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Enzalutamide Associated with stevens-johnson Syndrome/Toxic Epidermal Necrolysis (SjS/TEN) Overlap: A Case Report

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Surgical Science 2021年第12期12卷 421-426页

作者： Sharjeel Israr Christopher R. Mellon Haley j. Springs Asia N. Quan Marc R. Matthews Department of General Surgery Creighton University School of Medicine Phoenix Campus St. Joseph Hospital and Medical Center Phoenix AZ USA Honor Health Medical Center Department of Surgery Scottsdale AZ USA Department of General Surgery Honor Health John C. Lincoln Medical Center Phoenix AZ USA Department of Pharmacy Valleywise Health Medical Center Phoenix AZ USA The Arizona Burn Center Phoenix AZ USA

Enzalutamide is a hormonal therapy that blocks the action of androgens, such as testosterone in the treatment of metastatic castration-resistant prostate cancer. stevens-johnson syndrome and toxic epidermal necrolysis... 详细信息

Enzalutamide is a hormonal therapy that blocks the action of androgens, such as testosterone in the treatment of metastatic castration-resistant prostate cancer. Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) overlap and are part of an adverse drug reaction continuum of disease, in which there is a 10% - 30% involvement of the skin surface with mucositis, blisters, skin slough, and a macular rash. A 66-year-old male was treated with enzalutamide for metastatic prostate cancer and developed SJS/TEN overlap with 25% total body surface area skin involvement. The patient received a seven-day course of cyclosporine to which he responded by re-epithelialization but succumbed to multi-organ failure. While SJS/TEN has been reported with apalutamide, to our knowledge, this is the first case of SJS/TEN overlap with enzalutamide.

关键词： Prostate Cancer Enzalutamide stevens-johnson Syndrome Toxic Epidermal Necrolysis SjS/TEN

Search for the doubly charmed baryon ■

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Science China(Physics,Mechanics & Astronomy) 2020年第2期63卷 8-22页

作者： R.Aaij C.Abellán Beteta T.Ackernley B.Adeva M.Adinolfi H.Afsharnia C.A.Aidala S.Aiola Z.Ajaltouni S.Akar P.Albicocco j.Albrecht F.Alessio M.Alexander A.Alfonso Albero G.Alkhazov P.Alvarez Cartelle A.A.Alves jr S.Amato Y.Amhis L.An L.Anderlini G.Andreassi M.Andreotti F.Archilli j.Arnau Romeu A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier S.Bachmann j.j.Back S.Baker V.Balagura W.Baldini A.Baranov R.j.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov G.Bassi V.Batozskaya B.Batsukh A.Battig V.Battista A.Bay M.Becker F.Bedeschi I.Bediaga A.Beiter L.j.Bel V.Belavin S.Belin N.Beliy V.Bellee K.Belous I.Belyaev G.Bencivenni E.Ben-Haim S.Benson S.Beranek A.Berezhnoy *** D.Berninghoff H.C.Bernstein E.Bertholet A.Bertolin C.Betancourt F.Betti M.O.Bettler Ia.Bezshyiko S.Bhasin j.Bhom M.S.Bieker S.Bifani P.Billoir A.Birnkraut A.Bizzeti M.Bjφrn M.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska V.Bocci O.Boente Garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar S.Borghi M.Borisyak M.Borsato j.T.Borsuk T.j.V.Bowcock C.Bozzi S.Braun A.Brea Rodriguez M.Brodski j.Brodzicka A.Brossa Gonzalo D.Brundu E.Buchanan A.Buonaura C.Burr A.Bursche j.S.Butter j.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese S.Cali R.Calladine M.Calvi M.Calvo Gomez A.Camboni P.Campana D.H.Campora Perez L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini P.Carniti K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero R.Cenci j.Cerasoli M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis M.Chefdeville V.Chekalina C.Chen S.Chen A.Chernov S.-G.Chitic V.Chobanova M.Chrzaszcz A.Chubykin P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek F.Cindolo P.E.L.Clarke M.Clemencic H.V.Cliff j.Closier j.L.Cobbledick V.Coco j.A.B.Coelho j.Cogan E.Cogneras L.Cojocariu P.Collins T.Colombo A.Comerma-Montells A.Contu N.Cooke G.Coombs S.Coquereau G.Corti C.M.Costa Sobral B.Couturier D.C.Craik j.Crkovska A.Crocombe M.Cruz Torres R.Currie C.L.Da Silva E.Dall'Occo j.Dalseno C.D'Ambrosio A.Danilina P.d'Argent A.Davis O.De Aguiar Francisco K.De Bruyn S.De Capua M Centro Brasileiro de Pesquisas Fisicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de janeiro(UFRj) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of Sciences BeijingChina Institute Of High Energy Physics(IHEP) BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIN2P3-LAPPAnnecyFrance Universite Clermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance LAL Univ.Paris-SudCNRS/IN2P3Universite Paris-SaclayOrsayFrance LPNHE Sorbonne Universite Paris Diderot Sorbonne Paris Cite CNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano-Bicocca MilanoItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Cagliari MonserratoItaly INFN Sezione di Padova PadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma Tor Vergata RomaItaly INFN Sezione di Roma La Sapienza RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of Sciences KrakowPoland AGH-University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakowPoland Natio

