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Rifaximin on epigenetics and autophagy in animal model of hepatocellular carcinoma secondary to metabolic-dysfunction associated steatotic liver disease

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World Journal of Hepatology 2024年第1期16卷 75-90页

作者： Matheus Truccolo Michalczuk Larisse Longo Melina Belén Keingeski Bruno de Souza Basso Gabriel Tayguara Silveira Guerreiro Jessica T Ferrari JoséEduardo Vargas Cláudia P Oliveira Carolina Uribe-Cruz Carlos Thadeu Schmidt Cerski Eduardo Filippi-Chiela Mário ReisÁlvares-da-Silva Division of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Graduate Program in Gastroenterology and Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Experimental Laboratory of Hepatology and Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Laboratory of Inflammatory and neoplastic Cells Universidade Federal do ParanáParaná81530900Brazil Department of Gastroenterology(LIM07) Faculdade de Medicina da Universidade de São PauloSão Paulo 01246903Brazil Facultad de Ciencias de la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Unit of Surgical Pathology Hospital de Clinicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Center of Biotechnology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Department of Morphological Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90.050-170Rio Grande do SulBrazil Conselho nacional de Desenvolvimento Científico e Tecnológico(CnPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)ResearcherBrasília 71.605-001Brazil

BACKGROUnD Prevalence of hepatocellular carcinoma(HCC)is increasing,especially in patients with metabolic dysfunctionassociated steatotic liver disease(MASLD).AIM To investigate rifaximin(RIF)effects on epigenetic/autophagy markers in *** Adult Sprague-Dawley rats were randomly assigned(n=8,each)and treated from 5-16 wk:Control[standard diet,water plus gavage with vehicle(Veh)],HCC[high-fat choline deficient diet(HFCD),diethylnitrosamine(DEn)in drinking water and Veh gavage],and RIF[HFCD,DEn and RIF(50 mg/kg/d)gavage].Gene expression of epigenetic/autophagy markers and circulating miRnAs were *** All HCC and RIF animals developed metabolic-dysfunction associated steatohepatitis fibrosis,and cirrhosis,but three RIF-group did not develop *** animals who developed HCC with those who did not,miR-122,miR-34a,tubulin alpha-1c(Tuba-1c),metalloproteinases-2(Mmp2),and metalloproteinases-9(Mmp9)were significantly higher in the *** opposite occurred with Becn1,coactivator associated arginine methyltransferase-1(carm1),enhancer of zeste homolog-2(Ezh2),autophagy-related factor LC3A/B(Map1 Lc3b),and p62/sequestosome-1(p62/SQSTM1)-*** with controls,Map1 Lc3b,Becn1 and Ezh2 were lower in HCC and RIF-groups(Pcarm1 was lower in HCC compared to RIF(Pn of Mmp9 was higher in HCC in relation to the control;the opposite was observed for p62/Sqstm1(Pn of p62/SQSTM1 protein was lower in the RIF-group compared to the control(P=0.024).There was no difference among groups for Tuba-1c,Aldolase-B,alpha-fetoprotein,and Mmp2(P>0.05).miR-122 was higher in HCC,and miR-34a in RIF compared to controls(Pn HCC compared to RIF,and the inverse was observed for miR-224(Pno difference among groups regarding miR-33a,miR-143,miR-155,miR-375 and miR-21(P>0.05).COnCLUSIOn RIF might have a possible beneficial effect on preventing/delaying liver carcinogenesis throu

关键词： Animal model Autophagy Epigenetic Hepatocellular carcinoma Metabolic dysfunction-associated steatotic liver disease Rifaximin

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阿根廷的地震危险性

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地震学刊 1995年第A期15卷 111-113页

作者： carm.,JS 杨心平

1 地震危险性评定历史在执行SISRA计划期间(1985),编制了最大地震烈度图(图1)。阿根廷在过去的数十年里,开展了下列加强地震危险性评定和研究工作。(1)国家抗震建筑规范的修订和改进;(2)大型水坝、水电站和核电站的设计和建设;(3)高地... 详细信息

1 地震危险性评定历史在执行SISRA计划期间(1985),编制了最大地震烈度图(图1)。阿根廷在过去的数十年里,开展了下列加强地震危险性评定和研究工作。(1)国家抗震建筑规范的修订和改进;(2)大型水坝、水电站和核电站的设计和建设;(3)高地震危险区的城市地震小区划的研究。1965年,国家建筑规范采用了第一幅地震区划图(C.I.n.E.H,1966)。最近进行了修改。图2为阿根廷国家建筑规范最近所提供的地震危险性图.

关键词：地震危险性阿根廷

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Downregulation of the Basic Peroxidase Isoenzyme from Zinnia elegans by Gibberellic Acid

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Journal of Integrative Plant Biology 2010年第2期52卷 244-251页

作者： María Josefa López núez-Flores Jorge Gutirrez Laura V.Gómez-Ros Esther novo Uzal Mariana Sottomayor Alfonso Ros Barceló Department of Plant Biology University of MurciaE-30100MurciaSpain Department of Plant Biology University of La CoruaE-15071La CorunaSpain IBMC University of Porto4150 PortoPortugal

Hypocotyl formation during the epigeal germination of seedlings is under strict hormonal regulation. In a 3 d old Zinnia elegans seedling system, gibberellic acid （GA3） exerts an opposite effect to that exerted by light on hypocotyl photomorphogenesis because GAz promotes an etiolated-like growth with an inhibition of radial （secondary） growth. For this reason, the effect of GA3 on the basic peroxidase isoenzyme from Z. elegans （ZePrx）, an enzyme involved in hypocotyl lignin biosynthesis, was studied. The results showed that GA3 reduces ZePrx activity, similarly to the way in which it reduces seedling secondary growth. This hormonal response is supported by the analysis of the ZePrx promoter, which contains four types of GA3-responsive ***： the W Box/O2S; the Pyr Box; the GARE; and the Amy Box. Taken together, these results suggest that ZePrx is directly regulated by GA3, with this effect matching the inhibitory effect of GA on the hypocotyl secondary growth.

关键词： GA Downregulation of the Basic Peroxidase Isoenzyme from Zinnia elegans by Gibberellic Acid cis Figure

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