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Silymarin: An option to treat non-alcoholic fatty liver disease

World Journal of Gastroenterology 2017年第47期23卷 8437-8438页

作者： carmela colica Luigi Boccuto Ludovico Abenavoli CNR IBFM UOS of GermanetoUniversity“Magna Graecia” Research Department Greenwood Genetic CenterSchool of Health ResearchClemson University Department of Health Sciences University Magna GraeciaCampus GermanetoViale Europa

We have read with a great interest the review published by Singh et al, on the treatment options in alcoholic and non-alcoholic fatty liver disease, including various new targeted therapies that are currently under investigation. Recently, we described the health effects of the Mediterranean diet associated to an antioxidant complex rich in silymarin, to improve in overweight patients anthropometric parameters, glucose and lipid metabolism and intra-hepatic fat accumulation.

关键词： Mediterranean diet Antioxidant Silymarin Non-alcoholic fatty liver disease

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Non-Conventional MRI Techniques as an Alternative Role to the Clinical Diagnosis in Alzheimer’s Disease

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Health 2014年第19期6卷 2712-2723页

作者： Elisabetta Giugni Rita Vadalà Francesca Romana Pezzella Giuseppe Bomboi Stefano Galletti Giacomo Luccichenti carmela colica Orietta Picconi Stefano Bastianello European Biomedical Foundation Onlus Rome Italy IRCCS Santa Lucia Foundation Rome Italy Stroke Unit AOS Camillo-Forlanini Hospital Rome Italy Neurology Unit—II Faculty of Medicine—“Sapienza” University of Rome Rome Italy CNR—ISN—UOS Pharmacology Roccelletta di Borgia Catanzaro Italy Opera S.r.l. Genova Italy Department of Brain and Behavioral Sciences University of Pavia Pavia Italy

Improved methods for early diagnosis and non-invasive surrogates for the diagnosis of disease severity in Alzheimer’s disease (AD) are becoming the new challenge. Dementia can now be accurately determined through clinical evaluation, cognitive screening, basic laboratory evaluation and structural imaging. Magnetic resonance (MRI) techniques are being evaluated as possible surrogate measures to monitor disease progression. The purpose of this work is to correlate the results of combined advanced MR techniques with neuropsychological performance in order to identify a sensible and sensitive imaging approach to quantify neurodegenerative disease progression. One of the most relevant evidences in our study is the degeneration of the fibers of the corpus callosum in the pathogenesis of cognitive disorders in AD patients, as demonstrated by the relationship between altered neuropsychological tests and reduced FA (Fractional Anisotrophy) values of the corpus callosum in such patients. This data is also integrated by the evidence of anatomic reduction of the total volume of the corpus callosum assessed by FreeSurfer, thus supporting the hypothesis that the “brain disconnects” play a key role in the pathogenesis of AD. Statistical evaluation of regression consisting in the identification of different numerical coefficients that are multiplied by the thickness of the right fusiform value or by the volume of left inferoparietal region and left middle-temporal region, allows us to obtain the predictive numeric value of the related neuropsychological test. Combination of non-conventional magnetic resonance imaging, including morphometry, spectroscopy, MD (mean diffusivity) and FA evaluation, could be an alternative to clinic in the evaluation of neurodegeneration in AD.

关键词： Alzheimer’s Disease (AD) Non Conventional MRI Technique MRI Reproducible Marker

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