A search for the doubly charmed baryon ■^+cc is performed through its decay to theΛ^+c K^-π^+ final state,using proton-proton collision data collected with the LHCb detector at centre-of-mass energies of 7,8 and 13 *** data correspond to a total integrated luminosity of 9 fb^-*** significant signal is observed in the mass range from 3.4 to 3.8 GeV/c^*** limits are set at 95%credibility level on the ratio of the ■^+cc production cross-section times the branching fraction to that ofΛ^+c and ■^++cc *** limits are determined as functions of the ■^+cc mass for different lifetime hypotheses,in the rapidity range from 2.0 to 4.5 and the transverse momentum range from 4 to 15 GeV/c.

关键词： charmed baryons limits on production of particles charmed quarks experimental tests

Measurement of Ξcc++ production in pp collisions at s1/2=13 TeV

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Chinese Physics C 2020年第2期44卷 13-23页

作者： R.Aaij C.Abellán Beteta T.Ackernley B.Adeva M.Adinolfi H.Afsharnia C.A.Aidala S.Aiola Z.Ajaltouni S.Akar P.Albicocco j.Albrecht F.Alessio M.Alexander A.Alfonso Albero G.Alkhazov P.Alvarez Cartelle A.A.Alves jr S.Amato Y.Amhis L.An L.Anderlini G.Andreassi M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier S.Bachmann j.j.Back S.Baker V.Balagura W.Baldini A.Baranov R.j.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov j.M.Basels G.Bassi V.Batozskaya B.Batsukh A.Battig A.Bay M.Becker F.Bedeschi I.Bediaga A.Beiter L.j.Bel V.Belavin S.Belin V.Bellee K.Belous I.Belyaev G.Bencivenni E.Ben-Haim S.Benson S.Beranek A.Berezhnoy *** D.Berninghoff H.C.Bernstein C.Bertella E.Bertholet A.Bertolin C.Betancourt F.Betti M.O.Bettler Ia.Bezshyiko S.Bhasin j.Bhom M.S.Bieker S.Bifani P.Billoir A.Bizzeti M.Bjørn M.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska V.Bocci O.Boente Garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar S.Borghi M.Borisyak M.Borsato j.T.Borsuk T.j.V.Bowcock C.Bozzi M.j.Bradley S.Braun A.Brea Rodriguez M.Brodski j.Brodzicka A.Brossa Gonzalo D.Brundu E.Buchanan A.Buonaura C.Burr A.Bursche A.Butkevich j.S.Butter j.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese L.Calero Diaz S.Cali R.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes A.Camboni P.Campana D.H.Campora Perez A.F.Campoverde Quezada L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini I.Carli P.Carniti K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero S.Celani R.Cenci j.Cerasoli M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis M.Chefdeville V.Chekalina C.Chen S.Chen A.Chernov S.-G.Chitic V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek F.Cindolo P.E.L.Clarke M.Clemencic H.V.Cliff j.Closier j.L.Cobbledick V.Coco j.A.B.Coelho j.Cogan E.Cogneras L.Cojocariu P.Collins T.Colombo A.Comerma-Montells A.Contu N.Cooke G.Coombs S.Coquereau G.Corti C.M.Costa Sobral B.Couturier D.C.Craik j.Crkovska A.Crocombe M.Cruz Torres R.Currie C.L.Da Silva E.Dall'Occo j.Dalseno C.D' Centro Brasileiro de Pesquisas Físicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de janeiro(UFRj) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of