monte S. Angelo Via Cintia 1-80126 Napoli Italy

The structure of groups in which many subgroups have a certain property X has been investigated for several choices of the property χ.In particular, groups whose non-normal subgroups are supersoluble are studied ia t... 详细信息

关键词： supersoluble group polycyclic group normalizer subgroup

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Cretaceous alkaline volcanism in south Marzanabad,northern central Alborz,Iran:Geochemistry and petrogenesis

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Geoscience Frontiers 2016年第6期7卷 937-951页

作者： Roghieh Doroozi carmela Vaccaro Fariborz Masoudi Riccardo Petrini Faculty of Earth Science Shahid Beheshti UniversityVelenjakTehranlran Department of Mineralogy University of FerraraCorso Ercole I d'Este 3244100 FerraraItaly Department of Mathematics and Geosciences University of TriesteVia Weiss8-34100 TriesteItaly

The alkali-basalt and basaltic trachy-andesites volcanic rocks of south Marzanabad were erupted during Cretaceous in central Alborz, which is regarded as the northern part of the Alpine-Himalayan orogenic belt. Based on petrography and geochemistry, en route fractional crystallization of ascending magma was an important process in the evolution of the volcanic rocks. Geochemical characteristics imply that the south Marzanabad alkaline basaltic magma was originated from the asthenospheric mantle source, whereas the high ratios of （La/Yb）N and （Dy/Yb）N are related to the low degree of partial melting from the garnet bearing mantle source. Enrichment pattern of Nb and depletion of Rb, K and Y, are similar to the OIB pattern and intraplate alkaline magmatic rocks. The K/Nb and Zr/Nb ratios of volcanic rocks range from 62 to 588 and from 4.27 to 9 respectively, that are some higher in more evolved samples which may reflect minor crustal contamination. The isotopic ratios of Sr and Nd respectively vary from 0.70370 to 0.704387 and from 0.51266 to 0.51281 that suggest the depleted mantle as a magma source. The development of south Marzanabad volcanic rocks could be related to the presence of extensional phase, upwelling and decompressional melting of asthenospheric mantle in the rift basin which made the alkaline magmatism in Cretaceous, in northern central Alborz of lran.

关键词： Volcanic rocks Cretaceous Marzanabad Central Alborz Iran

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Silymarin: An option to treat non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2017年第47期23卷 8437-8438页

作者： carmela Colica Luigi Boccuto Ludovico Abenavoli CNR IBFM UOS of GermanetoUniversity“Magna Graecia” Research Department Greenwood Genetic CenterSchool of Health ResearchClemson University Department of Health Sciences University Magna GraeciaCampus GermanetoViale Europa

We have read with a great interest the review published by Singh et al, on the treatment options in alcoholic and non-alcoholic fatty liver disease, including various new targeted therapies that are currently under investigation. Recently, we described the health effects of the Mediterranean diet associated to an antioxidant complex rich in silymarin, to improve in overweight patients anthropometric parameters, glucose and lipid metabolism and intra-hepatic fat accumulation.

关键词： Mediterranean diet Antioxidant Silymarin Non-alcoholic fatty liver disease

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Properties of agricultural aerosol released during wheat harvest threshing,plowing and sowing

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Journal of Environmental Sciences 2014年第9期26卷 1903-1912页

作者： Chiara Telloli Antonella Malaguti Mihaela Mircea Renzo Tassinari carmela Vaccaro Massimo Berico ENEA National Agency for New TechnologiesEnergy and Sustainable Economic DevelopmentVia Martiri di Monte Sole 4Bologna 40129Italy Department of Earth Science Ferrara UniversityItaly

This study shows for the first time a chemical and morphological characterization of agricultural aerosols released during three important agricultural operations： threshing, plowing and sowing. The field campaigns were carried out in the eastern part of the Po Valley, Italy, in summer and autumn 2009. The aerosol particles were sampled on quartz fiber filters and polytetrafluoroethylene membranes in order to allow Inductively Coupled Plasma Mass Spectrometry （ICP-MS） analysis and Scanning Electron Microscopy equipped with an Energy Dispersive X-ray Spectrometer （SEM-EDS） investigations, respectively. The organic carbon mass concentrations were measured with a Sunset Laboratory Dual-Optical Organic Carbone/Elemental Carbon （OCEC） Aerosol analyzer. The morphological and chemical analyses by SEM-EDS allowed recognizing four main particle classes： organic, silica, calcite and clay minerals. The organic particles contribute to both fine and coarse aerosol fractions up to ca. 50% for all three agricultural activities. This was also confirmed by OCEC analysis for fine fraction. Most of the agricultural aerosols, about 60%, were single particles and the remaining 40% were agglomerations of particles. The ICP-MS results showed that threshing and plowing produce more aerosol particles than sowing, which was characterized by important amounts of clay minerals produced from land soils.

关键词： AerosolAgricultureSEM-EDSICP-MS and OCEC analyses

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