Sciences BeijingChina Institute Of High Energy Physics(IHEP) BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIN2P3-LAPPAnnecyFrance UniversitéClermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance LAL Univ.Paris-SudCNRS/IN2P3UniversitéParis-SaclayOrsayFrance LPNHE Sorbonne UniversitéParis Diderot Sorbonne Paris CitéCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultät Physik Technische Universität DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universität HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano-Bicocca MilanoItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Cagliari MonserratoItaly INFN Sezione di Padova PadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma Tor Vergata RomaItaly INFN Sezione di Roma La Sapienza RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of Sciences KrakówPoland AGH-University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakówPoland Nationa

The production of ■baryons in proton-proton collisions at a centre-of-mass energy of √s = 13 TeV is measured in the transverse-momentum range 4 详细信息

The production of ■baryons in proton-proton collisions at a centre-of-mass energy of √s = 13 TeV is measured in the transverse-momentum range 4

关键词： doubly charmed baryons hadron production QCD

Acute lung injury in mechanically ventilated patients with epidermal necrolysis:an exposed-unexposed retrospective cohort study

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Burns & Trauma 2020年第1期8卷 30-33页

作者： S.Lalevée j.Catano S.Ingen-Housz-Oro M.Surenaud j.Tran Van Nhieu F.Schlemmer I.Bendib A.Mekontso-Dessap S.Hue N.de Prost Service de dermatologie AP-HPhoital Henri MondorCréteilFrance UniversitéParis Est Créteil INSERM U955IMRBF-94010 CréteilFrance Service de Médecine Intensive Réanimation Hoitaux Universitaires Henri MondorAssistance Publique-Hoitaux de ParisCréteil Cedex 94010France EA7379 EpidermE UPECCréteilFrance Centre de référence des dermatoses bulleuses toxiques et toxidermies graves TOXIBUL CréteilFrance Service d’Anatomopathologie AP-HPhoital Henri MondorCréteilFrance Unitéde Pneumologie Service de Médecine Intensive RéanimationHoitaux Universitaires Henri MondorAssistance Publique-Hoitaux de ParisCréteil Cedex 94010France Groupe de Recherche Clinique CARMAS Facultéde Santéde CréteilUniversitéParis Est CréteilCréteil Cedex 94010France AP-HP Département d’Hématologie et d’Immunologie biologiquesGroupe hospitalouniversitaire Chenevier MondorAssistance Publique-Hoitaux de Paris F-94010 CréteilFrance

To the Editor,During the acute phase of epidermal necrolysis(EN,including stevens-johnson syndrome and toxic epidermal necrolysis),mucosal lesions involving the tracheo-bronchial tract have been reported[1,2]and approximately one in four EN patients develop acute respiratory failure and require endotracheal intubation and mechanical ventilation(MV)support[3].Asymptomatic respiratory sequelae may be detected on pulmonary function tests after the acute phase in as much as 50%of EN patients,possibly related to pulmonary lesions that occurred at the acute phase[4].

关键词： acute patients respiratory

包膜挛缩的危险因素分析：一项SIENTRA圆形光面及毛面假体隆乳术的5年研究分析

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中国美容整形外科杂志 2014年第2期25卷 J0010-J0016页

作者： W. Grant stevens Maurice Y. Nahabedian M. Bradley Calobrace jennifer L. Harrington Peter j.Capizzi Robert Cohen Rosalyn C. d'Incelli Maggi Beckstrand 魏峰(译) 高景恒(译) 张晨(译) 美国加利福尼亚州玛丽安德尔湾玛丽安整形外科联合会圣巴巴拉SIENTRA有限公司《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科

背景与目的尽管有一些广泛认可的相关因素，但导致包膜挛缩的多层面的因素在近几十年内仍未解决。本研究将调查首次隆乳术患者导致包膜挛缩的一些潜在危险因素。方法本研究资料包含2560例首次隆乳术患者，假体5109只，由34位医师在5年... 详细信息

背景与目的尽管有一些广泛认可的相关因素，但导致包膜挛缩的多层面的因素在近几十年内仍未解决。本研究将调查首次隆乳术患者导致包膜挛缩的一些潜在危险因素。方法本研究资料包含2560例首次隆乳术患者，假体5109只，由34位医师在5年内施行的SIENTRA临床研究结果。患者每年随访一次，记录包膜挛缩的Baker分级。潜在危险因素包括患者属性、假体属性、手术特征、腔隙冲洗和术后特征，对其进行频率和多变量模型分析。结果在5年中，共有179例患者的265只乳房假体发生包膜挛缩。由假体产生的包膜挛缩的总体Kaplan—Meier概率为7．6％。未调整的分析显示，以下因素会增加包膜挛缩的发生概率：光面假体、环乳晕切口、乳腺下层面置入、抗生素及类固醇腔隙冲洗、被建议按摩及外科胸罩（P值均〈0．05）。将所有危险因素调整为模型中的变量，其多变量分析的结果发现6种因素与包膜挛缩有独立关联（假体置入层次、假体表面、切口位置、血肿或血清肿发展、假体尺寸及外科胸罩；P值均〈0．05）。结论本研究分析证实，排除其他因素的情况下，肌肉下层次置人和选择毛面假体可显著减少包膜挛缩的发生。

关键词：潜在危险因素假体隆乳术包膜挛缩多变量分析圆形模型分析发生概率假体置入

低剂量CT筛查肺癌停车场预试验使英国向全国筛查又迈进了一步

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英国医学杂志中文版 2018年第11期21卷 619-620页

作者： David R Baldwin Kevin ten Haaf janette Rawlinson NCRI Lung Cancer Matthew E j Callister 彭伦希(译) 吴一龙(校) University of Nottingham Respiratory Medicine Unit Nottingham University HospitalsNottinghamUK Erasmus MC Department of Public Health RotterdamNetherlands Macmillan and Roy Castle Lung Cancer Foundation SandwellUK St james's University Hospital LeedsUK 南方医科大学广东省人民医院广东省人民医院

英格兰国家健康体系(NHS)的领导人Simon stevens最近宣布,计划将预试验方案扩大——在超市的停车场提供肺癌筛查。在发达国家,肺癌导致的死亡人数比乳腺癌和肠癌加起来还要多.这个扩大方案不可避免地会揭示出肺癌全国范围筛查存在的问题。

关键词：停车场肺癌筛查低剂量预试验 CT 英国 Simon

Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma

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Frontiers of Medicine 2021年第2期15卷 275-291页

作者： Na Qin Yuancheng Li Cheng Wang Meng Zhu juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan john KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean jHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria Lstevens Guangfu jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166China State Key Laboratory of Reproductive Medicine Center for Global HealthNanjing Medical UniversityNanjing 211166China Department of Bioinformatics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjing 211166China jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer MedicineNanjing Medical UniversityNanjing 211166China China International Cooperation Center for Environment and Human Health School of Public HealthNanjing Medical UniversityNanjing 211166China Division of Cancer Epidemiology and Genetics National Cancer InstituteBethesdaMD 20892-9304USA Department of Integrative Oncology British Columbia Cancer AgencyVancouverBC V5Z 1L3Canada Faculty of Medicine University of Oviedo and CIBERESPOviedo 33006Spain Program in Epidemiology Public Health Sciences DivisionFred Hutchinson Cancer Research CenterSeattleWA 98109-1024USA Public Health Sciences Division Swedish Cancer InstituteSeattleWA 98026USA Department of Clinical Biochemistry Copenhagen University HospitalCopenhagen DK-1017Denmark National Cancer Institute BethesdaMD 20892-9304USA Genetic Epidemiology Group International Agency for Research on CancerLyon 69372France Cancer Center Cluster Salzburg at PLUS Department of Molecular BiologyUniversity of SalzburgHeidelberg 5020Austria Institute of Medical Informatics Biometry and EpidemiologyChair of EpidemiologyLudwig Maximilians UniversityMunichBavaria 80539Germany Department of Genetic Epidemiology University Medical Center GoettingenGoettingen 37075Germany Technion Faculty of Medicine Carmel Medical CenterHaifa 3448516Israel Markey Cancer Center University of KentuckyLexingtonKY 40506-0054USA Department of Molecular and Clinical Cancer Medicine Roy Castle Lung Cancer Research ProgrammeThe University of Liverpool Institute of Translational MedicineLiverpool L697Z

Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely *** integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility *** identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive *** factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was *** annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency *** results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments.

关键词： lung cancer genome-wide association study function annotation immune homologous recombination repair deficiency genetic heterogeneity

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气体法测定有效孔隙率

石油实验地质 1965年第1期 39-40页

作者： j.W.阿密克斯,李汉忠美

(一) stevens孔隙计是测定有效颗粒体积的一个方法,如图2—10:仪器中的一个岩心室可与大气压力严密隔离,并通过一个针形真空阀与孔隙计的其他部分分隔开,岩心室体积是预先精确测定的,在工作时岩心放在岩心室中,

关键词：孔隙计孔隙体积岩心岩芯颗粒体积孔隙率孔隙度

Microbiological Status and Nutritional Composition of Spices Used in Food Preparation

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Food and Nutrition Sciences 2015年第12期6卷 1134-1140页

作者： Khalil I. Ereifej Hao Feng Taha M. Rababah Sufyan H. Tashtoush Muhammad H. Al-U’datt Ghaid j. Al-Rabadi Peter Torley Malek Alkasrawi Department of Food Science and Human Nutrition University of Illinois Urbana-Champaign Urbana USA Faculty of Agriculture Jordan University of Science and Technology Irbid Jordan Department of Animal Production Faculty of Agriculture Mutah University Al-Karak Jordan School of Applied Science RMIT University Melbourne Australia Engineering Department Stevens Point University of Wisconsin Stevens Point USA

The present study showed significant initial microbial load, as well nutritional value of ten spices used widely across the world in food preparation. The microbiological tests demonstrated that sumac and cloves had the highest antimicrobial activity with respect to total plate counting and spore forming count. Results showed that chemical composition of the spices and herbs varied significantly. Dry matter content ranged between 83.6% and 92.4%. The highest ash content 10.4% was found in sweet cumin, protein 21.2% in cumin, fat 19.7% in sumac, fiber 59.2% in turmeric and carbohydrates 27.3% in sumac. These spices were also differing in their minerals content. Substantial amounts of Ca, Na, K and Mg were found, while Cu, Fe, P, Mn and Zn were present in trace amounts in all investigated spices.

关键词： Microbial Status Minerals Proximate Chemical Composition Spices